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1. 发明申请

WO2022010677A1 ANALYZING ECAP SIGNALS 审中-公开
公开(公告)号：WO2022010677A1
公开(公告)日：2022-01-13
申请号：PCT/US2021/039319
申请日：2021-06-28
申请人： MEDTRONIC, INC.
发明人： COREY, Robert A. , HAGEMAN, Kristin N. , DINSMOOR, David A. , BINK, Hank , PULLIAM, Christopher L. , ADAMSKI, Thomas
IPC分类号： A61N1/36 , A61B5/316 , A61B5/388 , A61B5/00 , A61N1/05
摘要： Systems, devices, and techniques are described for analyzing evoked compound action potentials (ECAP) signals to assess the effect of a delivered electrical stimulation signal. In one example, a system includes a stimulation generator configured to deliver a stimulation pulse to a patient, sensing circuitry configured to sense an evoked compound action potential (ECAP) signal evoked from the stimulation pulse, and processing circuitry. The processing circuitry may be configured to determine a maximum value of a derivative of the ECAP signal, determine a minimum value of the derivative of the ECAP signal, determine, based on the maximum value of the derivative and the minimum value of the derivative, a characteristic value of the ECAP signal, and determine, based on the characteristic value of the ECAP signal, at least one parameter value at least partially defining electrical stimulation therapy to be delivered to the patient.

2. 发明申请

WO2018064193A1 ADAPTIVE DEEP BRAIN STIMULATION USING HOMEOSTATIC WINDOW 审中-公开
标题翻译：使用遥控窗口进行自适应深层脑刺激
公开(公告)号：WO2018064193A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/053770
申请日：2017-09-27
申请人： MEDTRONIC, INC.
发明人： STANSLASKI, Scott R. , ADAMSKI, Thomas , BOURGET, Duane L. , DENISON, Timothy J. , ISAACSON, Benjamin P. , PANKEN, Eric J. , RAIKE, Robert S. , PULLIAM, Christopher , ABRAHAM, Timothy R. , HERRON, Jeffrey
IPC分类号： A61N1/36 , A61B5/04 , A61B5/00 , A61N1/05
摘要： Techniques are disclosed for defining a homeostatic window for controlling delivery of electrical stimulation therapy to a patient. In one example, a method includes generating and delivering electrical stimulation therapy to tissue of a patient via electrodes. Further, the method includes adjusting a level of a parameter of the electrical stimulation therapy such that a signal of the patient is not less than a lower bound and not greater than an upper bound. The lower bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce one or more symptoms of a disease while the patient was receiving medication for reduction of the one or more symptoms. Further, the upper bound is determined to be the magnitude of the signal while receiving electrical stimulation therapy sufficient to reduce the one or more symptoms when the patient was not receiving the medication.
摘要翻译：公开了用于限定用于控制向患者递送电刺激治疗的稳态窗口的技术。在一个示例中，一种方法包括通过电极产生电刺激治疗并将其递送至患者组织。此外，该方法包括调整电刺激治疗的参数的水平，使得患者的信号不小于下限且不大于上限。确定下限是当接受电刺激治疗时信号的幅度，该电刺激治疗足以在患者接受用于减少一种或多种症状的药物的同时减少疾病的一种或多种症状。此外，当患者没有接受药物时，上限被确定为信号的幅度，同时接受足以减少一种或多种症状的电刺激疗法。

3. 发明申请

WO2020154370A1 MANAGING THERAPY DELIVERY BASED ON PHYSIOLOGICAL MARKERS 审中-公开
公开(公告)号：WO2020154370A1
公开(公告)日：2020-07-30
申请号：PCT/US2020/014565
申请日：2020-01-22
申请人： MEDTRONIC, INC.
发明人： BRINK, Thaddeus S. , ADAMSKI, Thomas , STANSLASKI, Scott R. , ZIRPEL, Lance , HERRON, Jeffrey
IPC分类号： A61N1/36 , A61B5/20
摘要： An adaptive system for providing electrical stimulation to a patient, the system comprising: memory configured to store one or more programs; and processor circuitry coupled to the memory and configured to execute the one or more programs, the processor circuitry being configured to: monitor a sensor signal and classify a physiological marker of the patient based upon the sensor signal, the physiological marker indicative of a phase of a physiological cycle; generate a control signal based on the classified physiological marker of the patient, wherein the control signal controls an implantable stimulation device to provide the electrical stimulation, in accordance with one or more stimulation parameters of a stimulation program, at a target site within the patient to one more of: enable a sphincter to open to allow a voiding event or constrict the sphincter to inhibit the voiding event; adapt one or more of a manner in which the processor circuitry classifies the physiological markers, generates the control signal, or the one or more stimulation parameters of the stimulation program based on the classified physiological markers or patient input so as to automatically adjust one or more of timing of the delivery of the electrical stimulation or the stimulation parameters of the electrical stimulation. Corresponding method of controlling an implantable medical device.

4. 发明公开

EP4178665A1 ANALYZING ECAP SIGNALS 审中-实审
公开(公告)号：EP4178665A1
公开(公告)日：2023-05-17
申请号：EP21745588.0
申请日：2021-06-28
申请人： Medtronic, Inc.
发明人： COREY, Robert A. , HAGEMAN, Kristin N. , DINSMOOR, David A. , BINK, Hank , PULLIAM, Christopher L. , ADAMSKI, Thomas
IPC分类号： A61N1/36 , A61B5/316 , A61B5/388 , A61B5/00 , A61N1/05

5. 发明公开

EP3519039A1 ADAPTIVE DEEP BRAIN STIMULATION USING HOMEOSTATIC WINDOW 审中-公开
公开(公告)号：EP3519039A1
公开(公告)日：2019-08-07
申请号：EP17781317.7
申请日：2017-09-27
申请人： Medtronic, Inc.
发明人： STANSLASKI, Scott R. , ADAMSKI, Thomas , BOURGET, Duane L. , DENISON, Timothy J. , ISAACSON, Benjamin P. , PANKEN, Eric J. , RAIKE, Robert S. , PULLIAM, Christopher , ABRAHAM, Timothy R. , HERRON, Jeffrey
IPC分类号： A61N1/36 , A61B5/04 , A61B5/00 , A61N1/05

6. 发明公开

EP3914340A1 MANAGING THERAPY DELIVERY BASED ON PHYSIOLOGICAL MARKERS 审中-实审
公开(公告)号：EP3914340A1
公开(公告)日：2021-12-01
申请号：EP20709789.0
申请日：2020-01-22
申请人： Medtronic, Inc.
发明人： BRINK, Thaddeus S. , ADAMSKI, Thomas , STANSLASKI, Scott R. , ZIRPEL, Lance , HERRON, Jeffrey
IPC分类号： A61N1/36 , A61B5/20

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