专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO0185022A3 OPTICAL COMPUTED TOMOGRAPHY IN A TURBID MEDIA 审中-公开
标题翻译：光学媒体中的光学计算机图像
公开(公告)号：WO0185022A3
公开(公告)日：2002-04-04
申请号：PCT/US0114643
申请日：2001-05-04
申请人： MASSACHUSETTS INST TECHNOLOGY , CHEN KUN , DASARI RAMACHANDRA R , FELD MICHAEL S , PERELMAN LEV T , ZHANG QINGGUO
发明人： CHEN KUN , DASARI RAMACHANDRA R , FELD MICHAEL S , PERELMAN LEV T , ZHANG QINGGUO
IPC分类号： G01N21/17 , A61B5/00 , A61B10/00 , G01N21/47 , G06T1/00
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0073
摘要： Photon migration methods are employed to image absorbing objects embedded in a turbid medium such as tissue. For improved resolution, early arriving photons are detected to provide data with image reconstruction based on optical computed tomography (CT). The CT method is generalized to take into account the distributions of photon paths. A point spread function (PSF) is expressed in terms of the Green's function for the transport equation. This PSF provides weighting functions for use in a generalized series expansion method. Measurements of turbid medium with scattering and absorption properties included coaxial transmission scans collected in two projections. Blurring associated with multiple scattering was removed and high-resolution images can be obtained.
摘要翻译：使用光子迁移方法来对包含在混浊介质（例如组织）中的吸收物体进行成像。为了提高分辨率，检测到早期到达的光子，以提供基于光学计算机断层摄影（CT）的图像重建的数据。 CT方法被广义化以考虑光子路径的分布。点扩散函数（PSF）以运输方程的格林函数表示。该PSF提供用于广义串联扩展方法的加权函数。具有散射和吸收特性的混浊介质的测量包括在两个投影中收集的同轴传播扫描。去除与多次散射相关联的模糊，并且可以获得高分辨率图像。

2. 发明申请

WO0184124A2 METHODS AND SYSTEMS USING FIELD-BASED LIGHT SCATTERING SPECTROSCOPY 审中-公开
标题翻译：使用基于场的光散射光谱的方法和系统
公开(公告)号：WO0184124A2
公开(公告)日：2001-11-08
申请号：PCT/US0140612
申请日：2001-04-27
申请人： MASSACHUSETTS INST TECHNOLOGY , YANG CHANGHUEI , WAX ADAM P , PERELMAN LEV T , DASARI RAMACHANDRA R , FELD MICHAEL S
发明人： YANG CHANGHUEI , WAX ADAM P , PERELMAN LEV T , DASARI RAMACHANDRA R , FELD MICHAEL S
IPC分类号： G01B9/02 , A61B5/00 , G01N21/17 , G01N21/27 , G01N21/45 , G01N21/47 , G01J3/44 , G01N15/02 , G01P5/00
CPC分类号： G01N21/4795 , A61B5/0059 , A61B5/0066 , G01N21/45
摘要： The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.
摘要翻译：本发明涉及基于场的光散射光谱的系统和方法。这些系统和方法通过测量细胞特征的大小和分布来提供对组织的诊断。基于场的测量提供由材料内的散射体与入射波前的相互作用产生的相位信息。这些测量可用于提供组织的三维图像。

3. 发明申请

WO2005001445A3 SYSTEMS AND METHODS FOR PHASE MEASUREMENTS 审中-公开
标题翻译：用于相位测量的系统和方法
公开(公告)号：WO2005001445A3
公开(公告)日：2005-12-15
申请号：PCT/US2004019456
申请日：2004-06-18
申请人： MASSACHUSETTS INST TECHNOLOGY , FANG-YEN CHRISTOPHER M , POPESCU GABRIEL , YANG CHANGHUEI , WAX ADAM P , DASARI RAMACHANDRA R , FELD MICHAEL S
发明人： FANG-YEN CHRISTOPHER M , POPESCU GABRIEL , YANG CHANGHUEI , WAX ADAM P , DASARI RAMACHANDRA R , FELD MICHAEL S
IPC分类号： G01B9/02 , G01J9/04 , G01N21/45
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention
摘要翻译：本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。实施例涉及用于用光成像小生物物体的光学装置。这些实施方案可以应用于例如细胞生理学和神经科学领域。这些优选实施例基于相位测量和成像技术的原理。使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生在本发明的系统中

4. 发明申请

WO2012019102A3 PORTABLE RAMAN DIAGNOSTIC SYSTEM 审中-公开
标题翻译：便携式拉曼诊断系统
公开(公告)号：WO2012019102A3
公开(公告)日：2012-10-18
申请号：PCT/US2011046750
申请日：2011-08-05
申请人： MASSACHUSETTS INST TECHNOLOGY , BARMAN ISHAN , DINGARI NARAHARA CHARI , DASARI RAMACHANDRA R , KONG CHAE-RYON , FELD DAVID , HEARN ALISON , FELD JONATHAN
发明人： BARMAN ISHAN , DINGARI NARAHARA CHARI , DASARI RAMACHANDRA R , KONG CHAE-RYON , FELD MICHAEL S
IPC分类号： A61B5/00 , A61B5/145 , G01N21/65
CPC分类号： A61B5/14532 , A61B5/1455 , A61B5/4312 , A61B5/444 , A61B2560/0223 , G01J3/0208 , G01J3/0216 , G01J3/0218 , G01J3/0272 , G01J3/44 , G01N21/65 , G01N2201/129
摘要： The present invention relates to an integrated approach to measuring biological samples utilizing a process of eliminating the uninformative or spurious spectral regions which simultaneously removes the necessity for a full spectrograph-CCD system. This approach enables the use of a portable Raman diagnostic system, having significantly reduced size and weight while retaining the required sensitivity. The selection of only a limited number of spectral bands allows the construction of a miniaturized Raman instrument by replacing the spectrograph-CCD combination with an array of optical bandpass filters and light detector(s). One of the embodiments of such a design can incorporate a single photodiode as a light detector. A preferred embodiment of the present invention uses wavelength interval selection based on non-linear representation, such as support vector regression. The wavelength selection protocol is based on the minimization of cross-validation error in the training data. tral information. To acquire the full spectrum necessary for the analysis, a dispersive spectrograph and a CCD detector is typically employed.
摘要翻译：本发明涉及利用消除不信息或杂散光谱区域的过程来测量生物样品的综合方法，其同时消除了对全光谱仪-CDC系统的必要性。这种方法使得能够使用便携式拉曼诊断系统，其具有显着减小的尺寸和重量，同时保持所需的灵敏度。仅选择有限数量的光谱带允许通过用光学带通滤光器和光检测器阵列替换光谱仪-CDC组合来构建小型化的拉曼仪器。这种设计的一个实施例可以结合单个光电二极管作为光检测器。本发明的优选实施例使用基于非线性表示的波长间隔选择，例如支持向量回归。波长选择协议基于训练数据中交叉验证错误的最小化。 tral信息。为了获得分析所需的全部光谱，通常采用色散光谱仪和CCD检测器。

5. 发明申请

WO02057757A3 SYSTEM AND METHODS OF FLUORESCENCE, REFLECTANCE AND LIGHT SCATTERING SPECTROSCOPY FOR MEASURING TISSUE CHARACTERISTICS 审中-公开
标题翻译：用于测量组织特征的荧光，反射和光散射光谱的系统和方法
公开(公告)号：WO02057757A3
公开(公告)日：2003-02-27
申请号：PCT/US0203094
申请日：2002-01-18
申请人： MASSACHUSETTS INSTITUE OF TECH , GEORGAKOUDI IRENE , FELD MICHAEL S , ZHANG QINGGUO , MUELLER MARKUS G
发明人： GEORGAKOUDI IRENE , FELD MICHAEL S , ZHANG QINGGUO , MUELLER MARKUS G
IPC分类号： A61B1/00 , A61B5/00 , A61B6/00 , G01N21/27 , G01N21/47 , G01N21/64
CPC分类号： G01N21/6486 , A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/1459 , A61B5/4331 , G01N21/47 , G01N21/64
摘要： The present invention utilizes a plurality of spectroscopic systems and methods to measure characteristics of tissue useful in the diagnosis of disease. In a preferred embodiment, a combination of fluorescence, reflectance and light scattered spectra can be measured and processed to provide biochemical, architectural and morphological state of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.
摘要翻译：本发明利用多个光谱系统和方法来测量可用于疾病诊断的组织的特征。在优选的实施方案中，可以测量和处理荧光，反射率和光散射光谱的组合以提供组织的生物化学，建筑和形态状态。方法和系统可以特别用于体内和体外组织内癌的早期检测。

6. 发明申请

WO0042912A9 POLARIZED LIGHT SCATTERING SPECTROSCOPY OF TISSUE 审中-公开
标题翻译：组织的偏振光散射光谱
公开(公告)号：WO0042912A9
公开(公告)日：2002-03-28
申请号：PCT/US0001967
申请日：2000-01-25
申请人： MASSACHUSETTS INST TECHNOLOGY , BACKMAN VADIM , DASARI RAMANCHANDRA R , GURJAR RAJAN , ITZKAN IRVING , PERELMAN LEV , FELD MICHAEL S
发明人： BACKMAN VADIM , DASARI RAMANCHANDRA R , GURJAR RAJAN , ITZKAN IRVING , PERELMAN LEV , FELD MICHAEL S
IPC分类号： G01N33/48 , A61B1/00 , A61B5/00 , A61B10/00 , C12Q1/02 , G01N21/21 , G01N21/27 , G01N21/35 , G01N33/483
CPC分类号： A61B5/0084 , A61B5/0075
摘要： The present invention relates to the use of polarized light to measure properties of tissue. More particularly, polarized light can be used to detect dysplasia in tissue as the polarization of backscattered light from such tissues is preserved while the contribution of diffusely scattered light from underlying tissues can be removed. A fiber optic system for delivery and collection of light can be used to measure tissues within the human body.
摘要翻译：本发明涉及使用偏振光来测量组织的性质。更具体地，偏振光可用于检测组织中的发育不良，因为来自这些组织的反向散射光的偏振被保留，同时可以去除来自下层组织的漫散射光的贡献。用于光的传送和收集的光纤系统可用于测量人体内的组织。

7. 发明申请

WO9629925A2 APPARATUS AND METHODS OF RAMAN SPECTROSCOPY FOR ANALYSIS OF BLOOD GASES AND ANALYTES 审中-公开
标题翻译：用于分析气体和分析物的拉曼光谱仪的装置和方法
公开(公告)号：WO9629925A2
公开(公告)日：1996-10-03
申请号：PCT/US9604136
申请日：1996-03-27
申请人： MASSACHUSETTS INST TECHNOLOGY , BERGER ANDREW J , BRENNAN JAMES F III , DASARI RAMANCHANDRA R , FELD MICHAEL S , ITZKAN IRVING , TANAKA KAZ , WANG YANG
发明人： BERGER ANDREW J , BRENNAN JAMES F III , DASARI RAMANCHANDRA R , FELD MICHAEL S , ITZKAN IRVING , TANAKA KAZ , WANG YANG
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , G01N21/65
CPC分类号： G01J3/02 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , A61B2562/12 , G01J3/021 , G01J3/0221 , G01N21/65 , G01N2021/656
摘要： The present invention relates to systems of methods of measuring selected analytes in blood and tissue using Raman spectroscopy to aid in diagnosis. More particularly, Raman spectra are collected and analyzed to measure the concentration of dissolved gases and other analytes of interest in blood. Methods include in vivo transdermal and continuous monitoring as well as in vitro blood analysis. Furthermore, a compound parabolic concentrator to increase the amount of detected Raman signal is disclosed.
摘要翻译：本发明涉及使用拉曼光谱法测量血液和组织中选定分析物以帮助诊断的方法的系统。更具体地，收集和分析拉曼光谱，以测量血液中溶解气体和其他分析物的浓度。方法包括体内透皮和连续监测以及体外血液分析。此外，公开了一种用于增加检测到的拉曼信号量的复合抛物面聚光器。

8. 发明申请

WO2007014173A3 INTRINSIC RAMAN SPECTROSCOPY 审中-公开
标题翻译：本征拉曼光谱
公开(公告)号：WO2007014173A3
公开(公告)日：2007-06-21
申请号：PCT/US2006028720
申请日：2006-07-24
申请人： MASSACHUSETTS INST TECHNOLOGY , BECHTEL KATE , SHIH WEI-CHUAN , FELD MICHAEL S
发明人： BECHTEL KATE , SHIH WEI-CHUAN , FELD MICHAEL S
IPC分类号： G01N21/65
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/1495 , A61B2560/0223 , G01N21/65
摘要： The present invention relates to systems and methods for the measurement of analytes such as glucose . Raman and reflectance spectroscopy are used to measure a volume, of material such as a blood sample or tissue within a subject and determine a concentration of a blood analyte based thereon. The present invention further relates to a calibration method, constrained regularization (CR) , and demonstrates its use for analyzing spectra including, for example, the measurement glucose concentrations using transcutaneous Raman spectroscopy.
摘要翻译：本发明涉及用于测量分析物如葡萄糖的系统和方法。拉曼和反射光谱用于测量受试者体内诸如血液样品或组织的体积，并基于此确定血液分析物的浓度。本发明进一步涉及校准方法，约束正则化（CR），并且示出了其用于分析光谱的用途，包括例如使用经皮拉曼光谱的测量葡萄糖浓度。

9. 发明申请

WO2007014213A2 TRI MODAL SPECTROSCOPIC IMAGING 审中-公开
标题翻译： TRI模式光谱成像
公开(公告)号：WO2007014213A2
公开(公告)日：2007-02-01
申请号：PCT/US2006028834
申请日：2006-07-25
申请人： MASSACHUSETTS INST TECHNOLOGY , YU CHUNG-CHIEH , LAU CONDON , FULGHUM STEPHEN , FANG-YEN CHRISTOPHER , DASARI RAMACHANDRA , FELD MICHAEL S
发明人： YU CHUNG-CHIEH , LAU CONDON , FULGHUM STEPHEN , FANG-YEN CHRISTOPHER , DASARI RAMACHANDRA , FELD MICHAEL S
IPC分类号： G01N21/47 , G01N21/49
CPC分类号： A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要： The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译：本发明涉及使用自发荧光和反射图像来诊断组织的光谱成像系统。本发明的优选实施例使用多个光源来照射组织区域以分别提供荧光和反射图像。

10. 发明申请

WO2009009081A3 TOMOGRAPHIC PHASE MICROSCOPY 审中-公开
标题翻译： TOMOGRAPHIC相显微镜
公开(公告)号：WO2009009081A3
公开(公告)日：2009-11-19
申请号：PCT/US2008008447
申请日：2008-07-10
申请人： MASSACHUSETTS INST TECHNOLOGY , CHOI WONSHIK , DASARI RAMACHANDRA RAO , FANG-YEN CHRISTOPHER M , FELD MICHAEL S
发明人： CHOI WONSHIK , DASARI RAMACHANDRA RAO , FANG-YEN CHRISTOPHER M , FELD MICHAEL S
IPC分类号： G01N21/47 , A61B3/12 , A61B5/00
CPC分类号： G01N21/45 , G01N21/51 , G01N21/6458 , G01N21/6486 , G01N2021/458 , G01N2201/061 , G01N2201/105 , G01N2201/12
摘要： The present invention relates to systems and methods for quantitative three-dimensional mapping of refractive index in living or non-living cells, tissues, or organisms using a phase- shifting laser interferometric microscope with variable illumination angle. A preferred embodiment provides tomographic imaging of cells and multicellular organisms, and time -dependent changes in cell structure and the quantitative characterization of specimen- induced aberrations in high-resolution microscopy with multiple applications in tissue light scattering.
摘要翻译：本发明涉及使用具有可变照明角度的相移激光干涉显微镜在活体或非活细胞，组织或生物体中定量三维映射折射率的系统和方法。优选的实施方案提供细胞和多细胞生物体的层析成像以及细胞结构的时间依赖性变化以及在组织光散射中具有多种应用的高分辨率显微镜中的样品诱导的像差的定量表征。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式