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1. 发明专利

AU2018269711A1 Self-righting systems and related components and methods 未知
公开(公告)号：AU2018269711A1
公开(公告)日：2019-12-05
申请号：AU2018269711
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , NOVO NORDISK AS , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

2. 发明专利

PE20200305A1 SISTEMAS AUTOENDEREZABLES Y COMPONENTES Y METODOS RELACIONADOS 未知
公开(公告)号：PE20200305A1
公开(公告)日：2020-02-06
申请号：PE2019002414
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , NOVO NORDISK AS
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61K9/00 , A61J3/07 , A61M5/00 , A61M5/14
摘要： Se proporcionan de manera general articulos autoenderezable, como capsulas autoenderezable para la administracion a un sujeto. En algunas modalidades, el articulo autoenderezable puede configurarse de modo que el articulo pueda orientarse en relacion con una superficie (por ejemplo, una superficie de un tejido de un sujeto). Los articulos autoenderezables descritos en el presente documento pueden comprender una o mas superficies de enganche de tejido configuradas para contactarse (por ejemplo, interactuar con, inyectarse, anclarse) con una superficie (por ejemplo, una superficie de un tejido de un sujeto). En algunas modalidades, el articulo autoenderezable puede tener una forma particular y/o distribucion de densidad (o masa) que, por ejemplo, permite el comportamiento de autoenderezado del articulo. En algunas modalidades, el articulo autoenderezable puede comprender un componente de interfaz de tejido y/o un agente farmaceutico (por ejemplo, para la administracion del agente farmaceutico activo a una ubicacion interior del sujeto). En algunos casos, tras el contacto del tejido con la superficie de contacto con el tejido del articulo, el articulo autoenderezable puede configurarse para liberar uno o mas componentes de interfaz del tejido. En algunos casos, el componente de interfaz de tejido esta asociado con un componente autoaccionable. Por ejemplo, el articulo autoenderezable puede comprender un componente autoaccionable configurado, tras la exposicion a un fluido, para liberar el componente de interfaz de tejido del articulo autoenderezable. En algunos casos, el componente de interfaz de tejido puede comprender y/o estar asociado con el agente farmaceutico (por ejemplo, para la entrega a una ubicacion interna de un sujeto).

3. 发明专利

PH12019502537A1 SELF-RIGHTING SYSTEMS AND RELATED COMPONENTS AND METHODS 未知
公开(公告)号：PH12019502537A1
公开(公告)日：2020-07-13
申请号：PH12019502537
申请日：2019-11-12
申请人： BRIGHAM & WOMENS HOSPITAL INC , MASSACHUSETTS INST TECHNOLOGY , NOVO NORDISK AS
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

4. 发明专利

CL2019003269A1 Sistemas de derecho automático y componentes relacionados y procedimientos. 未知
公开(公告)号：CL2019003269A1
公开(公告)日：2020-03-20
申请号：CL2019003269
申请日：2019-11-14
申请人： MASSACHUSETTS INST TECHNOLOGY , NOVO NORDISK AS , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Se proporcionan de manera general artículos autoenderezable, como cápsulas autoenderezable para la administración a un sujeto. En algunas modalidades, el artículo autoenderezable puede configurarse de modo que el artículo pueda orientarse en relación con una superficie (por ejemplo, una superficie de un tejido de un sujeto). Los artículos autoenderezables descritos en el presente documento pueden comprender una o más superficies de enganche de tejido configuradas para contactarse (por ejemplo, interactuar con, inyectarse, anclarse) con una superficie (por ejemplo, una superficie de un tejido de un sujeto). En algunas modalidades, el artículo autoenderezable puede tener una forma particular y/o distribución de densidad (o masa) que, por ejemplo, permite el comportamiento de autoenderezado del artículo. En algunas modalidades, el artículo autoenderezable puede comprender un componente de interfaz de tejido y/o un agente farmacéutico (por ejemplo, para la administración del agente farmacéutico activo a una ubicación interior del sujeto). En algunos casos, tras el contacto del tejido con la superficie de contacto con el tejido del artículo, el artículo autoenderezable puede configurarse para liberar uno o más componentes de interfaz del tejido. En algunos casos, el componente de interfaz de tejido está asociado con un componente autoaccionable. Por ejemplo, el artículo autoenderezable puede comprender un componente autoaccionable configurado, tras la exposición a un fluido, para liberar el componente de interfaz de tejido del artículo autoenderezable. En algunos casos, el componente de interfaz de tejido puede comprender y/o estar asociado con el agente farmacéutico (por ejemplo, para la entrega a una ubicación interna de un sujeto).

5. 发明专利

CO2019012773A2 Sistemas autoenderezables y componentes y métodos relacionados 未知
公开(公告)号：CO2019012773A2
公开(公告)日：2020-02-18
申请号：CO2019012773
申请日：2019-11-15
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , NOVO NORDISK AS
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： RESUMEN Se proporcionan de manera general artículos autoenderezable, como cápsulas autoenderezable para la administración a un sujeto. En algunas modalidades, el artículo autoenderezable puede configurarse de modo que el artículo pueda orientarse en relación con una superficie (por ejemplo, una superficie de un tejido de un sujeto). Los artículos autoenderezables descritos en el presente documento pueden comprender una o más superficies de enganche de tejido configuradas para contactarse (por ejemplo, interactuar con, inyectarse, anclarse) con una superficie (por ejemplo, una superficie de un tejido de un sujeto). En algunas modalidades, el artículo autoenderezable puede tener una forma particular y/o distribución de densidad (o masa) que, por ejemplo, permite el comportamiento de autoenderezado del artículo. En algunas modalidades, el artículo autoenderezable puede comprender un componente de interfaz de tejido y/o un agente farmacéutico (por ejemplo, para la administración del agente farmacéutico activo a una ubicación interior del sujeto). En algunos casos, tras el contacto del tejido con la superficie de contacto con el tejido del artículo, el artículo autoenderezable puede configurarse para liberar uno o más componentes de interfaz del tejido. En algunos casos, el componente de interfaz de tejido está asociado con un componente autoaccionable. Por ejemplo, el artículo autoenderezable puede comprender un componente autoaccionable configurado, tras la exposición a un fluido, para liberar el componente de interfaz de tejido del artículo autoenderezable. En algunos casos, el componente de interfaz de tejido puede comprender y/o estar asociado con el agente farmacéutico (por ejemplo, para la entrega a una ubicación interna de un sujeto).

6. 发明专利

CA3063928A1 SELF-RIGHTING SYSTEMS AND RELATED COMPONENTS AND METHODS 未知
公开(公告)号：CA3063928A1
公开(公告)日：2018-11-22
申请号：CA3063928
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC , NOVO NORDISK AS
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S , WATER JORRIT JEROEN , FREDERIKSEN MORTEN REVSGAARD , KRISTIANSEN BO ULDALL , JESPERSEN MIKKEL OLIVER , POULSEN METTE , HERSKIND PETER , JENSEN BRIAN
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

7. 发明专利

CA3063713A1 COMPONENTS WITH HIGH API LOADING 未知
公开(公告)号：CA3063713A1
公开(公告)日：2018-11-22
申请号：CA3063713
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61M37/00 , A61M31/00
摘要： Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt% versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, Gl mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle. In some cases, a physiologically relevant dose may be present in a single tissue interfacing component.

8. 发明专利

CA3063711A1 SELF-RIGHTING SYSTEMS, METHODS, AND RELATED COMPONENTS 未知
公开(公告)号：CA3063711A1
公开(公告)日：2018-11-22
申请号：CA3063711
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61J3/07 , A61K9/00 , A61M5/00 , A61M5/14
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

9. 发明专利

AU2018269547A1 Self-actuating articles 未知
公开(公告)号：AU2018269547A1
公开(公告)日：2019-11-28
申请号：AU2018269547
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , LANGER ROBERT S
IPC分类号： A61M5/32 , A61M5/20
摘要： Self-actuating articles including, for example, self-actuating needles and/or self- actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics). Those of ordinary skill in the art would understand that the term spring is not intended to be limited to coil springs, but generally encompass any reversibly compressive material and/or component which, after releasing an applied compressive force on the material/component, the material/component substantially returns to an uncompressed length of the material/component (e.g., the within 95% of the length of the material/component prior to compression).

10. 发明专利

AU2018269556A1 Tissue anchoring articles 未知
公开(公告)号：AU2018269556A1
公开(公告)日：2019-11-28
申请号：AU2018269556
申请日：2018-05-17
申请人： MASSACHUSETTS INST TECHNOLOGY , BRIGHAM & WOMENS HOSPITAL INC
发明人： TRAVERSO CARLO GIOVANNI , ABRAMSON ALEX G , CAFFAREL SALVADOR ESTER , ROXHED NICLAS , KHANG MINSOO , BENSEL TAYLOR , DELLAL DAVID , LANGER ROBERT S
IPC分类号： A61M31/00
摘要： Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self- righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self- righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

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