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1. 发明申请

WO2004096341A2 VENTRICULAR RATE STABILIZATION WITH CARDIAC RESYNCHRONIZATION 审中-公开
标题翻译：心脏再生能力的稳定性稳定性
公开(公告)号：WO2004096341A2
公开(公告)日：2004-11-11
申请号：PCT/US2004/012263
申请日：2004-04-20
申请人： MEDTRONIC, INC. , VAN OORT, Geeske , VAN HOVE, Jos, W.
发明人： VAN OORT, Geeske , VAN HOVE, Jos, W.
IPC分类号： A61N
CPC分类号： A61N1/368 , A61N1/3684
摘要： An implantable medical device (IMD) selectively switches to a more hemodynamically beneficial pacing mode upon detection of ventricular dysynchrony and/or reduced hemodynamic function during delivery of pacing pulses according to a ventricular rate stabilization algorithm. For example, in some embodiments of the invention, an IMD switches from right ventricular pacing according to a ventricular rate stabilization algorithm, to biventricular pacing according to the algorithm. The biventricular pacing can be provided according to a cardiac resynchronization therapy mode, and can involve use of an intraventricular delay between delivery of pacing pulses to the respective ventricles to improve hemodynamic functioning of a heart. The IMD monitors an electrogram signal to detect ventricular dysynchrony and/or decreased hemodynamic performance of the ventricles. The IMD can detect ventricular dysynchrony based on elongated QRS complex widths. The IMD can detect decreased hemodynamic performance based on shortened Q-T intervals and/or decreased ventricular evoked response amplitudes.
摘要翻译：根据心室速率稳定算法，可以在检测到心室异常和/或在递送起搏脉冲期间降低的血液动力学功能时，可植入医疗装置（IMD）选择性地切换到更有效的起搏方式。例如，在本发明的一些实施例中，IMD根据心室速率稳定算法从右心室起搏切换到根据该算法的双心室起搏。可以根据心脏再同步治疗模式提供双心室起搏，并且可以涉及在将起搏脉冲递送到各个心室之间使用室内延迟以改善心脏的血液动力学功能。 IMD监测电描记图信号以检测心室异常和/或降低心室的血液动力学性能。 IMD可以根据延长的QRS复杂宽度来检测心室异常。 IMD可以基于缩短的Q-T间期和/或降低的心室诱发反应幅度来检测血液动力学性能降低。

2. 发明申请

WO2010005804A1 SYSTEM AND METHOD FOR THE DETECTION OF ACUTE MYOCARDIAL INFARCTION 审中-公开
标题翻译：用于检测急性心肌梗塞的系统和方法
公开(公告)号：WO2010005804A1
公开(公告)日：2010-01-14
申请号：PCT/US2009/048744
申请日：2009-06-26
申请人： MEDTRONIC, INC. , BOUTE, Willem , VAN HOVE, Jos, W. , HAMPTON, David, R. , WESSELINK, Wilbert, A.
发明人： BOUTE, Willem , VAN HOVE, Jos, W. , HAMPTON, David, R. , WESSELINK, Wilbert, A.
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/0452 , A61N1/37 , G06F17/00 , G06F19/00
CPC分类号： A61B5/0452 , A61B5/0031 , A61B5/0205 , A61B5/02055 , A61B5/0816 , A61B5/7275 , A61B7/00 , A61N1/3702 , G06F19/00 , G16H10/20 , G16H50/20
摘要： A system and method are provided for the detection of acute myocardial infarction (AMI) using a staged approach for accurate and rapid detection. Physiological signals in a patient's body are sensed and corresponding physiological parameters are derived in a staged approach in order to determine the probability that AMI is occurring in a patient in a first detection stage. If the computed probability from physiological signals indicates the possibility of AMI, then the patient is prompted, such as through a patient-wearable device, to answer specific AMI-related questions to assist in diagnosis of AMI in a second stage. AMI is detected when the computed probability in the second stage exceeds a predefined detection threshold. A patient or physician alert may then be generated, which may further include the transfer of data via a communication link or network, in response to an AMI detection signal.
摘要翻译：提供了一种系统和方法，用于使用分阶段方法检测急性心肌梗死（AMI）以进行准确和快速的检测。检测患者身体中的生理信号，并且在分阶段方法中导出对应的生理参数，以便确定在第一检测阶段中患者发生AMI的可能性。如果来自生理信号的计算概率表明AMI的可能性，则提示患者，例如通过患者穿戴式装置，以回答特定AMI相关问题，以帮助诊断第二阶段的AMI。当计算出的第二级概率超过预定义的检测阈值时，检测到AMI。然后可以生成患者或医生警报，其可以响应于AMI检测信号而进一步包括经由通信链路或网络的数据传输。

3. 发明申请

WO2004096035A3 MONITORING QRS COMPLEX TO IDENTIFY LEFT VENTRICULAR DYSFUNTION 审中-公开
公开(公告)号：WO2004096035A3
公开(公告)日：2004-11-11
申请号：PCT/US2004/011497
申请日：2004-04-14
申请人： MEDTRONIC, INC. , VAN HOVE, Jos, W. , BOUTE, Willem
发明人： VAN HOVE, Jos, W. , BOUTE, Willem
IPC分类号： A61N1/365
摘要： An implantable medical device identifies onset and/or progression of left ventricular dysfunction (LVD). The implantable medical device receives a signal that represents electrical activity within a heart, e.g., an electrogram signal, and digitally processes the signal to assess left ventricular function. In particular, the implantable medical device measures at least one characteristic of QRS complexes within the signal, and assesses left ventricular function based on measurements. The implantable medical device may, for example, measure the width of the QRS complexes and/or the amplitude of the R-waves within the QRS complexes. The implantable medical device may alert a patient or clinician of the onset or progression of LVD, and may control delivery of therapies, such as rate-responsive pacing and cardiac resynchronization pacing, based on the measurements. The implantable medical device may also control delivery of a drug by an implanted drug delivery device, e.g., drug pump, based on the measurements.

4. 发明授权

EP1617902B1 MONITORING QRS COMPLEX TO IDENTIFY LEFT VENTRICULAR DYSFUNCTION 有权
标题翻译：监测QRS波群用于识别左心功能不全
公开(公告)号：EP1617902B1
公开(公告)日：2009-09-02
申请号：EP04760257.8
申请日：2004-04-14
申请人： MEDTRONIC, INC.
发明人： VAN HOVE, Jos, W. , BOUTE, Willem
IPC分类号： A61N1/365 , A61N1/362 , A61B5/04
CPC分类号： A61B5/4839 , A61B5/0472 , A61N1/3627
摘要： An implantable medical device identifies onset and/or progression of left ventricular dysfunction (LVD). The implantable medical device receives a signal that represents electrical activity within a heart, e.g., an electrogram signal, and digitally processes the signal to assess left ventricular function. In particular, the implantable medical device measures at least one characteristic of QRS complexes within the signal, and assesses left ventricular function based on measurements. The implantable medical device may, for example, measure the width of the QRS complexes and/or the amplitude of the R-waves within the QRS complexes. The implantable medical device may alert a patient or clinician of the onset or progression of LVD, and may control delivery of therapies, such as rate-responsive pacing and cardiac resynchronization pacing, based on the measurements. The implantable medical device may also control delivery of a drug by an implanted drug delivery device, e.g., drug pump, based on the measurements.

5. 发明公开

EP1654034A2 VENTRICULAR RATE STABILIZATION WITH CARDIAC RESYNCHRONIZATION 审中-公开
标题翻译：心室率BY心脏再同步化镇定
公开(公告)号：EP1654034A2
公开(公告)日：2006-05-10
申请号：EP04750418.8
申请日：2004-04-20
申请人： MEDTRONIC, INC.
发明人： VAN OORT, Geeske , VAN HOVE, Jos, W.
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3684
摘要： An implantable medical device (IMD) selectively switches to a more hemodynamically beneficial pacing mode upon detection of ventricular dysynchrony and/or reduced hemodynamic function during delivery of pacing pulses according to a ventricular rate stabilization algorithm. For example, in some embodiments of the invention, an IMD switches from right ventricular pacing according to a ventricular rate stabilization algorithm, to biventricular pacing according to the algorithm. The biventricular pacing can be provided according to a cardiac resynchronization therapy mode, and can involve use of an intraventricular delay between delivery of pacing pulses to the respective ventricles to improve hemodynamic functioning of a heart. The IMD monitors an electrogram signal to detect ventricular dysynchrony and/or decreased hemodynamic performance of the ventricles. The IMD can detect ventricular dysynchrony based on elongated QRS complex widths. The IMD can detect decreased hemodynamic performance based on shortened Q-T intervals and/or decreased ventricular evoked response amplitudes.

6. 发明公开

EP1617902A2 MONITORING QRS COMPLEX TO IDENTIFY LEFT VENTRICULAR DYSFUNTION 有权
标题翻译：监测QRS波群用于识别左心功能不全
公开(公告)号：EP1617902A2
公开(公告)日：2006-01-25
申请号：EP04760257.8
申请日：2004-04-14
申请人： MEDTRONIC, INC.
发明人： VAN HOVE, Jos, W. , BOUTE, Willem
IPC分类号： A61N1/365 , A61N1/362 , A61B5/04
CPC分类号： A61B5/4839 , A61B5/0472 , A61N1/3627
摘要： An implantable medical device identifies onset and/or progression of left ventricular dysfunction (LVD). The implantable medical device receives a signal that represents electrical activity within a heart, e.g., an electrogram signal, and digitally processes the signal to assess left ventricular function. In particular, the implantable medical device measures at least one characteristic of QRS complexes within the signal, and assesses left ventricular function based on measurements. The implantable medical device may, for example, measure the width of the QRS complexes and/or the amplitude of the R-waves within the QRS complexes. The implantable medical device may alert a patient or clinician of the onset or progression of LVD, and may control delivery of therapies, such as rate-responsive pacing and cardiac resynchronization pacing, based on the measurements. The implantable medical device may also control delivery of a drug by an implanted drug delivery device, e.g., drug pump, based on the measurements.

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