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1. 发明申请

WO1995008561A1 SYNTHESES OF AZAPEPTIDES BY THE FMOC/TERT-BUTYL/POLYAMIDE TECHNIQUE 审中-公开
标题翻译：通过FMOC /叔丁基/多胺技术合成腈肟酸
公开(公告)号：WO1995008561A1
公开(公告)日：1995-03-30
申请号：PCT/GB1994002103
申请日：1994-09-26
申请人： MEDICAL RESEARCH COUNCIL , JOHNSON, Tony , QUIBELL, Martin
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C07K01/04
CPC分类号： C07K1/04 , C07C271/12
摘要： Disclosed is a method of synthesising a peptide comprising at least one aza-amino acid residue, the method comprising: coupling one or more amino acids to a solid phase support so as to form a supported moiety; activating the supported moiety; reacting the activated supported moiety with one or more aza-amino acid precursors having a fluorenylmethoxycarbonyl (Fmoc)-protected free amino function, so as to form a supported azapeptide; releasing the azapeptide from the solid phase support and deprotecting (if necessary) the side chains of the one or more amino acid and one or more aza-amino acid residues, together with certain novel compounds of use in the method and more generally.
摘要翻译：公开了一种合成包含至少一个氮杂 - 氨基酸残基的肽的方法，所述方法包括：将一个或多个氨基酸偶联到固相载体上以形成负载部分; 活化支持的部分; 使活化的支持部分与一种或多种具有芴基甲氧基羰基（Fmoc）保护的游离氨基官能团的氮杂 - 氨基酸前体反应，以形成负载的氮杂肽; 从固相载体中释放azapeptide，并将一个或多个氨基酸和一个或多个氮杂氨基酸残基的侧链（如果需要）脱保护（连同某些在该方法中使用的新化合物）。

2. 发明申请

WO1998025145A1 IMPROVEMENTS IN OR RELATING TO SCREENING FOR PAPILLOMA VIRUSES 审中-公开
标题翻译：改进或相关于斑马鱼病毒的筛选
公开(公告)号：WO1998025145A1
公开(公告)日：1998-06-11
申请号：PCT/GB1997003321
申请日：1997-12-03
申请人： MEDICAL RESEARCH COUNCIL , DOORBAR, John
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , C07K16/084 , C07K2317/34 , C07K2317/55
摘要： Disclosed is a method of detecting a papilloma virus infection in an organism, the method comprising the steps of: obtaining a sample of the organism's cells from the site of potential infection; contacting the cells with a molecule that binds specifically to papilloma virus E4 protein; and monitoring said binding, together with a method of determining the type(s) of HPV infecting a patient, a method of screening a patient for the presence of a precancerous cervical lesion, and an antibody molecule of use in one of the above methods.
摘要翻译：公开了一种检测生物体中乳头状瘤病毒感染的方法，所述方法包括以下步骤：从潜在感染部位获得生物体细胞的样品; 使细胞与特异性结合乳头瘤病毒E4蛋白的分子接触; 以及监测所述结合以及确定感染患者的HPV的类型的方法，筛选患者癌前期宫颈病变的存在的方法以及在上述方法之一中使用的抗体分子。

3. 发明申请

WO1998015618A1 MAP KINASES: POLYPEPTIDES, POLYNUCLEOTIDES AND USES THEREOF 审中-公开
标题翻译：地图动物：多糖，多核苷酸及其用途
公开(公告)号：WO1998015618A1
公开(公告)日：1998-04-16
申请号：PCT/GB1997002779
申请日：1997-10-09
申请人： MEDICAL RESEARCH COUNCIL , COHEN, Philip , GOEDERT, Michel
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N09/12
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40
摘要： A substantially pure stress-activated protein kinase comprising the amino acid sequence (I) or a variant, fragment, fusion or derivative thereof, or a fusion of a said variant or fragment or derivative. The above stress-activated protein kinase and the related stress-activated protein kinase SAPK3 are useful in screening assays for drugs.
摘要翻译：包含氨基酸序列（I）或其变体，片段，融合物或衍生物或所述变体或片段或衍生物的融合物的基本上纯的应激活化蛋白激酶。上述应激活化蛋白激酶和相关应激活化蛋白激酶SAPK3可用于药物筛选试验。

4. 发明申请

WO1998013496A1 CHAPERONE FRAGMENTS 审中-公开
标题翻译： CHAPERONE片段
公开(公告)号：WO1998013496A1
公开(公告)日：1998-04-02
申请号：PCT/GB1997002652
申请日：1997-09-26
申请人： MEDICAL RESEARCH COUNCIL , FERSHT, Alan, Roy , ZAHN, Ralph , ALTAMIRANO, Myriam Marlenne
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/31
CPC分类号： C07K1/1133 , A61K38/00 , C07K14/245
摘要： The present invention provides a chaperone polypeptide having an amino acid sequence selected from at least amino acid residues 230-271 but no more than residues 150-455 or 151-456 of a GroEL sequence substantially as shown in Figure 7, or a corresponding sequence of a substantially homologous chaperone polypeptide, or a modified, mutated or variant sequence thereof having chaperone activity.
摘要翻译：本发明提供了具有选自如图7所示的GroEL序列的至少氨基酸残基230-271但不超过残基150-455或151-456的氨基酸序列的伴侣多肽，或者相应的序列基本上同源的伴侣多肽，或其具有伴侣活性的修饰的，突变的或变异的序列。

5. 发明申请

WO1998012304A1 CULTURE SYSTEM FOR HEMATOPOIETIC STEM CELLS 审中-公开
标题翻译： HEMATOPOIETIC干细胞培养系统
公开(公告)号：WO1998012304A1
公开(公告)日：1998-03-26
申请号：PCT/GB1997002549
申请日：1997-09-19
申请人： MEDICAL RESEARCH COUNCIL
发明人： MEDICAL RESEARCH COUNCIL , DZIERZAK, Elaine, A. , MEDVINSKY, Alexander , SANCHEZ, Maria-José
IPC分类号： C12N05/06
CPC分类号： C12Q1/6809 , A61K35/12 , A61K48/00 , C12N5/0647 , C12N5/0648 , C12N2501/39 , C12N2502/11
摘要： The invention relates to an in vitro culture system for the expansion of mammalian hematopoietic stem cells (HSCs).
摘要翻译：本发明涉及用于扩增哺乳动物造血干细胞（HSCs）的体外培养系统。

6. 发明申请

WO1998007876A2 SELF-REPLICATING EPISOMAL EXPRESSION VECTORS CONFERRING TISSUE-SPECIFIC GENE EXPRESSION 审中-公开
标题翻译：自组织表达表达载体表达特定基因表达
公开(公告)号：WO1998007876A2
公开(公告)日：1998-02-26
申请号：PCT/GB1997002213
申请日：1997-08-18
申请人： MEDICAL RESEARCH COUNCIL , ANTONIOU, Michael , GROSVELD, Franklin, Geradus
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/805 , C12N2710/16243 , C12N2800/108 , C12N2830/46
摘要： Self-replicating, locus control region (LCR)-containing, episomal expression vectors for tissue-specific gene expression for long-term persistent, tissue-specific expression of a gene of interest are described.
摘要翻译：描述了用于长期持续性，目的基因的组织特异性表达的组织特异性基因表达的自体复制，基因座控制区（LCR）的附加型表达载体。

7. 发明申请

WO1997040141A2 ISOLATION OF ENZYMES 审中-公开
标题翻译：酶的分离
公开(公告)号：WO1997040141A2
公开(公告)日：1997-10-30
申请号：PCT/GB1997001153
申请日：1997-04-25
申请人： MEDICAL RESEARCH COUNCIL , NERI, Dario , DEMARTIS, Salvatore , HUBER, Adrian , VITI, Francesca , TAWFIK, Dan, S. , WINTER, Gregory, Paul
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N09/00
CPC分类号： C12N15/1086 , C07K14/4728 , C07K14/72 , C07K2319/00 , C12N9/00 , C12N9/0002 , C12N9/1088 , C12N9/1205 , C12N15/1037 , C40B40/02
摘要： The present invention relates to a method of isolating an enzyme having a desired chemical or biological activity, the method comprising linking the enzyme to a substrate for the enzyme, reacting the enzyme and substrate such that a product is produced which remains linked to the enzyme and isolating the enzyme by selectively isolating the product linked to the enzyme.
摘要翻译：本发明涉及一种分离具有所需化学或生物活性的酶的方法，该方法包括将酶与酶的底物连接，使酶和底物反应，使得产生与酶连接的产物，通过选择性分离与酶连接的产物来分离酶。

8. 发明申请

WO1997038130A1 ANALYSIS OF DNA 审中-公开
标题翻译： DNA分析
公开(公告)号：WO1997038130A1
公开(公告)日：1997-10-16
申请号：PCT/GB1997000949
申请日：1997-04-04
申请人： MEDICAL RESEARCH COUNCIL , XU, Weiming
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6876 , C12Q2600/156
摘要： A novel highly polymorphic DNA marker based on the pentanucleotide repeat (CCTTT/GGAAA)n has been identified in the human inducible nitric oxide synthase (iNOS) gene. Twelve different alleles, having between 7 and 18 contiguous repeats, have been identified. The repeat is highly polymorphic in the human population and so lends itself to use as a microsatellite marker with uses in, for example, forensic medicine, population studies, family linkage studies and disease diagnosis.
摘要翻译：在人诱导型一氧化氮合酶（iNOS）基因中已经鉴定了基于五核苷酸重复（CCTTT / GGAAA）n的新型高度多态性DNA标记。已经确定了12个不同的等位基因，具有7到18个连续重复序列。重复在人群中高度多态，因此可以用作微卫星标记，用于例如法医学，人口研究，家族联系研究和疾病诊断。

9. 发明申请

WO1997022696A1 UTROPHIN GENE EXPRESSION 审中-公开
标题翻译： UTROPHIN基因表达
公开(公告)号：WO1997022696A1
公开(公告)日：1997-06-26
申请号：PCT/GB1996003156
申请日：1996-12-19
申请人： MEDICAL RESEARCH COUNCIL , TINSLEY, Jonathon, Mark , DAVIES, Kay, Elizabeth
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/12
CPC分类号： C07K14/4708 , A01K2217/05 , A61K38/00 , A61K48/00
摘要： Nucleic acid from which a polypeptide with utrophin function can be expressed, especially mini-genes and chimaeric constructs. Expression significantly decreases the severity of the dystrophic muscle phenotype in an animal model, indicating usefulness in treatment of muscular dystrophy. The nucleic acid and encoded polypeptides are also useful in screening for substances to modulate utrophin binding to actin and/or the dystrophin protein complex.
摘要翻译：具有utrophin功能的多肽可以从其中表达的核酸，特别是微型基因和嵌合体构建体。表达显着降低动物模型中营养不良肌肉表型的严重程度，表明在治疗肌营养不良症中的有用性。核酸和编码的多肽也可用于筛选调节utrophin结合肌动蛋白和/或肌营养不良蛋白复合物的物质。

10. 发明申请

WO1997022360A2 CONTROL OF PROTEIN SYNTHESIS, AND SCREENING METHOD FOR AGENTS 审中-公开
标题翻译：蛋白质合成的控制和代谢筛选方法
公开(公告)号：WO1997022360A2
公开(公告)日：1997-06-26
申请号：PCT/GB1996003186
申请日：1996-12-20
申请人： MEDICAL RESEARCH COUNCIL , THE UNIVERSITY OF DUNDEE , COHEN, Philip , ALESSI, Dario , CROSS, Darren
发明人： MEDICAL RESEARCH COUNCIL , THE UNIVERSITY OF DUNDEE
IPC分类号： A61K38/45
CPC分类号： C12N9/1205 , A61K38/00
摘要： A method for screening for agents capable of affecting the activity of kinases GSK3 and PKB is disclosed. The method involves assessing the phosphorylation of PKB on two amino acids on the PKB molecule particularly.
摘要翻译：公开了一种筛选能够影响激酶GSK3和PKB活性的试剂的方法。该方法包括评估PKB分子上两个氨基酸上PKB的磷酸化。

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