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1. 发明申请

WO2007090003A1 METHOD AND APPARATUS FOR DETERMINING OPTIMAL PACING THERAPY TIMING INTERVALS 审中-公开
标题翻译：用于确定最佳治疗时间间隔的方法和装置
公开(公告)号：WO2007090003A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/060848
申请日：2007-01-22
申请人： MEDTRONIC, INC. , PRAKASH, Rajan , CHINCHOY, Edward , MULLEN, Thomas J.
发明人： PRAKASH, Rajan , CHINCHOY, Edward , MULLEN, Thomas J.
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/368 , A61N1/3682
摘要： A method for determining an optimal pacing timing control parameter setting is provided for use in an implantable medical device programmed to deliver a pacing pulse in response to the timing control parameter. The method includes storing a user-selected optimization metric, iteratively adjusting the timing control parameter setting, sensing a first signal that varies in response to left ventricular wall acceleration, measuring the user-selected optimization metric in response to the sensed first signal, and determining an optimal timing control parameter value in response to the measured user-selected optimization metric.
摘要翻译：提供了一种用于确定最佳起搏定时控制参数设置的方法，用于被编程为响应于定时控制参数递送起搏脉冲的可植入医疗设备。该方法包括存储用户选择的优化度量，迭代地调整定时控制参数设置，感测响应于左心室壁加速度变化的第一信号，响应于感测的第一信号测量用户选择的优化度量，以及确定响应于所测量的用户选择的优化度量的最佳定时控制参数值。

2. 发明申请

WO2007090000A1 METHOD AND APPARATUS FOR DETERMINING EXCITATION-PHYSIOLOGIC RESPONSE DELAYS 审中-公开
标题翻译：用于确定激发生理反应延迟的方法和装置
公开(公告)号：WO2007090000A1
公开(公告)日：2007-08-09
申请号：PCT/US2007/060828
申请日：2007-01-22
申请人： MEDTRONIC, INC. , PRAKASH, Rajan , CHINCHOY, Edward , MULLEN, Thomas J.
发明人： PRAKASH, Rajan , CHINCHOY, Edward , MULLEN, Thomas J.
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3627 , A61N1/36542 , A61N1/3682
摘要： An implantable medical device system and associated method are provided for measuring an excitation-physiological response delay. The method includes sensing a first signal responsive to electrical activity in a first cardiac chamber, sensing a second signal responsive to a physiologic response to the electrical activity in the first cardiac chamber; and determining an excitation-physiologic response delay in response to the first signal and the second signal.
摘要翻译：提供了一种用于测量激发 - 生理反应延迟的可植入医疗装置系统和相关方法。所述方法包括响应于第一心室中的电活动来感测第一信号，感测响应于对第一心室中的电活动的生理反应的第二信号; 以及响应于所述第一信号和所述第二信号确定激发 - 生理响应延迟。

3. 发明申请

WO2009012030A1 MECHANICAL FUNCTION MARKER CHANNEL FOR CARDIAC MONITORING AND THERAPY CONTROL 审中-公开
标题翻译：机械功能标记通道用于心脏监测和治疗控制
公开(公告)号：WO2009012030A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/068343
申请日：2008-06-26
申请人： MEDTRONIC, INC. , PRAKASH, Rajan , SOWELAM, Sameh , MULLEN, Thomas J.
发明人： PRAKASH, Rajan , SOWELAM, Sameh , MULLEN, Thomas J.
IPC分类号： A61N1/372 , A61N1/365 , A61B5/00 , A61B5/0215 , A61B5/0245 , A61B5/04 , A61B5/044 , A61B5/0452
CPC分类号： A61B5/0031 , A61B5/0215 , A61B5/042 , A61B5/11 , A61B5/14546 , A61B5/1455 , A61B5/7239 , A61N1/36514 , A61N1/36564 , A61N1/36578
摘要： The implantable medical device (IMD) system disclosed here utilizes one or more cardiac sensors that measure mechanical characteristics of the heart, such as left ventricular acceleration or right ventricular pressure. The raw sensor data is collected and processed by the IMD, which derives one or more mechanical event marker signals from features, traits, and characteristics of the sensor data waveforms. The mechanical event marker signals are wirelessly transmitted to an external monitor device for display
摘要翻译：这里公开的可植入医疗装置（IMD）系统利用测量心脏的机械特性的一个或多个心脏传感器，例如左心室加速度或右心室压力。原始传感器数据由IMD收集和处理，IMD从特征，特征和传感器数据波形的特性中导出一个或多个机械事件标记信号。机械事件标记信号被无线传输到外部监视器装置进行显示

4. 发明申请

WO2008097959A1 FUSION PACING ENHANCEMENTS 审中-公开
标题翻译：融合增强
公开(公告)号：WO2008097959A1
公开(公告)日：2008-08-14
申请号：PCT/US2008/053037
申请日：2008-02-05
申请人： MEDTRONIC, INC. , BURNES, John E. , KLECKNER, Karin J. , MULLEN, Thomas J.
发明人： BURNES, John E. , KLECKNER, Karin J. , MULLEN, Thomas J.
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/3682 , A61N1/3684
摘要： The disclosure provides methods and apparatus of left ventricular pacing including automated adjustment of a atrio-ventricular (AV) pacing delay interval and intrinsic AV nodal conduction testing. It includes - upon expiration or reset of a programmable AV Evaluation Interval (AVEI) - performing the following: temporarily increasing a paced AV interval and a sensed AV interval and testing for adequate AV conduction and measuring an intrinsic atrio-ventricular (PR) interval for a right ventricular (RV) chamber. Thus, in the event that the AV conduction test reveals a physiologically acceptable intrinsic PR interval then storing the physiologically acceptable PR interval in a memory structure (e.g., a median P-R from one or more cardiac cycles). In the event that the AV conduction test reveals an AV conduction block condition or if unacceptably long PR intervals are revealed then a pacing mode-switch to a bi-ventricular (Bi-V) pacing mode occurs and the magnitude of the AVEI is increased.
摘要翻译：本公开提供了左心室起搏的方法和装置，包括自动调节心房（AV）起搏延迟间隔和内部AV节点传导测试。它包括 - 在可编程AV评估间隔（AVEI）到期或复位时 - 执行以下操作：临时增加节奏的AV间隔和感测到的AV间隔，并测试足够的AV传导并测量内在房室（PR）间隔右心室（RV）室。因此，在AV传导测试揭示生理上可接受的内在PR间隔的情况下，然后将生理上可接受的PR间期存储在存储器结构中（例如，来自一个或多个心动周期的中值P-R）。在AV传导测试显示AV传导阻滞状态或者如果不能接受的长PR间隔被揭示的情况下，则起搏模式切换到双心室（Bi-V）起搏模式并且AVEI的幅度增加。

5. 发明申请

WO2008134671A1 APPARATUS AND METHODS FOR AUTOMATIC DETERMINATION OF A FUSION PACING PRE-EXCITATION INTERVAL 审中-公开
标题翻译：用于自动确定熔融预处理间隔的装置和方法
公开(公告)号：WO2008134671A1
公开(公告)日：2008-11-06
申请号：PCT/US2008/061829
申请日：2008-04-29
申请人： MEDTRONIC, INC. , BURNES, John E. , MULLEN, Thomas J. , SAMBELASHVILI, Aleksandre T.
发明人： BURNES, John E. , MULLEN, Thomas J. , SAMBELASHVILI, Aleksandre T.
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： Automated adjustment of a pre-excitation interval (PEI) used to deliver hemodynamically efficient fusion pacing therapy.
摘要翻译：用于提供血液动力学有效的融合起搏治疗的预激发间隔（PEI）的自动调整。

6. 发明申请

WO2010144662A1 ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：绝对的校准组织氧饱和度和总HEMOGLOBIN体积分数
公开(公告)号：WO2010144662A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038111
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , ANDERSON, David A. , CINBIS, Can , O'BRIEN, Richard J. , CHO, Yong K, , MULLEN, Thomas J. , SCHEINER, Avram , KATRA, Rodolphe P.
发明人： KUHN, Jonathan L. , ANDERSON, David A. , CINBIS, Can , O'BRIEN, Richard J. , CHO, Yong K, , MULLEN, Thomas J. , KATRA, Rodolphe P.
IPC分类号： A61B5/00
CPC分类号： A61N1/36557 , A61B5/1459 , A61N1/37258
摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.
摘要翻译：用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用光检测器输出信号。

7. 发明申请

WO2010088040A1 PACING THERAPY ADJUSTMENT BASED ON VENTRICULO-ATRIAL DELAY 审中-公开
标题翻译：基于静脉血管延迟的PACING治疗调整
公开(公告)号：WO2010088040A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/020850
申请日：2010-01-13
申请人： MEDTRONIC, INC. , KAISER, Daniel R. , SKADSBERG, Nicholas D. , MULLEN, Thomas J. , HORNBERGER, Steven R.
发明人： KAISER, Daniel R. , SKADSBERG, Nicholas D. , MULLEN, Thomas J. , HORNBERGER, Steven R.
IPC分类号： A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3682
摘要： Techniques for adjusting pacing therapy based on ventriculo-atrial delay are described herein. These techniques may be used to control ventricular filling times during the delivery of pacing therapy. In some examples, a device or system delivers pre-excitation fusion pacing therapy to a ventricular chamber, determines a ventriculo-atrial delay interval for the ventricular chamber for at least one cardiac cycle, and adjusts the pacing therapy delivered by the implantable medical device to compensate for decreased ventricular filling time when the ventriculo-atrial delay interval is less than a threshold. In some examples, the device or system may adjust the pacing therapy by decreasing a pacing rate of the implantable medical device, increasing a pre-excitation interval for pacing of the ventricular chamber, and/or switching from a fusion pacing mode to a biventricular pacing mode.
摘要翻译：本文描述了基于心房 - 心房延迟来调节起搏治疗的技术。这些技术可用于控制起搏治疗期间的心室充盈时间。在一些示例中，装置或系统将预激发融合起搏治疗递送至心室，确定心室至少一个心动周期的心房 - 心房延迟间隔，并调整由可植入医疗装置递送的起搏疗法补偿当心室 - 心房延迟间隔小于阈值时心室充盈时间减少。在一些示例中，装置或系统可以通过降低可植入医疗装置的起搏速率，增加心室的起搏间隔和/或从融合起搏模式切换到双心室起搏来调节起搏治疗模式。

8. 发明申请

WO2009114360A1 METHOD AND APPARATUS FOR DETERMINING A PARAMETER ASSOCIATED WITH DELIVERY OF THERAPY IN A MEDICAL DEVICE 审中-公开
标题翻译：用于确定与在医疗设备中输送治疗相关的参数的方法和装置
公开(公告)号：WO2009114360A1
公开(公告)日：2009-09-17
申请号：PCT/US2009/036032
申请日：2009-03-04
申请人： MEDTRONIC, INC. , SAMBELASHVILI, Aleksandre T. , MULLEN, Thomas J. , GILLBERG, Jeffrey M.
发明人： SAMBELASHVILI, Aleksandre T. , MULLEN, Thomas J. , GILLBERG, Jeffrey M.
IPC分类号： A61N1/365 , A61N1/368 , A61N1/37 , A61N1/362 , A61N1/372
CPC分类号： A61N1/365 , A61B5/04525 , A61N1/36185 , A61N1/3627 , A61N1/36507 , A61N1/3684 , A61N1/3686
摘要： A medical device and method for determining a parameter for delivery of a predetermined pacing therapy that includes a plurality of electrodes to deliver a pacing therapy, including the predetermined pacing therapy, and a control unit to control the timing of the delivery of the pacing therapy, including the predetermined pacing therapy, by the electrodes. A processor generates a first template in response to the pacing therapy being delivered to only one of a right ventricle and a left ventricle, and a second template in response to the pacing therapy being delivered to only the other of the right ventricle and the left ventricle, and determines the parameter in response to a comparing of subsequently delivered pacing therapy to the first template and the second template.
摘要翻译：一种用于确定用于递送预定起搏疗法的参数的医疗装置和方法，所述起搏疗法包括多个电极以递送包括所述预定起搏治疗的起搏疗法，以及控制所述起搏治疗递送时间的控制单元，包括预定的起搏治疗。处理器响应于起搏治疗仅递送到右心室和左心室中的一个而产生第一模板，并且第二模板响应于起搏治疗被递送到仅右心室和左心室中的另一个并且响应于随后发送的起搏治疗与第一模板和第二模板的比较来确定参数。

9. 发明申请

WO2010088485A1 FUSION PACING INTERVAL DETERMINATION 审中-公开
标题翻译： FUSION PACING INTERVAL确定
公开(公告)号：WO2010088485A1
公开(公告)日：2010-08-05
申请号：PCT/US2010/022536
申请日：2010-01-29
申请人： MEDTRONIC, INC. , SAMBELASHVILI, Aleksandre T. , MULLEN, Thomas J. , STEGEMANN, Berthold
发明人： SAMBELASHVILI, Aleksandre T. , MULLEN, Thomas J. , STEGEMANN, Berthold
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/3627 , A61N1/36514 , A61N1/3684 , A61N1/3688
摘要： Delivery of fusion pacing therapy to a later depolarizing ventricle (V2) of a heart of a patient may be timed based on the depolarization of the V2 during at least one prior cardiac cycle. In some examples, a V2 pacing pulse is delivered upon the expiration of a pacing interval that begins at detection of an atrial sense or pace event (AP/S). The pacing interval may be substantially equal to the duration of time between an AP/S and a V2 sensing event of at least one prior cardiac cycle decremented by an adjusted pre-excitation interval (PEI). In another example, the V2 pacing pulse is delivered at the expiration of a pacing interval that begins upon detection of a V2 sensing event of a prior cardiac cycle. The pacing interval may be substantially equal to a duration of time between at least two subsequent V2 sensing events decremented by the adjusted PEI.
摘要翻译：将融合起搏治疗递送到患者心脏的后期去极化心室（V2）可以基于在至少一个在先的心动周期期间的V2的去极化来计时。在一些示例中，在起搏间隔期满后，在起搏时间间隔期间，起搏脉搏是在心房感觉或步速事件（AP / S）的检测开始时发送的。所述起搏间隔可以基本上等于在调整的预激励间隔（PEI）减小的至少一个先前心动周期的AP / S和V2感测事件之间的持续时间。在另一示例中，V2起搏脉冲在起搏间隔的期满时被递送，起搏间隔开始于检测到先前的心动周期的V2感测事件。该起搏间隔可以基本上等于由调整后的PEI递减的至少两个后续V2感测事件之间的持续时间。

10. 发明申请

WO2018140453A1 HEART RATE BASED CONTROL OF CARDIAC RESYNCHRONIZATION THERAPY 审中-公开
公开(公告)号：WO2018140453A1
公开(公告)日：2018-08-02
申请号：PCT/US2018/014982
申请日：2018-01-24
申请人： MEDTRONIC, INC.
发明人： GRENZ, Nathan A. , MULLEN, Thomas J.
IPC分类号： A61N1/368 , A61N1/37
摘要： In some examples, controlling delivery of cardiac resynchronization therapy (CRT) includes storing, in a memory of an implantable medical device system and in association with each of a plurality of heart rates, at least one respective value for an interval between an atrial event and a ventricular event. Processing circuitry of the implantable medical device system may determine a heart rate of a patient and select one of the stored values for the interval between the atrial event and the ventricular event associated with the determined heart rate. The processing circuitry may further determine whether to control therapy delivery circuitry of the implantable medical device system to deliver fusion pacing or biventricular pacing, based on the selected one of the stored values for the interval between the atrial event and the ventricular event.

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