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1. 发明申请

WO2015154052A1 ISOTYPING IMMUNOGLOBULINS USING ACCURATE MOLECULAR MASS 审中-公开
标题翻译：使用精确分子量的同种异体免疫球蛋白
公开(公告)号：WO2015154052A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/024379
申请日：2015-04-03
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , MURRAY, David L. , BARNIDGE, David R. , DASARI, Surendra , MILLS, John R.
发明人： MURRAY, David L. , BARNIDGE, David R. , DASARI, Surendra , MILLS, John R.
IPC分类号： G01N30/72 , G01N33/48
CPC分类号： G01N33/6848 , G01N30/7266 , G01N33/6857 , G01N2800/52 , G01N2800/7095
摘要： This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.
摘要翻译：本文件涉及使用质谱技术检测和定量免疫球蛋白重链和轻链的方法。

2. 发明申请

WO2019055634A1 IDENTIFICATION AND MONITORING OF APOPTOSIS INHIBITOR OF MACROPHAGE 审中-公开
公开(公告)号：WO2019055634A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/050849
申请日：2018-09-13
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , MURRAY, David L. , BARNIDGE, David R.
发明人： MURRAY, David L. , BARNIDGE, David R.
IPC分类号： A61K38/17 , A61K38/20 , A61P17/00
CPC分类号： A61K38/17 , A61K38/20 , A61P17/00
摘要： This document provides materials and methods for identifying and quantifying AIM polypeptides in a sample using mass spectrometry techniques. For example, methods of using mass spectrometry to identify and quantify AIM polypeptides in a serum sample are provided. In some cases, quantification of AIM polypeptides can be used to diagnose and/or treat patients having a disease or disorder characterized by altered (e.g., increased or decreased) AIM polypeptide levels.

3. 发明申请

WO2019055632A1 IDENTIFICATION AND MONITORING OF IMMUNOGLOBULIN J CHAINS 审中-公开
公开(公告)号：WO2019055632A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/050847
申请日：2018-09-13
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , MURRAY, David L. , BARNIDGE, David R.
发明人： MURRAY, David L. , BARNIDGE, David R.
IPC分类号： C07K16/00 , G01N33/53 , G01N33/50
摘要： This document relates to materials and methods for identifying and monitoring immunoglobulin J chains in a sample, such as a biological sample, using mass spectrometry techniques.

4. 发明申请

WO2019055631A1 IDENTIFICATION AND MONITORING OF ACID HYDROLYSIS PRODUCTS OF IMMUNOGLOBULIN HEAVY CHAINS 审中-公开
公开(公告)号：WO2019055631A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/050846
申请日：2018-09-13
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , MURRAY, David L. , BARNIDGE, David R.
发明人： MURRAY, David L. , BARNIDGE, David R.
IPC分类号： G01N33/68
CPC分类号： G01N33/6857 , G01N33/6848 , G01N33/6893
摘要： This document provides materials and methods for identifying and/or quantifying immunoglobulin heavy chains (e.g., IgG heavy chains) in a sample, such as a biological sample, using mass spectrometry techniques. For example, mass spectrometry techniques that can be used to identify and/or quantify IgG heavy chain acid hydrolysis products in a serum sample without the need for any IgG cleavage reagents (e.g., enzymes) are provided.

5. 发明申请

WO2014150170A1 IDENTIFICATION AND MONITORING OF MONOCLONAL IMMUNOGLOBULINS BY MOLECULAR MASS 审中-公开
标题翻译：通过分子量鉴定和监测单克隆免疫球蛋白
公开(公告)号：WO2014150170A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/022475
申请日：2014-03-10
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , BARNIDGE, David R. , MURRAY, David L.
发明人： BARNIDGE, David R. , MURRAY, David L.
IPC分类号： A01H1/06
CPC分类号： G01N33/6848 , G01N30/7233 , G01N33/57426 , G01N33/6851 , G01N33/6857 , G01N2800/52 , H01J49/0027 , H01J49/164
摘要： Disclosure herein are methods for determining whether or not an immunoglobulin is present above the polyclonal background level in a biological sample, and methods for determining whether an immunoglobulin contains a kappa or lambda light chain. These methods are useful for screening biological samples for the presence or absence of monoclonal gammopathy, and for diagnosing and monitoring monoclonal gammopathy in a subject.
摘要翻译：本文公开的方法是用于确定生物样品中多克隆背景水平以上存在免疫球蛋白的方法以及用于确定免疫球蛋白是否含有κ或λ轻链的方法。这些方法可用于筛选生物样品中存在或不存在单克隆丙种球蛋白病，以及用于诊断和监测受试者中的单克隆丙种球蛋白病。

6. 发明申请

WO2018049001A1 IDENTIFICATION AND MONITORING OF CLEAVED IMMUNOGLOBULINS BY MOLECULAR MASS 审中-公开
标题翻译：分子质量分析免疫球蛋白的鉴定和监测
公开(公告)号：WO2018049001A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050430
申请日：2017-09-07
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： BARNIDGE, David R. , MURRAY, David L.
IPC分类号： G01N30/72 , G01N33/48 , G01N33/68
摘要： This document relates to materials and methods for identifying and monitoring immunoglobulin cleavage (e.g., IgG cleavage) in a sample, such as a biological sample, using mass spectrometry techniques.
摘要翻译：本文涉及使用质谱技术鉴定和监测样品（例如生物样品）中的免疫球蛋白切割（例如IgG切割）的材料和方法。

7. 发明申请

WO2017053932A1 IDENTIFICATION OF IMMUNOGLOBULIN FREE LIGHT CHAINS BY MASS SPECTROMETRY 审中-公开
标题翻译：通过质谱鉴定免疫荧光素轻链
公开(公告)号：WO2017053932A1
公开(公告)日：2017-03-30
申请号：PCT/US2016/053675
申请日：2016-09-26
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： BARNIDGE, David R. , MURRAY, David L.
IPC分类号： C07K16/00 , G01N33/48 , G01N33/68
CPC分类号： C07K16/00 , G01N33/6848 , G01N33/6857 , G01N2800/22 , G01N2800/50
摘要： This document relates to methods for identifying one or more immunoglobulin free light chains in a sample using mass spectrometry. For example, this document relates to a method for identifying one or more immunoglobulin free light chains in a sample that includes (a) providing a sample; (b) subjecting the sample to a mass spectrometry technique to obtain a mass spectrum of the sample; and (c) identifying the presence of the one or more immunoglobulin free light chains.
摘要翻译：本文件涉及使用质谱鉴定样品中一种或多种免疫球蛋白免费轻链的方法。例如，本文件涉及用于鉴定样品中一种或多种免疫球蛋白免费轻链的方法，其包括（a）提供样品; （b）使样品进行质谱技术以获得样品的质谱; 和（c）鉴定一种或多种免疫球蛋白轻链的存在。

8. 发明申请

WO2017144900A1 MASS SPECTROMETRY KIT 审中-公开
标题翻译：质谱分析套件
公开(公告)号：WO2017144900A1
公开(公告)日：2017-08-31
申请号：PCT/GB2017/050489
申请日：2017-02-24
申请人： THE BINDING SITE GROUP LIMITED , MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： MURRAY, David L. , HARDING, Stephen , BARNIDGE, David R. , WALLIS, Gregg , MILLS, John , ASHBY, Jamie
IPC分类号： G01N33/68 , C07K16/00
CPC分类号： G01N33/6854 , C07K16/00 , G01N33/6893 , G01N2800/24
摘要： An anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof. A method purifying an anti-immunoglobulin specific antibody (or fragment thereof), characterised that the antibody or fragment thereof comprises one or more non-disulphide cross-links between at least one heavy chain or fragment thereof and at least one light chain or fragment thereof of the antibody or fragment thereof. A method of quantifying an amount of a subject analyte, or a fragment of an analyte in a sample from the subject comprising: (i) adding to the sample a predetermined amount of one or more control analytes or fragments thereof, which are distinguishable from the equivalent subject analyte or fragment; (ii) measuring the relative amount of the subject analyte or fragment and the amount of the control analyte or fragment in the sample; and (iii) comparing the relative amount of subject analyte or fragment to the relative amount of control analyte or fragment, to quantify the amount of analyte or fragment in the original subject sample.
摘要翻译：抗免疫球蛋白特异性抗体（或其片段），其特征在于所述抗体或其片段在至少一个重链或其片段与至少一个重链或其片段之间包含一个或多个非二硫键交联轻链或其抗体片段或其片段。纯化抗免疫球蛋白特异性抗体（或其片段）的方法，其特征在于所述抗体或其片段包含至少一个重链或其片段与至少一个轻链或其片段之间的一个或多个非二硫键交联的抗体或其片段。一种量化来自受试者的样品中的受试者分析物或分析物片段的量的方法，包括：（i）向样品中加入预定量的一种或多种控制分析物或其片段，其可与等效的主题分析物或片段; （ii）测量主题分析物或片段的相对量以及样品中对照分析物或片段的量; （iii）将主题分析物或片段的相对量与对照分析物或片段的相对量进行比较，以量化原始主题样品中的分析物或片段的量。

9. 发明申请

WO2016018978A1 QUANTIFYING MONOCLONAL ANTIBODY THERAPEUTICS BY LC-MS/MS 审中-公开
标题翻译：通过LC-MS / MS定量单克隆抗体治疗
公开(公告)号：WO2016018978A1
公开(公告)日：2016-02-04
申请号：PCT/US2015/042580
申请日：2015-07-29
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： BARNIDGE, David R. , WILLRICH, Maria Alice Vieira , MURRAY, David L. , SNYDER, Melissa
IPC分类号： G01N33/566 , G01N33/68 , G01N23/00
CPC分类号： G01N33/6848 , A61K39/3955 , G01N33/6854 , G01N2800/52
摘要： This document relates to methods for quantifying antibody therapeutics using mass spectrometry techniques by providing a sample comprising a monoclonal antibody therapeutic, adding an internal standard to the sample, wherein the internal standard is a nonisotopically labeled immunoglobulin from a non-human species, and subjecting the sample to a mass spectrometry technique to quantify the monoclonal antibody therapeutic in the sample.
摘要翻译：本文件涉及使用质谱技术定量抗体治疗的方法，提供包含单克隆抗体治疗剂的样品，向样品添加内标，其中内标是非人物种的非同位素标记的免疫球蛋白，样品进行质谱技术以量化样品中的单克隆抗体治疗剂。

10. 发明公开

EP3682249A1 IDENTIFICATION AND MONITORING OF ACID HYDROLYSIS PRODUCTS OF IMMUNOGLOBULIN HEAVY CHAINS 审中-实审
公开(公告)号：EP3682249A1
公开(公告)日：2020-07-22
申请号：EP18856232.6
申请日：2018-09-13
申请人： Mayo Foundation for Medical Education and Research
发明人： MURRAY, David L. , BARNIDGE, David R.
IPC分类号： G01N33/68

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