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1. 发明申请

WO2003014383A3 PHENOTYPIC EFFECTS OF UBIQUINONE DEFICIENCIES AND METHODS OF SCREENING THEREOF 审中-公开
公开(公告)号：WO2003014383A3
公开(公告)日：2003-02-20
申请号：PCT/CA2002/001230
申请日：2002-08-07
申请人： MCGILL UNIVERSITY , CHRONOGEN , HEKIMI, Siegfried , HIHI, Abdelmadjid , LEVAVASSEUR, Françoise , SHOUBRIDGE, Eric , GAO, Yuan , PAQUET, Michel , BÉNARD, Claire
发明人： HEKIMI, Siegfried , HIHI, Abdelmadjid , LEVAVASSEUR, Françoise , SHOUBRIDGE, Eric , GAO, Yuan , PAQUET, Michel , BÉNARD, Claire
IPC分类号： G01N33/50
摘要： The present invention relates to a method of screening for a compound allowing survival of clk1 homozygous mutant embryos; a method of screening for a compound suitable for rescue of mutant phenotype of mclk1 homozygous cell line; a method of screening for a compound suitable for partial or complete functional replacement of endogenous ubiquinone; a method for screening a compound capable of inhibiting activity of clk-1 and/or other processes required to make ubiquinone from demethoxyubiquinone; a non-ubiquinone-producer mouse; a DNA construct, which comprises an alteration of mclk1; a non-ubiquinone-producer ES cell line; a coq-3 mutant subject non-ubiquinone producer; a method of screening for a compound suitable for complete or partial functional ubiquinone or demethoxyubiquinone replacement; a method for reducing and/or increasing ubiquinone level in a multicellular subject; a method of screening for a genetic suppressor of clk-1; and a method of screening for a genetic suppressor of coq-3.

2. 发明公开

EP1417485A2 PHENOTYPIC EFFECTS OF UBIQUINONE DEFICIENCIES AND METHODS OF SCREENING THEREOF 审中-公开
标题翻译：证明方法以及UBICHINONMÄNGELN的表型效应
公开(公告)号：EP1417485A2
公开(公告)日：2004-05-12
申请号：EP02754011.1
申请日：2002-08-07
申请人： McGILL UNIVERSITY , Chronogen
发明人： HEKIMI, Siegfried , HIHI, Abdelmadjid , LEVAVASSEUR, Françoise , SHOUBRIDGE, Eric , GAO, Yuan , PAQUET, Michel , BENARD, Claire
IPC分类号： G01N33/50
CPC分类号： A01K67/0276 , A01K67/0336 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/03 , A61K49/0008 , C12N9/0073 , C12N9/1007 , C12N15/8509 , C12N2800/30 , G01N33/5085 , G01N33/5088 , G01N2500/00
摘要： The present invention relates to a method of screening for a compound allowing survival of clk1 homozygous mutant embryos; a method of screening for a compound suitable for rescue of mutant phenotype of mclk1 homozygous cell line; a method of screening for a compound suitable for partial or complete functional replacement of endogenous ubiquinone; a method for screening a compound capable of inhibiting activity of clk-1 and/or other processes required to make ubiquinone from demethoxyubiquinone; a non-ubiquinone-producer mouse; a DNA construct, which comprises an alteration of mclk1; a non-ubiquinone-producer ES cell line; a coq-3 mutant subject non-ubiquinone producer; a method of screening for a compound suitable for complete or partial functional ubiquinone or demethoxyubiquinone replacement; a method for reducing and/or increasing ubiquinone level in a multicellular subject; a method of screening for a genetic suppressor of clk-1; and a method of screening for a genetic suppressor of coq-3.

3. 发明公开

EP0862538A2 VERFAHREN UND VORRICHTUNG ZUR BEHANDLUNG VON MIT MIKROORGANISMEN UND/ODER SCHADSTOFFEN BELASTETEM WASSER 失效
标题翻译：方法和设备微生物有和/或有害物质污染水处理
公开(公告)号：EP0862538A2
公开(公告)日：1998-09-09
申请号：EP96938957.0
申请日：1996-09-25
申请人： The National Engineering Research Center For Urban Pollution Control , Gao, Yuan
发明人： GAO, Yuan , GAO, Tingyao , HAN, Baiping , ZHANG, Desheng , LI, Jie
IPC分类号： C02F1 , C02F9
CPC分类号： C02F1/46109 , C02F1/283 , C02F1/36 , C02F1/4602 , C02F1/463 , C02F1/4672 , C02F1/722 , C02F1/76 , C02F1/78 , C02F9/00 , C02F2001/46119 , C02F2001/46133 , C02F2001/46142 , C02F2001/46152 , C02F2001/46157 , C02F2103/003 , C02F2201/4611 , C02F2201/46125 , C02F2201/4615 , C02F2301/024 , C02F2301/026 , C02F2303/04 , C02F2305/023
摘要： The disclosure relates to a process for treating water contaminated with micro-organisms and/or harmful pollutants. A direct current is passed through the water between an anode and a cathode. The anode is provided with a coating containing titanium dioxide. The direct current is set to give a charge of 30 to 60 Coulomb per litre of water. The direct current has a catalytic effect promoting the loss of electrons from the titanium dioxide and the formation of oxygen radicals in the water. The process has a deposition effect promoting the disinfection of the water. The duration of that effect is proportional to the total electrical charge. The process also increases the quantity of dissolved oxygen in the water, which should be between 0.5 and 1.8 mg/l and is dependent specifically on the total charge in the water and on the anode material. Another effect of the process is a dramatic reduction in hard lime deposits on the cathode and in the water system as a whole.

4. 发明授权

EP0862538B1 VERFAHREN UND VORRICHTUNG ZUR BEHANDLUNG VON MIT MIKROORGANISMEN UND/ODER SCHADSTOFFEN BELASTETEM WASSER 失效
标题翻译：方法和设备微生物有和/或有害物质污染水处理
公开(公告)号：EP0862538B1
公开(公告)日：1999-07-07
申请号：EP96938957.6
申请日：1996-09-25
申请人： The National Engineering Research Center For Urban Pollution Control , Gao, Yuan
发明人： GAO, Yuan , GAO, Tingyao , HAN, Baiping , ZHANG, Desheng , LI, Jie
IPC分类号： C02F1/36 , C02F1/48
CPC分类号： C02F1/46109 , C02F1/283 , C02F1/36 , C02F1/4602 , C02F1/463 , C02F1/4672 , C02F1/722 , C02F1/76 , C02F1/78 , C02F9/00 , C02F2001/46119 , C02F2001/46133 , C02F2001/46142 , C02F2001/46152 , C02F2001/46157 , C02F2103/003 , C02F2201/4611 , C02F2201/46125 , C02F2201/4615 , C02F2301/024 , C02F2301/026 , C02F2303/04 , C02F2305/023
摘要： The disclosure relates to a process for treating water contaminated with micro-organisms and/or harmful pollutants. A direct current is passed through the water between an anode and a cathode. The anode is provided with a coating containing titanium dioxide. The direct current is set to give a charge of 30 to 60 Coulomb per litre of water. The direct current has a catalytic effect promoting the loss of electrons from the titanium dioxide and the formation of oxygen radicals in the water. The process has a deposition effect promoting the disinfection of the water. The duration of that effect is proportional to the total electrical charge. The process also increases the quantity of dissolved oxygen in the water, which should be between 0.5 and 1.8 mg/l and is dependent specifically on the total charge in the water and on the anode material. Another effect of the process is a dramatic reduction in hard lime deposits on the cathode and in the water system as a whole.

5. 发明申请

WO2012154221A1 TECHNIQUES FOR DETECTING NEW BROWSER WINDOWS 审中-公开
标题翻译：检测新浏览器窗口的技术
公开(公告)号：WO2012154221A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/020106
申请日：2012-01-03
申请人： ORACLE INTERNATIONAL CORPORATION , SULLIVAN, Blake , GAO, Yuan , WANG, Hongbing
发明人： SULLIVAN, Blake , GAO, Yuan , WANG, Hongbing
IPC分类号： G06F17/30
CPC分类号： H04L41/5041 , G06F9/547 , G06F17/30861 , H04L43/08 , H04L67/02 , H04L67/10 , H04L67/14
摘要： Embodiments of the present invention provide techniques for tracking the lifecycles of client-side browser windows in the context of a web application. In one set of embodiments, a server component of a web application can receive a request originating from a client-side browser window, where the request includes a resource locator (e.g., a URL) and a window identifier. In response, the server component can send a script to the window for retrieving the window's actual identifier/name. Based on the actual identifier returned by the script and the window identifier included in the initial request, the server component can determine whether the window is a new window or an existing window and can process the request as appropriate.
摘要翻译：本发明的实施例提供了用于在web应用的上下文中跟踪客户侧浏览器窗口的生命周期的技术。在一组实施例中，web应用的服务器组件可以接收源自客户端侧浏览器窗口的请求，其中请求包括资源定位符（例如URL）和窗口标识符。作为响应，服务器组件可以向窗口发送脚本以检索窗口的实际标识符/名称。基于脚本返回的实际标识符和包含在初始请求中的窗口标识符，服务器组件可以确定该窗口是新窗口还是现有窗口，并且可以适当地处理该请求。

6. 发明申请

WO2010020270A1 VERFAHREN ZUR DESINFEKTION VON WASSER 审中-公开
标题翻译：方法消毒的水
公开(公告)号：WO2010020270A1
公开(公告)日：2010-02-25
申请号：PCT/EP2008/007112
申请日：2008-08-22
申请人： GAO, Yuan
发明人： GAO, Yuan
IPC分类号： C02F1/467
CPC分类号： C02F1/4674 , C02F2303/04
摘要： Es wird ein Verfahren zur Desinfektion von durch eine Leitung (1) geführtem Wasser durch dosierte Zugabe einer aus dem Wasser gebildeten Desinfektionslösung offenbart. Aus der Leitung entnommenes Wasser wird in die in einem Vorratsbehälter (3) enthaltene Desinfektionslösung geführt und aus dem Vorratsbehälter entnommene Desinfektionslösung wird dosiert in die Leitung injiziert. Weiterhin wird aus dem Vorratsbehälter entnommene Desinfektionslösung im Kreislauf wiederholt einer anodischen Oxidation unterzogen und dem Vorratsbehälter wieder zugeführt wird. Dabei wird eine Aufsalzung durch Chemikalienzugabe möglichst vermieden.
摘要翻译：一种用于通过导管（1）的消毒方法公开了通过计量加入由水形成的消毒剂溶液的引导水。材料从自来水除去被引导到包含在贮存器（3），并从贮存消毒液中取出的消毒剂溶液计量注入导管。此外，从在电路中的贮存容器的消毒溶液萃取反复经受阳极氧化和贮存器再次供给。这里，盐化通过添加化学品尽可能避免。

7. 发明申请

WO2010000374A1 PROTEIN COMPLEXES AND SCREENING METHODS 审中-公开
标题翻译：蛋白复合物和筛选方法
公开(公告)号：WO2010000374A1
公开(公告)日：2010-01-07
申请号：PCT/EP2009/004181
申请日：2009-06-10
申请人： BIOCANT- ASSOCIAÇÃO DE TRANSFERÊNCIA DE TECNOLOGIA , VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION , VALENTE, André Xavier de Carvalho Negrão , GAO, Yuan , BUCK, Gregory, A. , ROBERTS, Seth
发明人： VALENTE, André Xavier de Carvalho Negrão , GAO, Yuan , BUCK, Gregory, A.
IPC分类号： C07K14/47 , C07K14/395 , A61P27/02
CPC分类号： C07K14/395 , C07K14/47
摘要： The application concerns an isolated protein complex comprising polypeptide components: (i) UTP20 HUMAN or a fragment, variant or homologue thereof; (ii) PWP2 HUMAN or a fragment, variant or homologue thereof; (iii) WDR46_HUMAN or a fragment, variant or homologue thereof; (iv) UTP18 HUMAN or a fragment, variant or homologue thereof; (v) MPPIO HUMAN or a fragment, variant or homologue thereof; (vi) WDR3_HUMAN or a fragment, variant or homologue thereof; (vii) TBL3 HUMAN or a fragment, variant or homologue thereof; (viii) WDR36_HUMAN or a fragment, variant or homologue thereof; and (ix) N0C4L HUMAN or a fragment, variant or homologue thereof. The application further concerns a method of identifying an agent that modulates the amount, function, activity, composition and/or formation of said protein complex; a method for the prevention or treatment of an eye disorder comprising administering to a subject in need thereof a suitable quantity of an agent that modulates the amount, function, activity, composition and/or formation of said protein complex; and a method of assessing whether a subject has or is likely to develop an eye disorder comprising determining whether the subject has an altered amount, function, activity, composition and/or formation of a protein complex.
摘要翻译：该应用涉及包含多肽组分的分离的蛋白质复合物：（i）UTP20Human或其片段，变体或同源物; （ii）PWP2人类或其片段，变体或同源物; （iii）WDR46_HUMAN或其片段，变体或同源物; （iv）UTP18人类或其片段，变体或同源物; （v）MPPIO HUMAN或其片段，变体或同源物; （vi）WDR3_HUMAN或其片段，变体或同源物; （vii）TBL3人类或其片段，变体或同源物; （viii）WDR36_HUMAN或其片段，变体或同源物; 和（ix）N0C4L HUMAN或其片段，变体或同源物。本申请还涉及鉴定调节所述蛋白质复合物的量，功能，活性，组成和/或形成的试剂的方法; 一种用于预防或治疗眼睛疾病的方法，包括向有需要的受试者施用适量的调节所述蛋白质复合物的量，功能，活性，组成和/或形成的试剂; 以及评估受试者是否具有或可能发展眼病的方法，包括确定受试者是否具有改变的蛋白质复合物的量，功能，活性，组成和/或形成。

8. 发明申请

WO2008143854A1 STABILIZED LITHIUM METAL POWDER FOR LI-ION APPLICATION, COMPOSITION AND PROCESS 审中-公开
标题翻译：稳定的锂离子金属粉末，用于锂离子应用，组成和工艺
公开(公告)号：WO2008143854A1
公开(公告)日：2008-11-27
申请号：PCT/US2008/006126
申请日：2008-05-14
申请人： FMC CORPORATION - LITHIUM DIVISION , YAKOVLEVA, Marina , GAO, Yuan , LI, Yangxing
发明人： YAKOVLEVA, Marina , GAO, Yuan , LI, Yangxing
IPC分类号： B22F9/06 , B22F1/02
CPC分类号： B22F1/0062 , B22F1/02 , B22F9/06 , H01M4/382 , Y10T428/2991
摘要： The present invention provides a method for stabilizing lithium metal powder. The method comprises the steps of heating the lithium metal powder to above its melting point to provide molten lithium metal, dispersing the molten lithium metal, and contacting the dispersed molten lithium metal with a phosphorous-containing compound to provide a substantially continuous protective layer of lithium phosphate on the lithium metal powder.
摘要翻译：本发明提供一种稳定锂金属粉末的方法。该方法包括以下步骤：将锂金属粉末加热到高于其熔点以提供熔融的锂金属，分散熔融的锂金属，并使分散的熔融锂金属与含磷化合物接触，以提供基本上连续的锂保护层磷酸盐在锂金属粉末上。

9. 发明申请

WO2007002907A2 LITHIUM MANGANESE COMPOUNDS AND METHODS OF MAKING THE SAME 审中-公开
标题翻译：锰锰化合物及其制备方法
公开(公告)号：WO2007002907A2
公开(公告)日：2007-01-04
申请号：PCT/US2006/025694
申请日：2006-06-29
申请人： FMC CORPORATION , GAO, Yuan , YAKOVLEVA, Marina , FITCH, Brian
发明人： GAO, Yuan , YAKOVLEVA, Marina , FITCH, Brian
IPC分类号： H01M4/131 , H01M4/1391 , H01M4/50 , H01M4/505 , H01M4/52 , H01M4/525 , H01M10/052 , H01M10/36
CPC分类号： C01D15/02 , C01G45/1228 , C01P2002/54 , C01P2002/72 , C01P2006/40 , H01M4/131 , H01M4/1391 , H01M4/505 , H01M4/525 , H01M10/052
摘要： Electrode materials such as LixMnO 2 where 0.2 2 O 4 compounds or manganese dioxide compounds with lithium metal or stabilized and non-stabilized lithium metal powders.
摘要翻译：用于可再充电锂离子电池的0.2 x = 2化合物的电极材料，例如LixMnO 2 N，可以通过混合LiMn 2 O 4 具有锂金属或稳定和非稳定的锂金属粉末的化合物或二氧化锰化合物。

10. 发明申请

WO2005051392A1 GTPASE INHIBITORS AND METHODS OF USE 审中-公开
标题翻译： GTPASE抑制剂及其使用方法
公开(公告)号：WO2005051392A1
公开(公告)日：2005-06-09
申请号：PCT/US2004/039090
申请日：2004-11-19
申请人： CHILDREN'S HOSPITAL MEDICAL CENTER , ST. JUDE CHILDREN'S RESEARCH HOSPITAL , ZHENG, Yi , ZHENG, Jie , GAO, Yuan , DICKERSON, John B. , MAZUR, Wieslaw, Adam
发明人： ZHENG, Yi , ZHENG, Jie , GAO, Yuan , DICKERSON, John B. , MAZUR, Wieslaw, Adam
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/47 , A61K31/505 , Y02A50/409
摘要： The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.
摘要翻译：优选的实施方案通常涉及影响Rho家族GTP酶，优选Rac（Rac1，Rac2和/或Rac3）成员的GTP结合活性的方法和组合物，所述组合物包括调节GTP / GDP交换活性的化合物用于化合物的用途，包括筛选识别Rac GTP酶的化合物，以及治疗与Rho家族GTP酶（包括Rac）相关或相关的病理状况的方法。优选实施方案还涉及使用这些化合物或其衍生物的方法，例如在治疗学，诊断学和研究工具中。

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