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1. 发明申请

WO2015154052A1 ISOTYPING IMMUNOGLOBULINS USING ACCURATE MOLECULAR MASS 审中-公开
标题翻译：使用精确分子量的同种异体免疫球蛋白
公开(公告)号：WO2015154052A1
公开(公告)日：2015-10-08
申请号：PCT/US2015/024379
申请日：2015-04-03
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH , MURRAY, David L. , BARNIDGE, David R. , DASARI, Surendra , MILLS, John R.
发明人： MURRAY, David L. , BARNIDGE, David R. , DASARI, Surendra , MILLS, John R.
IPC分类号： G01N30/72 , G01N33/48
CPC分类号： G01N33/6848 , G01N30/7266 , G01N33/6857 , G01N2800/52 , G01N2800/7095
摘要： This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.
摘要翻译：本文件涉及使用质谱技术检测和定量免疫球蛋白重链和轻链的方法。

2. 发明申请

WO2023086382A2 METHODS AND MATERIALS FOR ASSESSING AND TREATING ORAL LICHEN PLANUS 审中-公开
公开(公告)号：WO2023086382A2
公开(公告)日：2023-05-19
申请号：PCT/US2022/049402
申请日：2022-11-09
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： LEHMAN, Julia, S. , XIE, Fangyi , DASARI, Surendra
IPC分类号： C12Q1/6827 , A61K31/573 , A61P29/00 , C12Q1/6886
摘要： This document provides methods and materials for assessing and/or treating OLP. For example, methods and materials for using the presence of cells associated with OLP that have a mutated version of nucleic acid encoding a TP53 polypeptide, a mutated version of nucleic acid encoding a CELSR1 polypeptide, a mutated version of nucleic acid encoding a CASP8 polypeptide, a mutated version of nucleic acid encoding a KMT2D polypeptide, a mutated version of a nucleic acid encoding a TENM3 polypeptide, a mutated version of a nucleic acid encoding an ASH1L polypeptide, a mutated version of a nucleic acid encoding an OBSCN polypeptide, a mutated version of a nucleic acid encoding a TTRAP polypeptide, a mutated version of a nucleic acid encoding a LRP2 polypeptide, or combinations thereof to identify the OLP as being an OLP that is likely to proceed to OSCC are provided.

3. 发明申请

WO2023086627A1 ASSESSING AND TREATING MULTIPLE MYELOMA 审中-公开
公开(公告)号：WO2023086627A1
公开(公告)日：2023-05-19
申请号：PCT/US2022/049813
申请日：2022-11-14
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： DASARI, Surendra , SHAH, Mithun V. , CHEN, Dong
IPC分类号： C12Q1/6886 , A61P35/00 , G01N33/574
摘要： This document relates to methods and materials for assessing and/or treating mammals (e.g., humans) having multiple myeloma (MM). For example, methods and materials that can be used to determine whether or not a mammal (e.g., a human) having MM is likely to develop one or more therapy-related myeloid neoplasms (t-MNs) are provided. This document also relates to methods and materials for treating a mammal (e.g., a human) having MM where the treatment is selected based, at least in part, on whether or not the mammal is likely to develop one or more t-MNs.

4. 发明申请

WO2018094221A1 ASSESSING AND TREATING FIBRILLARY GLOMERULONEPHRITIS 审中-公开
公开(公告)号：WO2018094221A1
公开(公告)日：2018-05-24
申请号：PCT/US2017/062318
申请日：2017-11-17
申请人： MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
发明人： ALEXANDER, Mariam P. , KURTIN, Paul J. , DASARI, Surendra , NASR, Samih H.
IPC分类号： A61K38/17 , A61P13/12 , C12M1/00 , C12N9/99 , C12N15/09
CPC分类号： A61P13/12 , C07K14/47 , C12M1/00 , G01N33/6893 , G01N2800/347
摘要： This document relates to materials and methods for treating fibrillary glomerulonephritis (e.g., non-amyloid fibrillary glomerulonephritis) and/or a complication associated with fibrillary glomerulonephritis (e.g., high blood pressure, phosphorus imbalance, and/or anemia). For example, methods for using one or more inhibitors of DNAJB9 polypeptide expression or activity to treat a mammal having fibrillary glomerulonephritis are provided.

5. 发明公开

EP4433614A1 ASSESSING AND TREATING MULTIPLE MYELOMA 审中-实审
公开(公告)号：EP4433614A1
公开(公告)日：2024-09-25
申请号：EP22893709.0
申请日：2022-11-14
申请人： Mayo Foundation for Medical Education and Research
发明人： DASARI, Surendra , SHAH, Mithun V. , CHEN, Dong
IPC分类号： C12Q1/6886 , A61P35/00 , G01N33/574
CPC分类号： A61P35/00 , C12Q1/6886 , C12Q2600/10620130101 , C12Q2600/15420130101 , G01N33/57407 , G01N2800/5220130101

6. 发明公开

EP4430205A2 METHODS AND MATERIALS FOR ASSESSING AND TREATING ORAL LICHEN PLANUS 审中-实审
公开(公告)号：EP4430205A2
公开(公告)日：2024-09-18
申请号：EP22893557.3
申请日：2022-11-09
申请人： Mayo Foundation for Medical Education and Research
发明人： LEHMAN, Julia S. , XIE, Fangyi , DASARI, Surendra
IPC分类号： C12Q1/6827 , A61K31/573 , A61P29/00 , C12Q1/6886
CPC分类号： G01N30/72 , C12Q1/6886 , C12Q2600/15620130101 , G01N2030/883120130101

7. 发明公开

EP3126826A1 ISOTYPING IMMUNOGLOBULINS USING ACCURATE MOLECULAR MASS 有权
标题翻译：异国风ON ON EN EN EN EN SE SE SE SE SE SE SE SE SE SE SE SE SE SE SE SE SE
公开(公告)号：EP3126826A1
公开(公告)日：2017-02-08
申请号：EP15772546.6
申请日：2015-04-03
申请人： Mayo Foundation for Medical Education and Research
发明人： MURRAY, David L. , BARNIDGE, David R. , DASARI, Surendra , MILLS, John R.
IPC分类号： G01N30/72 , G01N33/48
CPC分类号： G01N33/6848 , G01N30/7266 , G01N33/6857 , G01N2800/52 , G01N2800/7095
摘要： This document relates to methods for detecting and quantifying heavy and light chains of immunoglobulin using mass spectrometry techniques.
摘要翻译：本文件涉及使用质谱技术检测和定量免疫球蛋白重链和轻链的方法。

8. 发明申请

WO2005088302A1 METHODS AND SYSTEMS FOR IDENTIFICATION OF MACROMOLECULES 审中-公开
标题翻译：用于鉴定大分子的方法和系统
公开(公告)号：WO2005088302A1
公开(公告)日：2005-09-22
申请号：PCT/US2005/005524
申请日：2005-02-22
申请人： PROTEOGENIX, INC. , NAGALLA, Srinivasa , SEARLE, Brian , DASARI, Surendra , TURNER, Mark, A.
发明人： NAGALLA, Srinivasa , SEARLE, Brian , DASARI, Surendra , TURNER, Mark, A.
IPC分类号： G01N33/48
CPC分类号： G06F19/22 , G06F19/28 , H01J49/0036
摘要： A method is provided for identifying sequences of molecules and sequence modifications form mass spectrometry data. At least one de novo sequence is produced from mass spectrometry data of sequences of molecules. A least one mass-based alignment is calculated between each de novo sequence and sequences in a sequence database. The molecular masses of molecules in the de novo sequence are compared to molecular masses of molecules in each sequence in the sequence database. Mass differences of modification sites are interpreted between the sequence in the sequence database and the novo sequence that have been identified by the mass-based alignment as modifications identified in a modification catalog. At least one match score for the mass-based alignment is calculated that provides an indication of matching between the sequence in the sequence database and the novo sequence. Sequences in the sequence database are identified from mass-based alignments in response to the match scores. Identifications of the sequence database are grouped from at least one de novo sequence into an identified macromolecule list that agrees with the novo sequencing results.
摘要翻译：提供了用于鉴定分子序列和形成质谱数据的序列修饰的方法。由分子序列的质谱数据产生至少一个从头序列。在序列数据库中的每个从头序列和序列之间计算至少一个基于质量的比对。将从头序列中的分子的分子质量与序列数据库中的每个序列中的分子的分子量进行比较。修饰位点的质量差异在序列数据库中的序列和通过基于质量的校准被鉴定为在修改目录中确定的修饰的新离子序列之间进行了解释。计算用于基于质量的比对的至少一个匹配得分，其提供序列数据库中的序列和新诗序列之间的匹配的指示。序列数据库中的序列根据匹配分数从基于质量的比对中确定。序列数据库的识别从至少一个从头序列分组到与新呼号测序结果一致的识别的大分子列表中。

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