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1. 发明专利

AU2014268298B2 Anti-B7-H5 antibodies and their uses 未知
公开(公告)号：AU2014268298B2
公开(公告)日：2019-01-17
申请号：AU2014268298
申请日：2014-05-27
申请人： MEDIMMUNE LLC , UNIV JOHNS HOPKINS
发明人： CHEN LIEPING , YAO SHENG , LIU LINDA , LANGERMANN SOLOMON
IPC分类号： C07K16/28 , A61K39/00 , C07K14/705
摘要： The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H5 ligand of the B7-H5:CD28H pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases.

2. 发明专利

CA2913312A1 ANTI-B7-H5 ANTIBODIES AND THEIR USES 未知
公开(公告)号：CA2913312A1
公开(公告)日：2014-11-27
申请号：CA2913312
申请日：2014-05-27
申请人： MEDIMMUNE LLC , UNIV JOHNS HOPKINS
发明人： CHEN LIEPING , YAO SHENG , LIU LINDA , LANGERMANN SOLOMON
IPC分类号： C07K14/705 , A61K39/00 , C07K16/28
摘要： The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H5 ligand of the B7-H5:CD28H pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases.

3. 发明专利

AU2017201231B2 ANTI-H7CR Antibodies 未知
公开(公告)号：AU2017201231B2
公开(公告)日：2019-02-14
申请号：AU2017201231
申请日：2017-02-23
申请人： MEDIMMUNE LLC , UNIV JOHNS HOPKINS
发明人： LANGERMANN SOLOMON , LIU LINDA , YAO SHENG , CHEN LIEPING
IPC分类号： C07K16/28
摘要： Antibodies and humanized variants thereof and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H7 counter-receptor, H7CR, and their uses in enhancing immune responses and the treatment and diagnosis of cancer and 5 other diseases are provided.

4. 发明专利

SG11201509618QA ANTI-B7-H5 ANTIBODIES AND THEIR USES 未知
公开(公告)号：SG11201509618QA
公开(公告)日：2015-12-30
申请号：SG11201509618Q
申请日：2014-05-27
申请人： MEDIMMUNE LLC , UNIV JOHNS HOPKINS
发明人： CHEN LIEPING , YAO SHENG , LIU LINDA , LANGERMANN SOLOMON
IPC分类号： C07K14/705 , A61K39/00 , C07K16/28
摘要： The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H5 ligand of the B7-H5:CD28H pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases.

5. 发明专利

SG10201709715RA ANTI-B7-H5 ANTIBODIES AND THEIR USES 未知
公开(公告)号：SG10201709715RA
公开(公告)日：2017-12-28
申请号：SG10201709715R
申请日：2014-05-27
申请人： MEDIMMUNE LLC , UNIV JOHNS HOPKINS
发明人： CHEN LIEPING , YAO SHENG , LIU LINDA , LANGERMANN SOLOMON
摘要： The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H5 ligand of the B7-H5:CD28H pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases.

6. 发明公开

EP2061504A4 COMBINATORIEAL THERAPY OF CANCER AND INFECTIOUS DISEASES WITH ANTI-B7-H1 ANTIBODIES 审中-公开
标题翻译：联合治疗癌症和感染性疾病的抗B7-H1抗体
公开(公告)号：EP2061504A4
公开(公告)日：2010-01-27
申请号：EP07872306
申请日：2007-09-20
申请人： UNIV JOHNS HOPKINS
发明人： PARDOLL DREW , CHEN LIEPING , DRAKE CHARLES , COX ANDREA
IPC分类号： A61K39/00 , A61K39/39 , A61K39/395 , C07K16/28
CPC分类号： C07K16/2827 , A61K39/0011 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/5152 , A61K2039/5156 , A61K2039/55516 , A61K2039/55522 , C07K16/2818 , C07K2317/76 , A61K2300/00

7. 发明公开

EP2195344A4 NOVEL COMPOSITIONS AND METHODS FOR STIMULATING ERYTHROPOIESIS IN A MAMMAL 审中-公开
标题翻译：新型复合物和方法，以刺激红细胞生成哺乳动物
公开(公告)号：EP2195344A4
公开(公告)日：2011-07-06
申请号：EP08836759
申请日：2008-10-03
申请人： UNIV MARYLAND , UNIV JOHNS HOPKINS
发明人： TAMADA KOJI , CHEN LIEPING
IPC分类号： C07K16/18 , C07K16/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/74

8. 发明申请

WO2011020024A3 METHODS OF MODULATING IMMUNE FUNCTION 审中-公开
标题翻译：调节免疫功能的方法
公开(公告)号：WO2011020024A3
公开(公告)日：2011-06-23
申请号：PCT/US2010045479
申请日：2010-08-13
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING
发明人： CHEN LIEPING
IPC分类号： C07K14/705 , A61P37/02 , C07K14/28
CPC分类号： C07K16/2827 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61N5/10 , C07K14/70521 , C07K14/70532 , C07K16/2818 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/73 , C07K2317/74 , C07K2317/76 , C07K2319/30
摘要： Presented herein are therapeutic agents that modulate one or more immune functions and uses of such therapeutic agents in the prevention, treatment and management of diseases. In one aspect, the therapeutic agents modulate one or more signal transduction pathways induced by the binding of B7-H7 to B7-H7CR, or the binding of B7-H2 to either ICOS, CD28, or CTLA-4. In another aspect, the therapeutic agents modulate the binding of B7-H7 to B7-H7CR, or the binding of B7-H2 to either ICOS, CD28, or CTLA-4. The therapeutic agents can be used in the prevention, treatment and/or management of diseases in which it might be useful to modulate one or more immune functions (e.g.,cancer, infectious disease, autoimmune disease, and transplantation rejection). In another aspect, presented herein are methods for identifying receptor-ligand interactions.
摘要翻译：本文提供了调节一种或多种免疫功能的治疗剂和这种治疗剂在预防，治疗和管理疾病中的用途。一方面，治疗剂调节由B7-H7与B7-H7CR的结合或B7-H2与ICOS，CD28或CTLA-4的结合诱导的一种或多种信号转导途径。另一方面，治疗剂调节B7-H7与B7-H7CR的结合或B7-H2与ICOS，CD28或CTLA-4的结合。治疗剂可用于预防，治疗和/或控制可能有助于调节一种或多种免疫功能（例如癌症，感染性疾病，自身免疫性疾病和移植排斥）的疾病。另一方面，本文提供了鉴定受体 - 配体相互作用的方法。

9. 发明申请

WO2014190356A2 ANTI-B7-H5 ANTIBODIES AND THEIR USES 审中-公开
标题翻译：抗B7-H5抗体及其用途
公开(公告)号：WO2014190356A2
公开(公告)日：2014-11-27
申请号：PCT/US2014039621
申请日：2014-05-27
申请人： AMPLIMMUNE INC , UNIV JOHNS HOPKINS
发明人： CHEN LIEPING , YAO SHENG , LIU LINDA , LANGERMANN SOLOMON
IPC分类号： C07K14/705
CPC分类号： C07K16/2827 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/76
摘要： The present invention relates to antibodies and their antigen-binding fragments and to other molecules that are capable of immunospecifically binding to the B7-H5 ligand of the B7-H5:CD28H pathway, and to the uses of such molecules in the treatment and diagnosis of autoimmune disease, transplant rejection and other inflammatory diseases.
摘要翻译：本发明涉及抗体及其抗原结合片段和能够免疫特异性结合B7-H5：CD28H途径的B7-H5配体的其他分子，以及这些分子在治疗和诊断中的用途自身免疫性疾病，移植排斥反应等炎症性疾病。

10. 发明申请

WO2008083169A3 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNOLOGIC DISORDERS 审中-公开
标题翻译：用于治疗免疫障碍的组合物和方法
公开(公告)号：WO2008083169A3
公开(公告)日：2008-08-28
申请号：PCT/US2007088841
申请日：2007-12-26
申请人： UNIV JOHNS HOPKINS , CHEN LIEPING , TAMADA KOJI
发明人： CHEN LIEPING , TAMADA KOJI
IPC分类号： C07K14/00
CPC分类号： C07K16/00 , C07K16/2875 , C07K2317/73 , C07K2319/30
摘要： Compositions and methods for preventing, reducing or inhibiting immunologic disorders are provided. Suitable compositions include one or more LIGHT-HVEM antagonists. LIGHT-HVEM antagonists include compounds that inhibit, reduce, or block the biological activity or expression of LIGHT and/or HVEM. LIGHT-HVEM antagonists can reduce or inhibit the binding of LIGHT to HVEM, but do not significantly modulate the binding of LTß to LTBR. Suitable compositions include antibodies and antibody fragments, decoy polypeptides, small molecule inhibitors and inhibitory nucleic acids. Methods for using LIGHT-HVEM antagonists to reduce or inhibit T cell activation and survival are also provided. Therapeutic uses for LIGHT-HVEM antagonists to prevent or treat immunologic diseases and disorders including graft rejection, graft-versus-host disease, inflammatory immune responses, and autoimmune disorders are provided.
摘要翻译：提供了用于预防，减少或抑制免疫疾病的组合物和方法。合适的组合物包括一种或多种LIGHT-HVEM拮抗剂。 LIGHT-HVEM拮抗剂包括抑制，降低或阻断LIGHT和/或HVEM的生物活性或表达的化合物。 LIGHT-HVEM拮抗剂可以降低或抑制LIGHT与HVEM的结合，但不会显着调节LTß与LTBR的结合。合适的组合物包括抗体和抗体片段，诱饵多肽，小分子抑制剂和抑制性核酸。还提供了使用LIGHT-HVEM拮抗剂降低或抑制T细胞活化和存活的方法。提供了用于预防或治疗免疫疾病和疾病的LIGHT-HVEM拮抗剂的治疗用途，包括移植排斥反应，移植物抗宿主病，炎性免疫应答和自身免疫性疾病。

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