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1. 发明申请

WO1994028139A1 tRNA BINDING-DEPENDENT INHIBITION OF MICROBIAL PATHOGEN GROWTH 审中-公开
标题翻译： tRNA结合依赖性抑制微生物病原生长
公开(公告)号：WO1994028139A1
公开(公告)日：1994-12-08
申请号：PCT/US1994005905
申请日：1994-05-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SCHIMMEL, Paul, R. , SCHMIDT, Eric, T.
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： C12N15/52
CPC分类号： C12N9/93 , A61K38/00 , Y02A50/473
摘要： The present invention relates to a method of specifically inhibiting growth of microbes, such as bacteria, fungi, or viruses, and to compositions useful in the present method. According to the method, specific tRNA-dependent inhibition of the growth of microbial pathogens can be achieved through use of tRNA binding molecules. For example, a tRNA binding molecule, such as a mutant aminoacyl-tRNA synthetase, which is capable of binding tRNA, but incapable of aminoacylation, can be selectively toxic to a selected microbial pathogen, leading to inhibition of (i.e., a reduction in or arrest of) growth of the pathogen, while sparing the host cell.
摘要翻译：本发明涉及特异性抑制微生物如细菌，真菌或病毒生长的方法，以及可用于本发明方法的组合物。根据该方法，可以通过使用tRNA结合分子来实现对微生物病原体生长的特异性tRNA依赖性抑制。例如，能够结合tRNA但不能进行氨基酰化的tRNA结合分子，例如突变型氨基酰基-tRNA合成酶，可以对选定的微生物病原体有选择性的毒性，导致抑制（即，抑制）病原体的生长，同时保护宿主细胞。

2. 发明公开

EP1576655A2 STABILIZED SEMICONDUCTOR NANOCRYSTALS 有权转让
标题翻译：稳定型半导体纳米晶体
公开(公告)号：EP1576655A2
公开(公告)日：2005-09-21
申请号：EP03810755.3
申请日：2003-08-15
申请人： Bawendi, Moungi G. , Kim, Sungjee , Stott, Nathan A. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： Bawendi, Moungi G. , Kim, Sungjee , Stott, Nathan A. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： H01L21/00
CPC分类号： C01B19/007 , B82Y30/00 , C01G9/08 , C01G11/02 , C01G13/00 , C01G21/21 , C01G28/00 , C01P2004/40 , C01P2004/64 , C01P2004/80 , C07F9/5004 , C09K11/02 , C09K11/565 , C09K11/883 , C30B7/00 , C30B29/60 , Y10T428/12597 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T428/2998
摘要： A semiconductor nanocrystal associated with a polydentate ligand. The polydentate ligand stabilizes the nanocyrstal.

3. 发明公开

EP2082075A4 AUTOMATED LAYER BY LAYER SPRAY TECHNOLOGY 有权
标题翻译：自动化层通过喷涂技术
公开(公告)号：EP2082075A4
公开(公告)日：2012-10-31
申请号：EP07837746
申请日：2007-09-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： C23C14/22
CPC分类号： B05D1/02 , B01D67/0088 , B01D2323/02 , B01D2323/26 , B05D7/50 , D06M15/233 , D06M15/263 , D06M15/3562 , D06M15/3566 , D06M15/61 , D06M23/005 , D06M23/06

4. 发明公开

EP1742873A2 MESOSTRUCTURED ZEOLITIC MATERIALS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：介孔结构的沸石材料及其制造方法和使用
公开(公告)号：EP1742873A2
公开(公告)日：2007-01-17
申请号：EP05812517.0
申请日：2005-04-25
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , Garcia-Martinez, Javier
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , Garcia-Martinez, Javier
IPC分类号： C01B39/00
CPC分类号： B01J29/40 , B01J20/18 , B01J20/186 , B01J29/005 , B01J29/0308 , B01J29/041 , B01J29/084 , B01J29/106 , B01J29/18 , B01J29/80 , B01J2229/62 , B82Y30/00 , C01B39/02 , C01B39/023 , C01B39/026 , C01B39/04 , C10G1/086 , C10G11/02 , C10G11/05 , C10G11/18 , C10G45/04 , C10G47/02 , C10G2300/1033 , C10G2300/1074 , C10G2300/1096 , C10G2400/02 , C10G2400/20 , Y10T428/26
摘要： One aspect of the present invention relates to mesostructured zeolites. The invention also relates to a method of preparing mesostructured zeolites, as well as using them as cracking catalysts for organic compounds and degradation catalysts for polymers.

5. 发明申请

WO1998018494A1 METHODS FOR THE SYNTHESIS OF FUNCTIONALIZABLE POLY(ETHYLENE OXIDE) STAR MACROMOLECULES 审中-公开
标题翻译：功能性聚（乙氧基）星形分子的合成方法
公开(公告)号：WO1998018494A1
公开(公告)日：1998-05-07
申请号：PCT/US1997019257
申请日：1997-10-27
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , MERRILL, Edward, W. , YEN, Diane, Rintzler , SAGAR, Ambuj
IPC分类号： A61K47/48
CPC分类号： B82Y5/00 , A61K47/6949 , C08G65/329 , C08G81/025 , C08G83/003
摘要： Methods are provided for the synthesis of poly(ethylene oxide) ("PEO") star macromolecules including functionalizable groups. In one embodiment, a core molecule including a plurality of dendritic branches or having a comb structure, and including a plurality of accessible reactive groups is reacted with functionalizable poly(ethylene oxide) ("PEO") molecules. The functionalizable poly(ethylene oxide) molecules include a reactive group capable of reacting with the reactive group on the core molecule, and a functionalizable group capable of being chemically modified, which optionally is protected. In the reaction, the PEO molecules are covalently attached to the core molecule, to form a PEO star macromolecule with terminal functionalizable groups. Preferably, the functionalizable PEO is a heterofunctional linear PEO which includes the reactive group at one terminus and the functionalizable group at the other terminus. The functionalizable groups on the PEO molecules then may be deprotected if necessary, and the further derivatized, for example, by the attachment of a biologically active molecule or polymer thereof.
摘要翻译：提供了用于合成包含可官能化基团的聚（环氧乙烷）（“PEO”）星型大分子的方法。在一个实施方案中，包含多个树枝状枝或具有梳结构并且包括多个可接触的反应性基团的核心分子与可官能化的聚（环氧乙烷）（“PEO”）分子反应。可官能化的聚（环氧乙烷）分子包括能够与芯分子上的反应性基团反应的反应性基团和能够被化学改性的可官能化基团，其任选被保护。在反应中，PEO分子共价连接到核心分子上，形成具有末端官能团的PEO星型大分子。优选地，可官能化PEO是异功能线性PEO，其包括一个末端的反应性基团和另一个末端的可官能化基团。如果需要，PEO分子上的可官能化基团可以被去保护，并且例如通过附着生物活性分子或其聚合物进一步衍生化。

6. 发明申请

WO1998015515A1 SYNTHESIS OF ARYL ETHERS, METHODS AND REAGENTS RELATED THERETO 审中-公开
标题翻译： ARYL ETHERS，与其相关的方法和试剂的合成
公开(公告)号：WO1998015515A1
公开(公告)日：1998-04-16
申请号：PCT/US1997018719
申请日：1997-10-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , BUCHWALD, Stephen, L. , WOLFE, John, P. , PALUCKI, Michael
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
IPC分类号： C07C43/20
CPC分类号： C07D307/79 , C07C41/16 , C07C253/30 , C07C2601/08 , C07C2601/16 , C07C2603/24 , C07D309/12 , C07D311/58 , C07D311/82 , C07D311/94 , C07D313/08 , C07C255/54 , C07C43/225 , C07C43/205 , C07C43/235
摘要： A method for preparing an aryl ether compound is provided in which an alcohol is reacted with an aromatic compound in the presence of a base, and a transition metal catalyst to form an aryl ether.
摘要翻译：提供了一种芳基醚化合物的制备方法，其中醇与芳族化合物在碱的存在下和过渡金属催化剂反应形成芳基醚。

7. 发明申请

WO1998009334A1 CHARGE MODULATION DEVICE 审中-公开
标题翻译：充电调制装置
公开(公告)号：WO1998009334A1
公开(公告)日：1998-03-05
申请号：PCT/US1997014638
申请日：1997-08-20
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , REICH, Robert, K. , SAVOYE, Eugene, D. , KOSICKI, Bernard, B.
IPC分类号： H01L27/148
CPC分类号： H01L29/76833 , H01L27/1464 , H01L31/1126
摘要： A charge modulation device having a semiconductor region of a first conductivity type. An epitaxial layer of second conductivity type is provided on a portion of the semiconductor region so as to define an FET channel region. A first epitaxial region of the second conductivity type is provided adjacent to and in contact with the epitaxial layer so as to define an FET drain region, the first epitaxial region being electrically isolated from the semiconductor region. A second epitaxial region of the second conductivity type is provided adjacent to and in contact with the epitaxial layer so as to define an FET source region, the second epitaxial region being electrically isolated from the semiconductor region. A third epitaxial region of the first conductivity type or a metal oxide semiconductor is provided to the channel region between the source and drain regions.
摘要翻译：一种具有第一导电类型的半导体区域的电荷调制装置。在半导体区域的一部分上设置第二导电类型的外延层，以限定FET沟道区。第二导电类型的第一外延区域设置成与外延层相邻并与外延层接触，以便限定FET漏区，该第一外延区域与半导体区域电绝缘。第二导电类型的第二外延区域被设置为与外延层相邻并与外延层接触，以限定FET源极区域，第二外延区域与半导体区域电隔离。第一导电类型的第三外延区域或金属氧化物半导体被提供给源区和漏区之间的沟道区。

8. 发明申请

WO1998000698A1 METHOD AND APPARATUS FOR THE EVALUATION OF A DEPTH PROFILE OF THERMO-MECHANICAL PROPERTIES OF LAYERED AND GRADED MATERIALS AND COATINGS 审中-公开
标题翻译：评估层状和分级材料和涂层的热机械性能深度剖面的方法和装置
公开(公告)号：WO1998000698A1
公开(公告)日：1998-01-08
申请号：PCT/US1997011689
申请日：1997-06-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , FINOT, Marc , KESLER, Olivera , SURESH, Subra
IPC分类号： G01N03/20
CPC分类号： G01N3/20 , B33Y80/00
摘要： A technique for determining properties such as Young's modulus, coefficient of thermal expansion, and residual stress of individual layers within a multi-layered sample is presented. The technique involves preparation of a series of samples, each including one additional layer relative to the preceding sample. By comparison of each sample to a preceding sample, properties of the topmost layer can be determined, and residual stress at any depth in each sample, resulting from deposition of the top layer, can be determined.
摘要翻译：提出了一种用于确定多层样品中各层的性能如杨氏模量，热膨胀系数和残余应力的技术。该技术包括制备一系列样品，每个样品相对于前述样品包括一个附加层。通过比较每个样品与前一个样品，可以确定最上层的性质，并且可以确定由顶层沉积产生的每个样品中任何深度的残余应力。

9. 发明申请

WO1997046998A1 FEATURE-BASED SPEECH RECOGNIZER HAVING PROBABILISTIC LINGUISTIC PROCESSOR PROVIDING WORD MATCHING BASED ON THE ENTIRE SPACE OF FEATURE VECTORS 审中-公开
标题翻译：基于特征的语音识别器，具有基于特征向量的整体空间的概念语音处理器提供字符匹配
公开(公告)号：WO1997046998A1
公开(公告)日：1997-12-11
申请号：PCT/US1997009267
申请日：1997-06-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , GLASS, James, Robert
IPC分类号： G10L03/00
CPC分类号： G10L15/04 , G10L15/10 , G10L2015/022
摘要： A feature-based speech recognizer having a probabilistic linguistic processor provides word matching based on the entire space of feature vectors. In this manner, the errors and inaccuracies associated with the heretofore known feature-based speech recognizers, which provided word matching on less than the entire space of feature vectors, are overcome, thereby resulting in improved-accuracy speech recognition. The word matching may be on feature vectors computed either from segments or from landmarks or from both segments and landmarks. For word matching on segment-based feature vectors, acoustic likelihoods may be normalized by extra-acoustic likelihoods defined by at least one extra-acoustic ("not" or "anti") model. Context-dependent and context-independent acoustic models may be employed.
摘要翻译：具有概率语言处理器的基于特征的语音识别器基于特征向量的整个空间提供词匹配。以这种方式，克服了与以前已知的基于特征的语音识别器相关联的误差和不准确性，其提供小于特征向量的整个空间的字匹配，由此导致改进的精度语音识别。词匹配可以是从段或从地标或从段和地标计算的特征向量。对于基于段的特征向量的字匹配，声学似然性可以通过由至少一个超声（“非”或“反”）模型限定的超声可能性进行归一化。可以使用与上下文有关的和与上下文无关的声学模型。

10. 发明申请

WO1997045773A1 INTERFEROMETRIC BROADBAND IMAGING 审中-公开
标题翻译：干涉宽带成像
公开(公告)号：WO1997045773A1
公开(公告)日：1997-12-04
申请号：PCT/US1997009005
申请日：1997-05-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , EVERETT, Patrick, N. , MOON, Euclid, Eberle , SMITH, Henry, I.
IPC分类号： G03F09/00
CPC分类号： G03F9/70 , G01B9/02043 , G01B9/02072 , G01B9/02078 , G01B9/0209 , G01B2290/30
摘要： Alignment marks on first and second plates include a plurality of periodic gratings. A grating on a first plate has a period or pitch p1 paired up with a grating on the second plate that has a slightly different period p2. A grating on the first plate having a period p3 is paired up with a grating on the second plate having a slightly different period p4. Illuminating the gratings produces a first interference pattern characterized by a first interference phase where beams diffracted from the first and second gratings overlap and a second interference pattern characterized by a second interference phase where beams diffracted from the third and fourth gratings overlap. The plates are moved until the difference between the first and second interference phases correspond to a predetermined interference phase difference. Further invention uses an interrupted-grating pattern on the second plate with certain advantages. Further advantages are obtained using a checkerboard pattern on the second plate. In addition two inventions are made for measuring gap. One method uses the same marks on the second plate as used in aligning, and the second uses no marks on the second plate, which is an advantage in some cases.
摘要翻译：第一和第二板上的对准标记包括多个周期性光栅。第一板上的光栅具有与第二板上的光栅成对的周期或间距p1，其具有稍微不同的周期p2。具有周期p3的第一板上的光栅与第二板上的光栅配对，具有稍微不同的周期p4。照亮光栅产生第一干涉图案，其特征在于第一干涉相位，其中从第一和第二光栅衍射的光束重叠，以及第二干涉图案，其特征在于第二干涉相位，其中从第三和第四光栅衍射的光束重叠。板移动直到第一和第二干涉相位之间的差对应于预定的干涉相位差。另外，本发明使用了具有某些优点的第二板上的中断光栅图案。使用第二板上的棋盘图案获得更多的优点。另外还有两个发明用于测量差距。一种方法在对准中使用与第二板相同的标记，而第二板在第二板上不使用标记，这在某些情况下是有利的。

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