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1. 发明申请

WO2010144662A1 ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：绝对的校准组织氧饱和度和总HEMOGLOBIN体积分数
公开(公告)号：WO2010144662A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038111
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , ANDERSON, David A. , CINBIS, Can , O'BRIEN, Richard J. , CHO, Yong K, , MULLEN, Thomas J. , SCHEINER, Avram , KATRA, Rodolphe P.
发明人： KUHN, Jonathan L. , ANDERSON, David A. , CINBIS, Can , O'BRIEN, Richard J. , CHO, Yong K, , MULLEN, Thomas J. , KATRA, Rodolphe P.
IPC分类号： A61B5/00
CPC分类号： A61N1/36557 , A61B5/1459 , A61N1/37258
摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.
摘要翻译：用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用光检测器输出信号。

2. 发明申请

WO2010144668A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144668A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038117
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
发明人： CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device for monitoring delivery of a therapy that includes a therapy delivery module to deliver a therapy, a controller to set a therapy delivery control parameter, an optical sensor to produce a signal corresponding to tissue light attenuation, and a processor configured to compute a tissue oxygenation measurement from the optical sensor signal, wherein the controller, the optical sensor, and the processor operate cooperatively to determine a setting of the therapy delivery control parameter corresponding to a maximum tissue oxygenation.
摘要翻译：一种用于监测治疗递送的医疗装置，其包括用于递送疗法的治疗递送模块，用于设置治疗递送控制参数的控制器，用于产生对应于组织光衰减的信号的光学传感器，以及被配置为计算来自光学传感器信号的组织氧合测量，其中所述控制器，所述光学传感器和所述处理器协同工作以确定对应于最大组织氧合的所述治疗传递控制参数的设置。

3. 发明申请

WO2010144649A1 SHOCK REDUCTION USING ABSOLUTE CALIBRATED TISSUE OXYGEN SATURATION AND TOTAL HEMOGLOBIN VOLUME FRACTION 审中-公开
标题翻译：使用绝对标准组织氧气饱和和总HEMOGLOBIN体积分数减少减少
公开(公告)号：WO2010144649A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038084
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
IPC分类号： A61B5/1455 , A61B5/00 , A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3622 , A61B5/02028 , A61B5/0215 , A61B5/042 , A61B5/1116 , A61B5/14542 , A61B5/1459 , A61N1/36557 , A61N1/3956
摘要： An implantable medical device that includes an optical sensor for providing a signal corresponding to light attenuation by a volume of blood perfused tissue, a control module coupled to the optical sensor controlling the light emitted by the optical sensor, a monitoring module receiving an optical sensor output signal and measuring light attenuation, a tissue electrode for stimulating the volume of blood perfused tissue, a pulse generator coupled to the tissue electrode for delivering electrical stimulation to the volume of blood-perfused tissue, and a processor coupled to the cardiac electrode and the monitoring module and configured to detect an arrhythmia in response to the depolarization signals, compute a tissue oxygenation measurement and control the pulse generator to deliver electrical stimulation to the volume of blood-perfused tissue in response to detecting the arrhythmia, and detect a hemodynamic status of the arrhythmia in response to at least one of a detected rate of tissue oxygenation decline and a detected rate of tissue oxygenation recovery.
摘要翻译：一种可植入医疗装置，其包括：光学传感器，用于通过一定量的血液灌注组织提供对应于光衰减的信号;耦合到所述光学传感器的控制模块，所述控制模块控制由所述光学传感器发射的光;监测模块，其接收光学传感器输出信号和测量光衰减的组织电极，用于刺激血液灌注组织的体积的组织电极，耦合到组织电极的脉冲发生器，用于向血液灌注组织的体积输送电刺激，以及耦合到心脏电极和监测器模块并且被配置为响应于去极化信号检测心律失常，计算组织氧合测量并控制脉冲发生器以响应于检测到心律失常而向血液灌注组织的体积递送电刺激，并且检测血液动力学状态响应于检测到的tis的速率中的至少一种的心律失常检测氧合反应的下降和组织氧合恢复率。

4. 发明申请

WO2011031739A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031739A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048103
申请日：2010-09-08
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极;治疗递送模块，其耦合到所述电极，以响应于所感测的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近光学传感器的组织体积散射的光以产生相应的检测到的光强度输出信号;耦合到传感器的控制模块，用于响应于递送治疗来控制传感器的光发射;以及控制器，耦合到治疗递送模块和传感器，所述控制器被配置为响应于输出信号确定组织氧合测量，响应于组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能趋势。

5. 发明申请

WO2010144665A1 DEVICE AND METHOD FOR MONITORING OF ABSOLUTE OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION 审中-公开
标题翻译：用于监测绝对氧化饱和度和总HEMOGLOBIN浓度的装置和方法
公开(公告)号：WO2010144665A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038114
申请日：2010-06-10
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
发明人： KUHN, Jonathan L. , CINBIS, Can , CARNEY, James K. , ANDERSON, David A.
IPC分类号： A61B5/00
CPC分类号： A61B5/14552 , A61B5/0084 , A61B5/14546 , A61B5/1459 , A61B5/7239 , A61N1/36557
摘要： A medical device for monitoring of oxygen saturation includes an optical sensor adapted for positioning adjacent to a tissue volume. The optical sensor has a light emitting portion capable of emitting light at a plurality of wavelengths and a light detecting portion capable of generating an electrical output signal corresponding to light incident on the detecting portion. A control module coupled to the optical sensor controls the light emitted by the light emitting portion. A monitoring module receives the output signal from the light detecting portion and computes a volume-independent measure of oxygen saturation in the volume of tissue using the output signal.
摘要翻译：用于监测氧饱和度的医疗装置包括适于邻近组织体积定位的光学传感器。光学传感器具有能够发射多个波长的光的发光部和能够产生与入射到检测部上的光对应的电输出信号的光检测部。耦合到光学传感器的控制模块控制由发光部分发射的光。监测模块接收来自光检测部分的输出信号，并使用输出信号计算组织体积中的氧饱和度的体积无关测量。

6. 发明申请

WO2011031597A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031597A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/047450
申请日：2010-09-01
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , HAVEL, William J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy; and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine a tissue oxygenation measurement in response to the output signal, and determine whether the delivered therapy was successful in restoring cardiac hemodynamic function in response to the tissue oxygenation measurement.
摘要翻译：一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器发射由邻近传感器的组织体积散射的光，以产生相应的检测到的光强度输出信号;控制模块，其耦合到所述传感器以响应于递送所述治疗来控制所述传感器的光发射; 以及耦合到所述治疗递送模块和所述传感器的控制器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，并且确定所递送的治疗是否成功响应于所述组织氧合测量来恢复心脏血液动力学功能。

7. 发明申请

WO2010144667A1 TISSUE OXYGENATION MONITORING IN HEART FAILURE 审中-公开
标题翻译：心脏失效组织氧化监测
公开(公告)号：WO2010144667A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/038116
申请日：2010-06-10
申请人： MEDTRONIC, INC. , CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
发明人： CINBIS, Can , CARNEY, James K. , KUHN, Jonathan L. , ANDERSON, David A.
IPC分类号： A61N1/365
CPC分类号： A61N1/36557
摘要： A medical device system and associated method control the delivery of a heart failure therapy to a patient. The system includes an activity sensor and detects a change in activity level of the patient. The system further include an optical sensor to sense signal corresponding to tissue light attenuation. The system computes a tissue oxygenation measurement in response to detecting a change in activity level. A parameter controlling delivery of the heart failure therapy is adjusted in response to detecting the decreased tissue oxygenation.
摘要翻译：医疗装置系统和相关联的方法控制对患者的心力衰竭治疗的递送。该系统包括活动传感器并检测患者的活动水平的变化。该系统还包括用于感测对应于组织光衰减的信号的光学传感器。响应于检测到活动水平的变化，系统计算组织氧合测量。响应于检测到减少的组织氧合而调整控制心力衰竭治疗递送的参数。

8. 发明申请

WO2012067906A1 COEFFICENT DETERMINATION FOR BLOOD OXYGEN SATURATION AND TOTAL HEMOGLOBIN CONCENTRATION INDICES 审中-公开
标题翻译：血氧饱和度和总HEMOGLOBIN浓度指标的系数测定
公开(公告)号：WO2012067906A1
公开(公告)日：2012-05-24
申请号：PCT/US2011/059875
申请日：2011-11-09
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David A. , CARNEY, James K.
IPC分类号： A61B5/1455 , A61B5/1459
CPC分类号： A61B5/1459 , A61B5/0075 , A61B5/14535 , A61B5/14542 , A61B5/14551 , A61B5/1495 , A61B5/4836
摘要： A first concentration of a chromophore corresponding to a measurement volume of an optical sensor is determined. A second concentration of the chromophore is obtained in the vicinity of the measurement volume corresponding to a change in at least one of a total concentration of the chromophore and a relative concentration of a first form of the chromophore to the total concentration of the chromophore in the measurement volume. Light remittance measurements including a first light wavelength and a second light wavelength are obtained corresponding to the first chromophore concentration and the second chromophore concentration. A coefficient for computing an index of a change in the chromophore concentration is computed using the difference between the first and second chromophore concentrations and the first and second light remittance measurements.
摘要翻译：确定对应于光学传感器的测量体积的发色团的第一浓度。在测量体积附近获得发色团的第二浓度，其对应于发色团的总浓度和发色团的第一形式的相对浓度与发色团的总浓度中的至少一个的变化相关测量体积。对应于第一发色团浓度和第二发色团浓度获得包括第一光波长和第二光波长的光汇率测量。使用第一和第二生色团浓度与第一和第二光汇率测量之间的差来计算计算发色团浓度变化指数的系数。

9. 发明申请

WO2011031727A1 METHOD AND APPARATUS FOR POST-SHOCK EVALUATION USING TISSUE OXYGENATION MEASUREMENTS 审中-公开
标题翻译：使用组织氧化测量法进行后期评估的方法和装置
公开(公告)号：WO2011031727A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/048088
申请日：2010-09-08
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David, A. , HAVEL, William, J.
发明人： KUHN, Jonathan L. , CINBIS, Can , ANDERSON, David, A. , HAVEL, William, J.
IPC分类号： A61N1/39 , A61B5/00
CPC分类号： A61B5/14551 , A61B5/1459 , A61B5/6846 , A61B5/7285 , A61N1/36557 , A61N1/3925 , A61N1/3956
摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a monitoring module detecting a cardiac event in response to the sensed cardiac signals using first detection criteria, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the monitoring module, the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, determine a recovery index in response to the determined tissue oxygenation trend, and control one or both of detecting a cardiac event by the monitoring module and delivery of therapy by the therapy delivery module in response to the determined recovery index.
摘要翻译：一种用于递送疗法的方法和装置，其包括用于感测心脏信号并递送治疗的电极，监测模块，响应于使用第一检测标准的所感测到的心脏信号检测心脏事件;发射光的传感器，检测由与所述传感器相邻的组织体积以产生相应的检测到的光强度输出信号;耦合到所述传感器的控制模块，以响应于递送所述治疗而控制所述传感器的光发射;以及控制器，耦合到所述监测模块，所述治疗递送模块以及所述传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，响应于所确定的组织氧合趋势确定恢复指数，并且控制一个或两个通过监测模块检测心脏事件并进行治疗 y由治疗递送模块响应于确定的恢复指数。

10. 发明申请

WO2009076063A1 IMPLANTABLE OPTICAL SENSOR AND METHOD FOR MANUFACTURE 审中-公开
标题翻译：可植入的光学传感器及其制造方法
公开(公告)号：WO2009076063A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/084675
申请日：2008-11-25
申请人： MEDTRONIC, INC. , KUHN, Jonathan L. , CINBIS, Can , ECKER, Robert M. , DAVIS, Timothy J. , KNOWLES, Shawn D.
发明人： KUHN, Jonathan L. , CINBIS, Can , ECKER, Robert M. , DAVIS, Timothy J. , KNOWLES, Shawn D.
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/0084 , A61B5/0086 , A61B5/14532 , A61B5/14552 , A61B5/1459 , A61B5/6846 , A61B2562/02 , A61B2562/043 , A61B2562/146
摘要： An implantable optical sensor and associated manufacturing method include a sensor housing having an inner surface and an outer surface and a window formed in the housing extending between the housing inner surface and the housing outer surface. An opto-electronic device enclosed within the housing and having a photonic surface is operatively positioned proximate the window for emitting light through the window or detecting light through the window. An optical coupling member is positioned between the opto-electronic device and the window for reducing light reflection at a surface within the implantable optical sensor.
摘要翻译：可植入光学传感器和相关联的制造方法包括具有内表面和外表面的传感器外壳和形成在壳体中的窗口，该壳体在壳体内表面和壳体外表面之间延伸。封闭在壳体内并具有光子表面的光电器件可操作地定位在窗口附近，用于通过窗口发射光或通过窗口检测光。光耦合构件位于光电器件和窗口之间，用于减少可植入光学传感器内的表面处的光反射。

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