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1. 发明申请

WO2011040973A3 TNF-IMMUNOCONJUGATES WITH FIBROBLAST ACTIVATION PROTEIN ANTIBODIES AND METHODS AND USES THEREOF 审中-公开
标题翻译：具有纤维蛋白激活蛋白抗体的TNF-免疫球蛋白及其方法及用途
公开(公告)号：WO2011040973A3
公开(公告)日：2011-11-24
申请号：PCT/US2010002661
申请日：2010-10-01
申请人： LUDWIG INST FOR CANCER RES LTD , BAUER STEFAN , WUEST THOMAS , RENNER CHRISTOPH
发明人： BAUER STEFAN , WUEST THOMAS , RENNER CHRISTOPH
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/646 , A61K47/66
摘要： Protein-immunoco?jugates are provided, particularly TNF conjugates to antibodies and fragments thereof which bind to Fibroblast Activation Protein (FAP). TNF-FAP antibody conjugates are provided wherein the FAP antibody recognizes both human and mouse FAP. These immunoconjugates are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis, and more broadly in TNF responsive conditions and disorders, including cancer and hyperproliferative diseases. In addition, the FAP-immunoconjugates can be used for the diagnosis and treatment of FAP positive tumors such as pancreatic cancer, melanoma and sarcomas. The immunoconjugates, antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the present invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译：提供蛋白质免疫缺陷蛋白，特别是与结合成纤维细胞活化蛋白（FAP）的抗体及其片段的TNF缀合物。提供TNF-FAP抗体缀合物，其中FAP抗体识别人和小鼠FAP。这些免疫缀合物可用于诊断和治疗与活化基质相关的病症，包括伤口愈合，上皮癌，骨关节炎，类风湿性关节炎，肝硬化和肺纤维化，更广泛地涉及TNF反应性病症和疾病，包括癌症和过度增生性疾病。此外，FAP-免疫缀合物可用于诊断和治疗FAP阳性肿瘤如胰腺癌，黑素瘤和肉瘤。本发明的免疫缀合物，抗体，可变区或CDR结构域序列及其片段也可用于与化学治疗剂，免疫调节剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。

2. 发明申请

WO2011041319A2 SPECIFIC BINDING PROTEINS AND USES THEREOF 审中-公开
标题翻译：特异性结合蛋白及其用途
公开(公告)号：WO2011041319A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/050559
申请日：2010-09-28
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , OLD, Lloyd, J. , JOHNS, Terrance, Grant , PANOUSIS, Con , SCOTT, Andrew, Mark , RENNER, Christoph , JUNGBLUTH, Achim , STOCKERT, Elizabeth , COLLINS, Peter , CAVENEE, Webster, K. , HUANG, Huei-Jen, Su , BURGESS, Antony, Wilks , NICE, Edouard, Collins , MURRAY, Anne , MARK, George , RITTER, Gerd
发明人： OLD, Lloyd, J. , JOHNS, Terrance, Grant , PANOUSIS, Con , SCOTT, Andrew, Mark , RENNER, Christoph , JUNGBLUTH, Achim , STOCKERT, Elizabeth , COLLINS, Peter , CAVENEE, Webster, K. , HUANG, Huei-Jen, Su , BURGESS, Antony, Wilks , NICE, Edouard, Collins , MURRAY, Anne , MARK, George , RITTER, Gerd
IPC分类号： A61K51/10
CPC分类号： C07K16/2863 , A61K39/39558 , A61K51/103 , A61K51/1045 , A61K2039/505 , A61K2039/507 , A61K2039/545 , C07K16/30 , C07K16/4266 , C07K2317/24 , C07K2317/32 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , A61K2300/00
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译：本发明涉及结合扩增的表皮生长因子受体（EGFR）和EGFR的de2-7 EGFR截短的特异性结合成员，特别是抗体及其片段。特别地，特异性结合成员识别的表位，特别是其抗体及其片段，在异常翻译后修饰时增强或明显。这些特异性结合成员可用于癌症的诊断和治疗。本发明的结合成员也可用于与化学治疗剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。

3. 发明申请

WO2011040973A2 TNF-IMMUNOCONJUGATES WITH FIBROBLAST ACTIVATION PROTEIN ANTIBODIES AND METHODS AND USES THEREOF 审中-公开
标题翻译：具有成纤维细胞活化蛋白抗体的TNF-免疫偶联物及其方法和用途
公开(公告)号：WO2011040973A2
公开(公告)日：2011-04-07
申请号：PCT/US2010/002661
申请日：2010-10-01
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. , BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
发明人： BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
IPC分类号： A61K47/48 , A61P35/00
CPC分类号： B82Y5/00 , A61K47/646 , A61K47/66
摘要： Protein-immunocoηjugates are provided, particularly TNF conjugates to antibodies and fragments thereof which bind to Fibroblast Activation Protein (FAP). TNF-FAP antibody conjugates are provided wherein the FAP antibody recognizes both human and mouse FAP. These immunoconjugates are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis, and more broadly in TNF responsive conditions and disorders, including cancer and hyperproliferative diseases. In addition, the FAP-immunoconjugates can be used for the diagnosis and treatment of FAP positive tumors such as pancreatic cancer, melanoma and sarcomas. The immunoconjugates, antibodies, variable regions or CDR domain sequences thereof, and fragments thereof of the present invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof.
摘要翻译：提供了蛋白 - 免疫偶联物，特别是与结合成纤维细胞活化蛋白（FAP）的抗体及其片段的TNF缀合物。提供了TNF-FAP抗体偶联物，其中FAP抗体识别人和小鼠FAP。这些免疫缀合物可用于诊断和治疗与激活的间质相关的病症，包括伤口愈合，上皮癌，骨关节炎，类风湿性关节炎，肝硬化和肺纤维化，更广泛地用于TNF反应性病症和病症，包括癌症和过度增殖性疾病。此外，FAP-免疫缀合物可用于诊断和治疗FAP阳性肿瘤，例如胰腺癌，黑素瘤和肉瘤。本发明的免疫缀合物，抗体，其可变区或CDR结构域序列及其片段也可以与化疗剂，免疫调节剂或抗癌剂和/或其他抗体或其片段组合用于治疗。 / p>

4. 发明申请

WO2011040972A1 ANTI-FIBROBLAST ACTIVATION PROTEIN ANTIBODIES AND METHODS AND USES THEREOF 审中-公开
标题翻译：抗纤维蛋白激活蛋白抗体及其方法及用途
公开(公告)号：WO2011040972A1
公开(公告)日：2011-04-07
申请号：PCT/US2010/002660
申请日：2010-10-01
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. , FISCHER, Eliane , BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
发明人： FISCHER, Eliane , BAUER, Stefan , WUEST, Thomas , RENNER, Christoph
IPC分类号： C07K16/40 , A61K39/395 , C07K16/30
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Specific binding members, particularly antibodies and fragments thereof, which bind to Fibroblast Activation Protein (FAP) are provided, particularly recognizing both human and mouse FAP. These antibodies are useful in the diagnosis and treatment of conditions associated with activated stroma, including wound healing, epithelial cancers, osteoarthritis, rheumatoid arthritis, cirrhosis and pulmonary fibrosis. The anti-FAP antibodies, variable regions or CDR domain sequences thereof, and fragments thereof may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies ESCl 1 and ESC 14 whose sequences are provided herein.
摘要翻译：提供了结合成纤维细胞激活蛋白（FAP）的特异性结合成员，特别是其抗体及其片段，特别是识别人和小鼠FAP。这些抗体可用于诊断和治疗与激活的基质相关的病症，包括伤口愈合，上皮癌，骨关节炎，类风湿性关节炎，肝硬化和肺纤维化。抗FAP抗体，其可变区或CDR结构域序列及其片段也可用于与化学治疗剂，免疫调节剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。这种抗体以本文提供其序列的新型抗体ESC1 1和ESC 14为例。

5. 发明申请

WO2005087177A3 CHIMERIC ANTI-VEGF-D ANTIBODIES AND HUMANIZED ANTI-VEGF-D ANTIBODIES AND METHODS OF USING SAME 审中-公开
标题翻译：嵌合抗VEGF-D抗体和人源化抗VEGF-D抗体及其使用方法
公开(公告)号：WO2005087177A3
公开(公告)日：2005-10-20
申请号：PCT/US2005007283
申请日：2005-03-07
申请人： LUDWIG INST CANCER RES , ACHEN MARC G , STACKER STEPHEN , RENNER CHRISTOPH
发明人： ACHEN MARC G , STACKER STEPHEN , RENNER CHRISTOPH
IPC分类号： C07K16/22 , A61K39/395 , A61P29/00 , A61P35/00
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to materials and methods for modulating angiogenesis and lymphangiogenesis. The compositions of the invention provide chimeric and/or humanized VEGF-D antibody substances, antibodies, polypeptides and fragments thereof useful for modulating angiogenesis and lymphangiogenesis in a subject.
摘要翻译：本发明涉及用于调节血管生成和淋巴管生成的材料和方法。本发明的组合物提供了可用于调节受试者的血管生成和淋巴管生成的嵌合和/或人源化VEGF-D抗体物质，抗体，多肽及其片段。

6. 发明申请

WO2005087177A2 CHIMERIC ANTI-VEGF-D ANTIBODIES AND HUMANIZED ANTI-VEGF-D ANTIBODIES AND METHODS OF USING SAME 审中-公开
标题翻译： CHIMERIC抗VEGF-D抗体和人类抗VEGF-D抗体及其使用方法
公开(公告)号：WO2005087177A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/007283
申请日：2005-03-07
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , ACHEN, Marc, G. , STACKER, Stephen , RENNER, Christoph
发明人： ACHEN, Marc, G. , STACKER, Stephen , RENNER, Christoph
IPC分类号： A61K
CPC分类号： C07K16/22 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76
摘要： The present invention relates to materials and methods for modulating angiogenesis and lymphangiogenesis. The compositions of the invention provide chimeric and/or humanized VEGF-D antibody substances, antibodies, polypeptides and fragments thereof useful for modulating angiogenesis and lymphangiogenesis in a subject.
摘要翻译：本发明涉及调节血管发生和淋巴管生成的材料和方法。本发明的组合物提供用于调节受试者血管生成和淋巴管生成的嵌合和/或人源化VEGF-D抗体物质，抗体，多肽及其片段。

7. 发明申请

WO0217970A3 METAL RADIONUCLIDE LABELLED CD-30 ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：金属放射性核素标记的CD-30抗体及其用途
公开(公告)号：WO0217970A3
公开(公告)日：2003-01-09
申请号：PCT/US0126335
申请日：2001-08-23
申请人： LUDWIG INST CANCER RES , LEE FOOK THEAN , SCOTT ANDREW , RENNER CHRISTOPH , PEREUNDSCHUH MICHAEL
发明人： LEE FOOK THEAN , SCOTT ANDREW , RENNER CHRISTOPH , PEREUNDSCHUH MICHAEL
IPC分类号： A61K51/10
CPC分类号： A61K51/1093 , A61K51/1021
摘要： The invention relates to metallic radionuclide containing immunoconjugates. The immunoconjugates bind specifically to the CD30 molecule. Both diagnostic and therapeutic uses of the immunoconjugates are described. The preferred immunoconjugates are monoclonal antibodies to which In or Y is bound via a chelator.
摘要翻译：本发明涉及含有免疫缀合物的金属放射性核素。免疫缀合物特异性结合CD30分子。描述了免疫缀合物的诊断和治疗用途。优选的免疫偶联物是通过螯合剂结合<111> In或90 Y的单克隆抗体。

8. 发明申请

WO2010106431A2 HIGH AFFINITY T-CELL RECEPTOR-LIKE NY-ESO-1 PEPTIDE ANTIBODIES, METHODS, AND USES THEREOF 审中-公开
标题翻译：高亲和力T细胞受体 - 如NY-ESO-1肽抗体，方法及其用途
公开(公告)号：WO2010106431A2
公开(公告)日：2010-09-23
申请号：PCT/IB2010/000597
申请日：2010-03-19
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH LTD , CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD , UNIVERSITY OF ZURICH , RENNER, Christoph , WADLE, Andreas , CERUNDOLO, Vincenzo , STEWART-JONES, Guillaume , JONES, E., Yvonne
发明人： RENNER, Christoph , WADLE, Andreas , CERUNDOLO, Vincenzo , STEWART-JONES, Guillaume , JONES, E., Yvonne
IPC分类号： C07K16/30
CPC分类号： C07K16/30 , A61K2039/505 , C07K16/2833 , C07K2317/21 , C07K2317/32 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to NY-ESO- 1 tumor antigen peptide/MHC molecule complexes, particularly in a manner like T cell receptors and with greater affinity than T cell receptors recognizing NY-ESO-I peptide/HLA complexes. These antibodies, particularly human antibodies are useful in the diagnosis and treatment of cancer, including melanoma, lung, esophageal, liver, gastric, prostate, ovarian, bladder and synovial sarcoma. The antibodies and fragments thereof of the present invention may also be used in therapy in combination with chemotherapeutics, immune modulators, or anti-cancer agents and/or with other antibodies or fragments thereof. Antibodies of this type are exemplified by the novel antibodies Tl, T2 and T3 whose sequences are provided herein.
摘要翻译：本发明涉及特异性结合成员，特别是其结合NY-ESO-1肿瘤抗原肽/ MHC分子复合物的特异性结合成员，特别是以类似T细胞受体的方式，并且具有比识别NY- ESO-1肽/ HLA复合物。这些抗体，特别是人抗体可用于诊断和治疗癌症，包括黑素瘤，肺癌，食管癌，肝癌，胃癌，前列腺癌，卵巢癌，膀胱癌和滑膜肉瘤。本发明的抗体及其片段也可用于与化学治疗剂，免疫调节剂或抗癌剂和/或与其它抗体或其片段组合的治疗中。这种抗体以本文提供其序列的新型抗体T1，T2和T3为例。

9. 发明申请

WO2007080259A1 SYSTEME MICRO-ELECTROMECANIQUE COMPRENANT UNE PARTIE DEFORMABLE ET UN DETECTEUR DE CONTRAINTE 审中-公开
标题翻译：包含可变部分和应力传感器的微机电系统
公开(公告)号：WO2007080259A1
公开(公告)日：2007-07-19
申请号：PCT/FR2006/002713
申请日：2006-12-12
申请人： ECOLE POLYTECHNIQUE , ROWE, Alistair , RENNER, Christoph , ARSCOTT, Steve
发明人： ROWE, Alistair , RENNER, Christoph , ARSCOTT, Steve
IPC分类号： B81B3/00 , G01L1/22
CPC分类号： G01L1/2293 , G01L9/0052 , G01P15/12 , G01P2015/0828 , G01Q20/04 , G01Q60/38
摘要： Un système micro-électromécanique comprend une partie déformable (1) et au moins un détecteur de contrainte (10) solidaire de la partie déformable. Le détecteur comprend lui-même une portion de base (2) et une portion de shunt (3) juxtaposées sur la partie déformable (1), et des connexions (4a-4d) agencées pour détecter une modification d'une répartition d'un courant électrique dans les portions de base et de shunt. Un tel système est adapté pour de nombreuses applications, en particulier pour former une partie d'un bras de microscope à force atomique ou pour entrer dans la constitution d'un biodétecteur.
摘要翻译：微机电系统包括可变形部分（1）和固定地连接到可变形部分的至少一个应力传感器（10）。传感器本身包括并置在可变形部分（1）上的基部部分（2）和分流部分（3），以及连接部分（4a-4d），用于检测基部和分流器中的电流分布的变化部分。这种系统适用于许多应用，特别是用于形成原子力显微镜的臂的一部分或用于进入生物传感器的构造。

10. 发明申请

WO2003068924A3 FUSION PROTEINS OF HUMANIZED G250 SPECIFIC ANTIBODIES AND USES THEREOF 审中-公开
公开(公告)号：WO2003068924A3
公开(公告)日：2003-08-21
申请号：PCT/US2003/004243
申请日：2003-02-12
申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH , RENNER, Christoph , SCOTT, Andrew
发明人： RENNER, Christoph , SCOTT, Andrew
IPC分类号： C12N15/00
摘要： Chimeric antibodies, as well as fusion proteins which comprise chimeric antibodies, are disclosed. The antibodies bind to GM-CSF, CD-30, and G250 antigen. The fusion proteins include biologically active portions of tumor necrosis factor, or full length tumor necrosis factor. Expression vectors adapted for production of the antibodies, as well as methods for manufacturing these, are also disclosed.

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