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1. 发明申请

WO2011139375A1 ANTIBODIES DIRECTED AGAINST CARBONIC ANHYDRASE IX AND METHODS AND USES THEREOF 审中-公开
标题翻译：针对碳氢化合物IX的抗体方法及其用途
公开(公告)号：WO2011139375A1
公开(公告)日：2011-11-10
申请号：PCT/US2011/000796
申请日：2011-05-06
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , UNIVERSITY OF ZURICH , RENNER, Christoph , BAUER, Stefan , PLESKO, Margarita , HULIKOVA, Alzbeta , SWIETACH, Pawel
发明人： RENNER, Christoph , BAUER, Stefan , PLESKO, Margarita , HULIKOVA, Alzbeta , SWIETACH, Pawel
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/55 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Specific binding members, particularly antibodies and fragments thereof, which bind to Carbonic Anhydrase IX (CAIX) are provided, particularly including recognizing both human and mouse CAIX and blocking or inhibiting CAIX activity. These antibodies are useful in the diagnosis and treatment of cancer and in conditions associated with hypoxia and/or elevated CAIX activity. The anti-CAIX antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti¬ cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies MSC 1 through MSC 12 whose sequences are provided herein.
摘要翻译：提供了结合碳酸酐酶IX（CAIX）的特异性结合成员，特别是其抗体及其片段，特别包括识别人和小鼠CAIX以及阻断或抑制CAIX活性。这些抗体可用于诊断和治疗癌症以及与缺氧和/或升高的CAIX活性有关的病症。抗CAIX抗体，其可变区或CDR结构域序列及其片段也可用于与化学治疗剂，免疫调节剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。这种抗体以本文提供其序列的新型抗体MSC1至MSC12为例。

2. 发明申请

WO2011040973A2 TNF-IMMUNOCONJUGATES WITH FIBROBLAST ACTIVATION PROTEIN ANTIBODIES AND METHODS AND USES THEREOF 审中-公开
标题翻译：具有成纤维细胞活化蛋白抗体的TNF-免疫偶联物及其方法和用途
公开(公告)号：WO2011040973A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/002661
申请日：2010-10-01
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. , BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
发明人： BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/646 , A61K47/66
摘要： Protein-immunocoηjugates are provided, particularly TNF conjugates to antibodies and fragments thereof which bind to Fibroblast Activation Protein (FAP). TNF-FAP antibody conjugates are provided wherein the FAP antibody recognizes both human and mouse FAP. These immunoconjugates are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis, and more broadly in TNF responsive conditions and disorders, including cancer and hyperproliferative diseases. In addition, the FAP-immunoconjugates can be used for the diagnosis and treatment of FAP positive tumors such as pancreatic cancer, melanoma and sarcomas. The immunoconjugates, antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the present invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译：提供了蛋白 - 免疫偶联物，特别是与结合成纤维细胞活化蛋白（FAP）的抗体及其片段的TNF缀合物。提供了TNF-FAP抗体偶联物，其中FAP抗体识别人和小鼠FAP。这些免疫缀合物可用于诊断和治疗与激活的间质相关的病症，包括伤口愈合，上皮癌，骨关节炎，类风湿性关节炎，肝硬化和肺纤维化，更广泛地用于TNF反应性病症和病症，包括癌症和过度增殖性疾病。此外，FAP-免疫缀合物可用于诊断和治疗FAP阳性肿瘤，例如胰腺癌，黑素瘤和肉瘤。本发明的免疫缀合物，抗体，其可变区或CDR结构域序列及其片段也可以与化疗剂，免疫调节剂或抗癌剂和/或其他抗体或其片段组合用于治疗。 / p>

3. 发明申请

WO2011040972A1 ANTI-FIBROBLAST ACTIVATION PROTEIN ANTIBODIES AND METHODS AND USES THEREOF 审中-公开
标题翻译：抗纤维蛋白激活蛋白抗体及其方法及用途
公开(公告)号：WO2011040972A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/002660
申请日：2010-10-01
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. , FISCHER, Eliane , BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
发明人： FISCHER, Eliane , BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
IPC分类号： C07K16/40 , A61K39/395 , C07K16/30
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Specific binding members, particularly antibodies and fragments thereof, which bind to Fibroblast Activation Protein (FAP) are provided, particularly recognizing both human and mouse FAP. These antibodies are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis. The anti-FAP antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies ESCl 1 and ESC 14 whose sequences are provided herein.
摘要翻译：提供了结合成纤维细胞激活蛋白（FAP）的特异性结合成员，特别是其抗体及其片段，特别是识别人和小鼠FAP。这些抗体可用于诊断和治疗与激活的基质相关的病症，包括伤口愈合，上皮癌，骨关节炎，类风湿性关节炎，肝硬化和肺纤维化。抗FAP抗体，其可变区或CDR结构域序列及其片段也可用于与化学治疗剂，免疫调节剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。这种抗体以本文提供其序列的新型抗体ESC1 1和ESC 14为例。

4. 发明公开

EP2483316A1 ANTI-FIBROBLAST ACTIVATION PROTEIN ANTIBODIES AND METHODS AND USES THEREOF 审中-公开
标题翻译： ANTI-成纤维细胞激活蛋白抗体，方法和用途
公开(公告)号：EP2483316A1
公开(公告)日：2012-08-08
申请号：EP10766374.2
申请日：2010-10-01
申请人： Ludwig Institute for Cancer Research Ltd.
发明人： FISCHER, Eliane , BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
IPC分类号： C07K16/40 , A61K39/395 , C07K16/30
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Specific binding members, particularly antibodies and fragments thereof, which bind to Fibroblast Activation Protein (FAP) are provided, particularly recognizing both human and mouse FAP. These antibodies are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis. The anti-FAP antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies ESCl 1 and ESC 14 whose sequences are provided herein.

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