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1. 发明申请

WO2004068137A3 METHODS AND DEVICE FOR IN VITRO DETECTION AND CHARACTERIZATION OF PSYCHOACTIVES USING ANALYSIS OF REPETITIVE ELECTRICAL ACTIVITY IN A NEURONAL SAMPLE 审中-公开
公开(公告)号：WO2004068137A3
公开(公告)日：2004-08-12
申请号：PCT/JP2004/000723
申请日：2004-01-27
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LYNCH, Gary , SHIMONO, Ken , TAKETANI, Makoto , SUGIHARA, Hirokazu , COLGIN, Laura, L. , JIA, Yousheng
发明人： LYNCH, Gary , SHIMONO, Ken , TAKETANI, Makoto , SUGIHARA, Hirokazu , COLGIN, Laura, L. , JIA, Yousheng
IPC分类号： G01N33/483
摘要： This invention relates to methods for the detection and characterization of psychoactives in neuronal tissue by comparing parameters measured for a set of baseline oscillations with those same parameters measured for a set of resulting oscillations. The baseline oscillations are induced or stimulated by such agents as chemical compounds that effect cholinergic interactions, co-deposited neuronal tissue, or electrical stimulations. The resulting set of oscillations is obtained after exposing the neuronal tissue to a sample composition that may or may not contain a psychoactive. By comparing the parameters for the baseline and resulting oscillations, the psychoactive in the sample composition may be detected and characterized as belonging to a specific psychoactive compound class and in some instances, may be distinguished from other members of the psychoactive compound class.

2. 发明申请

WO2005038042A2 SYSTEMS AND METHODS FOR ASSESSING NEURONAL DEGENERATION 审中-公开
标题翻译：用于评估神经衰弱的系统和方法
公开(公告)号：WO2005038042A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/034986
申请日：2004-10-15
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. , SHIMONO, Ken , PANCHENKO, Victor , TAKETANI, Makoto , KRAUSE, Michael
发明人： SHIMONO, Ken , PANCHENKO, Victor , TAKETANI, Makoto , KRAUSE, Michael
IPC分类号： C12Q
CPC分类号： A61K33/00 , A61K33/40 , G01N33/48707 , G01N33/5438 , G01N2500/00
摘要： The invention relates to systems and methods for assessing neuronal degeneration in vitro . A multielectrode probe is used to culture and measure synaptic transmission of a neuronal sample in the presence of various compounds and culturing conditions capable of inducing or protecting against neuronal damage.
摘要翻译：本发明涉及用于评估体外神经元变性的系统和方法。多电极探针用于在存在各种化合物和能够诱导或保护免受神经损伤的培养条件下培养和测量神经元样品的突触传递。

3. 发明授权

EP1192461B1 METHODS AND DEVICE FOR IN VITRO DETECTION AND CHARACTERIZATION OF PSYCHOACTIVES USING ANALYSIS OF REPETITIVE ELECTRICAL ACTIVITY IN A NEURONAL SAMPLE 有权
标题翻译：方法和装置体外检测和标签PSYCHO采用电重复性活动的解读IN A神经探针活性物质
公开(公告)号：EP1192461B1
公开(公告)日：2007-04-18
申请号：EP00944867.1
申请日：2000-06-21
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. , The Regents of the University of California
发明人： LYNCH, Gary , TAKETANI, Makoto , SHIMONO, Ken , SUGIHARA, Hirokazu
IPC分类号： G01N33/483 , G01N33/487 , C12M1/34
CPC分类号： G01N33/48714 , G01N33/48707 , G01N33/5088 , G01N33/94
摘要： This relates to methods for the detection of psychoactive compounds in an in vitro neuronal tissue sample by detecting oscillations of extracellular voltage desirably before and after the introduction of a candidate sample onto an in vitro neuronal tissue sample and for devices useful in practicing the methods. Analysis of the extracellular voltage parameters leads to indication of the presence of psychoactive material in the candidate sample and information as to its pharmacological activity and/or composition. Further, it relates to a process of initiating and maintaining the presence of repetitive neuronal activity within the in vitro sample. Additionally, this includes a method for the stimulation of or initiation of repetitive neuronal activity, e.g., EEG, in an in vitro nueronal tissue sample by introducing a stimulating composition comprising compounds that facilitate or mimic the actions of acetylcholine, serotonin, or catecholamines, such as carbachol, or by subjecting the in vitro neuronal sample to electrical stimulation parameters.

4. 发明授权

EP1590665B1 METHODS AND DEVICE FOR IN VITRO DETECTION AND CHARACTERIZATION OF PSYCHOACTIVES USING ANALYSIS OF REPETITIVE ELECTRICAL ACTIVITY IN A NEURONAL SAMPLE 有权
标题翻译：线法和体外检测与表征PSYCHO活性物质的设备通过分析重复电生理学活动IN A神经探针
公开(公告)号：EP1590665B1
公开(公告)日：2006-06-07
申请号：EP04705527.2
申请日：2004-01-27
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. , The Regents of the University of California
发明人： LYNCH, Gary , SHIMONO, Ken , TAKETANI, Makoto , SUGIHARA, Hirokazu , COLGIN, Laura, L. , JIA, Yousheng
IPC分类号： G01N33/483 , G01N33/487 , G01N33/50
CPC分类号： G01N33/94 , G01N33/48707 , G01N33/48714 , G01N33/5088
摘要： This invention relates to methods for the detection and characterization of psychoactives in neuronal tissue by comparing parameters measured for a set of baseline oscillations with those same parameters measured for a set of resulting oscillations. The baseline oscillations are induced or stimulated by such agents as chemical compounds that effect cholinergic interactions, co-deposited neuronal tissue, or electrical stimulations. The resulting set of oscillations is obtained after exposing the neuronal tissue to a sample composition that may or may not contain a psychoactive. By comparing the parameters for the baseline and resulting oscillations, the psychoactive in the sample composition may be detected and characterized as belonging to a specific psychoactive compound class and in some instances, may be distinguished from other members of the psychoactive compound class.

5. 发明公开

EP1590665A2 METHODS AND DEVICE FOR IN VITRO DETECTION AND CHARACTERIZATION OF PSYCHOACTIVES USING ANALYSIS OF REPETITIVE ELECTRICAL ACTIVITY IN A NEURONAL SAMPLE 有权
标题翻译：线法和体外检测与表征PSYCHO活性物质的设备通过分析重复电生理学活动IN A神经探针
公开(公告)号：EP1590665A2
公开(公告)日：2005-11-02
申请号：EP04705527.2
申请日：2004-01-27
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. , The Regents of the University of California
发明人： LYNCH, Gary , SHIMONO, Ken , TAKETANI, Makoto , SUGIHARA, Hirokazu , COLGIN, Laura, L. , JIA, Yousheng
IPC分类号： G01N33/483 , G01N33/487 , G01N33/50
CPC分类号： G01N33/94 , G01N33/48707 , G01N33/48714 , G01N33/5088
摘要： This invention relates to methods for the detection and characterization of psychoactives in neuronal tissue by comparing parameters measured for a set of baseline oscillations with those same parameters measured for a set of resulting oscillations. The baseline oscillations are induced or stimulated by such agents as chemical compounds that effect cholinergic interactions, co-deposited neuronal tissue, or electrical stimulations. The resulting set of oscillations is obtained after exposing the neuronal tissue to a sample composition that may or may not contain a psychoactive. By comparing the parameters for the baseline and resulting oscillations, the psychoactive in the sample composition may be detected and characterized as belonging to a specific psychoactive compound class and in some instances, may be distinguished from other members of the psychoactive compound class.

6. 发明申请

WO2005094476A2 HIGH THROUGHPUT ELECTROPHYSIOLOGY SYSTEM 审中-公开
标题翻译：高通电生理系统
公开(公告)号：WO2005094476A2
公开(公告)日：2005-10-13
申请号：PCT/US2005/009569
申请日：2005-03-21
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD. , SAAVEDRA BARRERA, Rafael, H. , TAKETANI, Makoto
发明人： SAAVEDRA BARRERA, Rafael, H. , TAKETANI, Makoto
IPC分类号： A61N1/18 , A61N1/28 , G01N33/487
CPC分类号： A61N1/18 , A61N1/36185 , G01N33/4836
摘要： A system and method for monitoring electrophysiological information from a tissue slice includes at least one probe having a plurality of electrodes. The system also comprises a controller configured to select tissue sites to be monitored and to be electrically stimulated. In one variation of the invention, a plurality of multi-electrode proves are managed by the controller. The system may further include a plurality of amplifier modules, one amplifier module associated with each probe. The amplifier module may serve a number of functions including amplifying electrical signals sensed by the electrodes, distributing stimulation signals to selected electrodes, and filtering signals evoked from the tissue sites. The system can provide automatic selection and switching of electrodes for monitoring and stimulating multiple tissue sites. Multiple probes, each adapted to monitor multiple tissue sites, may be associated with the controller such that multiple tissue slices may be interrogated in parallel.
摘要翻译：用于从组织切片监测电生理信息的系统和方法包括具有多个电极的至少一个探针。该系统还包括被配置为选择待监测并被电刺激的组织部位的控制器。在本发明的一个实施例中，多个多电极证明由控制器管理。该系统还可以包括多个放大器模块，与每个探针相关联的一个放大器模块。放大器模块可以服务于多种功能，包括放大由电极感测的电信号，将刺激信号分配到所选择的电极，以及过滤从组织部位诱发的信号。该系统可以自动选择和切换用于监测和刺激多个组织部位的电极。适于监测多个组织部位的多个探针可以与控制器相关联，使得可以并行询问多个组织切片。

7. 发明授权

EP1040345B1 CELL POTENTIAL MEASURING ELECTRODE AND MEASURING APPARATUS USING THE SAME 有权
标题翻译：铅和用于测量细胞电位
公开(公告)号：EP1040345B1
公开(公告)日：2006-03-22
申请号：EP98966077.4
申请日：1998-12-22
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： SUGIHARA, Hirokazu , OKA, Hiroaki, Hirakata Garden Hills 913 , SHIMONO, Ken , OGAWA, Ryuta , TAKETANI, Makoto
IPC分类号： G01N27/403 , G01N33/487 , C12M1/34
CPC分类号： G01N33/4836
摘要： This invention relates to a low impedance cell potential measuring electrode assembly typically having a number of microelectrodes on an insulating substrate and having a wall enclosing the region including the microelectrodes. The device is capable of measuring electrophysiological activities of a monitored sample using the microelectrodes while cultivating those cells or tissues in the region of the microelectrodes. The invention utilizes independent reference electrodes to lower the impedance of the overall system and to therefore lower the noise often inherent in the measured data. Optimally the microelectrodes are enclosed by a physical wall used for controlling the atmosphere around the monitored sample.

8. 发明公开

EP1740261A2 HIGH THROUGHPUT ELECTROPHYSIOLOGY SYSTEM 审中-公开
标题翻译：具有高吞吐量电生理系统
公开(公告)号：EP1740261A2
公开(公告)日：2007-01-10
申请号：EP05732635.7
申请日：2005-03-21
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： SAAVEDRA BARRERA, Rafael, H. , TAKETANI, Makoto
IPC分类号： A61N1/18
CPC分类号： A61N1/18 , A61N1/36185 , G01N33/4836
摘要： A system and method for monitoring electrophysiological information from a tissue slice includes at least one probe having a plurality of electrodes. The system also comprises a controller configured to select tissue sites to be monitored and to be electrically stimulated. In one variation of the invention, a plurality of multi-electrode proves are managed by the controller. The system may further include a plurality of amplifier modules, one amplifier module associated with each probe. The amplifier module may serve a number of functions including amplifying electrical signals sensed by the electrodes, distributing stimulation signals to selected electrodes, and filtering signals evoked from the tissue sites. The system can provide automatic selection and switching of electrodes for monitoring and stimulating multiple tissue sites. Multiple probes, each adapted to monitor multiple tissue sites, may be associated with the controller such that multiple tissue slices may be interrogated in parallel.

9. 发明公开

EP1040345A1 CELL POTENTIAL MEASURING ELECTRODE AND MEASURING APPARATUS USING THE SAME 有权
标题翻译：铅和用于测量细胞电位
公开(公告)号：EP1040345A1
公开(公告)日：2000-10-04
申请号：EP98966077.4
申请日：1998-12-22
申请人： Matsushita Electric Industrial Co., Ltd.
发明人： SUGIHARA, Hirokazu , OKA, Hiroaki,Hirakata Garden Hills 913 , SHIMONO, Ken , OGAWA, Ryuta , TAKETANI, Makoto
IPC分类号： G01N27/403 , G01N33/487 , C12M1/34
CPC分类号： G01N33/4836
摘要： This invention relates to a low impedance cell potential measuring electrode assembly typically having a number of microelectrodes on an insulating substrate and having a wall enclosing the region including the microelectrodes. The device is capable of measuring electrophysiological activities of a monitored sample using the microelectrodes while cultivating those cells or tissues in the region of the microelectrodes. The invention utilizes independent reference electrodes to lower the impedance of the overall system and to therefore lower the noise often inherent in the measured data. Optimally the microelectrodes are enclosed by a physical wall used for controlling the atmosphere around the monitored sample.

10. 发明公开

EP1673467A2 SYSTEMS AND METHODS FOR ASSESSING NEURONAL DEGENERATION 审中-公开
标题翻译：系统和评估方法神经元变性
公开(公告)号：EP1673467A2
公开(公告)日：2006-06-28
申请号：EP04796049.7
申请日：2004-10-15
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： SHIMONO, Ken , PANCHENKO, Victor , TAKETANI, Makoto , KRAUSE, Michael
IPC分类号： C12Q1/00
CPC分类号： A61K33/00 , A61K33/40 , G01N33/48707 , G01N33/5438 , G01N2500/00
摘要： The invention relates to systems and methods for assessing neuronal degeneration in vitro. A multielectrode probe is used to culture and measure synaptic transmission of a neuronal sample in the presence of various compounds and culturing conditions capable of inducing or protecting against neuronal damage.

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