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1. 发明申请

WO1995019638A2 ION SPRAY WITH INTERSECTING FLOW 审中-公开
标题翻译：离子喷雾与交联流
公开(公告)号：WO1995019638A2
公开(公告)日：1995-07-20
申请号：PCT/CA1995000014
申请日：1995-01-09
申请人： MDS HEALTH GROUP LIMITED , COVEY, Thomas, R. , ANACLETO, Joseph, F.
发明人： MDS HEALTH GROUP LIMITED
IPC分类号： H01J49/04
CPC分类号： H01J49/165 , G01N30/7246 , H01J49/044 , H01J49/0477
摘要： Liquid from a liquid chromatograph or other sample source, preferably assisted by a high velocity coaxial gas jet, is sprayed through a capillary tube (40') producing a flow in a first direction of charged droplets (50'). A flow of heated gas (60), in a second direction different from the first direction, intersects the droplet flow at a region (64) upstream of an orifice (20'). The flows mix turbulently, with the second flow helping to evaporate the droplets to produce ions and helping to move the evaporating droplets toward the orifice (20'), providing a focusing effect. Ions are drawn through the orifice (20') into a mass analyzer and analyzed. Alternatively the flows of liquid and heating gas can be directed toward each other and at right angles to the axis through the orifice, and the inhaling effect of the orifice can be used to draw droplets toward it, or a third gas flow can be used for this purpose. The heated intersecting gas flow typically provides an increase in sensitivity (ion counts per second) of between 10 and 100 times. Heating the droplet plume also allows controlled desaturation of ions and an increase in the number of charges on them, without degrading the ions.
摘要翻译：来自液相色谱仪或其它样品源的液体优选由高速同轴气体射流辅助通过毛细管（40'）喷射，产生沿带电液滴（50'）的第一方向的流动。在与第一方向不同的第二方向上的加热气体（60）的流动在孔口（20'）上游的区域（64）处与液滴流相交。流动紊乱地混合，第二流有助于蒸发液滴以产生离子并帮助将蒸发的液滴移向孔口（20'），从而提供聚焦效果。离子通过孔口（20'）被吸入质量分析器并进行分析。或者，液体和加热气体的流动可以彼此指向并且通过孔口与轴线成直角，并且可以使用孔口的吸入效应来朝向其喷射液滴，或者可以使用第三气流这个目的加热的相交气流通常提供10至100倍的灵敏度（每秒离子计数）的增加。加热液滴羽流还允许控制离子的去饱和和其上的电荷数量的增加，而不降低离子。

2. 发明申请

WO1994027311A2 METHOD OF PLASMA MASS ANALYSIS WITH REDUCED SPACE CHARGE EFFECTS 审中-公开
标题翻译：具有减少空间充电效应的等离子体质量分析方法
公开(公告)号：WO1994027311A2
公开(公告)日：1994-11-24
申请号：PCT/CA1994000247
申请日：1994-05-04
申请人： MDS HEALTH GROUP LIMITED
发明人： MDS HEALTH GROUP LIMITED , TANNER, Scott, D. , DOUGLAS, Donald, J. , COUSINS, Lisa
IPC分类号： H01J49/04
CPC分类号： H01J49/067 , H01J49/044 , H01J49/105
摘要： A method of analyzing an analyte contained in a plasma, in inductively coupled plasma mass spectrometry (ICP-MS). A sample of the plasma is drawn through an orifice in a sampler. The sample is then skimmed in a skimmer orifice, and the skimmed sample is directed at supersonic velocity onto a blunt reducer having a small orifice therein, forming a shock wave on the reducer. Gas in the shock wave is sampled through an offset aperture in the reducer into a vacuum chamber containing ion optics and a mass spectrometer. Because the gas sampled through the skimmer and reducer orifices is substantially neutral (ions and free electrons are in close proximity), and also because the reducer orifice is very small, space charge effects are reduced, thus reducing mass bias and also reducing the mass dependency of matrix effects. Separation of ions from free electrons and focusing of ions into the mass spectrometer largely occurs in and downstream of the ion optics in the vacuum chamber. Since the region between the skimmer and the reducer can operate at about 0.1 Torr, which is the same pressure as that produced by the roughing pump which backs the high vacuum pump for the vacuum chamber, a single common pump can be used for both purposes, thus reducing the hardware needed.
摘要翻译：在电感耦合等离子体质谱（ICP-MS）中分析包含在等离子体中的分析物的方法。等离子体的样品通过采样器中的孔抽出。然后将样品撇取在分离器孔口中，并将脱脂样品以超声速度引导到其中具有小孔口的钝化还原剂上，在还原剂上形成冲击波。冲击波中的气体通过减速器中的偏移孔被采样到包含离子光学器件和质谱仪的真空室中。由于通过分离器和还原剂孔抽取的气体基本上是中性的（离子和自由电子非常接近），并且由于还原剂孔口非常小，所以空间电荷效应降低，从而减少了质量偏差并且还降低了质量依赖性的矩阵效应。分离离子与自由电子并将离子聚焦到质谱仪中大部分发生在真空室内离子光学器件的下游。由于撇渣器和减速器之间的区域可以在大约0.1托的范围内工作，这是与用于真空室的高真空泵背对的粗抽泵产生的压力相同的压力，因此可以使用单个公共泵用于两个目的，从而减少所需的硬件。

3. 发明申请

WO1996008034A1 MASS SPECTROMETER SYSTEM AND METHOD USING SIMULTANEOUS MODE DETECTOR AND SIGNAL REGION FLAGS 审中-公开
标题翻译：质谱仪系统和方法同时使用模式检测器和信号区域标志
公开(公告)号：WO1996008034A1
公开(公告)日：1996-03-14
申请号：PCT/CA1995000506
申请日：1995-09-06
申请人： MDS HEALTH GROUP LIMITED , BUCKLEY, Peter , COUSINS, Lisa , DAYNES, Todd , GRETCHEV, Val , HIRASAWA, Drake , LEITH, Graham
发明人： MDS HEALTH GROUP LIMITED
IPC分类号： H01J49/02
CPC分类号： H01J49/025 , H01J43/30 , H01J49/022 , H01J49/105
摘要： A mass analyzer system uses a simultaneous mode electron multiplier detector which outputs both a pulse count and an analog signal. Depending on the ion flux intensity, the signals define a pulse count only region in which the pulse count only signal is valid, an overlap region in which both the pulse count and analog signals are valid, an analog signal only region in which only the analog signal is valid, and a neither analog nor pulse region in which neither signal is valid. The system produces a separate flag for each region. When a mass spectrum is scanned, for each dwell the pulse count and analog data are recorded together with their associated flag and are placed in memory. The signals, with the flag, can then be used to produce a mass spectrum using the pulse count only signal, the analog only signal, or both. In addition numeric displays can be produced for each peak or a variety of peaks, using the pulse count only signal, the analog signal, or both, together with a display of the flag or flags which have been set at the peak being displayed.
摘要翻译：质量分析器系统使用输出脉冲计数和模拟信号的同时模式电子倍增器检测器。根据离子通量强度，这些信号仅限于仅脉冲计数信号有效的脉冲计数区域，脉冲计数和模拟信号都有效的重叠区域，仅模拟信号区域信号有效，既不是两个信号都无效的模拟和脉冲区域。系统为每个区域生成一个单独的标志。当扫描质谱时，对于每个驻留，脉冲计数和模拟数据与其相关联的标志一起记录并放置在存储器中。然后，使用标志的信号可以用于使用仅脉冲计数信号，仅模拟信号或两者来产生质谱。此外，可以使用仅脉冲计数信号，模拟信号或两者来为每个峰值或各种峰值产生数字显示，以及在显示峰值时设置的标志或标志的显示。

4. 发明申请

WO1997022233A1 TORCH FOR INDUCTIVELY COUPLED PLASMA SPECTROMETRY 审中-公开
标题翻译：感应耦合等离子体光谱仪
公开(公告)号：WO1997022233A1
公开(公告)日：1997-06-19
申请号：PCT/CA1996000823
申请日：1996-12-10
申请人： MDS HEALTH GROUP LIMITED , FRENCH, John, Barry , JONG, Raymond , ETKIN, Bernard
发明人： MDS HEALTH GROUP LIMITED
IPC分类号： H05H01/30
CPC分类号： H05H1/30 , H05H2001/3468 , H05H2001/3478
摘要： A torch for Inductively Coupled Plasma Spectrometry (ICPS) is formed from quartz and has inner and outer tubes defining an annular channel. The end of the inner tube is within an end portion of the outer tube, to define a chamber for a plasma ball. An inlet for a main gas flow opens tangentially into the annular channel. The annular channel is configured so as to maximize the swirl component of this flow. To this end, a connection to the inlet is provided with an annular toroidal shape, having a cross section to or larger than the inlet. Further, the inlet is mounted relatively close to the end of the inner tube, so as to minimise decay of the swirl component as the gas flows along the annular channel, the length of the annular channel being sufficient to ensure that the flow leaving the annular channel is uniform and has a uniform swirl component. This arrangement enables a significantly reduced consumption of gas to generate a plasma ball, and can give improved performance, in terms of a higher detection rate in a spectrometer.
摘要翻译：电感耦合等离子体光谱仪（ICPS）的手电筒由石英形成，并具有限定环形通道的内外管。内管的端部在外管的端部内，以限定用于等离子体球的腔室。主气流的入口切向进入环形通道。环形通道被配置为使该流动的漩涡分量最大化。为此，与入口的连接设置有环形环形，具有大于或大于入口的横截面。此外，入口相对靠近内管的端部安装，以便随着气体沿着环形通道流动而最小化漩涡部件的衰减，环形通道的长度足以确保离开环形管通道均匀，具有均匀的涡流分量。这种布置能够显着降低气体的消耗以产生等离子体球，并且可以在光谱仪中以更高的检测率提供改进的性能。

5. 发明申请

WO1996015547A1 METHOD AND APPARATUS FOR PLASMA MASS ANALYSIS WITH REDUCED SPACE CHARGE EFFECTS 审中-公开
标题翻译：具有减少空间充电效应的等离子体质量分析的方法和装置
公开(公告)号：WO1996015547A1
公开(公告)日：1996-05-23
申请号：PCT/CA1995000619
申请日：1995-10-31
申请人： MDS HEALTH GROUP LIMITED
发明人： MDS HEALTH GROUP LIMITED , TANNER, Scott, D. , DOUGLAS, Donald, J. , COUSINS, Lisa
IPC分类号： H01J49/10
CPC分类号： H01J49/067 , H01J49/044 , H01J49/105
摘要： A method of analyzing an analyte contained in a plasma, in inductively coupled plasma mass spectrometry (ICP-MS). A sample of the plasma is drawn through an orifice in a sampler, then skimmed in a skimmer orifice, and the skimmed sample is directed at supersonic velocity onto a blunt reducer having a small orifice therein, forming a shock wave on the reducer. Gas in the shock wave is sampled through an offset aperture in the reducer into a vacuum chamber containing ion optics and a mass spectrometer. This reduces space charge effects, thus reducing mass bias and also reducing the mass dependency of matrix effects. Since the region between the skimmer and the reducer can operate at about 0.1 Torr, which is the same pressure as that produced by the roughing pump which backs the high vacuum pump for the vacuum chamber, a single common pump can be used for both purposes, thus reducing the hardware needed. In a simplified version, the skimmer can be replaced by a small beam blocking finger which extends across a line of sight between the sampler and reducer orifices and occludes the reducer orifice from the sampler orifice.
摘要翻译：在电感耦合等离子体质谱（ICP-MS）中分析包含在等离子体中的分析物的方法。等离子体的样品通过采样器中的孔被抽吸，然后在分离器孔口中被撇去，并将脱脂样品以超声速度引导到具有小孔口的钝化还原剂上，在还原剂上形成冲击波。冲击波中的气体通过减速器中的偏移孔被采样到包含离子光学器件和质谱仪的真空室中。这减少了空间电荷效应，从而减少了质量偏差并且还降低了矩阵效应的质量依赖性。由于撇渣器和减速器之间的区域可以在大约0.1托的范围内工作，这是与用于真空室的高真空泵背对的粗抽泵产生的压力相同的压力，因此可以使用单个公共泵用于两个目的，从而减少所需的硬件。在简化版本中，撇渣器可以由小梁阻挡手指代替，该手指延伸穿过取样器和减速器孔之间的视线并且从采样器孔口封闭减速器孔口。

6. 发明申请

WO1997007530A1 SPECTROMETER WITH AXIAL FIELD 审中-公开
标题翻译：带轴向场的光谱仪
公开(公告)号：WO1997007530A1
公开(公告)日：1997-02-27
申请号：PCT/CA1996000541
申请日：1996-08-09
申请人： MDS HEALTH GROUP LIMITED , THOMSON, Bruce, A. , JOLLIFFE, Charles, L.
发明人： MDS HEALTH GROUP LIMITED
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/005
摘要： In a mass spectrometer, typically a quadrupole, one of the rod sets is constructed to create an axial field, e.g. a DC axial field, thereon. The axial field can be created by tapering the rods, or arranging the rods at angles with respect to each other, or segmenting the rods, or by providing a segmented case around the rods, or by providing resistively coated or segmented auxiliary rods, or by providing a set of conductive metal bands spaced along each rod with a resistive coating between the bands, or by forming each rod as a tube with a resistive exterior coating and a conductive inner coating, or by other appropriate methods. When the axial field is applied to Q0 in a tandem quadrupole set, it speeds passages of ions through Q0 and reduces delay caused by the need to refill Q0 with ions when jumping from low to high mass in Q1. When used as collision cell Q2, the axial field reduces the delay needed for daughter ions to drain out of Q2. The axial field can also be used to help dissociate ions in Q2, either by driving the ions forwardly against the collision gas, or by oscillating the ions axially within the collision cell.
摘要翻译：在质谱仪中，通常是四极杆，其中一个棒组被构造成产生轴向场，例如。一个直流轴向场。可以通过使棒变细或者将杆彼此成角度地设置或者将杆分段，或者通过在棒周围提供分段的壳体，或者通过提供电阻涂层或分段的辅助棒，或者通过提供一组沿每个杆间隔开的导电金属带，在带之间具有电阻涂层，或者通过将每个棒形成为具有电阻外部涂层和导电内涂层的管，或通过其它合适的方法。当串联四极组中的轴向场施加到Q0时，它会加速离子通过Q0的通道，并减少在Q1中从低质量跳跃到高质量时需要从离子中重新填充Q0所引起的延迟。当用作碰撞单元Q2时，轴向场减小了子离子在Q2中排出所需的延迟。轴向场也可以用来帮助离子在Q2中离解，无论是通过向前驱动离子抵抗碰撞气体，还是通过在碰撞室内轴向振荡离子。

7. 发明申请

WO1994022580A1 METHOD AND APPARATUS FOR LABELLING AND TRACKING MEDICAL SPECIMENS 审中-公开
标题翻译：标签和跟踪医学标本的方法和装置
公开(公告)号：WO1994022580A1
公开(公告)日：1994-10-13
申请号：PCT/CA1994000189
申请日：1994-03-31
申请人： MDS HEALTH GROUP LIMITED , GAUVIN, James , RAVENHILL, Kevin , SHINDLER, Karen , WILKINSON, Annette
发明人： MDS HEALTH GROUP LIMITED
IPC分类号： B01L03/14
CPC分类号： G01N35/00732 , A61B5/117 , B01L3/5453 , G01N2035/00752 , G01N2035/00762 , G01N2035/00782 , G06K17/00 , G06K2017/009
摘要： A system for generating a plurality of labels for use in identifying and tracking specimens which are to be tested in a laboratory facility and for use with a patient card (30) having encoded patient data. The system comprises a card reader (24) for reading patient data from the patient card (30), a bar-code reader (26) for scanning test codes from a template (34), and a computer (10) for generating labels (36) from the patient data and scanned test codes. The labels (36) are printed on adhesive strips and include a Requisition Label, Test List Label, Form Label and Test Label. The Requisition, Test List and Form labels are used to track the paper forms associated with testing the specimen. The Test Label, on the other hand, is attached directly to a tube containing the specimen and used to track and sort the specimen from the point of collection to the testing bench. The Test label has an number of information conveying fields which include a machine-readable code that provides a unique identification code for tracking and sorting the specimen. The Test label also includes a second machine-readable code which indicates the test to be performed on the specimen. The machine-readable code format allows the specimens to be sorted by automated machines. The machine-readable codes can also be used in conjunction with a machine-readable shipping bin code to produce a waybill for shipping (and receiving) the specimens to a remote laboratory facility. The system also includes the capability of determining the number of Test labels which are required for a particular specimen, so that the printing of unnecessary labels is minimized.
摘要翻译：一种用于产生多个标签的系统，用于识别和跟踪在实验室设备中被测试并与具有编码的患者数据的患者卡（30）一起使用的样本。该系统包括用于从患者卡（30）读取患者数据的读卡器（24），用于从模板（34）扫描测试代码的条形码读取器（26）和用于生成标签的计算机（10） 36）从患者数据和扫描测试代码。标签（36）打印在胶带上，包括申请标签，测试列表标签，表格标签和测试标签。申请，测试列表和表单标签用于跟踪与样本测试相关的纸张形式。另一方面，测试标签直接连接到含有样品的管中，用于从收集点到测试台跟踪和分类样品。测试标签具有多个信息传递领域，包括机器可读代码，其提供用于跟踪和分类样本的唯一识别码。测试标签还包括第二个机器可读代码，指示要在样本上执行的测试。机器可读代码格式允许通过自动化机器对样本进行分类。机器可读代码也可以与机器可读的运输箱代码一起使用，以生成运送（并接收）标本到远程实验室设施的运单。该系统还包括确定特定样本所需的测试标签的数量的能力，使得不必要的标签的打印被最小化。

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