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1. 发明申请

WO2003061759A1 METHODS AND APPARATUS FOR DETECTION AND TREATMENT OF SYNCOPE 审中-公开
标题翻译：方法和装置用于同位素的检测和治疗
公开(公告)号：WO2003061759A1
公开(公告)日：2003-07-31
申请号：PCT/US2003/001714
申请日：2003-01-21
申请人： MEDTRONIC, INC.
发明人： SCHULER, Andreas , SAHAKIAN, Alav, V. , MARKOWITZ, Toby, H. , ERICKSON, Mark, K.
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： The present invention relates to methods and apparatus for detection and treatment of syncope in an implantable medical device, and particularly to detection of syncope as a function of a predetermined increase in one or more respiration parameter and drop in heart rate and optionally delivering a pacing therapy in response thereto. The onset of a syncopal episode is declared when the patient's respiration rate and/or tidal volume and/or minute ventilation increases by a predetermined increment or threshold and a heart rate drops below a threshold heart rate drop. The threshold heart rate drop is preferably established as a function of the change in the respiration parameter.
摘要翻译：本发明涉及用于在可植入医疗装置中检测和治疗晕厥的方法和装置，特别涉及作为一个或多个呼吸参数的预定增加和心率下降以及可选地递送起搏疗法的功能的晕厥检测作为响应。当患者的呼吸速率和/或潮气量和/或分钟通气增加预定增量或阈值并且心率下降到阈值心率下降以下时，声明发作性晕厥发作。阈值心率下降优选地建立为呼吸参数变化的函数。

2. 发明申请

WO2005042088A1 IMPLANTABLE MEDICAL DEVICE AND METHOD FOR DELIVERING THERAPY FOR SLEEP-DISORDERED BREATHING 审中-公开
标题翻译：可移植的医疗装置和用于治疗慢性呼吸道疾病的方法
公开(公告)号：WO2005042088A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/034845
申请日：2004-10-21
申请人： MEDTRONIC, INC. , CHO, Yong, Kyun , MARKOWITZ, Toby, H.
发明人： CHO, Yong, Kyun , MARKOWITZ, Toby, H.
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61B5/08 , A61B5/082 , A61N1/36521 , A61N1/36557
摘要： An implantable medical device delivers augmentation therapy to ntervene in a pattern of sleep-disordered breathing. Augmentation therapy includes the delivery of electrical stimulation to cardiac tissue above and/or below a capture threshold. PESP and NES/CCM are possible augmentation therapies that are used alone or in combination. In addition, augmentation therapies can be used with other pacing therapies such as atrial overdrive pacing and atrial coordinated pacing as a therapy for sleep-disordered breathing.
摘要翻译：可植入式医疗装置以睡眠呼吸障碍的形式向ntervene递送增强疗法。增强疗法包括将电刺激递送到高于和/或低于捕获阈值的心脏组织。 PESP和NES / CCM是单独使用或组合使用的可能的增强疗法。此外，增强疗法可以与其他起搏疗法一起使用，例如心房超速起搏和心房协调起搏作为睡眠呼吸障碍的治疗方法。

3. 发明授权

EP1960042B1 METHOD AND SYSTEM FOR DETECTING AND TREATING JUNCTIONAL RHYTHMS 有权
标题翻译：方法和系统检测和连接节律的治疗
公开(公告)号：EP1960042B1
公开(公告)日：2012-01-04
申请号：EP06840080.3
申请日：2006-11-30
申请人： Medtronic, Inc.
发明人： MARKOWITZ, Toby, H. , HARRIS, Matthew , BRAND, Trina, A.
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/365 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first, arid second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.

4. 发明授权

EP1478434B1 APPARATUS FOR DETECTION AND TREATMENT OF SYNCOPE 有权
标题翻译：设备检测和晕厥治疗
公开(公告)号：EP1478434B1
公开(公告)日：2007-04-18
申请号：EP03732007.4
申请日：2003-01-21
申请人： MEDTRONIC, INC.
发明人： SCHULER, Andreas , SAHAKIAN, Alav, V. , MARKOWITZ, Toby, H. , ERICKSON, Mark, K.
IPC分类号： A61N1/365
CPC分类号： A61N1/36521
摘要： The present invention relates to methods and apparatus for detection and treatment of syncope in an implantable medical device, and particularly to detection of syncope as a function of a predetermined increase in one or more respiration parameter and drop in heart rate and optionally delivering a pacing therapy in response thereto. The onset of a syncopal episode is declared when the patient's respiration rate and/or tidal volume and/or minute ventilation increases by a predetermined increment or threshold and a heart rate drops below a threshold heart rate drop. The threshold heart rate drop is preferably established as a function of the change in the respiration parameter.

5. 发明申请

WO2011025708A2 COMBINATION LOCALIZATION SYSTEM 审中-公开
公开(公告)号：WO2011025708A2
公开(公告)日：2011-03-03
申请号：PCT/US2010/046066
申请日：2010-08-20
申请人： MEDTRONIC, INC. , MARKOWITZ, Toby, H. , GARDESKI, Kenneth, C. , CARVER, Jean, M. , YASGER, Kendra , NEIDERT, Michael, R. , VERARD, Laurent , HARTMANN, Steven, L. , BZOSTEK, Andrew , JASCOB, Bradley, A.
发明人： MARKOWITZ, Toby, H. , GARDESKI, Kenneth, C. , CARVER, Jean, M. , YASGER, Kendra , NEIDERT, Michael, R. , VERARD, Laurent , HARTMANN, Steven, L. , BZOSTEK, Andrew , JASCOB, Bradley, A.
IPC分类号： A61B19/00
CPC分类号： A61B90/13 , A61B18/1492 , A61B34/20 , A61B34/25 , A61B2017/00026 , A61B2034/2051 , A61B2090/0818
摘要： A navigation system or combination of navigation systems can be used to provide two or more navigation modalities to navigate a single instrument in a volume. For example, both an Electromagnetic (EM) and Electropotential (EP) navigation system can be used to navigate an instrument within the volume. Image data can also be illustrated relative to a tracked position of the instrument in the volume for navigation.

6. 发明申请

WO1996004956A3 ATRIAL AND VENTRICULAR CAPTURE DETECTION AND THRESHOLD-SEEKING PACEMAKER 审中-公开
公开(公告)号：WO1996004956A3
公开(公告)日：1996-02-22
申请号：PCT/US1995009610
申请日：1995-07-31
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , MARKOWITZ, Toby, H. , STROEBEL, John, C. , ZHOU, Ren , RUETER, John, C.
IPC分类号： A61N01/37

7. 发明申请

WO1995029734A1 PACEMAKER WITH VASOVAGAL SYNCOPE DETECTION 审中-公开
标题翻译： PASMAKER与VASOVAGAL SYNCOPE检测
公开(公告)号：WO1995029734A1
公开(公告)日：1995-11-09
申请号：PCT/US1995002913
申请日：1995-03-08
申请人： MEDTRONIC, INC.
发明人： MEDTRONIC, INC. , MARKOWITZ, Toby, H. , HESS, Michael, F. , SHELTON, Michael, Brent , RIFF, Kenneth, M. , JENSEN, Donald, Nick
IPC分类号： A61N01/365
CPC分类号： A61N1/36514 , A61N1/365
摘要： Pacemaker with improved detection methods for occurrence of vasovagal syncope episodes. Increased rate pacing followed by fallback to lower rate is a retained feature. The lower rate need not be related to the increased pacing rate. One alternative detects stable or persistent rate below a threshold rate after a rapid rate drop through the threshold rate. Another alternative detects a "top rate" as a highest persistent rate and compares the difference between it and the rate that follows a rate drop through a "drop rate" or other threshold level. Yet another alternative finds a persistent rate above a first threshold rate before initiating the rate drop detection function. Once initiated, this embodiment preferably detects a rate drop from above said first threshold to below a second threshold rate, and also preferably detects a stable rate below said second threshold rate. Adaptations to avoiding pacing activation during sleep and combinations of the various embodiments are discussed.
摘要翻译：起搏器具有改善的血管迷走性晕厥发作检测方法。增加速率起搏紧随其后，降低速率是一个保留的特征。较低的比率不需要与增加的起搏率相关。一个替代方案是在通过阈值速率快速下降之后检测稳定或持续速率低于阈值速率。另一个替代方案将“最高速率”检测为最高持续速率，并通过“丢弃率”或其他阈值水平比较其与速率下降之间的差异。另一种替代方案是在启动速率丢失检测功能之前，发现持续速率高于第一阈值速率。一旦启动，该实施例优选地检测从高于所述第一阈值到低于第二阈值速率的速率下降，并且还优选地检测低于所述第二阈值速率的稳定速率。讨论了在睡眠期间避免起搏激活的适应和各种实施例的组合。

8. 发明申请

WO2007065123A1 METHOD AND SYSTEM FOR DETECTING AND TREATING JUNCTIONAL RHYTHMS 审中-公开
标题翻译：检测和处理关节炎的方法和系统
公开(公告)号：WO2007065123A1
公开(公告)日：2007-06-07
申请号：PCT/US2006/061398
申请日：2006-11-30
申请人： MEDTRONIC, INC. , MARKOWITZ, Toby, H. , HARRIS, Matthew , BUHR, Trina, A.
发明人： MARKOWITZ, Toby, H. , HARRIS, Matthew , BUHR, Trina, A.
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/365 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first, arid second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.
摘要翻译：提供了一种治疗心律失常的方法和装置。确定具有第一和第二室类型的心脏的第一和第二连续节拍之间的间隔。如果第一次搏动来自第一腔室类型并且第二搏动来自第二腔室类型并且间隔小于预定量的时间，或如果第一次干扰的第二搏动都来自第二室型。如果第一搏动来自第一腔室类型，第二搏动来自第二腔室类型，并且间隔大于预定时间量，心脏以第二速度进行起搏。

9. 发明申请

WO2004062485A2 APPARATUS AND METHOD FOR MONITORING FOR DISORDERED BREATHING 审中-公开
标题翻译：用于监测异常呼吸的装置和方法
公开(公告)号：WO2004062485A2
公开(公告)日：2004-07-29
申请号：PCT/US2004/000674
申请日：2004-01-09
申请人： MEDTRONIC, INC.
发明人： CHO, Young, Kyun , LAWABNI, Abed, E. , SHELDON, Todd, J. , MARKOWITZ, Toby, H. , SOWELAM, Sameh , PITSCHNEIDER, Raylene
IPC分类号： A61B
CPC分类号： A61B5/4818 , A61B5/0205 , A61B5/0809 , A61B5/0816 , G06F19/00
摘要： The present invention relates to a device and method for monitoring for sleep disordered breathing or other types of disordered breathing such as Cheyne-Stokes breathing. More specifically, a device and method for detecting disordered breathing is provided that monitors a physiological parameter, which becomes cyclical due to apnea-hyperpnea (or arousal) alternation and provides the basis for the determination of a number of breathing disorder metrics.
摘要翻译：本发明涉及一种用于监测睡眠呼吸紊乱或其他类型无序呼吸（例如Cheyne-Stokes呼吸）的装置和方法。更具体地，提供了一种用于检测无序呼吸的装置和方法，其监测由于呼吸暂停呼吸（或唤醒）交替而变得周期性的生理参数，并且提供了确定多个呼吸障碍度量的基础。

10. 发明公开

EP1960042A1 METHOD AND SYSTEM FOR DETECTING AND TREATING JUNCTIONAL RHYTHMS 有权
标题翻译：方法和系统检测和连接节律的治疗
公开(公告)号：EP1960042A1
公开(公告)日：2008-08-27
申请号：EP06840080.3
申请日：2006-11-30
申请人： MEDTRONIC, INC.
发明人： MARKOWITZ, Toby, H. , HARRIS, Matthew , BUHR, Trina, A.
IPC分类号： A61N1/362 , A61N1/365 , A61N1/368
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/365 , A61N1/368 , A61N1/3682 , A61N1/3684
摘要： A method and an apparatus for treating cardiac arrhythmias are provided. An interval between first and second consecutive beats of a heart, having first and second chamber types, is determined. The heart is paced at a first rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is less than a predetermined amount of time or if the first, arid second beats are both from the second chamber type. The heart is paced at a second rate if the first beat is from the first chamber type and the second beat is from the second chamber type and the interval is more than the predetermined amount of time.

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