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1. 发明申请

WO2008131301A1 SURFACES, METHODS AND DEVICES EMPLOYING CELL ROLLING 审中-公开
标题翻译：表面，方法和使用细胞滚动的装置
公开(公告)号：WO2008131301A1
公开(公告)日：2008-10-30
申请号：PCT/US2008/060934
申请日：2008-04-18
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KARP, Jeffrey, M. , MOORE, Michael, J. , KHADEMHOSSEINI, Ali , LANGER, Robert, S. , HONG, Seungpyo
发明人： KARP, Jeffrey, M. , MOORE, Michael, J. , KHADEMHOSSEINI, Ali , LANGER, Robert, S. , HONG, Seungpyo
IPC分类号： A61K38/36
CPC分类号： A61L27/3808 , A61L27/34 , A61L27/507 , A61L27/54 , A61L27/58 , A61L31/005 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2400/06
摘要： In various aspects, the present invention provides surfaces and materials for cell rolling applications, methods of making such surfaces and materials, and devices having such surfaces and materials. In some embodiments, the present invention provides surfaces with at least partial coatings of an ordered layer of cell adhesion molecules, or fragments, analogs, or modifications thereof, covalently bound to the surface of the substrate through an immobilization moiety. In some embodiments, the layer of a cell adhesion molecules further comprises a cell modifying ligand that can be targeted, e.g ., to one or more specific cell types.
摘要翻译：在各个方面，本发明提供了用于电池轧制应用的表面和材料，制造这种表面和材料的方法，以及具有这种表面和材料的装置。在一些实施方案中，本发明提供具有细胞粘附分子或其片段，类似物或修饰的有序层的至少部分涂层的表面，其通过固定部分共价结合到所述底物的表面。在一些实施方案中，细胞粘附分子的层还包含可靶向例如一种或多种特定细胞类型的细胞修饰配体。

2. 发明申请

WO2009043057A2 CELL ROLLING SEPARATION 审中-公开
标题翻译：细胞滚动分离
公开(公告)号：WO2009043057A2
公开(公告)日：2009-04-02
申请号：PCT/US2008/078204
申请日：2008-09-29
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , KARNIK, Rohit, Nandkumar , HONG, Seungpyo , MEI, Ying , ANDERSON, Daniel, Griffith , KARP, Jeffrey, Michael , LANGER, Robert, S. , BOSE, Suman
发明人： KARNIK, Rohit, Nandkumar , HONG, Seungpyo , MEI, Ying , ANDERSON, Daniel, Griffith , KARP, Jeffrey, Michael , LANGER, Robert, S. , BOSE, Suman
IPC分类号： C12N5/08 , C07K16/28
CPC分类号： C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
摘要： The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.
摘要翻译：本发明提供了基于在细胞粘附分子包被的区域的边缘上的表面上的细胞滚动的细胞分离系统。公开了涂覆区域和边缘的各种设计。

3. 发明申请

WO2010044509A1 MOTION TRACKING METHOD USING SCANNING DEVICE 审中-公开
标题翻译：使用扫描设备的运动跟踪方法
公开(公告)号：WO2010044509A1
公开(公告)日：2010-04-22
申请号：PCT/KR2008/006881
申请日：2008-11-21
申请人： KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY , KIM, Jinwook , HONG, Seungpyo , KO, Heedong
发明人： KIM, Jinwook , HONG, Seungpyo , KO, Heedong
IPC分类号： H04N1/04 , H04N5/00
CPC分类号： G01S17/66
摘要： The motion tracking method disclosed herein suggests a method for precisely tracking the motion of a scanning device by correcting the surrounding information distortedly recognized due to the time differences between pieces of information regarding the surroundings of the device over one scanning cycle. The method, as a motion tracking method of a scanning device collecting the surrounding information corresponding to a plurality of the points of the surroundings, includes collecting the surrounding information, obtaining the displacement data of the scanning device using the surrounding information, updating the velocity of the scanning device using the displacement data of the scanning device, correcting the surrounding information using the updated velocity of the scanning device, and determining location and position information of the scanning device using the corrected surrounding information. According to the method herein, the motion of the scanning device may be more precisely tracked because the surrounding information is corrected based on the velocity of the scanning device.
摘要翻译：本文公开的运动跟踪方法提出了一种通过校正由于在一个扫描周期上与设备的周围环境相关的信息之间的时间差异而失真识别的周围信息来精确跟踪扫描设备的运动的方法。作为收集与周围的多个点对应的周围信息的扫描装置的运动跟踪方法，包括收集周围信息，使用周围信息获取扫描装置的位移数据，更新速度所述扫描装置使用所述扫描装置的位移数据，使用所述扫描装置的更新速度来校正所述周围信息，以及使用所述校正的周围信息来确定所述扫描装置的位置和位置信息。根据本文的方法，可以更精确地跟踪扫描装置的运动，因为基于扫描装置的速度来校正周围的信息。

4. 发明公开

EP2148696A1 SURFACES, METHODS AND DEVICES EMPLOYING CELL ROLLING 审中-公开
标题翻译：表面上，方法和设备能否与电芯绕组
公开(公告)号：EP2148696A1
公开(公告)日：2010-02-03
申请号：EP08746368.3
申请日：2008-04-18
申请人： Massachusetts Institute of Technology
发明人： KARP, Jeffrey, M. , MOORE, Michael, J. , KHADEMHOSSEINI, Ali , LANGER, Robert, S. , HONG, Seungpyo
IPC分类号： A61K38/36
CPC分类号： A61L27/3808 , A61L27/34 , A61L27/507 , A61L27/54 , A61L27/58 , A61L31/005 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2400/06
摘要： In various aspects, the present invention provides surfaces and materials for cell rolling applications, methods of making such surfaces and materials, and devices having such surfaces and materials. In some embodiments, the present invention provides surfaces with at least partial coatings of an ordered layer of cell adhesion molecules, or fragments, analogs, or modifications thereof, covalently bound to the surface of the substrate through an immobilization moiety. In some embodiments, the layer of a cell adhesion molecules further comprises a cell modifying ligand that can be targeted, e.g., to one or more specific cell types.

5. 发明公开

EP2205725A2 CELL ROLLING SEPARATION 审中-公开
标题翻译： CELL辊分离
公开(公告)号：EP2205725A2
公开(公告)日：2010-07-14
申请号：EP08834284.5
申请日：2008-09-29
申请人： Massachusetts Institute of Technology
发明人： KARNIK, Rohit, Nandkumar , HONG, Seungpyo , MEI, Ying , ANDERSON, Daniel, Griffith , KARP, Jeffrey, Michael , LANGER, Robert, S. , BOSE, Suman
IPC分类号： C12N5/08 , C12M1/00 , C07K16/28
CPC分类号： C12N5/0068 , B01L3/502715 , B01L3/502761 , B01L2200/0647 , B01L2300/0877 , B01L2300/16 , C12M23/16 , C12M47/02 , C12N5/0062 , C12N2501/58 , C12N2501/585 , C12N2533/50 , C12N2533/52 , C12N2535/10
摘要： The present invention provides systems for cell separation based on cell rolling on surfaces along edges of regions coated with cell adhesion molecules. A variety of designs of coated regions and edges are disclosed.

6. 发明申请

WO2014130846A1 TRANSDERMAL DRUG DELIVERY USING AMPHIPHILIC DENDRON-COIL MICELLES 审中-公开
标题翻译：使用AMPHIPHILIC DENDRON-COIL MICELLES的超导药物递送
公开(公告)号：WO2014130846A1
公开(公告)日：2014-08-28
申请号：PCT/US2014/017762
申请日：2014-02-21
申请人： HONG, Seungpyo , YANG, Yang
发明人： HONG, Seungpyo , YANG, Yang
IPC分类号： A61K9/107 , C08G63/91 , C08L53/00
CPC分类号： A61K9/1075 , A61K9/0014 , A61K31/138 , A61K47/10 , A61K47/34 , C08G63/664 , C08G63/6852 , C08G83/004 , C08G83/008
摘要： The invention generally relates to the field of drug delivery. In particular, the invention relates to amphiphilic dendron-coils, micelles thereof and their use for the transdermal delivery of drugs.
摘要翻译：本发明一般涉及药物递送领域。特别地，本发明涉及两亲性树突状线圈，其胶束及其用于经皮递送药物的用途。

7. 发明申请

WO2012116073A2 AMPHIPHILIC DENDRON-COILS, MICELLES THEREOF AND USES 审中-公开
标题翻译： AMPHIPHILIC DENDRON-COILS，MICELLES THEREOF AND USES
公开(公告)号：WO2012116073A2
公开(公告)日：2012-08-30
申请号：PCT/US2012/026133
申请日：2012-02-22
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , HONG, Seungpyo , BAE, Jin, Woo
发明人： HONG, Seungpyo , BAE, Jin, Woo
CPC分类号： A61K9/1075 , A61K9/5031 , A61K31/352 , A61K31/405 , A61K47/10 , A61K47/34 , A61K47/44 , C08G63/66 , C08G63/912 , C08G81/00 , C08G83/003 , C08G83/004 , C08G83/008 , C12Q1/02 , G01N33/574
摘要： The invention generally relates to the fields of drug delivery and cell capture. In particular, the invention relates to amphiphilic dendron-coils, micelles thereof and their use for drug delivery vehicles and/or cell capture.
摘要翻译：本发明一般涉及药物递送和细胞捕获的领域。特别地，本发明涉及两亲性树突状线圈，其胶束及其用于药物递送载体和/或细胞捕获的用途。

8. 发明申请

WO2011133617A1 NANO-HYBRID DELIVERY SYSTEM FOR SEQUENTIAL UTILIZATION OF PASSIVE AND ACTIVE TARGETING 审中-公开
标题翻译：用于无源和有源目标的连续使用的纳米混合交付系统
公开(公告)号：WO2011133617A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033158
申请日：2011-04-20
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , HONG, Seungpyo , LIU, Ying
发明人： HONG, Seungpyo , LIU, Ying
IPC分类号： A01N25/26 , A61K9/14
CPC分类号： A61K9/127 , A61K9/1273 , A61K9/14 , A61K9/146 , A61K9/5153
摘要： The present invention features nanohybrid drug delivery composition which combines both passive and active targeting for the prevention and treatment of disease. The composition is shell-encapsulated multivalent polymeric scaffold with a therapeutic agent and targeting agent attached thereto.
摘要翻译：本发明的特征在于纳米杂交药物递送组合物，其组合用于预防和治疗疾病的被动和主动靶向。该组合物是具有与其连接的治疗剂和靶向剂的壳包封的多价聚合物支架。

9. 发明申请

WO2017218638A1 METHODS FOR TREATING SUBJECTS SUFFERING FROM ACUTE MYELOID LEUKEMIA WITH FLT3 LIGAND-TARGETED MIR-150 NANOPARTICLES 审中-公开
标题翻译：用FLT3配体靶向的MIR-150纳米颗粒治疗患有急性髓细胞性白血病的受试者的方法
公开(公告)号：WO2017218638A1
公开(公告)日：2017-12-21
申请号：PCT/US2017/037424
申请日：2017-06-14
申请人： CHEN, Jianjun , HONG, Seungpyo , JIANG, Xi , LI, Zejuan
发明人： CHEN, Jianjun , HONG, Seungpyo , JIANG, Xi , LI, Zejuan
IPC分类号： A61K31/7088 , A61K38/17 , A61K38/19 , A61K38/20 , A61K39/00
CPC分类号： A61K47/6935 , A61K31/551 , A61K31/7105 , A61K38/19 , A61K45/06 , A61K47/595 , A61K47/62 , A61P35/02 , C12N15/1138 , C12N2310/141 , C12N2310/321 , A61K2300/00
摘要： A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3 -overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.
摘要翻译：设计用于持续递送microRNA-150（miR-150）至FLT3-过表达急性骨髓性白血病（AML）细胞的纳米粒子递送系统，所述递送系统包含聚（（PAMAM）树枝状化合物与miR-150复合，其中至少一个树枝状聚合物用FLT3受体特异性配体表面官能化，并提供了治疗特征在于FLT3过表达的AML的方法。 / p>

10. 发明申请

WO2010124227A2 METHODS AND DEVICES FOR CAPTURING CIRCULATING TUMOR CELLS 审中-公开
标题翻译：用于捕获循环肿瘤细胞的方法和装置
公开(公告)号：WO2010124227A2
公开(公告)日：2010-10-28
申请号：PCT/US2010/032266
申请日：2010-04-23
申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS , HONG, Seungpyo , EDDINGTON, David , MYUNG, Ja Hye , LAUNIERE, Cari
发明人： HONG, Seungpyo , EDDINGTON, David , MYUNG, Ja Hye , LAUNIERE, Cari
IPC分类号： G01N33/574 , G01N33/68 , C12N5/09
CPC分类号： G01N33/574
摘要： A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The flow modification surface induces a rotational flow within the sample as it flows through the microfluidic device.
摘要翻译：从样品捕获循环肿瘤细胞（CTC）的方法包括将样品引入到具有细胞捕获表面和流动修饰表面的微流体装置中，该条件允许CTC结合细胞转导诱导剂和捕获药剂置于细胞捕获表面上。流动修饰表面在样品流过微流体装置时会引起样品内的旋转流动。

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