专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4382940A Ercoline derivatives and therapeutic compositions having CNS affecting activity 失效
标题翻译：具有CNS影响活性的Ercoline衍生物和治疗组合物
公开(公告)号：US4382940A
公开(公告)日：1983-05-10
申请号：US211920
申请日：1980-12-01
申请人： Luigi Bernardi , Germano Bosisio , Sergio Mantegani , Alessandro Rossi , Aldemio Temperilli
发明人： Luigi Bernardi , Germano Bosisio , Sergio Mantegani , Alessandro Rossi , Aldemio Temperilli
IPC分类号： A61K31/48 , A61P9/12 , A61P25/20 , A61P25/24 , A61P25/26 , C07D457/02 , A61K31/55
CPC分类号： C07D457/02
摘要： Compounds are disclosed of formula (I) ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group; R.sub.2 represents a hydrogen atom or a methoxy group;X represents an oxygen or sulphur atom or an NH or NCH.sub.3 group;R.sub.3 represents a hydrogen atom, a trifluoromethyl or phenyl group or a hydrocarbon group having from 1 to 4 carbon atoms;R.sub.4 represents a hydrogen atom, a methyl or acetyl group or a hydrocarbon having from 1 to 4 carbon atoms, or R.sub.3 and R.sub.4 together represent a 3- or 4-membered carbon atom chain;Y represents an electron-withdrawing group such as a cyano, nitro, alkylsulphonyl or alkylsulprinyl group or a group of the formula COR.sub.5 wherein R.sub.5 represents an alkyl group having from 1 to 4 carbon atoms or a phenyl, alkoxy, amino or N-substituted amino group or R.sub.5 and R.sub.3 together represent a 2- or 3-membered carbon atom chain;R.sub.6 represents a hydrocarbon group having from 1 to 4 carbon atoms or a benzyl or phenethyl group; andR.sub.7 represents a hydrogen or halogen atom or a methyl or formyl group or a group of the formula SR.sub.8 wherein R.sub.8 represents a hydrocarbon group having from 1 to 4 carbon atoms or a phenyl group;and the pharmaceutically acceptable addition salts with organic or inorganic acids thereof. A process for producing these compounds is also disclosed.These compounds are useful antidepressant, anxiolytic and neuroleptic agents. They also display from moderate to good antiprolactinic and antihypertensive activity.
摘要翻译：公开了式（I）的化合物：其中R 1表示氢原子或甲基; R2表示氢原子或甲氧基; X表示氧或硫原子或NH或NCH 3基团; R3表示氢原子，三氟甲基或苯基或具有1至4个碳原子的烃基; R4表示氢原子，甲基或乙酰基或具有1至4个碳原子的烃，或R3和R4一起表示3-或4-元碳原子链; Y表示吸电子基团，例如氰基，硝基，烷基磺酰基或烷基磺基，或式COR5的基团，其中R5表示具有1至4个碳原子的烷基或苯基，烷氧基，氨基或N-取代的氨基基团或R 5和R 3一起表示2-或3-元碳原子链; R6表示具有1至4个碳原子的烃基或苄基或苯乙基; 并且R 7表示氢或卤素原子或甲基或甲酰基或式SR 8的基团，其中R 8表示具有1至4个碳原子的烃基或苯基; 和其药学上可接受的加成盐与其有机酸或无机酸。还公开了制备这些化合物的方法。这些化合物是有用的抗抑郁药，抗焦虑剂和抗精神病药。它们还显示从中度到良好的促乳素和抗高血压活性。

2. 发明授权

US4675404A 8-pyridazinylcarbamoyl ergolines 失效
标题翻译： 8-哒嗪基氨基甲酰基麦角碱
公开(公告)号：US4675404A
公开(公告)日：1987-06-23
申请号：US885315
申请日：1986-07-14
申请人： Luigi Bernardi , Aldemio Temperilli , Germano Bosisio , Gabriella Traquandi , Rosanna Eccel , Alessandro Rossi , Patricia Salvati
发明人： Luigi Bernardi , Aldemio Temperilli , Germano Bosisio , Gabriella Traquandi , Rosanna Eccel , Alessandro Rossi , Patricia Salvati
IPC分类号： C07D457/02 , C07D457/06 , A61K31/48
CPC分类号： C07D457/06 , C07D457/02
摘要： Ergoline derivatives of formula: ##STR1## wherein n=0,1,2; R.sub.1 =H, CH.sub.3 ; R.sub.2 =H, CH.sub.3, halogen; R.sub.3 =H, OCH.sub.3 ; R.sub.4 =hydrocarbon group and R.sub.5 is a residue of general formula II, III, IV, V, VI, VII: ##STR2## wherein R.sub.6 =H, Cl, OCH.sub.3, NR.sub.11 R.sub.12, wherein R.sub.11 and R.sub.12 =H, lower alkyl; phenyl or are bonded together to form a heterocyclic ring, R.sub.7, R.sub.8 and R.sub.9 and R.sub.10 =H or C.sub.1 -C.sub.3 alkyl, with the proviso that if R.sub.5 is of formula II and R.sub.2 =R.sub.7 =R.sub.8 =H, then R.sub.4 is not methyl or n is not 0.Pharmaceutically acceptable acid addition salts are also provided. A method for their preparation is also provided.The compounds have anti-depressive, anti-hypertensive and antiprolactin activity.
摘要翻译：式：其中n = 0,1,2; R1 = H，CH3; R2 = H，CH3，卤素; R3 = H，OCH3; R4 =烃基，R5是通式Ⅱ，Ⅲ，Ⅳ，Ⅴ，Ⅵ，Ⅶ的残基：其中R6 = H，Cl，OCH3，NR11R12，其中R11和R12 = H，低级烷基; 苯基或键合在一起形成杂环，R 7，R 8和R 9和R 10 = H或C 1 -C 3烷基，条件是如果R 5为式II且R 2 = R 7 = R 8 = H，则R 4不是甲基或n不为0.还提供药学上可接受的酸加成盐。还提供了它们的制备方法。该化合物具有抗抑郁，抗高血压和抗催乳素活性。

3. 发明授权

US4746666A Ergoline compounds useful as antiparkinson agents 失效
标题翻译：可用作抗帕金森病药物的魔芋醇化合物
公开(公告)号：US4746666A
公开(公告)日：1988-05-24
申请号：US874413
申请日：1986-06-16
申请人： Luigi Bernardi , Sergio Mantegani , Aldemio Temperilli , Gabriella Traquandi , Alessandro Rossi
发明人： Luigi Bernardi , Sergio Mantegani , Aldemio Temperilli , Gabriella Traquandi , Alessandro Rossi
IPC分类号： A61K31/48 , A61K31/50 , A61K31/505 , A61P25/00 , C07D457/02 , C07D457/04
CPC分类号： C07D457/02
摘要： Ergoline derivatives of the formula I ##STR1## wherein R.sub.1 =H,CH.sub.3 ; R.sub.2 =H, halogen, CH.sub.3, CN, C.sub.1 -C.sub.4 alkylthio or phenylthio; R.sub.3 =C.sub.1 -C.sub.4 hydrocarbon; R.sub.4 =H, OCH.sub.3 ; R.sub.5 =H and R.sub.6 =--CH.dbd.CH--CONHR.sub.7 or R.sub.5 and R.sub.6 =.dbd.CH--CONHR.sub.7 ; R.sub.7 =2-thiazolyl, 3-pyridazinyl, 1,3,4-thiadiazol-2-yl or 4-pyrimidinyl group optionally substituted, and pharmaceutically acceptable salts thereof, display activity on the Central Nervous System and are useful as antiprolactinic agents. Their preparation and pharmaceutical compositions containing them are also described.
摘要翻译：式I的吡咯啉衍生物其中R 1 = H，CH 3; R2 = H，卤素，CH3，CN，C1-C4烷硫基或苯硫基; R3 = C1-C4烃; R4 = H，OCH3; R5 = H，R6 = -CH = CH-CONHR7或R5和R6 = CH-CONHR7; R7 = 2-噻唑基，3-哒嗪基，1,3,4-噻二唑-2-基或任选取代的4-嘧啶基及其药学上可接受的盐，在中枢神经系统上显示活性，并且可用作抗孕激素。还描述了它们的制备方法和含有它们的药物组合物。

4. 发明授权

US4839363A Ergolinyl heterocycles for the treatment of Parkinson's disease and dyskinetic symptoms 失效
标题翻译：用于治疗帕金森氏病和运动障碍症状的二元杂环化合物
公开(公告)号：US4839363A
公开(公告)日：1989-06-13
申请号：US149012
申请日：1988-01-27
申请人： Enzo Brambilla , Sergio Mantegani , Lorenzo Pegrassi , Alessandro Rossi , Aldemio Temperilli
发明人： Enzo Brambilla , Sergio Mantegani , Lorenzo Pegrassi , Alessandro Rossi , Aldemio Temperilli
IPC分类号： A61K31/48 , A61P25/00 , C07D457/00 , C07D457/02
CPC分类号： C07D457/00 , C07D457/02
摘要： Ergoline derivatives of the formula I ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group; R.sub.2 represents a hydrogen atom or a methoxy group;R.sub.3 represents a hydrocarbon group having from 1 to 4 carbon atoms;X represents a nitrogen atom and Y represents an oxygen atom, a ##STR2## group wherein R.sub.4 represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl or a phenyl group, R.sub.5 represents a hydrogen atom, a C.sub.1 -C.sub.4 alkyl, a phenyl, an amino or di(C.sub.1 -C.sub.4 alkyl)amino group and the nitrogen atom of the group ##STR3## is not joined to the nitrogen atom represented by X, or Y represents a nitrogen atom and X represents an oxygen atom or a ##STR4## group wherein R.sub.4 is as above defined; and the pharmaceutically acceptable salt thereof; are useful for treatment of Parkinsonism and dyskinetic symptoms.

5. 发明授权

US4728649A 3-oxo-piperazin-1-yl-ergolines exhibiting antidopaminergic activity 失效
标题翻译：具有抗癌剂活性的3-氧代 - 哌嗪-1-基 - 麦角酰胺
公开(公告)号：US4728649A
公开(公告)日：1988-03-01
申请号：US817135
申请日：1986-01-08
申请人： Sergio Mantegani , Aldemio Temperilli , Gabriella Traquandi , Alessandro Rossi , Lorenzo Pegrassi
发明人： Sergio Mantegani , Aldemio Temperilli , Gabriella Traquandi , Alessandro Rossi , Lorenzo Pegrassi
IPC分类号： A61K31/48 , A61P9/12 , A61P25/00 , A61P25/20 , C07D457/02 , C07D457/12 , A61K31/445
CPC分类号： C07D457/02
摘要： The invention relates to ergoline derivatives having the general formula (I): ##STR1## where R=H, CH.sub.3 ; R.sub.1 =H, halogen, CH.sub.3, phenylthio, C.sub.1 -C.sub.4 alkylthio; R.sub.2 =H, CH.sub.3 O, and R.sub.3 =H or R.sub.2 +R.sub.3 =chemical bond; R.sub.4 =C.sub.1 -C.sub.4 hydrocarbon; R.sub.5, R.sub.6, R.sub.8, R.sub.9 independently=H, C.sub.1 -C.sub.4 alkyl, or R.sub.5, R.sub.8 independently=H, C.sub.1 -C.sub.4 alkyl and R.sub.6 +R.sub.9 =CH.sub.2 CH.sub.2, CH.sub.2 CH.sub.2 CH.sub.2 ; R.sub.7 =H, C.sub.1 -C.sub.4 alkyl, phenyl, NR'R"; R',R" independently=H, C.sub.1 -C.sub.4 alkyl, acyl or NR'R"=heterocyclic ring; W=0, H.sub.2 ; n=0, 1, 2, and their pharmaceutically acceptable salts, these compounds exhibiting antihypertensive activity making them useful anxiolytic and antipsychotic agents. A process for their preparation and pharmaceutical compositions containing them are also described.
摘要翻译：本发明涉及具有通式（I）的麦角灵衍生物：其中R = H，CH 3; R1 = H，卤素，CH3，苯硫基，C1-C4烷硫基; R2 = H，CH3O，R3 = H或R2 + R3 =化学键; R4 = C1-C4烃; R5，R6，R8，R9独立地为H，C1-C4烷基或R5，R8独立地为H，C1-C4烷基和R6 + R9 = CH2CH2，CH2CH2CH2; R7 = H，C1-C4烷基，苯基，NR'R“ R'，R“独立地为H，C 1 -C 4烷基，酰基或NR'R”=杂环; W = 0，H2; n = 0,1,2及其药学上可接受的盐，这些具有抗高血压活性的化合物使它们成为抗焦虑药和抗精神病药。还描述了其制备方法和含有它们的药物组合物。

6. 发明授权

US4847253A Antiparkinson ergoline derivatives 失效
标题翻译：抗帕金森麦角因衍生物
公开(公告)号：US4847253A
公开(公告)日：1989-07-11
申请号：US273021
申请日：1988-11-18
申请人： Metilde Buonamici , Lorenzo Pegrassi , Alessandro Rossi , Sergio Mantegani
发明人： Metilde Buonamici , Lorenzo Pegrassi , Alessandro Rossi , Sergio Mantegani
IPC分类号： C07D457/02 , A61K31/48 , A61K31/495 , A61P25/00 , A61P43/00
CPC分类号： A61K31/48
摘要： Compounds of the formula I ##STR1## wherein R.sub.1 represents a hydrogen atom or a methyl group, either R.sub.2 and R.sub.3 represent hydrogen atoms or together represent a chemical bond, R.sub.4 represents a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, R.sub.5 represents a C.sub.1 -C.sub.4 alkyl group or an allyl group and R.sub.6 represents a hydrogen or halogen atom, and pharmaceutically acceptable salts thereof, are disclosed as being useful for the treatment of extrapyramidal syndromes such as Parkinson's disease.

7. 发明授权

US4558049A Antipsycotic benzoxazines 失效
标题翻译：抗精神病药物
公开(公告)号：US4558049A
公开(公告)日：1985-12-10
申请号：US493618
申请日：1983-05-11
申请人： Luigi Bernardi , Ettore Lazzari , Maria L. Malnati , Giuseppe Mazzini , Lorenzo Pegrassi , Alessandro Rossi
发明人： Luigi Bernardi , Ettore Lazzari , Maria L. Malnati , Giuseppe Mazzini , Lorenzo Pegrassi , Alessandro Rossi
IPC分类号： A61K31/535 , A61P25/18 , C07D211/52 , C07D498/10
CPC分类号： C07D211/52
摘要： There are provided compounds of formula 1: ##STR1## wherein R=halogen atom or CN, NH.sub.2 and NO.sub.2 group, and pharmaceutically acceptable salts thereof.The compounds are antipsycotic agents.
摘要翻译：提供式1化合物：其中R =卤素原子或CN，NH 2和NO 2基团，及其药学上可接受的盐。这些化合物是抗精神病药。

8. 发明授权

US08733131B2 Apparatus and method for chemical deposition on a rod member in an optical fibre manufacturing process 有权
标题翻译：在光纤制造工艺中在杆件上进行化学沉积的装置和方法
公开(公告)号：US08733131B2
公开(公告)日：2014-05-27
申请号：US10496866
申请日：2001-11-29
申请人： Franco Cocchini , Antonio Schiaffo , Alessandro Rossi
发明人： Franco Cocchini , Antonio Schiaffo , Alessandro Rossi
IPC分类号： C03B37/027
CPC分类号： C03B37/01486 , Y02P40/57
摘要： An apparatus and method for chemical deposition on a rod member having a support structure for supporting the rod member substantially coaxial to a deposition axis; a burner for depositing chemical substances on the rod member; and a rotation device for imparting a rotation motion to the rod member. The rotation device has a joint member of a type suitable to transmit torque between two misaligned members, for example, a double universal joint or a flexible joint, positioned between a motor and a rod gripping member.
摘要翻译：一种用于化学沉积在杆构件上的装置和方法，所述杆构件具有用于支撑所述杆构件的支撑结构，所述支撑结构基本上与沉积轴线同轴; 用于在所述杆构件上沉积化学物质的燃烧器; 以及用于向杆构件施加旋转运动的旋转装置。旋转装置具有适于在位于马达和杆夹持构件之间的两个不对准构件（例如，双万向接头或柔性接头）之间传递扭矩的接头构件。

9. 发明授权

US07574875B2 Method for vapour deposition on an elongated substrate 有权
标题翻译：在细长基板上气相沉积的方法
公开(公告)号：US07574875B2
公开(公告)日：2009-08-18
申请号：US10108364
申请日：2002-03-29
申请人： Alessandro Rossi , Franco Cocchini , Stefano Grieco
发明人： Alessandro Rossi , Franco Cocchini , Stefano Grieco
IPC分类号： C03B37/018
CPC分类号： C03B37/01486 , C03B19/1484 , C03B37/01884
摘要： Device and method for chemical deposition on an elongated member of vitreous material in which a rotating gripping member causes a first end portion of the elongated member to rotate. The second end portion of the elongated member is borne by a pair of supporting members which are axially spaced apart (L1) and are capable of permitting angular rotational movement and axial sliding of the second end portion. Each supporting member also applies a radial constraint preventing the second end portion from moving away from the axis of rotation, thus forcing the second portion and the elongated member to lie with a longitudinal axis coaxial with the axis of rotation. Any curvature of the elongated member is corrected and recovered in this way.
摘要翻译：在玻璃质材料的细长构件上进行化学沉积的装置和方法，其中旋转夹持构件使细长构件的第一端部旋转。细长构件的第二端部由轴向间隔开的一对支撑构件（L1）承载，并且能够允许第二端部的角度旋转运动和轴向滑动。每个支撑构件还施加径向约束，以防止第二端部远离旋转轴线移动，从而迫使第二部分和细长构件与与旋转轴线同轴的纵向轴线位于其中。以这种方式校正和恢复细长构件的任何曲率。

10. 发明授权

US08695379B2 Apparatus and method for applying traction to an elongate element produced by fusing a preform of glass material and usable in a process for producing an optical fibre 有权
标题翻译：用于将牵引力施加到通过熔化玻璃材料的预制件而产生并可用于制造光纤的工艺中的细长元件的装置和方法
公开(公告)号：US08695379B2
公开(公告)日：2014-04-15
申请号：US10169125
申请日：2000-12-21
申请人： Marco Antonio Caiata , Franco Cocchini , Giuseppe Ferri , Andrea Mazzotti , Alessandro Rossi , Antonio Schiaffo
发明人： Marco Antonio Caiata , Franco Cocchini , Giuseppe Ferri , Andrea Mazzotti , Alessandro Rossi , Antonio Schiaffo
IPC分类号： C03B23/045
CPC分类号： C03B37/01242 , C03B23/047 , C03B37/0124 , C03B37/01251
摘要： Apparatus for applying traction to an elongate cylindrical element produced by fusion of an end portion of a preform of glass material, in which a traction device is capable of being connected to a portion of the elongate cylindrical element to provide traction of the elongate cylindrical element along an axis. A device for the rotation of the elongate cylindrical element applies a twist to the elongate cylindrical element about the axis simultaneously with the traction.
摘要翻译：用于将牵引力施加到通过熔化玻璃材料预成型件的端部而产生的细长圆柱形元件的装置，其中牵引装置能够连接到细长圆柱形元件的一部分以提供细长圆柱形元件沿着一个轴。用于旋转细长圆柱形元件的装置在与牵引力同时围绕轴线对细长圆柱形元件施加扭曲。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式