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1. 发明申请

WO2022182611A1 DETERMINING ELECTRODE COMBINATIONS FOR SENSING 审中-公开
公开(公告)号：WO2022182611A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/017157
申请日：2022-02-21
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , HINCAPIE, Juan G. , LITVAK, Leonid M.
IPC分类号： A61N1/36 , A61N1/05 , A61B5/24 , A61N1/372
摘要： Systems, devices, and techniques for analyzing evoked compound action potentials (ECAP) signals to evaluate and select an electrode combination. A method includes controlling, by processing circuitry, deliver of a plurality of stimulation pulses via at least one stimulation electrode combination, receiving, by the processing circuitry, evoked compound action potential (ECAP) signal information representing different ECAP signals evoked from respective stimulation pulses of the plurality of stimulation pulses and obtained from respective different sensing electrode combinations, selecting, by the processing circuitry and based on the ECAP signal information, one electrode combination from the different sensing electrode combinations.

2. 发明申请

WO2021126587A1 ECAP AND POSTURE STATE CONTROL OF ELECTRICAL STIMULATION 审中-公开
公开(公告)号：WO2021126587A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/063690
申请日：2020-12-08
申请人： MEDTRONIC, INC.
发明人： PULLIAM, Christopher , DINSMOOR, David A. , BINK, Hank , HAGEMAN, Kristin N.
IPC分类号： A61N1/36 , A61B5/383 , A61B5/11 , A61B5/1116 , A61B5/4836 , A61N1/36062 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36107 , A61N1/36139 , A61N1/36153 , A61N1/36171 , A61N1/36175
摘要： Systems, devices, and techniques for adjusting electrical stimulation based on a posture state of a patient are described. For example, a system may include sensing circuitry configured to sense an ECAP signal and processing circuitry configured to control delivery of the electrical stimulation to a patient according to a first value of a stimulation parameter and determine a characteristic value of the ECAP signal. The processing circuitry may also be configured to receive, from a sensor, a posture state signal representing a posture state of the patient, determine, based on the posture state signal, a gain value for the stimulation parameter, adjust, based on the characteristic value of the ECAP signal and the gain value, the first value of the stimulation parameter to a second value of the stimulation parameter, and control delivery of the electrical stimulation according to the second value of the stimulation parameter.

3. 发明申请

WO2021126432A1 HYSTERESIS COMPENSATION FOR DETECTION OF ECAPS 审中-公开
公开(公告)号：WO2021126432A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/060329
申请日：2020-11-13
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , PULLIAM, Christopher , BINK, Hank , HAGEMAN, Kristin N.
IPC分类号： A61N1/36 , A61B5/1116 , A61N1/025 , A61N1/36031 , A61N1/36125 , A61N1/36128 , A61N1/36135 , A61N1/36139 , A61N1/37247
摘要： Systems, devices, and techniques are described for adjusting electrical stimulation based on detected ECAPs. In one example, a medical device includes processing circuitry configured to control stimulation circuitry to deliver a first electrical stimulation pulse and sensing circuitry to detect, after delivery of the first electrical stimulation pulse, an ECAP signal. The processing circuitry may be configured to determine a characteristic value of the ECAP signal, determine an ECAP differential value that indicates whether the characteristic value of the ECAP signal is one of greater than a selected ECAP characteristic value or less than the selected ECAP characteristic value, determine, based on the ECAP differential value, a gain value, determine, based on the gain value, a parameter value that at least partially defines a second electrical stimulation pulse, and control the stimulation circuitry to deliver the second electrical stimulation pulse according to the parameter value.

4. 发明申请

WO2014089390A1 MINIMALLY INVASIVE IMPLANTABLE NEUROSTIMULATION SYSTEM 审中-公开
标题翻译：微型可入侵神经系统
公开(公告)号：WO2014089390A1
公开(公告)日：2014-06-12
申请号：PCT/US2013/073481
申请日：2013-12-06
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , ANDERSON, Joel A. , PAPE, Forrest C.M. , SMITH, Todd V. , BONDE, Eric H.
IPC分类号： A61N1/36 , A61N1/378
CPC分类号： A61B17/00234 , A61N1/02 , A61N1/05 , A61N1/0551 , A61N1/36 , A61N1/36007 , A61N1/36021 , A61N1/3605 , A61N1/36053 , A61N1/36057 , A61N1/36067 , A61N1/36071 , A61N1/36139 , A61N1/37205 , A61N1/37211 , A61N1/37223 , A61N1/37235 , A61N1/37247 , A61N1/37252 , A61N1/3727 , A61N1/375 , A61N1/3754 , A61N1/3756 , A61N1/3787 , F04C2270/0421
摘要： Various embodiments of a minimally invasive implantable medical device (IMD) system are described. In one embodiment, the implantable medical device system includes an external device for transmitting a communication signal and an implantable device for receiving the communication signal by inductive coupling. The implantable device is configured to harvest power from the inductively coupled communication signal and power a signal generator from the harvested power to generate a therapeutic electrical stimulation signal.
摘要翻译：描述了微创可植入医疗装置（IMD）系统的各种实施例。在一个实施例中，可植入医疗设备系统包括用于发送通信信号的外部设备和用于通过电感耦合接收通信信号的可植入设备。可植入装置被配置为从感应耦合的通信信号中获取功率，并从收集的功率对信号发生器供电以产生治疗性电刺激信号。

5. 发明申请

WO2022182656A1 INDEPENDENT MODULATION OF STIMULATION THERAPY WAVEFORMS 审中-公开
公开(公告)号：WO2022182656A1
公开(公告)日：2022-09-01
申请号：PCT/US2022/017309
申请日：2022-02-22
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , LITVAK, Leonid M. , KRAMER, Jeffery M.
IPC分类号： A61N1/36 , A61N1/05
摘要： Devices, systems, and techniques are configured for independently modulating two or more concurrent signals of electrical stimulation therapy. In one example, a system includes stimulation generation circuitry and processing circuitry configured to control the stimulation generation circuitry to deliver first electrical stimulation to a patient via a first electrode combination, wherein the first electrical stimulation is defined by at least a first set of stimulation parameters selected that the first electrical stimulation exceeds a first perception threshold, and control the stimulation generation circuitry to deliver second electrical stimulation, concurrent with the first electrical stimulation, to the patient via a second electrode combination. The second electrical stimulation may be defined by at least a second set of stimulation parameters selected that the second electrical stimulation is below a second perception threshold. The processing circuitry may also determine a triggering condition and independently modulate the first and/or second electrical stimulation.

6. 发明申请

WO2022150638A1 DETERMINING ESTIMATED NEURAL THRESHOLD WITH ECAP SIGNALS 审中-公开
公开(公告)号：WO2022150638A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/011690
申请日：2022-01-07
申请人： MEDTRONIC, INC.
发明人： LITVAK, Leonid M. , DINSMOOR, David A. , HINCAPIE, Juan G. , KRAMER, Jeffrey M. , MUELLER, Jerel K. , NEDRUD, Joshua J. , STRAKA, Malgorzata M.
IPC分类号： A61N1/36
摘要： Systems, devices, and techniques are described for analyzing evoked compound action potential (ECAP) signals to determine an estimated neural threshold of a patient. In one example, a method includes controlling, by processing circuitry, delivery of a plurality of stimulation pulses to a patient, wherein each stimulation pulse of the plurality of stimulation pulses is at least partially defined by a different respective value of a stimulation parameter; receiving, by the processing circuitry, ECAP signal information, wherein the ECAP signal information comprises ECAP signals sensed by sensing circuitry and elicited by the plurality of stimulation pulses; determining, by the processing circuitry and based on the ECAP signal information, ECAP characteristic values for each of the ECAP signals elicited by the plurality' of stimulation pulses; and determining, by the processing circuitry and based on the ECAP characteristic values, an estimated neural threshold of the patient.

7. 发明申请

WO2019246582A1 ECAP BASED CONTROL OF ELECTRICAL STIMULATION THERAPY 审中-公开
公开(公告)号：WO2019246582A1
公开(公告)日：2019-12-26
申请号：PCT/US2019/038579
申请日：2019-06-21
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , HAGEMAN, Kristin N. , BINK, Hank
IPC分类号： A61N1/36 , A61B5/04 , A61B5/00
摘要： Devices, systems, and techniques for controlling electrical stimulation therapy are described. In one example, a system may be configured to deliver electrical stimulation therapy to a patient, the electrical stimulation therapy comprising a plurality of therapy pulses at a predetermined pulse frequency over a period of time and deliver, over the period of time, a plurality of control pulses interleaved with at least some therapy pulses of the plurality of therapy pulses. The system may also be configured to sense, after one or more control pulses and prior to an immediately subsequent therapy pulse of the plurality of therapy pulses, a respective evoked compound action potential (ECAP), adjust, based on at least one respective ECAP, one or more parameter values that at least partially defines the plurality of therapy pulses, and deliver the electrical stimulation therapy to the patient according to the adjusted one or more parameter values.

8. 发明申请

WO2018089418A1 STIMULATION VECTOR SELECTION USING PULSE WIDTH DATA 审中-公开
标题翻译：使用脉冲宽度数据的刺激向量选择
公开(公告)号：WO2018089418A1
公开(公告)日：2018-05-17
申请号：PCT/US2017/060529
申请日：2017-11-08
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , SU, Xin
IPC分类号： A61N1/36 , A61N1/37
摘要： A method of programming an implantable medical device (IMD) configured to provide electrical stimulation via a plurality of stimulation vectors during delivery of the electrical stimulation of a plurality of pulse widths to a neural target. The method may comprise comparing strength-duration curve data for the plurality of stimulation vectors to one another, the strength-duration curve data representing, for respective pulse widths and stimulation vectors, a corresponding stimulation strength that evokes a physiological response associated with the neural target. The method may comprise selecting at least one stimulation vector of the plurality of stimulation vectors based on the comparison of the strength-duration curve data for the plurality of stimulation vectors. The method may comprise programming, in response to the selection, the IMD to deliver the electrical stimulation to the neural target via the selected at least one stimulation vector.
摘要翻译：一种对可植入医疗装置（IMD）进行编程的方法，所述可植入医疗装置被配置为在将多个脉冲宽度的电刺激递送至神经靶标期间经由多个刺激向量提供电刺激。该方法可以包括将多个刺激矢量的强度 - 持续时间曲线数据相互比较，强度 - 持续时间曲线数据针对各个脉冲宽度和刺激矢量表示唤起与神经靶标相关联的生理反应的对应刺激强度。该方法可以包括基于多个刺激向量的强度 - 持续时间曲线数据的比较来选择多个刺激向量中的至少一个刺激向量。该方法可以包括响应于该选择而编程IMD以经由所选择的至少一个刺激向量将电刺激递送至神经靶标。

9. 发明申请

WO2022154894A1 HYBRID CONTROL POLICY FOR ECAP-SERVOED NEUROMODULATION 审中-公开
公开(公告)号：WO2022154894A1
公开(公告)日：2022-07-21
申请号：PCT/US2021/061636
申请日：2021-12-02
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , HAGEMAN, Kristin N.
IPC分类号： A61N1/36
摘要： Systems, devices, and techniques for adjusting electrical stimulation are described. In some examples, processing circuitry is configured to receive, via a sensing electrode located at a target region of a patient, a plurality of evoked compound action potential (ECAP) signals elicited from respective electrical stimuli delivered to the patient; determine, based on the plurality of ECAP signals, an aggressor category for at least some ECAP signals of the plurality of ECAP signals, the aggressor category determined from a plurality of aggressor categories; determine, based on the aggressor category, a set of control policy parameters that at least partially define closed-loop control of stimulation therapy; and controlling delivery of the stimulation therapy according to at least the set of control policy parameters and one or more subsequent ECAP signals.

10. 发明申请

WO2022140529A1 ELECTRICAL STIMULATION THERAPY 审中-公开
公开(公告)号：WO2022140529A1
公开(公告)日：2022-06-30
申请号：PCT/US2021/064833
申请日：2021-12-22
申请人： MEDTRONIC, INC.
发明人： DINSMOOR, David A. , VALLEJO, Ricardo , SKERKER, Abigail Lauren , LITVAK, Leonid M. , HAGEMAN, Kristin N. , BINK, Hank
IPC分类号： A61N1/36
摘要： Examples for controlling electrical stimulation therapy are described. One example includes delivering a pulse train at a frequency to a patient, the pulse train comprising a plurality of first pulses at least partially interleaved with a plurality of second pulses, wherein the plurality of first pulses are configured to facilitate sensing elicited electrical signals, each pulse of the plurality of first pulses having an active first phase and active second phase. Each pulse of the plurality of second pulses may include an active first phase and a passive second phase. Additionally, or alternatively, the plurality of second pulses may alternate between a cathodic active first phase and an anodic active first phase according to a ratio. At least one pulse of the plurality' of second pulses may have an interphase interval that is longer than an interphase interval of at least one pulse of the plurality of first pulses.

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