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1. 发明申请

WO2004096344A3 IMPLANTABLE LEAD-BASED SENSOR POWERED BY PIEZOELECTRIC TRANSFORMER 审中-公开
标题翻译：由压电变压器驱动的基于导线的传感器
公开(公告)号：WO2004096344A3
公开(公告)日：2005-01-27
申请号：PCT/US2004009842
申请日：2004-03-31
申请人： MEDTRONIC INC , HOUBEN RICHARD P M , CHRISTOPHERSON MARK A , DONDERS ADRIANUS P , LEINDERS ROBERT , DENO CURTIS D
发明人： HOUBEN RICHARD P M , CHRISTOPHERSON MARK A , DONDERS ADRIANUS P , LEINDERS ROBERT , DENO CURTIS D
IPC分类号： A61N1/08 , A61N1/365 , A61N1/362 , A61N1/05
CPC分类号： A61N1/08 , A61N1/36542
摘要： In general, the invention is directed to an IMD having a piezoelectric transformer to power a lead-based sensor. The IMD powers the piezoelectric transformer with a low amplitude signal. The piezoelectric transformer serves to convert the voltage level of the low amplitude signal to a higher voltage level to drive the sensor. produced by a battery in the IMD to voltage levels appropriate for IMD operation. A piezoelectric transformer offers small size and low profile, as well as operational efficiency, and permits the IMD to transmit a low amplitude signal to a remote sensor deployed within an implantable lead. In addition, the piezoelectric transformer provides electrical isolation that reduces electromagnetic interference among different sensors.
摘要翻译：通常，本发明涉及具有压电变压器以为基于铅的传感器供电的IMD。 IMD用低幅度信号为压电变压器供电。压电变压器用于将低振幅信号的电压电平转换为更高的电压电平以驱动传感器。由IMD中的电池产生的电压水平适合于IMD操作。压电变压器提供小尺寸和低轮廓以及操作效率，并允许IMD将低振幅信号传输到部署在可植入导线内的远程传感器。此外，压电变压器提供电隔离，减少不同传感器之间的电磁干扰。

2. 发明专利

DE60325199D1 未知
公开(公告)号：DE60325199D1
公开(公告)日：2009-01-22
申请号：DE60325199
申请日：2003-03-25
申请人： MEDTRONIC INC
发明人： TORGERSON NATHAN A , GOBLISH TODD P , LEINDERS ROBERT , STEIN MARC T , RODRIQUEZ JOHN D , HEATHERSHAW TODD
IPC分类号： A61N1/36 , A61N1/05
摘要： Apparatus and method provide flexibility in generating a stimulation waveform to an electrode of an Implantable Neuro Stimulator (INS). The stimulation waveform is synthesized for each rate period interval. Each rate period interval is partitioned into time intervals, during which stimulation pulses, recharging, and time duration delays may be induced. With the embodiment of the invention, a second stimulation pulse, having different electrical characteristics than a first stimulation pulse, may be generated during the rate period interval. An embodiment utilizes apparatus comprising a waveform controller and a waveform generator that are controlled by the waveform controller. The waveform controller uses waveform parameters to instruct the waveform generator to form stimulation pulses. Any of the components may be adjusted or deleted in the generation of the stimulation waveform. The embodiment enables any of the associated waveform parameters to be updated at the waveform controller in order to alter the stimulation waveform.

3. 发明专利

DE69836990T2 未知
公开(公告)号：DE69836990T2
公开(公告)日：2007-11-08
申请号：DE69836990
申请日：1998-12-07
申请人： MEDTRONIC INC
发明人： BAKELS ARNOLDUS , LEINDERS ROBERT , DE ROOS COBUS
IPC分类号： A61N1/368 , A61N1/362 , A61N1/365
摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

4. 发明专利

AU2003220543A1 RECHARGE DELAY FOR AN IMPLANTABLE MEDICAL DEVICE 未知
公开(公告)号：AU2003220543A1
公开(公告)日：2003-11-10
申请号：AU2003220543
申请日：2003-03-26
申请人： MEDTRONIC INC
发明人： HEATHERSHAW TODD , RODRIQUEZ JOHN D , LEINDERS ROBERT , TORGERSON NATHAN A , STEIN MARC T , GOBLISH TODD P
IPC分类号： A61N1/05 , A61N1/36 , A61N1/372
摘要： In the embodiment of the invention, apparatus and method provide flexibility in generating a stimulation waveform to an electrode of an Implantable Neurological Stimulator (INS). The embodiment provides a time delay interval between a first stimulation pulse and a recharging of the apparatus, in which the time delay interval is adjustable. The embodiment utilizes apparatus comprising a waveform controller and a waveform generator that is controlled by the waveform controller. With a variation of the embodiment, the apparatus utilizes passive recharging. In another variation of the embodiment, the apparatus utilizes a second stimulation to balance an accumulated charge. In another embodiment of the invention, a clinician is able to adjust the time delay interval through a telemetry channel. The waveform controller receives information about the time delay interval, and the waveform control instructs the waveform generator to adjust the time delay interval.

5. 发明专利

AU9115198A Pacing system with lead having a single conductor for connecting to pressure sensor and electrode 未知
公开(公告)号：AU9115198A
公开(公告)日：1999-05-10
申请号：AU9115198
申请日：1998-08-21
申请人： MEDTRONIC INC
发明人： WEIJAND KOEN , LEINDERS ROBERT
IPC分类号： A61N1/05 , A61N1/365
摘要： A pacing system is provided having a lead with a pressure transducer or other sensor, the lead being characterized by having only a single conductor connecting the pacemaker with the signals from the sensor and the signals to and from the lead tip electrode. A connecting circuit mounted in the lead near the distal end is powered by a low level alternating constant current square wave to provide multiplexed signals on the conductor. The lead connecting circuit comprises a switching device connected to a sensor, such as a piezoelectric pressure transducer, so that for positive current pulses delivered to the lead, the transducer output is added in series with any cardiac signal sensed by the tip electrode; while for negative currents the pressure transducer is isolated and only the tip electrode signal information is connected back to the pacemaker. The pacemaker contains processing circuitry for decoding the respective cardiac signals and pressure signals from the multiplexed signals.

6. 发明专利

CA2171010A1 END-OF-LIFE INDICATION SYSTEM FOR IMPLANTABLE PULSE GENERATOR 未知
公开(公告)号：CA2171010A1
公开(公告)日：1995-03-30
申请号：CA2171010
申请日：1994-08-26
申请人： MEDTRONIC INC
发明人： GRANDJEAN PIERRE A , LEINDERS ROBERT , BOURGEOIS IVAN
IPC分类号： A61N1/36 , A61N1/37 , A61N1/378 , H02J7/00
摘要： An end-of-life (EOL) indicator for an implantable pulse generator (IPG)- especially of the neuromuscular stimulation variety - indicates an approaching battery EOL condition via an electrocardiogram (ECG) by changing the nature of the muscle stimulation burst signals. IPG internal circuitry detects an approaching EOL condition and modifies the burst signals by, for example, decreasing the number of pulses in a burst, increasing the heart contractionto-powering-muscle contraction ratio, or alternating between two numbers of pulses in successive burst cycles. The approaching battery EOL condition can be easily ascertained via trans-telephonic monitoring by analyzing a transmitted ECG alone for the above-mentioned burst signal changes. By observing the patterns in the ECG caused by the burst signal changes, a clinician could be aware of an approaching EOL without having known the original muscle stimulation burst signal parameters.

7. 发明专利

DE69200526T2 未知
公开(公告)号：DE69200526T2
公开(公告)日：1995-02-16
申请号：DE69200526
申请日：1992-01-03
申请人： MEDTRONIC INC
发明人： CARPENTIER ALAIN , LEINDERS ROBERT , CAMPS ANTOINE
IPC分类号： A61N1/375
摘要： An implantable pulse generator particularly adapted for implantation in the abdomen. The pulse generator displays a generally flattened configuration having two generally opposed major surfaces and a smaller, circumferential edge surface, and includes a plurality of electrical connectors located in a connector module mounted to one of the major surfaces of the pulse generator. The housing of the pulse generator contains a hybrid circuit mounted generally parallel to the major surfaces of the pulse generator, connected to the electrical connectors by means of feedthroughs passing through one of the major surfaces of the pulse generator, located adjacent to the edges of the hybrid circuit and perpendicular thereto.

8. 发明专利

DE69836991T2 未知
公开(公告)号：DE69836991T2
公开(公告)日：2007-12-06
申请号：DE69836991
申请日：1998-12-07
申请人： MEDTRONIC INC
发明人： BAKELS ARNOLDUS , LEINDERS ROBERT , DE ROOS COBUS
IPC分类号： A61N1/368 , A61N1/362 , A61N1/365
摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

9. 发明专利

DE69836991D1 未知
公开(公告)号：DE69836991D1
公开(公告)日：2007-03-15
申请号：DE69836991
申请日：1998-12-07
申请人： MEDTRONIC INC
发明人： BAKELS ARNOLDUS , LEINDERS ROBERT , DE ROOS COBUS
IPC分类号： A61N1/368 , A61N1/362 , A61N1/365
摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

10. 发明专利

DE69829207D1 未知
公开(公告)号：DE69829207D1
公开(公告)日：2005-04-07
申请号：DE69829207
申请日：1998-12-07
申请人： MEDTRONIC INC
发明人： BAKELS ARNOLDUS , LEINDERS ROBERT , DE ROOS COBUS
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
摘要： A pacing system and method for providing multiple chamber pacing of a patient's heart, and in particular, pacing programmed for treatment of various forms of heart failure. The system utilizes impedance sensing for determining optimum pacing parameters, e.g., for pacing the left ventricle so that left heart output is maximized. The impedance sensing also is used for determination of arrhythmias or progression of heart failure. Impedance sensing is provided for between selected pairs of the four chambers, to enable optimizing of information for control and diagnosis. In a preferred embodiment of the invention, impedance measurements are obtained for determining the timing of right heart valve closure or right ventricular contractions, and the timing of delivery of left ventricular pace pulses is adjusted so as to optimally synchronize left ventricular pacing with the right ventricular contractions. Impedance sensing in the left heart also provides timing of mechanical contraction, and the pacemaker controls pacing to maintain bi-ventricular mechanical synchronization adjusted for maximum cardiac output.

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