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1. 发明申请

WO2012030436A2 SYMMETRICAL PHYSIOLOGICAL SIGNAL SENSING WITH A MEDICAL DEVICE 审中-公开
标题翻译：医疗器械的对称生理信号检测
公开(公告)号：WO2012030436A2
公开(公告)日：2012-03-08
申请号：PCT/US2011/043965
申请日：2011-07-14
申请人： MEDTRONIC, INC. , MOLNAR, Gabriela C. , STANSLASKI, Scott R.
发明人： MOLNAR, Gabriela C. , STANSLASKI, Scott R.
IPC分类号： A61N1/05 , A61B5/04
CPC分类号： A61N1/0534 , A61N1/0553 , A61N1/36125
摘要： A physiological signal of a patient is sensed with sense electrodes symmetrically arranged relative to a stimulation electrode. In some examples, a member includes a plurality of relatively small electrodes that are configured to function as both sense and stimulation electrodes. One or more of the electrodes may be selected as stimulation electrodes and two or more different electrodes of the member may be selected as sense electrodes that are symmetrically arranged relative to the one or more selected stimulation electrodes. In some examples, a member includes a plurality of levels of segmented sense electrodes and a plurality of levels of stimulation electrodes. The levels of sense electrodes are arranged such that each level of stimulation electrodes is adjacent at least two levels of sense electrodes symmetrically arranged relative to the level of stimulation electrodes.
摘要翻译：利用相对于刺激电极对称布置的感测电极来感测患者的生理信号。在一些示例中，构件包括配置成充当感测电极和刺激电极两者的多个相对较小的电极。可以选择一个或多个电极作为刺激电极，并且可以选择该构件的两个或更多个不同的电极作为相对于一个或多个选择的刺激电极对称地布置的感测电极。在一些示例中，构件包括多个级别的分段感测电极和多个级别的刺激电极。感测电极的水平被布置为使得每个刺激电极水平相邻于相对于刺激电极的水平对称地布置的至少两个水平的感测电极。

2. 发明申请

WO2010044989A3 STIMULATION ELECTRODE SELECTION 审中-公开
公开(公告)号：WO2010044989A3
公开(公告)日：2010-04-22
申请号：PCT/US2009/057862
申请日：2009-09-22
申请人： MEDTRONIC, INC. , CARLSON, David L. , JENSEN, Randy M. , DENISON, Timothy J. , WU, Jianping , MOLNAR, Gabriela C. , STANSLASKI, Scott R. , MARKS, William J.
发明人： CARLSON, David L. , JENSEN, Randy M. , DENISON, Timothy J. , WU, Jianping , MOLNAR, Gabriela C. , STANSLASKI, Scott R. , MARKS, William J.
IPC分类号： A61N1/36 , A61N1/372
摘要： Bioelectrical signals may be sensed within a brain of a patient with a plurality of sense electrode combinations. A stimulation electrode combination for delivering stimulation to the patient to manage a patient condition may be selected based on the frequency band characteristics of the sensed signals. In some examples, a stimulation electrode combination associated with the sense electrode combination that sensed a bioelectrical brain signal having a relatively highest relative beta band power level may be selected to deliver stimulation therapy to the patient. Other frequency bands characteristics may also be used to select the stimulation electrode combination.

3. 发明申请

WO2008016847A2 SYSTEM AND METHOD FOR DETERMINING PHSYIOLOGIC EVENTS DURING PACING MODE OPERATION 审中-公开
标题翻译：用于确定PAC模式运行期间的PHSYIOLOGIC事件的系统和方法
公开(公告)号：WO2008016847A2
公开(公告)日：2008-02-07
申请号：PCT/US2007/074589
申请日：2007-07-27
申请人： MEDTRONIC, INC. , SHELDON, Todd J. , STANSLASKI, Scott R. , SWEENEY, Michael O. , BETZHOLD, Robert A. , HETTRICK, Douglas A. , BELK, Paul A.
发明人： SHELDON, Todd J. , STANSLASKI, Scott R. , SWEENEY, Michael O. , BETZHOLD, Robert A. , HETTRICK, Douglas A. , BELK, Paul A.
IPC分类号： A61N1/368
CPC分类号： A61N1/3702 , A61N1/3622 , A61N1/3688
摘要： An implantable medical device operates according to a ventricular pacing protocol (VPP) that precludes ventricular pacing in any cardiac cycle where a sensed ventricular event has occurred in the preceding cycle. Improved ventricular sensing, detection and classification is provided.
摘要翻译：植入式医疗装置根据心室起搏方案（VPP）进行操作，其排除在前一周期中发生感测到的心室事件的任何心动周期中的心室起搏。提供改善的心室感测，检测和分类。

4. 发明申请

WO2013028680A2 METHOD AND APPARATUS FOR DETECTING A BIOMARKER IN THE PRESENCE OF ELECTRICAL STIMULATION 审中-公开
标题翻译：在存在电刺激下检测生物标志物的方法和设备
公开(公告)号：WO2013028680A2
公开(公告)日：2013-02-28
申请号：PCT/US2012/051705
申请日：2012-08-21
申请人： MEDTRONIC, INC. , CARLSON, David L. , AFSHAR, Pedram , DENISON, Timothy J. , GIFTAKIS, Jonathon E. , LINDE, David E. , STANSLASKI, Scott R.
发明人： CARLSON, David L. , AFSHAR, Pedram , DENISON, Timothy J. , GIFTAKIS, Jonathon E. , LINDE, David E. , STANSLASKI, Scott R.
IPC分类号： A61B5/04
CPC分类号： A61B5/04012 , A61B5/04001 , A61B5/04014 , A61B5/0476 , A61B5/0488 , A61B5/0496 , A61B5/4082 , A61B5/4094 , A61B5/7264 , A61B5/7282
摘要： Various embodiments concern identifying a biomarker in the presence of electrical stimulation. Various embodiments concern delivering electrical stimulation to a patient and sensing one or more signals while the electrical stimulation is being delivered, the one or more signals including data indicative of physiological activity. Various embodiments further include determining an intensity of the electrical stimulation and determining whether the data indicates the presence of a biomarker based on a variable threshold, the variable threshold being variable based on the intensity of the electrical stimulation. Various embodiments concern determining a relationship between stimulation intensity and a biomarker parameter to determine the variability of the variable threshold.
摘要翻译：各种实施方案涉及在存在电刺激的情况下鉴定生物标志物。各种实施例涉及在电刺激正被递送的同时向患者递送电刺激并且感测一个或多个信号，所述一个或多个信号包括指示生理活动的数据。各种实施例还包括确定电刺激的强度并且基于可变阈值确定数据是否指示生物标志物的存在，可变阈值基于电刺激的强度是可变的。各种实施例涉及确定刺激强度与生物标志物参数之间的关系以确定可变阈值的可变性。

5. 发明申请

WO2021141814A1 BURR CAP-MOUNTED ELECTRODES 审中-公开
公开(公告)号：WO2021141814A1
公开(公告)日：2021-07-15
申请号：PCT/US2020/067493
申请日：2020-12-30
申请人： MEDTRONIC, INC.
发明人： PETERSON, Erik J. , STANSLASKI, Scott R. , SHI, Alan
IPC分类号： A61N1/05 , A61B5/00 , A61N1/36 , A61B5/271 , A61B5/293 , A61B5/383 , A61B5/4836 , A61B5/6864 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36139
摘要： A system provides a burr hole cap assembly configured to secure a position of a lead implanted through a burr hole in a cranium of a patient. One or more electrodes are coupled to one or more components of the burr hole cap assembly. The one or more electrode is disposed within the burr hole cap assembly for sensing signals within a brain of the patient or stimulating a portion of the brain of the patient.

6. 发明申请

WO2019246579A1 ECAP BASED CONTROL OF ELECTRICAL STIMULATION THERAPY 审中-公开
公开(公告)号：WO2019246579A1
公开(公告)日：2019-12-26
申请号：PCT/US2019/038573
申请日：2019-06-21
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , ORSER, Heather Diane , STANSLASKI, Scott R. , PETERSON, Erik J.
IPC分类号： A61N1/36
摘要： Devices, systems, and techniques for controlling electrical stimulation therapy are described. In one example, a system may be configured to deliver electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a plurality of therapy pulses at a predetermined pulse frequency over a period of time and deliver, over the period of time, a plurality of control pulses interleaved with at least some therapy pulses of the plurality of therapy pulses. The system may also be configured to sense, after one or more control pulses and prior to an immediately subsequent therapy pulse of the plurality of therapy pulses, a respective evoked compound action potential (ECAP), adjust, based on at least one respective ECAP, one or more parameter values that at least partially defines the plurality of therapy pulses, and deliver the electrical stimulation therapy to the patient according to the adjusted one or more parameter values.

7. 发明申请

WO2018064193A1 ADAPTIVE DEEP BRAIN STIMULATION USING HOMEOSTATIC WINDOW 审中-公开
标题翻译：使用遥控窗口进行自适应深层脑刺激
公开(公告)号：WO2018064193A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/053770
申请日：2017-09-27
申请人： MEDTRONIC, INC.
发明人： STANSLASKI, Scott R. , ADAMSKI, Thomas , BOURGET, Duane L. , DENISON, Timothy J. , ISAACSON, Benjamin P. , PANKEN, Eric J. , RAIKE, Robert S. , PULLIAM, Christopher , ABRAHAM, Timothy R. , HERRON, Jeffrey
IPC分类号： A61N1/36 , A61B5/04 , A61B5/00 , A61N1/05
摘要： Techniques are disclosed for defining a homeostatic window for controlling delivery of electrical stimulation therapy to a patient. In one example, a method includes generating and delivering electrical stimulation therapy to tissue of a patient via electrodes. Further, the method includes adjusting a level of a parameter of the electrical stimulation therapy such that a signal of the patient is not less than a lower bound and not greater than an upper bound. The lower bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce one or more symptoms of a disease while the patient was receiving medication for reduction of the one or more symptoms. Further, the upper bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce the one or more symptoms when the patient was not receiving the medication.
摘要翻译：公开了用于限定用于控制向患者递送电刺激治疗的稳态窗口的技术。在一个示例中，一种方法包括通过电极产生电刺激治疗并将其递送至患者组织。此外，该方法包括调整电刺激治疗的参数的水平，使得患者的信号不小于下限且不大于上限。确定下限是当接受电刺激治疗时信号的幅度，该电刺激治疗足以在患者接受用于减少一种或多种症状的药物的同时减少疾病的一种或多种症状。此外，当患者没有接受药物时，上限被确定为信号的幅度，同时接受足以减少一种或多种症状的电刺激疗法。

8. 发明申请

WO2015065599A1 DEVICES FOR SENSING PHYSIOLOGICAL SIGNALS DURING STIMULATION THERAPY 审中-公开
标题翻译：在刺激治疗期间用于感测生理信号的装置
公开(公告)号：WO2015065599A1
公开(公告)日：2015-05-07
申请号：PCT/US2014/055553
申请日：2014-09-15
申请人： MEDTRONIC, INC.
发明人： STANSLASKI, Scott R. , CONG, Peng , SANTA, Wesley A. , DENISON, Timothy J.
IPC分类号： A61N1/36 , A61B5/00 , A61B5/04
CPC分类号： A61B5/04001 , A61B5/40 , A61B5/4836 , A61B5/7217 , A61B5/7225 , A61N1/36 , A61N1/3605 , A61N1/36125
摘要： Devices and methods provide for the sensing of physiological signals during stimulation therapy by preventing stimulation waveform artifacts from being passed through to the amplification of the sensed physiological signal. Thus, the amplifiers are not adversely affected by the stimulation waveform and can provide for successful sensing of physiological signals between stimulation waveform pulses. A blanking switch may be used to blank the stimulation waveform artifacts where the blanking switch is operated in a manner synchronized with the stimulation waveform so that conduction in the sensing path is blocked during the stimulation pulse as well as during other troublesome artifacts such as a peak of a recharge pulse. A limiter may be used to limit the amplitude of the sensed signal, and hence the stimulation artifacts, that are passed to the amplifier without any synchronization of the limiter to the stimulation waveform.
摘要翻译：装置和方法通过防止刺激波形伪影通过到感测的生理信号的放大来提供在刺激治疗期间感测生理信号。因此，放大器不受刺激波形的不利影响，并且可以提供刺激波形脉冲之间的生理信号的成功感测。消隐开关可以用于消除刺激波形伪影，其中消隐开关以与刺激波形同步的方式操作，使得感测路径中的传导在刺激脉冲期间以及在其他麻烦的伪像期间被阻塞，例如峰值的充电脉冲。可以使用限制器来限制感测信号的幅度，并且因此限制器将刺激伪影传递到放大器而不限制器与刺激波形的任何同步。

9. 发明申请

WO2022026493A1 STIMULATION INDUCED NEURAL RESPONSE FOR DETECTION OF LEAD MOVEMENT 审中-公开
公开(公告)号：WO2022026493A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/043362
申请日：2021-07-28
申请人： MEDTRONIC, INC.
发明人： MOLINA, Rene A. , STANSLASKI, Scott R. , JACKSON, Jadin C. , PULLIAM, Christopher L. , PANKEN, Eric J. , CASE, Michelle A. , BECKER, Abbey Beuning Holt
IPC分类号： A61N1/36
摘要： Devices, systems, and techniques are described for identifying stimulation parameter values based on electrical stimulation that induces dyskinesia for the patient. For example, a method may include controlling, by processing circuitry, a medical device to deliver electrical stimulation to a portion of a brain of a patient, receiving, by the processing circuitry, information representative of an electrical signal sensed from the brain after delivery of the electrical stimulation, determining, by the processing circuitry and from the information representative of the electrical signal, a peak in a spectral power of the electrical signal at a second frequency lower than a first frequency of the electrical stimulation, and responsive to determining the peak in the spectral power of the electrical signal at the second frequency, performing, by the processing circuitry, an action.

10. 发明申请

WO2020086119A1 SIGNAL-BASED AUTOMATED DEEP BRAIN STIMULATION PROGRAMMING 审中-公开
公开(公告)号：WO2020086119A1
公开(公告)日：2020-04-30
申请号：PCT/US2019/039132
申请日：2019-06-26
申请人： MEDTRONIC, INC.
发明人： XIAO, YiZi , PANKEN, Eric J. , STANSLASKI, Scott R. , JACKSON, Jadin C. , PULLIAM, Christopher
IPC分类号： A61N1/36 , A61B5/048 , A61B5/0484
摘要： Techniques are disclosed to automate determination of therapy parameter values for adaptive deep brain stimulation (aDBS). A medical device may determine differences in power values between a present and a previous power value. Based on the difference being greater than or equal to a threshold value, the medical device may iteratively adjust a present therapy parameter value until the difference in the power values between a present and a previous power value is less than the threshold value.

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