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1. 发明授权

EP1300678B1 EXTRACELLULAR RECORDING INTEGRATED COMPOSITE ELECTRODE 有权
标题翻译： FOR外记录INTEGRATED复合电极
公开(公告)号：EP1300678B1
公开(公告)日：2006-11-22
申请号：EP01949965.6
申请日：2001-07-12
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： YUKIMASA, Tetsuo , OKA, Hiroaki , OGAWA, Ryuta , SUGIHARA, Hirokazu
IPC分类号： G01N27/30 , G01N27/416 , C12M1/00 , G01N33/483 , G01N33/487
CPC分类号： G01N33/48728
摘要： An integrated composite electrode for measuring an electrophysiologic characteristic of a biological sample comprising microelectrodes arranged in a first area on a substrate and reference electrodes arranged in a second area on the substrate and including one or more stimulating reference electrodes for imparting electric signals to the microelectrodes. Preferably, the reference electrodes include one or more measuring reference electrodes for measuring electric signals from the microelectrodes, and the stimulating reference electrodes are insulated from the measuring reference electrodes in an electric circuit way. Preferably, the second area is provided at a distance from the periphery of the first area and encompasses it.

2. 发明公开

EP1398625A1 EXTRACELLULAR RECORDING ELECTRODE 审中-公开
标题翻译：细胞外记录电极
公开(公告)号：EP1398625A1
公开(公告)日：2004-03-17
申请号：EP01941137.0
申请日：2001-06-20
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： OKA, Hiroaki , YUKIMASA, Tetsuo , OGAWA, Ryuta , SUGIHARA, Hirokazu , TSUJI, Katsuyuki , YOSHIMOTO, Yukifumi
IPC分类号： G01N27/30 , G01N27/416
CPC分类号： A61N1/0492 , A61N1/0476 , A61N1/0551 , G01N33/4836
摘要： A multiple electrode includes a plurality of micro-electrodes provided on a substrate, and a wiring portion for providing an electrical signal to the micro-electrodes or extracting an electrical signal from the micro-electrodes. Each micro-electrode has porous conductive material on its surface, and the impedance of the micro-electrode is 50 kΩ or less. Preferably, the porous conductive material is gold, and formed by the passage of current at a current density of 1.0 to 5.0 A/dm 2 for 10 to 360 sec. The multiple electrode may include micro-electrodes provided on a substrate in the form of a matrix, a lead line connected to the micro-electrodes, and an electrical junction connected to an end of the lead line.

3. 发明公开

EP1382937A1 SIGNIFICANT SIGNAL EXTRACTING METHOD, RECORDING MEDIUM, AND PROGRAM 审中-公开
标题翻译： AUFZEICHNUNGSMEDIUM UND PROGRAMM的SIGNIFIKANTES SIGNALEXTRAKTIONSVERFAHREN
公开(公告)号：EP1382937A1
公开(公告)日：2004-01-21
申请号：EP02722886.5
申请日：2002-04-26
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： OGAWA, Ryuta , OKA, Hiroaki; , OZAKI, Nobuhiko , SUGIHARA, Hirokazu
IPC分类号： G01D1/16 , C12Q1/68 , G01N33/48 , G01N27/30 , G01N27/416 , G01N27/64
CPC分类号： G01D1/14
摘要： A method for extracting a signal of interest from a signal generated from at least one subject, comprises the steps of (A) obtaining a time-series signal generated from the subject as a data group consisting of a plurality of pieces of data, (B) obtaining a plurality of extracted data groups from the data group, wherein each extracted data group comprises a predetermined number of pieces of data selected from the data group, (C) calculating standard deviations of the plurality of extracted data groups to obtain a standard deviation group, and (D) referencing each standard deviation included in the standard deviation group and selecting the signal of interest.
摘要翻译：一种用于从至少一个对象产生的信号中提取感兴趣的信号的方法，包括以下步骤：（A）获得由对象产生的时间序列信号作为由多个数据组成的数据组（B ）从所述数据组中获取多个提取的数据组，其中每个提取的数据组包括从所述数据组中选择的预定数量的数据，（C）计算所述多个提取的数据组的标准偏差以获得标准偏差组，（D）参考标准偏差组中包含的每个标准偏差并选择感兴趣的信号。

4. 发明公开

EP1040345A1 CELL POTENTIAL MEASURING ELECTRODE AND MEASURING APPARATUS USING THE SAME 有权
标题翻译：铅和用于测量细胞电位
公开(公告)号：EP1040345A1
公开(公告)日：2000-10-04
申请号：EP98966077.4
申请日：1998-12-22
申请人： Matsushita Electric Industrial Co., Ltd.
发明人： SUGIHARA, Hirokazu , OKA, Hiroaki,Hirakata Garden Hills 913 , SHIMONO, Ken , OGAWA, Ryuta , TAKETANI, Makoto
IPC分类号： G01N27/403 , G01N33/487 , C12M1/34
CPC分类号： G01N33/4836
摘要： This invention relates to a low impedance cell potential measuring electrode assembly typically having a number of microelectrodes on an insulating substrate and having a wall enclosing the region including the microelectrodes. The device is capable of measuring electrophysiological activities of a monitored sample using the microelectrodes while cultivating those cells or tissues in the region of the microelectrodes. The invention utilizes independent reference electrodes to lower the impedance of the overall system and to therefore lower the noise often inherent in the measured data. Optimally the microelectrodes are enclosed by a physical wall used for controlling the atmosphere around the monitored sample.

5. 发明授权

EP1234540B1 APPARATUS FOR SCREENING, 有权
标题翻译：设备技术分析
公开(公告)号：EP1234540B1
公开(公告)日：2007-03-21
申请号：EP01941230.3
申请日：2001-06-25
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： OKA, Hiroaki , OGAWA, Ryuta , YUKIMASA, Tetsuo
IPC分类号： A61B5/0484 , A61B5/0478 , A61N1/05 , A01K67/00 , G01N33/50 , G01N33/15
CPC分类号： G01N33/5088 , A01K1/031 , A01K29/005 , A61B5/0478 , A61B5/04847 , A61B5/4011 , A61B2562/0209 , A61B2562/046 , G01N2333/46
摘要： A method and apparatus for screening olfactory mucosa stimulating compounds, wherein an olfactory mucosa stimulating compound is sprayed toward the olfactory mucosa of a rat fixed in an experimental animal fixing device (32) through a spraying nozzle (33), an electric signal generated at an olfactory bulb of the rat is measured by means of an electrode section for measurement(10) imbedded in the olfactory bulb, and the utility of an olfactory mucosa stimulating compound is evaluated on the basis of the correlation between the electric signal measured by the electrode section (10) and physiologic reactions induced in a rat when the olfactory mucosa stimulating compound is sprayed toward the olfactory mucosa of the rat.

6. 发明授权

EP1040345B1 CELL POTENTIAL MEASURING ELECTRODE AND MEASURING APPARATUS USING THE SAME 有权
标题翻译：铅和用于测量细胞电位
公开(公告)号：EP1040345B1
公开(公告)日：2006-03-22
申请号：EP98966077.4
申请日：1998-12-22
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： SUGIHARA, Hirokazu , OKA, Hiroaki, Hirakata Garden Hills 913 , SHIMONO, Ken , OGAWA, Ryuta , TAKETANI, Makoto
IPC分类号： G01N27/403 , G01N33/487 , C12M1/34
CPC分类号： G01N33/4836
摘要： This invention relates to a low impedance cell potential measuring electrode assembly typically having a number of microelectrodes on an insulating substrate and having a wall enclosing the region including the microelectrodes. The device is capable of measuring electrophysiological activities of a monitored sample using the microelectrodes while cultivating those cells or tissues in the region of the microelectrodes. The invention utilizes independent reference electrodes to lower the impedance of the overall system and to therefore lower the noise often inherent in the measured data. Optimally the microelectrodes are enclosed by a physical wall used for controlling the atmosphere around the monitored sample.

7. 发明公开

EP1352952A1 DEVICE FOR MEASURING EXTRACELLULAR POTENTIAL, METHOD OF MEASURING EXTRACELLULAR POTENTIAL BY USING THE SAME AND APPARATUS FOR QUICKLY SCREENING DRUG PROVIDED THEREWITH 审中-公开
标题翻译：设备和方法测量外电位和设备ARRZNEIMITTELN快速筛选
公开(公告)号：EP1352952A1
公开(公告)日：2003-10-15
申请号：EP02729529.4
申请日：2002-01-09
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： OKA, Hiroaki , OGAWA, Ryuta , YUKIMASA, Tetsuo , SUGIHARA, Hirokazu , KONISHI, Satoshi , JIKOH, Hideyasu , OZAKI, Nobuhiko , EMOTO, Fumiaki
IPC分类号： C12M1/34 , C12Q1/02 , G01N33/15 , G01N33/48 , G01N33/50 , G01N27/28 , G01N27/416
CPC分类号： G01N33/48728 , G01N33/49
摘要： An extracellular potential measuring device capable of simply and highly reliably detecting a change in a minute electrical signal emitted by a biological sample, and an extracellular potential measuring method using the device, and an apparatus comprising the device, are provided. The extracellular potential measuring device measures an extracellular potential with great precision and a high output. The device comprises at least one well comprising means for holding a cell provided on a substrate, a measuring electrode for detecting an electrical signal of each of the at least one well, and a reference electrode. The cell holding means comprises at least one depression provided within the well, and has a throughhole at a bottom surface thereof, the throughhole being linked to means for suctioning the cell.
摘要翻译：能够简单且高精度可靠地检测在由生物样品发射的微小电信号的变化，并且在使用该装置的细胞外电位测量方法以及装置，包括该装置的一个细胞外电位测量装置中，设置。在以很高的精度和高的输出外电位的胞外电位测量装置测量。该装置包括至少一个阱包括：用于保持设置在基板的单元，对于每个所述至少一个孔的的电信号的检测的测量电极和参考电极。保持装置包括至少一个凹陷在细胞内所提供的很好，并且在其底表面上，所述通孔被连接到用于抽吸单元的通孔。

8. 发明公开

EP1300678A1 EXTRACELLULAR RECORDING INTEGRATED COMPOSITE ELECTRODE 有权
标题翻译： FOR外记录INTEGRATED复合电极
公开(公告)号：EP1300678A1
公开(公告)日：2003-04-09
申请号：EP01949965.6
申请日：2001-07-12
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： YUKIMASA, Tetsuo , OKA, Hiroaki , OGAWA, Ryuta , SUGIHARA, Hirokazu
IPC分类号： G01N27/30 , G01N27/416 , C12M1/00 , G01N33/483
CPC分类号： G01N33/48728
摘要： A multiple electrode for measuring electro-physiological characteristics of a biological specimen includes a plurality of micro-electrode provided on a first region on a substrate, and a reference electrode provided in a second region on the substrate. The reference electrode includes at least one stimulus reference electrode for applying an electrical signal to the plurality of micro-electrodes. Preferably, the reference electrode includes at least one measurement reference electrode for detecting an electrical signal from the plurality of micro-electrodes, and the stimulus reference electrode is electrically insulated from the measurement reference electrode. Preferably, the second region is placed at a distance from an outer edge of the first region, and surrounds the first region.

9. 发明公开

EP1234540A1 APPARATUS AND METHOD FOR SCREENING, OLFACTORY MUCOSA STIMULATING COMPOUND FOUND BY THE SCREENING METHOD, AND THERAPEUTIC APPARATUS AND ELECTRODE SECTION FOR MEASUREMENT 有权
标题翻译： GERÄTZUR分析
公开(公告)号：EP1234540A1
公开(公告)日：2002-08-28
申请号：EP01941230.3
申请日：2001-06-25
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD.
发明人： OKA, Hiroaki , OGAWA, Ryuta , YUKIMASA, Tetsuo
IPC分类号： A61B5/0484 , A61B5/0478 , A61N1/05 , A01K67/00 , G01N33/50 , G01N33/15
CPC分类号： G01N33/5088 , A01K1/031 , A01K29/005 , A61B5/0478 , A61B5/04847 , A61B5/4011 , A61B2562/0209 , A61B2562/046 , G01N2333/46
摘要： A method and apparatus for readily and reliably screening olfactory mucosa stimulating compounds are provided. An olfactory mucosa stimulating compound is sprayed through an atomizing nozzle 33 to an olfactory mucosa of a rat fixed in a test animal fixing device 32. A measuring electrode portion 10 is implanted in an olfactory bulb of the rat for measuring an electrical signal generated in the olfactory bulb. Efficacy of the olfactory mucosa stimulating compound is determined based on a correlation between an electrical signal measured by the measuring electrode portion 10 when the olfactory mucosa stimulating compound is sprayed on the olfactory mucosa of the rat and a physiological response induced in the rat.
摘要翻译：提供了一种容易可靠地筛选嗅觉粘膜刺激化合物的方法和装置。将嗅粘膜刺激化合物通过雾化喷嘴33喷射到固定在测试动物固定装置32中的大鼠的嗅觉粘膜上。测量电极部分10被植入大鼠的嗅球中，用于测量在嗅球基于当将嗅觉粘膜刺激性化合物喷洒在大鼠的嗅粘膜上时由测量电极部分10测量的电信号与在大鼠中诱导的生理反应之间的相关性来确定嗅觉粘膜刺激化合物的功效。

10. 发明公开

EP0823483A1 METHOD FOR MEASURING PHYSICOCHEMICAL PROPERTIES OF TISSUES OR CELLS, METHOD FOR EXAMINING CHEMICALS, AND APPARATUS THEREFOR 失效
标题翻译：法测量的物理化学性质的组织或细胞，化学品及其装置性能试验方法
公开(公告)号：EP0823483A1
公开(公告)日：1998-02-11
申请号：EP97900768.9
申请日：1997-01-24
申请人： MATSUSHITA ELECTRIC INDUSTRIAL CO., LTD
发明人： SUGIHARA, Hirokazu , KOBAYASHI, Yasushi , OKA, Hiroaki , OGAWA, Ryuta , TAKETANI, Makoto
IPC分类号： C12Q1/02
CPC分类号： G01N33/5005 , C12M21/08 , C12M23/12 , C12M29/00 , C12M41/46 , C12Q1/02
摘要： A method of measuring the physical and chemical properties of tissue or cells and a device for the same is provided, with which the physical and chemical environment of the tissue or cells can be changed arbitrarily corresponding to experimental necessities. The device comprises a system (40) for keeping the physical and chemical environment surrounding the biological tissue or cells constant, a system (50) for arbitrarily changing the physical and chemical environment, observation systems (10) and (20) for observing the physical and chemical properties of the tissue or cells, and a system (30) for comparing the change of the physical and chemical properties of the tissue or cells before and after changing the physical and chemical environment. The observation system (10) is a potential measurement device for measuring the electrophysiological properties of the tissue or cells. This device comprises an integrated cell placement device (1) provided with a plurality of microelectrodes (11) on a substrate, a cell placement portion (6) for placing the tissue or cells on the microelectrodes (11), and a wiring pattern (12) for applying an electrical signal to the microelectrodes (11) and extracting an electrical signal from the microelectrodes (11).
摘要翻译：提供了一种测量组织或细胞，并对于相同的一个设备的物理和化学特性的方法，利用该组织或细胞的物理化学环境可以改变任意地对应于实验必需品。该装置包括用于保持周边为任意改变物理化学环境，观测系统（10）和（20）的生物组织或细胞恒定，系统（50）的物理化学环境，用于观察的物理一个系统（40）和上述组织或细胞，以及用于比较上述组织或细胞之前的物理和化学性质的变化，改变物理化学环境后的系统（30）的化学性质。观察系统（10）是用于测量所述组织或细胞的电生理学特性的电位测定装置。此装置上的包括设置有微电极（11）的多元一体化细胞设置器（1）底物，细胞放置部（6），用于放置上述组织或细胞上的微电极（11），和布线图案（12 ）用于施加到电信号到微电极（11）和从所述微电极（11）的电信号的提取。

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