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1. 发明授权

US5932619A Method for preventing sexually transmitted diseases 失效
公开(公告)号：US5932619A
公开(公告)日：1999-08-03
申请号：US965935
申请日：1997-11-07
申请人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II , Darrick S. H. L. Kim
发明人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II , Darrick S. H. L. Kim
IPC分类号： A61K31/192 , A61K31/70 , A61K31/775 , A61K37/10
CPC分类号： A61K31/192 , A61K31/70 , A61K31/775
摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H.sub.2 SO.sub.4 -modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.

2. 发明授权

US5925621A Method for preventing sexually transmitted diseases 失效
公开(公告)号：US5925621A
公开(公告)日：1999-07-20
申请号：US949793
申请日：1997-10-14
申请人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
发明人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
IPC分类号： A61K31/192 , A61K31/70 , A61K31/775 , A61K43/04
CPC分类号： A61K31/192 , A61K31/70 , A61K31/775
摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H.sub.2 SO.sub.4 -modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.

3. 发明授权

US6028115A Method for preventing sexually transmitted diseases 有权
标题翻译：防治性传播疾病的方法
公开(公告)号：US6028115A
公开(公告)日：2000-02-22
申请号：US243035
申请日：1999-02-03
申请人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
发明人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
IPC分类号： A61K31/192 , A61K31/70 , A61K31/775 , A01N31/10 , A01N31/14 , A01N35/00 , A61K31/74 , A61K47/48
CPC分类号： A61K31/192 , A61K31/70 , A61K31/775
摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H.sub.2 SO.sub.4 -modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.
摘要翻译：提供了一种在性活动期间降低传播性传播疾病（特别是艾滋病毒和/或HSV）风险的方法。该方法通常包括在进行性活动之前将有效量的抑制剂，优选作为局部制剂施用于性接触的区域或区域。可用于本发明的抑制剂包括例如磷酸化的hesperidins，磺化的hesperidins，聚苯乙烯磺酸盐，取代的苯磺酸甲醛共聚物，H2SO4改性的扁桃酸等。这种方法可以被从事各种性活动的异性恋者，同性恋者和/或双性恋者使用。除了抗STD活动外，这些药物还可以作为阴道避孕药具; 此外，它们通常具有比常规阴道避孕药（例如壬苯醇酯-9）更少的副作用。例如，本发明中有用的化合物通常对天然和有益的阴道菌群是无毒的，因此不会扰乱局部的微生物平衡。本发明的抗STD方法具有附加的优点，可以由任何一方实施和控制。还提供了减少导致STD的生物传播给可能与生物样品和标本接触的保健提供者和实验室人员（或其他人员）的风险的方法。

4. 发明授权

US06239182B1 Method for preventing sexually transmitted diseases 失效
标题翻译：防治性传播疾病的方法
公开(公告)号：US06239182B1
公开(公告)日：2001-05-29
申请号：US09252417
申请日：1999-02-18
申请人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
发明人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
IPC分类号： A61K31015
CPC分类号： A61K31/70 , A61K31/775
摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease—especially HIV and/or HSV—during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.
摘要翻译：提供了一种在性活动期间降低传播性传播疾病（特别是艾滋病毒和/或HSV）风险的方法。该方法通常包括在进行性活动之前将有效量的抑制剂，优选作为局部制剂施用于性接触的区域或区域。可用于本发明的抑制剂包括例如磷酸化的hesperidins，磺化的hesperidins，聚苯乙烯磺酸盐，取代的苯磺酸甲醛共聚物，H2SO4改性的扁桃酸等。这种方法可以被从事各种性活动的异性恋者，同性恋者和/或双性恋者使用。除了抗STD活动外，这些药物还可以作为阴道避孕药具; 此外，它们通常具有比常规阴道避孕药（例如壬苯醇酯-9）更少的副作用。例如，本发明中有用的化合物通常对天然和有益的阴道菌群是无毒的，因此不会扰乱局部的微生物平衡。本发明的抗STD方法具有附加的优点，可以由任何一方实施和控制。还提供了减少导致STD的生物传播给可能与生物样品和标本接触的保健提供者和实验室人员（或其他人员）的风险的方法。

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