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1. 发明授权

US08008326B2 4-benzyledene-piperidin derivatives 失效
标题翻译： 4-苄基芘 - 哌啶衍生物
公开(公告)号：US08008326B2
公开(公告)日：2011-08-30
申请号：US11658789
申请日：2005-07-21
申请人： Istvan Borza , Csilla Horvath , Sandor Farkas , Istvan Gyertyan , Jozsef Nagy , Sandor Kolok , Kornel Galgoczy , Katalin Saghy
发明人： Istvan Borza , Csilla Horvath , Sandor Farkas , Istvan Gyertyan , Jozsef Nagy , Sandor Kolok , Kornel Galgoczy , Katalin Saghy
IPC分类号： A61K31/445 , C07D401/12 , C07D413/12 , C07D417/12
CPC分类号： C07D417/12 , C07D401/12 , C07D413/12
摘要： The present invention relates to new 4-benzylidene-piperidin derivatives of formula (I), useful as NMDA, in a particular NR2B subunit containing receptor antagonists and analgesica.
摘要翻译：本发明涉及用作NMDA的式（I）的新的4-亚苄基 - 哌啶衍生物，其在含有受体拮抗剂和镇痛药的特定NR2B亚单位中。

2. 发明授权

US07365083B2 Amide derivatives as NMDA receptor antagonists 失效
标题翻译：酰胺衍生物作为NMDA受体拮抗剂
公开(公告)号：US07365083B2
公开(公告)日：2008-04-29
申请号：US11024638
申请日：2004-12-28
申请人： Csilla Horvath , Sandor Farkas , György Domany , Istvan Borza , Gizella Bartane Szalai , Jozsef Nagy , Sandor Kolok
发明人： Csilla Horvath , Sandor Farkas , György Domany , Istvan Borza , Gizella Bartane Szalai , Jozsef Nagy , Sandor Kolok
IPC分类号： A61K31/445 , C07D401/06
CPC分类号： C07D401/06 , A61K31/404 , A61K31/445 , A61K31/4523 , C07D209/42 , C07D211/16 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/06 , C07D487/04
摘要： Compounds having NR2B selective NMDA receptor antagonist activity are disclosed of the formula (I) wherein two of the neighboring R1, R2, R3 and R4 groups form an oxo-oxazolidine ring fused to the benzene ring of the indole nucleus, and the other two of R1, R2, R3 and R4 groups are hydrogen atoms, R5 and R6 together with the nitrogen between them form a saturated or unsaturated, 4-6 membered heterocyclic ring, which is substituted by phenoxy, phenyl-(C1-C4 alkyl), phenyl-(C1-C4 alkoxy), phenoxy-(C1-C4 alkyl), or benzoyl, optionally substituted on the aromatic ring by one or more halogen atoms, cyano or hydroxy groups, C1-C4 alkyl or C1-C4 alkoxy groups, X is NH—, Y is a —CH— group, or pharmaceutically acceptable salts thereof formed with acids or bases.
摘要翻译：具有NR2B选择性NMDA受体拮抗剂活性的化合物公开于式（I）中，其中相邻的R 1，R 2，R 3， R 4和R 4组合形成与吲哚核的苯环稠合的氧代 - 恶唑烷环，另外两个R 1，R 2， >，R 3和R 4基团是氢原子，R 5和R 6以及R 6之间的氮在它们形成饱和或不饱和的4-6元杂环，其被苯氧基，苯基 - （C 1 -C 4 -C 4烷基），苯基 - （C 1 -C 6）苯氧基 - （C 1 -C 4烷基）或苯甲酰基，任选取代的（C 1 -C 4）烷氧基），苯氧基 - （C 1 -C 4烷基）在一个或多个卤素原子的芳环上，氰基或羟基，C 1 -C 4烷基或C 1 -C 3 > 4个烷氧基，X是NH-，Y是-CH-基或其与酸或碱形成的药学上可接受的盐。

3. 发明申请

US20050159451A1 Amide derivatives as NMDA receptor antagonists 失效
标题翻译：酰胺衍生物作为NMDA受体拮抗剂
公开(公告)号：US20050159451A1
公开(公告)日：2005-07-21
申请号：US11025287
申请日：2004-12-29
申请人： Csilla Horvath , Sandor Farkas , Gyorgy Domany , Istvan Borza , Gizella Szalai , Jozsef Nagy , Sandor Kolok
发明人： Csilla Horvath , Sandor Farkas , Gyorgy Domany , Istvan Borza , Gizella Szalai , Jozsef Nagy , Sandor Kolok
IPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , A61K31/445 , A61K31/4523 , A61K31/454 , A61P3/08 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/10 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/10 , A61P31/12 , A61P43/00 , C07D209/42 , C07D211/16 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/06 , C07D487/04 , C07D498/04
CPC分类号： C07D401/06 , A61K31/404 , A61K31/445 , A61K31/4523 , C07D209/42 , C07D211/16 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/06 , C07D487/04
摘要： Compounds having NR2B selective NMDA receptor antagonist activity are disclosed of the formula (I) where two of the neighboring R1, R2, R3 and R4 groups form an imidazole ring fused to the benzene ring of the indole nucleus, and the other two of R1, R2, R3 and R4 groups are hydrogen atoms, R5 and R6 together with the nitrogen between them form a saturated or unsaturated, 4-6 membered heterocyclic ring, which is substituted by phenoxy, phenyl-(C1-C4 alkyl), phenyl-(C1-C4 alkoxy), phenoxy-(C1-C4 alkyl), or benzoyl, optionally substituted on the aromatic ring by one or more halogen atoms, cyano or hydroxy groups, C1-C4 alkyl or C1-C4 alkoxy groups, X is NH—, Y is a —CH— group, or pharmaceutically acceptable salts thereof formed with acids or bases.
摘要翻译：公开了具有NR2B选择性NMDA受体拮抗剂活性的化合物，其中相邻的R 1，R 2，R 3， R 4和R 4组合形成与吲哚核的苯环稠合的咪唑环，另外两个R 1，R 2， R 3和R 4基团是氢原子，R 5和R 6和它们之间的氮原子一起形成被苯氧基，苯基 - （C 1 -C 4烷基），苯基 - （C 1 -C 4）烷基取代的饱和或不饱和的4-6元杂环， C 1 -C 4烷氧基），苯氧基 - （C 1 -C 4 -C 4烷基）或苯甲酰基，任选在一个或多个卤素原子的芳香环，氰基或羟基，C 1 -C 4 -C 4烷基或C 1 -C 4 烷氧基，X是NH-，Y是-CH-基或其与酸或碱形成的药学上可接受的盐。

4. 发明授权

US06919355B2 Amide derivatives as NMDA receptor antagonists 失效
公开(公告)号：US06919355B2
公开(公告)日：2005-07-19
申请号：US10412977
申请日：2003-04-11
申请人： Csilla Horvath , Sandor Farkas , György Domany , Istvan Borza , Gizella Bartane Szalai , Jozsef Nagy , Sandor Kolok
发明人： Csilla Horvath , Sandor Farkas , György Domany , Istvan Borza , Gizella Bartane Szalai , Jozsef Nagy , Sandor Kolok
IPC分类号： A61K31/404 , A61K31/405 , A61K31/4439 , A61K31/445 , A61K31/4523 , A61K31/454 , A61P3/08 , A61P9/00 , A61P9/10 , A61P11/06 , A61P13/10 , A61P21/02 , A61P21/04 , A61P25/00 , A61P25/02 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P27/02 , A61P27/16 , A61P29/00 , A61P31/10 , A61P31/12 , A61P43/00 , C07D209/42 , C07D211/16 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/06 , C07D487/04 , C07D498/04
CPC分类号： C07D401/06 , A61K31/404 , A61K31/445 , A61K31/4523 , C07D209/42 , C07D211/16 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/06 , C07D487/04
摘要： New Formula (I) compounds are disclosed having NR2B selective NMDA receptor antagonist activity: wherein one of the neighboring R1, R2, R3 and R4 groups is OH or NH2 and the others are each hydrogen , or two of the neighboring R1, R2 R3 and R4 groups in given case together with one or more identical or different additional hetero atom and —CH═ and/or —CH2— groups forms a 5-6 membered homo- or heterocyclic ring, preferably pyrrole, pyrazole, imidazole, oxazole, oxo-oxazolidine, or 3-oxo-1,4-oxazine ring, and the other two of R1, R2, R3 and R4 groups are hydrogen atoms, R5 and R6 together with the nitrogen between them form a saturated or unsaturated, 4-6 membered heterocyclic ring, which is substituted by hydroxy group, and/or in given case phenyl or phenoxy, phenyl-(C1-C4 alkyl), phenyl-(C1-C4 alkoxy), phenoxy-(C1-C4 alkyl), anilino, phenyl-(C1-C4 alkylamino), [phenyl-(C1-C4 alkyl)]-amino, benzoyl, hydroxy-diphenylmethyl, C1-C4 alkoxycarbonyl-phenoxymethyl or benzhydrylidene group, optionally substituted on the aromatic ring by one or more halogen atom, cyano or hydroxy group, C1-C4 alkyl or C1-C4 alkoxy group, X is independently oxygen, —NH— or a CH2 group, Y is independently a nitrogen atom or a —CH— group, and the salts thereof formed with acids and bases.

5. 发明授权

US4670429A Synergistic fungicidal compositions 失效
标题翻译：协同杀菌组合物
公开(公告)号：US4670429A
公开(公告)日：1987-06-02
申请号：US633380
申请日：1984-07-23
申请人： Zsolt Dombay , Erzsebet Grega nee Toth , Jozsef Nagy , Csaba Pavliscsak , Laszlo Tasi , Andras Toth , Oszkar Toth , Judit Vitanyi , Ferenc Bihari , Peter Bohus , Peter Inczedy , Istvan Magyari , Marianna Kertesz nee Szabo , Laszlo Wohl , Attila Ferenczi
发明人： Zsolt Dombay , Erzsebet Grega nee Toth , Jozsef Nagy , Csaba Pavliscsak , Laszlo Tasi , Andras Toth , Oszkar Toth , Judit Vitanyi , Ferenc Bihari , Peter Bohus , Peter Inczedy , Istvan Magyari , Marianna Kertesz nee Szabo , Laszlo Wohl , Attila Ferenczi
IPC分类号： A01N43/42 , A01N47/10 , A01N47/14 , A01P3/00 , A01N55/02 , A01N43/32
CPC分类号： A01N43/42 , A01N47/14
摘要： The invention relates to a synergistic fungicidal composition containing more active ingredients comprising 2,3-dihydroxy-6-methyl-5-phenylcarbamoyl-1,4-oxathiine or 2.3-dihydro-6-methyl-5-phenylcarbamoyl-1,4-oxathiine-4,4-dioxide and the zinc and manganese complexes of (8-oxyquinolinate)-(dimethyl dithiocarbamate) as active ingredients, optionally solid and/or liquid carriers and other excipients. The compositions is of value especially in the treatment of infections caused by ustilaginales and yellow rust on cereals.
摘要翻译：本发明涉及包含更多活性成分的协同杀真菌组合物，其包含2,3-二羟基-6-甲基-5-苯基氨基甲酰基-1,4-氧硫杂环丁烷或2,3-二氢-6-甲基-5-苯基氨基甲酰基-1,4-氧硫杂（8-羟基喹啉酸盐） - （二甲基二硫代氨基甲酸盐）作为活性成分的锌和锰络合物，任选的固体和/或液体载体和其它赋形剂。该组合物特别值得用于治疗谷物上的茜草和黄锈引起的感染。

6. 发明授权

US4488901A Compositions for increasing the cold resistance of cultivated plants and a method for the utilization of such compositions 失效
标题翻译：用于增加栽培植物的耐寒性的组合物和利用这种组合物的方法
公开(公告)号：US4488901A
公开(公告)日：1984-12-18
申请号：US331921
申请日：1981-12-17
申请人： Tibor Farkas , Ibolya Horvath , Laszlo I. Horvath , Laszlo Vigh , Zsolt Dombay , Jozsef Nagy , Emilia Nagy nee Gera , Csaba Pavliscsak , Gyula Tarpai
发明人： Tibor Farkas , Ibolya Horvath , Laszlo I. Horvath , Laszlo Vigh , Zsolt Dombay , Jozsef Nagy , Emilia Nagy nee Gera , Csaba Pavliscsak , Gyula Tarpai
IPC分类号： A01N25/30 , A01N33/04 , A01N33/08 , A01N33/12 , A01P21/00 , A01N33/02
CPC分类号： A01N33/08 , A01N33/12
摘要： The invention relates to new compositions for increasing the cold resistance of cultivated plants. These compositions contain as active ingredient at least one compound of the general formula (I), ##STR1## wherein n is an integer of 2 to 5 and R.sub.1, R.sub.2 and R.sub.3 each stand for hydrogen or C.sub.1-5 alkyl, or an acid addition salt thereof in an amount of 0.01 to 70% by weight, together with a conventional diluent and/or additive.The plants treated with the compositions according to the invention are more resistant to cold and frost.
摘要翻译：本发明涉及用于增加栽培植物耐寒性的新组合物。这些组合物含有至少一种通式（I）的化合物，其中n为2〜5的整数，R 1，R 2和R 3各自代表氢或C 1-5烷基，或其酸加成盐的量与常规的稀释剂和/或添加剂一起为0.01〜70重量％。用根据本发明的组合物处理的植物更耐寒和霜。

7. 发明授权

US3960630A process and apparatus for the production of wound sandwich structures 失效
标题翻译：用于生产伤口夹心结构的方法和设备
公开(公告)号：US3960630A
公开(公告)日：1976-06-01
申请号：US490884
申请日：1974-07-22
申请人： Zsuzsa Pataki, nee Nagy , Ferenc Windisch , Jozsef Nagy , Geza Kecskemethy , Gyorgy Virag
发明人： Zsuzsa Pataki, nee Nagy , Ferenc Windisch , Jozsef Nagy , Geza Kecskemethy , Gyorgy Virag
IPC分类号： B29C53/44 , B29C41/22 , B29C53/60 , B29L22/00 , B65H81/00 , B31C9/00
CPC分类号： B29C53/60
摘要： The invention relates to a process and an apparatus for the production of wound sandwich structures, wherein the inner shell, made of a galss-reinforced plastic, is prepared in a known way, then solid core elements are wound onto the inner shell, and finally an outer shell, made of a glass-reinforced plastic, is formed on the wound core. Thus rigid articles (e.g. containers), consisting of inner and outer shells of glass-reinforced plastic and a core of wound core elements, are obtained. The core elements are wound up by forwarding the individual elements directly one after another onto a thread which carries the core elements, presses them onto the rotating mandrel, and is also wound up, or by forming a flexible band by adhesion, from the core elements and the carrier thread or band, and this flexible band is wound up. The inner and outer shells, and the surface of the core material are prepared preferably on a conventional winding machine, provided with auxiliary equipments according to the invention.The wound sandwich structures prepared according to the invention are several times higher in mechanical strength than the articles made by the known techniques.
摘要翻译：本发明涉及一种用于生产缠绕夹层结构的方法和设备，其中由已知方式制备由加强筋塑料制成的内壳，然后将固体芯元件缠绕到内壳上，最后在卷绕的芯上形成由玻璃增强塑料制成的外壳。因此，获得由玻璃增强塑料的内外壳和卷绕的芯元件的芯组成的刚性制品（例如容器）。通过将各个元件一个接一个地直接运送到承载芯元件的线上，将它们压入旋转心轴上，并且还通过粘附形成柔性带，从芯元件和载体线或带，并且该柔性带被卷起。内外壳和芯材的表面优选在具有根据本发明的辅助设备的常规绕线机上制备。

8. 发明申请

US20090205356A1 Cabinet refrigerating system 有权
标题翻译：橱柜制冷系统
公开(公告)号：US20090205356A1
公开(公告)日：2009-08-20
申请号：US10562750
申请日：2004-07-01
申请人： Martin Collins , Jack Bailey , Jozsef Nagy , Dan Joslin
发明人： Martin Collins , Jack Bailey , Jozsef Nagy , Dan Joslin
IPC分类号： F25D17/06 , F25D11/02 , F25D23/02 , F25B39/02
CPC分类号： F25D17/062 , F25C1/24 , F25D17/067 , F25D21/08 , F25D21/14 , F25D23/026 , F25D2303/0822 , F25D2303/08222 , F25D2317/062 , F25D2317/0651 , F25D2317/0664 , F25D2317/0665 , F25D2317/067 , F25D2317/0672 , F25D2400/10
摘要： The present invention relates to a refrigerated air supply system (21) for a freezer and/or refrigerator cabinet having at least one cabinet compartment (17) at least partly defined by inner walls (16), an insulation layer at least partly enclosing said cabinet compartment. Said cabinet compartment (17) has an compartment opening facing substantially upwards, which compartment opening connects said cabinet compartment (17) with the space surrounding said cabinet, said cabinet also comprising, a door which in one position covers said compartment opening and substantially encloses said cabinet compartment (17). The cabinet further comprises a machine compartment (23) for storing at least a compressor, at least one of said inner walls (16) having a substantially horizontal shelf plane (52) where at least one off the planes (52) is being positioned vertically above said machine compartment (23). The refrigerated air supply system (21) of the present invention is positioned inside at least one of said cabinet compartments, the system comprising at least one evaporator (26), at least one return ducting part and at least one fan (28). Said refrigerated air supply system (21) further comprises at least one air supply outlet which provides an airflow (47) into at least one of said cabinet compartments (17) and at least one air supply inlet which brings an airflow (50) out from at least one of said cabinet compartments (17).
摘要翻译：本发明涉及一种用于冷冻和/或冰箱柜的冷藏空气供应系统（21），其具有至少部分地由内壁（16）限定的至少一个柜室（17），绝缘层至少部分地包围所述柜隔间所述柜室（17）具有面向大致向上的隔室开口，所述隔室开口将所述柜室（17）与围绕所述柜的空间连接，所述柜还包括门，所述门在一个位置上覆盖所述隔间开口并且基本上包围所述柜室（17）。所述柜还包括用于至少存储压缩机的机舱（23），所述内壁（16）中的至少一个具有基本水平的搁架平面（52），其中所述平面（52）中的至少一个垂直地定位在机舱（23）的上方。本发明的冷藏空气供应系统（21）位于至少一个所述柜室内，所述系统包括至少一个蒸发器（26），至少一个返回管道部分和至少一个风扇（28）。所述冷藏空气供应系统（21）还包括至少一个空气供应出口，其向至少一个所述柜室（17）和至少一个空气供应入口提供气流（47），所述至少一个供气入口将气流（50）从至少一个所述柜室（17）。

9. 发明申请

US20090048303A1 Indole-2-carboxamidine derivatives as nmda receptor antago 审中-公开
标题翻译：吲哚-2-甲脒衍生物作为nmda受体拮抗剂
公开(公告)号：US20090048303A1
公开(公告)日：2009-02-19
申请号：US11658787
申请日：2005-07-21
申请人： Istvan Borza , Csilla Horvath , Sandor Farkas , Jozsef Nagy , Sandor Kolok
发明人： Istvan Borza , Csilla Horvath , Sandor Farkas , Jozsef Nagy , Sandor Kolok
IPC分类号： A61K31/4439 , C07D209/14 , A61K31/404 , C07D401/02
CPC分类号： C07D401/12 , C07D209/42 , C07D405/12
摘要： The present invention relates therefore first to new indole-2-carboxamidine derivatives of formula (I)—wherein the meaning of X is hydrogen or halogen atom, C1-C4 alkyl, C1-C4 alkoxy, trifluoromethyl group, Y, V and Z independently are hydrogen or halogen atom, hydroxy, cyano, C1-C4 alkylsulfonamido optionally substituted by a halogen atom or halogen atoms, C1-C4 alkanoylamido optionally substituted by a halogen atom or halogen atoms, trifluoromethyl, trifluoromethoxy, C1-C4 alkyl, C1-C4 alkoxy group, or the neighboring V and Z groups in given case together with one or more identical or different additional hetero atom and —CH═ and/or —CH2— groups can form an optionally substituted 4-7 membered homo- or heterocyclic ring, preferably benzene, dioxolane ring, A, B and C independently are substituted carbon atom or one of them is nitrogen atom, and the salts thereof. Further objects of the invention are the processes for producing indole-2-carboxamidine derivatives of formula (I), and the pharmaceutical manufacture of medicaments containing these compounds, as well as the process of treatments with these compounds, which means administering to a mammal to be treated—including human—effective amount/amounts of indole-2-carboxamidine derivatives of formula (I) of the present invention as such or as medicament. The new indole-2-carboxamidine derivatives of formula (I) of the present invention are highly effective and selective antagonists of NMDA receptor, and moreover most of the compounds are selective antagonist of NR2B subtype of NMDA receptor.
摘要翻译：因此，本发明首先涉及式（I）的新的吲哚-2-甲脒衍生物，其中X的含义是氢或卤素原子，C1-C4烷基，C1-C4烷氧基，三氟甲基，Y，V和Z独立地任选被卤素原子或卤原子取代的C 1 -C 4烷酰基氨基酰胺，任选被卤素原子或卤原子取代的C 1 -C 4烷酰胺基，三氟甲基，三氟甲氧基，C 1 -C 4烷基，C 1 -C 4 烷氧基或相邻的V和Z基团与一个或多个相同或不同的另外的杂原子和-CH-和/或-CH 2 - 基团可以形成任选取代的4-7元均 - 或杂环，优选苯，二氧戊环，A，B和C独立地是取代的碳原子或其中一个是氮原子，及其盐。本发明的另外的目的是制备式（I）的吲哚-2-甲脒衍生物和含有这些化合物的药物的药物制备方法以及用这些化合物处理的方法，这意味着给哺乳动物施用包括人的有效量/本发明式（I）的吲哚-2-甲脒衍生物的量或作为药物。本发明式（I）的新的吲哚-2-甲脒衍生物是NMDA受体的高效和选择性拮抗剂，而且大多数化合物是NMDA受体NR2B亚型的选择性拮抗剂。

10. 发明授权

US07378431B2 Amide derivatives as NMDA receptor antagonists 失效
标题翻译：酰胺衍生物作为NMDA受体拮抗剂
公开(公告)号：US07378431B2
公开(公告)日：2008-05-27
申请号：US11025288
申请日：2004-12-29
申请人： Csilla Horvath , Sandor Farkas , György Domany , Istvan Borza , Gizella Bartane Szalai , Jozsef Nagy , Sandor Kolok
发明人： Csilla Horvath , Sandor Farkas , György Domany , Istvan Borza , Gizella Bartane Szalai , Jozsef Nagy , Sandor Kolok
IPC分类号： A61K31/445 , C07D401/06
CPC分类号： C07D401/06 , A61K31/404 , A61K31/445 , A61K31/4523 , C07D209/42 , C07D211/16 , C07D403/06 , C07D405/06 , C07D409/06 , C07D417/06 , C07D487/04
摘要： Compounds having NR2B selective NMDA receptor antagonist activity are disclosed of the formula (I) wherein one of the neighboring R1, R2, R3 and R4 groups is hydroxy, and the others are each hydrogen atoms, R5 and R6 together with the nitrogen between them form a saturated or unsaturated, 4-6 membered heterocyclic ring, which is substituted by phenoxy, phenyl-(C1-C4 alkyl), phenyl-(C1-C4 alkoxy), phenoxy-(C1-C4 alkyl), or benzoyl, optionally substituted on the aromatic ring by one or more halogen atoms, cyano or hydroxy groups, C1-C4 alkyl or C1-C4 alkoxy groups, X is NH—, Y is a nitrogen atom, or pharmaceutically acceptable salts thereof formed with acids or bases.
摘要翻译：具有NR2B选择性NMDA受体拮抗剂活性的化合物公开于式（I）中，其中相邻的R 1，R 2，R 3， R 4和R 4各自为羟基，其余各为氢原子，R 5和R 6与它们之间的氮一起形成饱和的或被苯氧基，苯基 - （C 1 -C 4烷基），苯基 - （C 1 -C 4烷基）取代的不饱和的4-6元杂环， / C 1 -C 4烷氧基），苯氧基 - （C 1 -C 4 -C 4烷基）或任选在芳环上被取代的苯甲酰基一个或多个卤素原子，氰基或羟基，C 1 -C 4 -C 4烷基或C 1 -C 4 - N是NH-，Y是氮原子，或其与酸或碱形成的药学上可接受的盐。

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