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1. 发明申请

WO2008083313A3 METHODS AND SYSTEMS FOR INTEGRATED RADIOPHARMACEUTICAL GENERATION, PREPARATION, TRANSPORTATION, AND ADMINISTRATION 审中-公开
标题翻译：综合放射免疫法生成，制备，运输和管理的方法与系统
公开(公告)号：WO2008083313A3
公开(公告)日：2009-07-23
申请号：PCT/US2007089101
申请日：2007-12-28
申请人： MEDRAD INC , HIRSCHMAN ALAN D , UBER ARTHUR E III , COWAN KEVIN P , REILLY DAVID M , RHINEHART EDWARD J , KALAFUT JOHN F , UBER BRONWYN , TROMBLEY FREDERICK W III , REMIS STEVEN J , LEVIN PAUL , GRIFFITH SCOTT , DESCALZI DOUGLAS , DEWIT RICHARD
发明人： HIRSCHMAN ALAN D , UBER ARTHUR E III , COWAN KEVIN P , REILLY DAVID M , RHINEHART EDWARD J , KALAFUT JOHN F , UBER BRONWYN , TROMBLEY FREDERICK W III , REMIS STEVEN J , LEVIN PAUL , GRIFFITH SCOTT , DESCALZI DOUGLAS , DEWIT RICHARD
IPC分类号： A61M5/172 , A61B6/00 , G21G4/08
CPC分类号： A61N5/1001 , A61B5/0205 , A61B5/055 , A61B5/7289 , A61B6/032 , A61B6/037 , A61B6/0478 , A61B6/107 , A61B6/4057 , A61B6/4258 , A61B6/4423 , A61B6/507 , A61B6/508 , A61B6/5288 , A61B6/548 , A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/16827 , A61M5/16881 , A61M5/1723 , A61M5/1785 , A61M2205/3576 , A61N5/1071 , A61N2005/1021 , A61N2005/1094 , G06F19/3468 , G21F5/015 , G21G4/08
摘要： An integrated radiopharmaceutical patient treatment system is disclosed including a patient support platform with an associated patient stimulus apparatus, an imager proximate the patient support platform, a radiopharmaceutical fluid delivery system for infusing a radiopharmaceutical fluid into a patient, a patient monitor to be associated with a patient, and an integrated system controller operably associated with the patient stimulus apparatus, imager, radiopharmaceutical fluid delivery system, and patient monitor to control and coordinate their operations. Within the patient treatment system the radiopharmaceutical fluid delivery system may be included comprising a radionuclide supply module, a radiopharmaceutical processing module, a quality control module, a patient injection module, and a controller. A hazardous fluid handling system including a docking station and a hazardous fluid transport device adapted to detachably dock with the docking station is further disclosed.
摘要翻译：公开了一种集成的放射性药物患者治疗系统，其包括具有相关联的患者刺激装置的患者支撑平台，靠近患者支撑平台的成像器，用于将放射性药物流体输入患者的放射性药物流体输送系统，与患者以及与患者刺激装置，成像器，放射性药物流体输送系统和患者监护器可操作地相关联以控制和协调其操作的集成系统控制器。在患者治疗系统内，可以包括放射性药物流体递送系统，包括放射性核素供应模块，放射性药物处理模块，质量控制模块，患者注射模块和控制器。进一步公开了一种危险的流体处理系统，其包括对接站和适于与对接站可拆卸地对接的危险流体输送装置。

2. 发明申请

WO2007053779A3 DELIVERY OF AGENTS TO TISSUE 审中-公开
标题翻译：药剂运送到组织
公开(公告)号：WO2007053779A3
公开(公告)日：2007-11-08
申请号：PCT/US2006043134
申请日：2006-11-06
申请人： MEDRAD INC , UBER ARTHUR E III , TROMBLEY FREDERICK W III , GELBLUM EUGENE A , RHINEHART EDWARD J , REILLY DAVID M , CEDARHOLM PAGE , COWAN KEVIN P , TROCKI MARK , HIRSCHMAN ALAN D
发明人： UBER ARTHUR E III , TROMBLEY FREDERICK W III , GELBLUM EUGENE A , RHINEHART EDWARD J , REILLY DAVID M , CEDARHOLM PAGE , COWAN KEVIN P , TROCKI MARK , HIRSCHMAN ALAN D
IPC分类号： A61M5/30 , A61M31/00
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for injecting an injectate into patient includes a first pressurizable container for holding the injectate; a patient interface in fluid connection with the first pressurizable container, the patient interface being adapted to pass the injectate into tissue of the patient; a powered injector in operative connection with the first pressurizable container to pressurize the injectate; a controller system in operative connection with powered injector; and a stereotactic localization frame adapted to be placed in operative connection with the patient interface to assist in controlling localization of the patient interface. A system for processing cells (and/or other injectate components) includes a container and a plunger adapted to be slidably positioned within the container. The system includes at least one inlet port through which a fluid can enter the system and at least one effluent port through which an effluent can exit the system. The plunger section forms a sealing engagement with the inner wall of the container such that rearward motion of the plunger is adapted to draw fluid into the system via the inlet and forward motion of the plunger is adapted to force effluent out of the system via the effluent port.
摘要翻译：一种用于将注射剂注入患者体内的系统包括用于保持注射剂的第一可加压容器; 与第一可加压容器流体连接的患者接口，患者接口适于将注射液传递到患者的组织; 动力注射器，其与第一可加压容器可操作地连接以对注射物加压; 与动力注射器可操作连接的控制器系统; 以及立体定位框架，适于与患者接口操作连接，以帮助控制患者接口的定位。用于处理细胞（和/或其他注射组分）的系统包括容器和适于可滑动地定位在容器内的柱塞。该系统包括流体可以通过其进入系统的至少一个入口和至少一个流出物可以通过其流出系统的流出口。柱塞部分与容器的内壁形成密封接合，使得柱塞的向后运动适于经由入口将流体吸入系统中，并且柱塞的向前运动适于通过流出物将流出物排出系统港口。

3. 发明申请

WO2007056247A3 DELIVERY OF AGENTS SUCH AS CELLS TO TISSUE 审中-公开
标题翻译：递送代理作为细胞组织
公开(公告)号：WO2007056247A3
公开(公告)日：2009-05-07
申请号：PCT/US2006043133
申请日：2006-11-06
申请人： MEDRAD INC , UBER ARTHUR E III , HIRSCHMAN ALAN D , FACHER EVAN , GELBLUM EUGENE A , GRIFFITHS DAVID M , RHINEHART EDWARD J , REILLY DAVID M , COWAN KEVIN P , CEDARHOLM PAGE , TUCKER BARRY L , TROCKI MARK , MISHLER DAVID , BARTONY HENRY E JR , PARKS ROBERT
发明人： UBER ARTHUR E III , HIRSCHMAN ALAN D , FACHER EVAN , GELBLUM EUGENE A , GRIFFITHS DAVID M , RHINEHART EDWARD J , REILLY DAVID M , COWAN KEVIN P , CEDARHOLM PAGE , TUCKER BARRY L , TROCKI MARK , MISHLER DAVID , BARTONY HENRY E JR , PARKS ROBERT
IPC分类号： A61M31/00 , B65D25/04
CPC分类号： A61J1/1443 , A61J1/1456 , A61J1/1475 , A61M5/142 , A61M5/1723 , A61M5/3145 , A61M31/005 , B01L3/502 , B01L2300/044 , B01L2300/0681 , G06F19/3468
摘要： A system for delivering a fluid comprising cells to tissue of a patient, includes: a least a first container for holding an injection fluid in which the agent is carried; a first powered drive in operative connection with the container, the first powered drive being operable to pressurize contents of the container; a control system in operative connection with the first powered drive and operative to control the first powered drive; a fluid path in fluid connection with the container, the fluid path including a patient interface adapted to deposit the cells within tissue of the patient; a sensor system; and a communication system in connection with at least the control system and the sensor system. The communication system is adapted to provide information to the control system. The control system in adapted to transmit a control signal to at least the first powered drive based at least in part on information provided to the control system. The cells can for example be progenitor cells or stem cells.
摘要翻译：一种用于将包含细胞的流体输送到患者的组织的系统，包括：用于保持其中携带有药剂的注射液体的至少第一容器; 与容器操作性连接的第一动力驱动器，第一动力驱动器可操作以对容器的内容物进行加压; 控制系统，其与第一动力驱动器操作连接并且可操作以控制第一动力驱动; 与容器流体连接的流体路径，流体路径包括适于将细胞沉积在患者组织内的患者界面; 传感器系统; 以及至少与控制系统和传感器系统相关的通信系统。通信系统适于向控制系统提供信息。控制系统适于至少部分地基于提供给控制系统的信息将控制信号发送到至少第一动力驱动器。细胞可以例如是祖细胞或干细胞。

4. 发明申请

WO2008067362A3 MULTIPLE LUMEN DIFFUSION CATHETER 审中-公开
标题翻译：多功能扩散吸管
公开(公告)号：WO2008067362A3
公开(公告)日：2008-10-16
申请号：PCT/US2007085736
申请日：2007-11-28
申请人： MEDRAD INC , SCHWARTZ ROBERT S , VAN TASSEL ROBERT A , GELBLUM EUGENE A , HIRSCHMAN ALAN D , KALAFUT JOHN F , REILLY DAVID M , RHINEHART EDWARD J , TROMBLEY FREDERICK W , UBER ARTHUR E
发明人： SCHWARTZ ROBERT S , VAN TASSEL ROBERT A , GELBLUM EUGENE A , HIRSCHMAN ALAN D , KALAFUT JOHN F , REILLY DAVID M , RHINEHART EDWARD J , TROMBLEY FREDERICK W , UBER ARTHUR E
IPC分类号： A61M25/14
CPC分类号： A61M25/007 , A61M25/003
摘要： A method and device for the simultaneous or sequential introduction of multiple fluids into the bloodstream including a multiple lumen catheter with corresponding multiple hole sets. By introducing a second fluid such as saline, the concentration and bolus of a first fluid, such as a contrast agent, can be controlled and optimized.
摘要翻译：一种用于同时或顺序地将多种流体引入血流中的方法和装置，包括具有相应多孔组的多腔导管。通过引入诸如盐水的第二流体，可以控制和优化第一流体如造影剂的浓度和推注。

5. 发明申请

WO2007124340A2 IMPROVEMENTS IN CENTRAL VENOUS CATHETERS AND RELATED EQUIPMENT 审中-公开
标题翻译：中央通风管和相关设备的改进
公开(公告)号：WO2007124340A2
公开(公告)日：2007-11-01
申请号：PCT/US2007066930
申请日：2007-04-19
申请人： MEDRAD INC , COWAN KEVIN P , HIRSCHMAN ALAN D , REILLY DAVID M , GELBLUM EUGENE A , RHINEHRT EDWARD J , TROMBLEY III FREDERICK W
发明人： COWAN KEVIN P , HIRSCHMAN ALAN D , REILLY DAVID M , GELBLUM EUGENE A , RHINEHRT EDWARD J , TROMBLEY III FREDERICK W
IPC分类号： A61M25/06 , A61F2/958
CPC分类号： A61M25/0125 , A61M25/0053 , A61M25/007 , A61M25/0082 , A61M25/0113 , A61M25/0116 , A61M25/0119 , A61M25/0122 , A61M2025/0058
摘要： Systems, devices, and methods towards improved diagnosis and therapy in connection with central venous catheters (including PICC lines). Included among the many improvements broadly contemplated herein are: arrangements via which a venous catheter can move passively into position in central venous circulation; arrangements via which a catheter can be actively guided without the use of a needle or guide wire; arrangements via which a catheter can be packaged to facilitate easy, rapid, and positionally accurate deployment by medical personnel while maintaining device sterility; and arrangements via which a catheter tip can be imaged during and after insertion.
摘要翻译：与中心静脉导管（包括PICC系）相关的改进诊断和治疗的系统，装置和方法。包括在这里广泛考虑的许多改进之中：静脉导管可以被动地移动到中心静脉循环中的位置的布置; 可以不使用针或引导线而可以主动地引导导管的布置; 导管可以被包装的布置，以便医疗人员容易，快速和定位准确的部署，同时保持装置不育; 以及在插入期间和之后可以使导管尖端成像的布置。

6. 发明申请

WO2005086874A2 ENERGY ASSISTED MEDICAL DEVICES, SYSTEMS AND METHODS 审中-公开
标题翻译：能量辅助医疗设备，系统和方法
公开(公告)号：WO2005086874A2
公开(公告)日：2005-09-22
申请号：PCT/US2005007829
申请日：2005-03-11
申请人： MEDRAD INC , UBER ARTHUR E III , GRIFFITHS DAVID M , HIRSCHMAN ALAN D
发明人： UBER ARTHUR E III , GRIFFITHS DAVID M , HIRSCHMAN ALAN D
IPC分类号： A61B10/02
CPC分类号： A61B10/0233 , A61B2010/0208
摘要： A device for penetrating tissue and removing a biological sample includes a biological sampling element to remove a biological sample. The biological sampling element includes a passage therethrough. The device further includes a penetrator positioned within the passage. The penetrator is energized in a repetitive manner to assist in penetrating tissue. The biological sample element can be adapted to remove a tissue sample or a biological fluid sample (for example, blood). A device for penetrating tissue and positioning a tissue resident conduit (for example, a catheter), includes a tissue resident conduit (for example, a catheter) including a passage therethrough; and a penetrator in operative connection with the catheter. A device for inserting a tissue resident conduit includes at least one component that is energized during penetration to assist in penetrating tissue. In one embodiment, the tissue resident conduit is flexible and the energized component is positioned or a forward end of the tissue resident conduit. The device can further include a mechanism for directing the penetration of the tissue resident conduit. A needle for penetrating tissue includes a first effector including a surface and at least one actuator in operative connection with the first effector. The actuator is adapted to cause motion of the first effector such that tearing of tissue takes place in regions where there is close proximity of tissue to the surface of the first effector.
摘要翻译：用于穿透组织并去除生物样品的装置包括用于去除生物样品的生物取样元件。生物采样元件包括通过其中的通道。该装置还包括定位在通道内的穿透器。穿透器以重复的方式通电以辅助穿透组织。生物样品元件可以适于去除组织样品或生物流体样品（例如血液）。用于穿透组织并定位组织驻留导管（例如导管）的装置包括组织驻留导管（例如导管），其包括穿过其中的通道; 以及与导管可操作地连接的穿透器。用于插入组织固定导管的装置包括至少一个在穿透期间被激发以帮助穿透组织的部件。在一个实施例中，组织驻留导管是柔性的，并且通电部件被定位或组织固定导管的前端。该装置还可以包括用于引导组织驻留导管穿透的机构。用于穿透组织的针包括包括表面的第一执行器和与第一执行器可操作地连接的至少一个致动器。致动器适于引起第一效应器的运动，使得组织的撕裂发生在组织靠近第一效应器的表面的区域中。

7. 发明申请

WO02056934A3 ENCODING AND SENSING OF SYRINGE INFORMATION 审中-公开
标题翻译：编码和感染注射信息
公开(公告)号：WO02056934A3
公开(公告)日：2003-10-30
申请号：PCT/US0201052
申请日：2002-01-16
申请人： MEDRAD INC , COWAN KEVIN P , IDDON BARRY , YANNIELLO MICHAEL J , BROSOVICH JOHN A , HIRSCHMAN ALAN D
发明人： COWAN KEVIN P , IDDON BARRY , YANNIELLO MICHAEL J , BROSOVICH JOHN A , HIRSCHMAN ALAN D
IPC分类号： G01R33/28 , A61B5/055 , A61M5/145
CPC分类号： G01D5/12 , A61M5/1452 , A61M5/3129 , A61M2005/3125 , A61M2205/6036 , A61M2205/6063
摘要： A syringe (1200) for use with a powered injector to inject a fluid into a patient inclides an encoder. The encoder includes at least a first indicator (1210A-1210E) positioned on the encoder. The first indicator is adapted to interact with at least a portion of energy being propagated through or adjacent the encoder in a manner that is detectable. The presence (or absence) of the first indicator provides or corresponds to information about the syringe configuration. The indicator(s) of the present invention can, for example, provide information about syringe configuration by the number and/or position thereof. A plurality or set of such syringes can be provided, with the configuration of each such syringe being represented by the presence or absence of indicator(s) of that syringe.
摘要翻译：一种与动力注射器一起使用以将流体注射到患者中的注射器（1200）倾斜编码器。编码器至少包括位于编码器上的第一指示器（1210A-1210E）。第一指示符适于与以可检测的方式与正在传播或邻近编码器的能量的至少一部分相互作用。第一个指示器的存在（或不存在）提供或对应于关于注射器配置的信息。例如，本发明的指示器可以通过其数量和/或位置提供关于注射器构造的信息。可以提供多个或一组这样的注射器，每个这样的注射器的构造由该注射器的指示器的存在或不存在表示。

8. 发明申请

WO2007002154A3 MEDICAL FLUID INJECTION AND INFLATION SYSTEM 审中-公开
标题翻译：医用流体注射和灌注系统
公开(公告)号：WO2007002154A3
公开(公告)日：2007-04-05
申请号：PCT/US2006024081
申请日：2006-06-21
申请人： MEDRAD INC , GRIFFITHS DAVID M , ALMON-MARTIN ROSEMARY , HIRSCHMAN ALAN D , REILLY DAVID M , TROCKI MARK , TROMBLEY FREDERICK W , WEICH THOMAS R , JAECKLEIN WILLIAM J , SPOHN MICHAEL A , JOYCE THOMAS P
发明人： GRIFFITHS DAVID M , ALMON-MARTIN ROSEMARY , HIRSCHMAN ALAN D , REILLY DAVID M , TROCKI MARK , TROMBLEY FREDERICK W , WEICH THOMAS R , JAECKLEIN WILLIAM J , SPOHN MICHAEL A , JOYCE THOMAS P
IPC分类号： A61M31/00
CPC分类号： A61M25/10184 , A61M5/007 , A61M5/14566 , A61M5/16827 , A61M5/16854 , A61M25/007 , A61M25/104 , A61M2025/102 , A61M2025/1022
摘要： A combined fluid injection and inflation system is disclosed and includes a fluid delivery system including at least one pressurizing device, a fluid path, and a control unit. The fluid path is adapted to connect the pressurizing device to a patient via a catheter including a balloon and inserted in the patient. The control unit is operable to control the fluid delivery system. In operation, the control unit selectively actuates the fluid delivery system to operate in a fluid injection mode or in a balloon inflation mode. In the fluid injection mode the pressurizing device delivers fluid to the fluid path for a fluid injection procedure. In the balloon inflation mode, the pressurizing device delivers fluid to the fluid path for inflating the balloon associated with the catheter. An operator control may be connected to the control unit for controlling the fluid delivery system and may be a handheld device.
摘要翻译：公开了组合的流体注入和充气系统，并且包括包括至少一个加压装置，流体路径和控制单元的流体递送系统。流体路径适于经由包括球囊并且插入患者体内的导管将加压装置连接到患者。控制单元可操作以控制流体输送系统。在操作中，控制单元选择性地致动流体输送系统以流体注射模式或气球充气模式操作。在流体注射模式中，加压装置将流体输送到流体路径用于流体注射程序。在球囊膨胀模式中，加压装置将流体输送到流体路径，用于使与导管相关联的球囊膨胀。操作员控制可以连接到控制单元以控制流体输送系统，并且可以是手持装置。

9. 发明专利

JP2010179120A Fluid delivery systems, fluid delivery devices, and method for delivery of hazardous fluids 审中-公开
标题翻译：流体输送系统，流体输送装置和用于输送危险液体的方法
公开(公告)号：JP2010179120A
公开(公告)日：2010-08-19
申请号：JP2010071353
申请日：2010-03-26
申请人： Medrad Inc , メドラッドインコーポレーテッドMedrad,Inc.
发明人： UBER III ARTHUR E , HIRSCHMAN ALAN D , GRIFFITHS DAVID M , TROMBLEY III FREDERICK W , REILLY DAVID M
IPC分类号： A61M5/145 , A61M20060101 , A61M5/00 , A61M5/14 , A61M25/00 , A61M31/00
CPC分类号： A61M25/0045 , A61J1/2096 , A61M5/007 , A61M5/1408 , A61M5/142 , A61M5/1452 , A61M5/44 , A61M2202/049 , A61N5/1001
摘要： PROBLEM TO BE SOLVED: To provide a system for injecting a patient including a container enclosing a hazardous pharmaceutical; a first pump to deliver a hazardous pharmaceutical to the patient; and a fluid path operably connected to the first pump, the container, and the patient. SOLUTION: The patient has a catheter 31 inserted via a femoral approach into the patient's heart. The catheter 31 is connected to a manifold 30 to enable injection of various fluids. A syringe 10 is filled with contrast medium from a line 20 and then injected. The syringe 10 is operated by a mechanical injector 40 including a piston 40a that pushes or pulls on the syringe plunger extension, thereby moving the fluid in and out of the syringe 10. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供一种用于注射患者的系统，所述患者包括包围危险药物的容器; 向患者提供危险药物的第一个泵; 以及可操作地连接到第一泵，容器和患者的流体路径。解决方案：患者具有通过股动脉插入患者心脏的导管31。导管31连接到歧管30以能够喷射各种流体。注射器10填充有来自管线20的造影剂，然后注射。注射器10由包括推动或拉动注射器柱塞延伸部的活塞40a的机械注射器40操作，从而将流体移入和注出注射器10.版权所有（C）2010，JPO＆INPIT

10. 发明专利

JP2007222656A Fluid delivery system, pressure isolation mechanism, injector control mechanism, and method of using them 审中-公开
标题翻译：流体输送系统，压力隔离机构，喷射器控制机构及其使用方法
公开(公告)号：JP2007222656A
公开(公告)日：2007-09-06
申请号：JP2007102326
申请日：2007-04-10
申请人： Medrad Inc , メドラッドインコーポレーテッドMedrad,Inc.
发明人： TROMBLEY FREDERIK W III , SCHMIDT ROBERT M , REILLY DAVID M , HIRSCHMAN ALAN D , GRIFFITHS DAVID M , CALLAN GERALD W , PEDRAZA LUIS A , KWO JENNIE , ZIRPS CHRISTOPHER T , BEAULIEU RODERICK H
IPC分类号： A61M5/142 , A61M5/148
摘要： PROBLEM TO BE SOLVED: To provide a fluid delivery system equipped with a manual controller to feed back pressure in a fluid path to an operator tactually, and to provide a pressure isolation mechanism and an injector control mechanism. SOLUTION: A manual controller of an injector system includes an actuator to control the injector by force applied by the operator. The actuator gives the operator tactual feedback of pressure in the fluid path by connecting the fluid path to the fluid so as to permit fluid communication therebetween. The pressure isolation mechanism includes a first state generated when a lumen and an isolation port are connected and a second state generated when they are separated. A valve is usually in the first state and is switchable to the second state when fluid pressure in the lumen reaches predetermined pressure. A pressure transducer 980 can be connected to the isolation port of the pressure isolation mechanism so as to permit fluid communication therebetween. The fluid delivery system includes a manual syringe and the pressure isolation mechanism. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种配备有手动控制器的流体输送系统，以在流体路径中将压力反馈到操作者，并提供压力隔离机构和喷射器控制机构。解决方案：喷射器系统的手动控制器包括致动器，以通过操作者施加的力来控制喷射器。致动器通过将流体路径连接到流体来使操作者对流体路径中的压力进行触觉反馈，从而允许流体连通。压力隔离机构包括当管腔和隔离端口连接时产生的第一状态和当它们分离时产生的第二状态。阀门通常处于第一状态，并且当管腔内的流体压力达到预定压力时可切换到第二状态。压力传感器980可以连接到压力隔离机构的隔离端口，以允许它们之间的流体连通。流体输送系统包括手动注射器和压力隔离机构。版权所有（C）2007，JPO＆INPIT

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