专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4873249A Pharmaceutical composition 失效
标题翻译：药物组成
公开(公告)号：US4873249A
公开(公告)日：1989-10-10
申请号：US17090
申请日：1987-02-20
申请人： Lujza Petocz , Istvan Simonyi , Ivan Beck , Gabor Gigler , Marton Fekete , Eniko Kiszelly , Attila Mandi , Frigyes Gorgenyi , Andras Dietz , Katalin Sumeg nee Zukovics , Elemer Jakfalvi
发明人： Lujza Petocz , Istvan Simonyi , Ivan Beck , Gabor Gigler , Marton Fekete , Eniko Kiszelly , Attila Mandi , Frigyes Gorgenyi , Andras Dietz , Katalin Sumeg nee Zukovics , Elemer Jakfalvi
IPC分类号： C07D239/49 , A61K31/505 , A61P25/04 , A61P29/00
CPC分类号： A61K31/505 , Y10S514/825
摘要： The invention relates to pharmaceutical compositions having analgesic and/or anti-inflammatory effect comprising as active ingredient 2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine or a pharmaceutically acceptable acid addition salt thereof.The pharmaceutical compositions of the present invention exhibit the desired analgesic and anti-inflammatory effect without causing undesired ulcerogenic side-effects.
摘要翻译：本发明涉及包含作为活性成分2,4-二氨基-5-（3,4-二甲氧基 - 苄基） - 嘧啶或其药学上可接受的酸加成盐的镇痛和/或抗炎作用的药物组合物。本发明的药物组合物显示出期望的止痛和抗炎作用，而不引起不希望的溃疡发生副作用。

2. 发明授权

US4208410A Dibenzo[d,g][1,3,6]dioxazocine derivatives 失效
标题翻译：二苯并[d，g] [1,3,6]二氧杂吖庚因衍生物
公开(公告)号：US4208410A
公开(公告)日：1980-06-17
申请号：US927934
申请日：1978-07-25
申请人： Laszlo Rozsa , Lujza Petocz , Katalin Grasser , Ibolya Kosoczky , Eniko Kiszelly , Jozsef Nagy
发明人： Laszlo Rozsa , Lujza Petocz , Katalin Grasser , Ibolya Kosoczky , Eniko Kiszelly , Jozsef Nagy
IPC分类号： A61K31/553 , C07D273/00 , C07D273/01 , C07D267/22 , A61K31/395
CPC分类号： C07D273/00 , Y10S514/818
摘要： This invention relates to novel dibenzo[d,g][1,3,6]dioxazocine derivatives represented by the general formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, cyano or trifluoromethyl,Y stands for hydrogen or a group of formula ##STR2## wherein A stands for a straight or branched chained alkylene having from 2 to 5 carbon atoms andR.sub.3 and R.sub.4 independently stand for an alkyl having from 1 to 4 carbon atoms, orR.sub.3 and R.sub.4 together with the nitrogen atom they are attached to and optionally together with a further nitrogen atom or with an additional oxygen atom may form a five- or six-membered heterocyclic ring optionally substituted with an alkyl having from 1 to 4 carbon atoms,and pharmaceutically acceptable acid addition salts thereof formed with an inorganic or organic acid.The above compounds possess valuable pharmaceutical properties, for instance they are effective local anaesthetics and can be used for treating Parkinson syndrome.
摘要翻译：本发明涉及由通式I（I）表示的新的二苯并[d，g] [1,3,6]二氧杂吖庚因衍生物，其中R 1和R 2独立地表示氢，卤素，氰基或三氟甲基，Y代表氢或一组式（I）其中A代表具有2至5个碳原子的直链或支链链状亚烷基，R3和R4独立代表具有1至4个碳原子的烷基，或R3和R4与氮原子一起它们与另外的氮原子或与另外的氧原子连接并且可选地与另外的氧原子连接的原子可以形成任选被具有1至4个碳原子的烷基取代的五元或六元杂环，及其药学上可接受的酸加成盐由无机或有机酸形成。上述化合物具有有价值的药物性质，例如它们是有效的局部麻醉剂，并且可用于治疗帕金森综合征。

3. 发明授权

US4285942A Cyclododecanone oximes 失效
标题翻译：环十二酮肟
公开(公告)号：US4285942A
公开(公告)日：1981-08-25
申请号：US099507
申请日：1979-12-03
申请人： Zoltan Budai , Aranka Lay nee Konya , Tibor Mezei , Katalin Grasser , Lujza Petocz , Eniko Kiszelly , Ibolya Kosoczky
发明人： Zoltan Budai , Aranka Lay nee Konya , Tibor Mezei , Katalin Grasser , Lujza Petocz , Eniko Kiszelly , Ibolya Kosoczky
IPC分类号： A61K31/15 , A61K31/395 , A61P21/00 , A61P25/02 , C07C249/04 , C07C251/58 , C07D295/088 , C07C131/02 , A61K31/535
CPC分类号： C07D295/088
摘要： The invention relates to novel cyclododecane derivatives of the general formula ##STR1## wherein R.sup.1 and R.sup.2 represent independently from each other a hydrogen atom, a C.sub.1-6 alkyl group or a C.sub.3-8 cycloalkyl group, or R.sup.1 and R.sup.2 form together with the nitrogen atom to which they are attached a heterocyclic ring containing 4 to 7 carbon atoms and optionally a further heteroatom selected from the group consisting of oxygen, sulphur and nitrogen, said ring may be optionally substituted by a C.sub.1-3 alkyl or benzyl group; and A represents a C.sub.2-6 straight or branched alkylene chain, and optically active isomers, acid addition salts and quaternary ammonium derivatives thereof. The invention relates further to an analogous process for the preparation of said compounds, to pharmaceutical compositions containing said compounds as the active ingredient and to a process for the preparation of said pharmaceutical compositions.The cyclododecane derivatives of the invention possess valuable biological properties.
摘要翻译：本发明涉及通式为（I）的新的环十二烷衍生物，其中R 1和R 2彼此独立地表示氢原子，C 1-6烷基或C 3-8环烷基，或者R 1和R 2一起形成与它们所连接的氮原子一起含有4至7个碳原子的杂环和任选的另外的选自氧，硫和氮的杂原子，所述环可任选被C 1-3烷基或苄基取代 ; A表示C2-6直链或支链亚烷基链，以及旋光异构体，其酸加成盐和季铵衍生物。本发明进一步涉及制备所述化合物的类似方法，含有所述化合物作为活性成分的药物组合物和制备所述药物组合物的方法。本发明的环十二烷衍生物具有宝贵的生物学特性。

4. 发明授权

US4229350A Dibenzo[d,g][1,3,6]dioxazocine derivatives 失效
标题翻译：二苯并[d，g] [1,3,6]二氧杂吖庚因衍生物
公开(公告)号：US4229350A
公开(公告)日：1980-10-21
申请号：US61042
申请日：1979-07-26
申请人： Laszlo Rozsa , Lujza Petocz , Katalin Grasser , Ibolya Kosoczky , Eniko Kiszelly , Jozsef Nagy
发明人： Laszlo Rozsa , Lujza Petocz , Katalin Grasser , Ibolya Kosoczky , Eniko Kiszelly , Jozsef Nagy
IPC分类号： A61K31/553 , C07D273/00 , C07D273/01 , C07D413/06
CPC分类号： C07D273/00 , Y10S514/818
摘要： This invention relates to novel dibenzo[d,g][1,3,6]dioxazocine derivatives represented by the general formula I ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, cyano or trifluoromethyl,Y stands for hydrogen or a group of formula ##STR2## wherein A stands for a straight or branched chained alkylene having from 2 to 5 carbon atoms andR.sub.3 and R.sub.4 independently stand for an alkyl having from 1 to 4 carbon atoms, orR.sub.3 and R.sub.4 together with the nitrogen atom they are attached to and optionally together with a further nitrogen atom or with an additional oxygen atom may form a five- or six-membered heterocyclic ring optionally substituted with an alkyl having from 1 to 4 carbon atoms,and pharmaceutically acceptable acid addition salts thereof formed with an inorganic or organic acid.A process for the preparation of these compounds is also within the scope of this invention.The above compounds possess valuable pharmaceutical properties, for instance they are effective local anaesthetics and can be used for treating Parkinson syndrome.
摘要翻译：本发明涉及由通式I（I）表示的新的二苯并[d，g] [1,3,6]二氧杂吖庚因衍生物，其中R 1和R 2独立地表示氢，卤素，氰基或三氟甲基，Y代表氢或一组式（I）其中A代表具有2至5个碳原子的直链或支链链状亚烷基，R3和R4独立代表具有1至4个碳原子的烷基，或R3和R4与氮原子一起它们与另外的氮原子或与另外的氧原子连接并且可选地与另外的氧原子连接的原子可以形成任选被具有1至4个碳原子的烷基取代的五元或六元杂环，及其药学上可接受的酸加成盐由无机或有机酸形成。制备这些化合物的方法也在本发明的范围内。上述化合物具有有价值的药物性质，例如它们是有效的局部麻醉剂，并且可用于治疗帕金森综合征。

5. 发明授权

US3956312A Indazole-3-carboxylic acid hydrazides and a process for the preparation thereof 失效
标题翻译：吲唑-3-羧酸酰肼及其制备方法
公开(公告)号：US3956312A
公开(公告)日：1976-05-11
申请号：US497676
申请日：1974-08-15
申请人： Laszlo Magdanyi , Lujza Petocz , Eniko Kiszelly , Ibolya Kosoczky , Attila Varga
发明人： Laszlo Magdanyi , Lujza Petocz , Eniko Kiszelly , Ibolya Kosoczky , Attila Varga
IPC分类号： C07D231/54 , A61K31/13 , A61K31/395 , A61K31/415 , A61K31/416 , A61K31/4427 , A61K31/443 , A61K31/445 , A61P1/04 , A61P25/24 , A61P25/26 , C07D231/56 , C07D401/12 , C07D405/12
CPC分类号： C07D231/56 , A61K31/415
摘要： New compounds of the general formula (I) ##SPC1##and salts thereof were prepared by reacting a compound of the general formula (II) ##SPC2##with a compound of the general formula (III) or (IV) ##EQU1## and optionally saturating the --C=N-- bond. In the above formulaeR.sup.1 and R.sup.2 are always the same and represent a C.sub.1-4 alkyl group,R.sup.3 stands for hydrogen,R.sup.4 and R.sup.5 each represent hydrogen or a straight-chained or branched C.sub.1-16 alkyl group optionally having an unsubstituted or substituted phenyl, furyl or naphthyl substituent, wherein said substituted aryl groups may contain up to 3 alkyl, C.sub.1-3 alkoxy, benzyloxy, nitro, amino, lower alkylamino, di-lower alkylamino, methylenedioxy, alkylmercapto, alkylsulfonyl or halogen substituents, orR.sup.4 and R.sup.5 may form together with the adjacent carbon atom a C.sub.3-12 cycloalkyl or C.sub.3-12 cycloalkylidene group, one of the methylene ring members of which being optionally replaced by an imino, lower alkylimino, or phenyl-lower alkylimino group, andR.sup.6 and R.sup.7 may stand for hydrogen, or R.sup.6 and R.sup.7 may form together a valence bond, andThe R.sup.8 groups may each represent hydrogen, lower alkyl or alkanoyl, or the two R.sup.8 groups may form together a lower alkylene or alkanoylene group.The compounds of the general formula (I) possess primarily gastric acid secretion inhibiting and central nervous activities, furthermore they exert favourable action on the development of certain microorganisms which can be utilized in therapy.
摘要翻译：通式（I）的新化合物及其盐通过使通式（II）的化合物与通式（III）或（IV）的化合物反应，R 5 = C（R）R 8 R 5 R 5 （IV）R8OR4并且任选地饱和-C = N-键。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式