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1. 发明授权

US5925621A Method for preventing sexually transmitted diseases 失效
公开(公告)号：US5925621A
公开(公告)日：1999-07-20
申请号：US949793
申请日：1997-10-14
申请人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
发明人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
IPC分类号： A61K31/192 , A61K31/70 , A61K31/775 , A61K43/04
CPC分类号： A61K31/192 , A61K31/70 , A61K31/775
摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H.sub.2 SO.sub.4 -modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.

2. 发明授权

US6028115A Method for preventing sexually transmitted diseases 有权
标题翻译：防治性传播疾病的方法
公开(公告)号：US6028115A
公开(公告)日：2000-02-22
申请号：US243035
申请日：1999-02-03
申请人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
发明人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
IPC分类号： A61K31/192 , A61K31/70 , A61K31/775 , A01N31/10 , A01N31/14 , A01N35/00 , A61K31/74 , A61K47/48
CPC分类号： A61K31/192 , A61K31/70 , A61K31/775
摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H.sub.2 SO.sub.4 -modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.
摘要翻译：提供了一种在性活动期间降低传播性传播疾病（特别是艾滋病毒和/或HSV）风险的方法。该方法通常包括在进行性活动之前将有效量的抑制剂，优选作为局部制剂施用于性接触的区域或区域。可用于本发明的抑制剂包括例如磷酸化的hesperidins，磺化的hesperidins，聚苯乙烯磺酸盐，取代的苯磺酸甲醛共聚物，H2SO4改性的扁桃酸等。这种方法可以被从事各种性活动的异性恋者，同性恋者和/或双性恋者使用。除了抗STD活动外，这些药物还可以作为阴道避孕药具; 此外，它们通常具有比常规阴道避孕药（例如壬苯醇酯-9）更少的副作用。例如，本发明中有用的化合物通常对天然和有益的阴道菌群是无毒的，因此不会扰乱局部的微生物平衡。本发明的抗STD方法具有附加的优点，可以由任何一方实施和控制。还提供了减少导致STD的生物传播给可能与生物样品和标本接触的保健提供者和实验室人员（或其他人员）的风险的方法。

3. 发明授权

US06239182B1 Method for preventing sexually transmitted diseases 失效
标题翻译：防治性传播疾病的方法
公开(公告)号：US06239182B1
公开(公告)日：2001-05-29
申请号：US09252417
申请日：1999-02-18
申请人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
发明人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II
IPC分类号： A61K31015
CPC分类号： A61K31/70 , A61K31/775
摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease—especially HIV and/or HSV—during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.
摘要翻译：提供了一种在性活动期间降低传播性传播疾病（特别是艾滋病毒和/或HSV）风险的方法。该方法通常包括在进行性活动之前将有效量的抑制剂，优选作为局部制剂施用于性接触的区域或区域。可用于本发明的抑制剂包括例如磷酸化的hesperidins，磺化的hesperidins，聚苯乙烯磺酸盐，取代的苯磺酸甲醛共聚物，H2SO4改性的扁桃酸等。这种方法可以被从事各种性活动的异性恋者，同性恋者和/或双性恋者使用。除了抗STD活动外，这些药物还可以作为阴道避孕药具; 此外，它们通常具有比常规阴道避孕药（例如壬苯醇酯-9）更少的副作用。例如，本发明中有用的化合物通常对天然和有益的阴道菌群是无毒的，因此不会扰乱局部的微生物平衡。本发明的抗STD方法具有附加的优点，可以由任何一方实施和控制。还提供了减少导致STD的生物传播给可能与生物样品和标本接触的保健提供者和实验室人员（或其他人员）的风险的方法。

4. 发明授权

US5932619A Method for preventing sexually transmitted diseases 失效
公开(公告)号：US5932619A
公开(公告)日：1999-08-03
申请号：US965935
申请日：1997-11-07
申请人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II , Darrick S. H. L. Kim
发明人： Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Xiao Hui Diao , Paul Robert Young, Jr. , Donald Paul Waller , Sanjay Garg , Calvin J. Chany, II , Darrick S. H. L. Kim
IPC分类号： A61K31/192 , A61K31/70 , A61K31/775 , A61K37/10
CPC分类号： A61K31/192 , A61K31/70 , A61K31/775
摘要： A method for the reduction in the risk of transmitting a sexually transmitted disease--especially HIV and/or HSV--during sexual activity is provided. This method generally comprises the application of an effective amount of an inhibitory agent, preferably as a topical formulation, to the area or areas of sexual contact prior to engaging in sexual activity. Inhibitory agents which are useful in the present invention include, for example, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H.sub.2 SO.sub.4 -modified mandelic acids, and the like. This method can be used by heterosexuals, homosexuals, and/or bisexuals engaged in a wide variety of sexual activities. In addition to anti-STD activity, these agents may also act as vaginal contraceptives; moreover, they generally have fewer side effects than conventional vaginal contraceptives (e.g., nonoxynol-9). For example, the compounds useful in this invention are generally not toxic to natural and beneficial vaginal flora and, thus, do not upset the local microbiological balance. The anti-STD method of the present invention has the added advantage that it can be implemented and controlled by either sexual party. Methods are also provided for reducing the risk of transmission of STD-causing organisms to health care providers and laboratory personnel (or other persons) who may come into contact with biological samples and specimens.

5. 发明授权

US06706276B2 Compositions and methods for trapping and inactivating pathogenic microbes and spermatozoa 有权
标题翻译：用于诱导和灭活致病微生物和精子的组合物和方法
公开(公告)号：US06706276B2
公开(公告)日：2004-03-16
申请号：US09800036
申请日：2001-03-06
申请人： Sanjay Garg , Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Donald Paul Waller
发明人： Sanjay Garg , Lourens Jan Dirk Zaneveld , Robert Anthony Anderson, Jr. , Donald Paul Waller
IPC分类号： A61F1300
CPC分类号： A61K47/12 , A61K9/0034 , A61K31/00 , A61K31/085 , A61K31/14 , A61K31/192 , A61K31/7048 , A61K31/795 , A61K47/10 , A61K47/183 , A61K47/36
摘要： Antimicrobial and contraceptive compositions and methods which prevent and/or reduce the risk of transmission of sexually transmitted diseases through sexual activity as well as prevent and/or reduce the risk of pregnancy are provided. The compositions contain (1) a matrix-forming agent, (2) a bio-adhesive agent, (3) a buffering agent, (4) optionally a humectant, (5) optionally a preservative, and (6) water; wherein the composition is suitable for application within the vagina; wherein the compositions forms a semisolid matrix on contact with ejaculate (thereby trapping ejaculated microbes and spermatozoa); wherein the composition causes hardening of cervical mucus (thereby decreasing the probability of sperm entry); wherein the composition forms a bio-adhesive layer over vaginal surfaces (thereby preventing or reducing the risk of contact of STD-causing microbes with the vaginal surfaces); wherein the composition maintains an acidic vaginal pH of less than about 5 in the presence of semen ejaculated from the male; and wherein the composition does not significantly impair the natural microbiological balance within the vagina. The antimicrobial and contraceptive compositions may also contain additional antimicrobial and/or contraceptive agents (e.g., nonoxynol-9, octoxynol-9, benzalkonium chloride, phosphorylated hesperidins, sulfonated hesperidins, polystyrene sulfonates, substituted benzenesulfonic acid formaldehyde co-polymers, H2SO4-modified mandelic acids, povidone iodine, itraconazole, ketoconazole, metronidazole, clotrimazole, fluconazole, teraconazole, miconazole, tinidazole, iconazole, chloramphenicol, nystatin, cyclopiroxolamine, and the like).
摘要翻译：提供了防止和/或降低通过性活动传播性传播疾病以及预防和/或降低妊娠风险的抗微生物和避孕组合物和方法。组合物含有（1）基质形成剂，（2）生物粘合剂，（3）缓冲剂，（4）任选的保湿剂，（5）任选的防腐剂，和（6）水; 其中所述组合物适于在所述阴道内施用; 其中所述组合物在与射精接触时形成半固体基质（从而捕获射精的微生物和精子）; 其中所述组合物引起宫颈粘液的硬化（从而降低精子进入的可能性）; 其中所述组合物在阴道表面上形成生物粘合剂层（从而防止或降低STD引起的微生物与阴道表面接触的风险）; 其中所述组合物在从男性射精的精液存在下维持小于约5的酸性阴道pH; 并且其中所述组合物不会显着损害所述阴道内的天然微生物平衡。抗微生物剂和避孕组合物还可以含有另外的抗微生物剂和/或避孕药（例如壬苯醇9，辛苯氧醇-9，苯扎氯铵，磷酸化橙皮苷，磺化橙皮苷，聚苯乙烯磺酸盐，取代苯磺酸甲醛共聚物，H 2 SO 4改性扁桃酸酸，聚维酮碘，伊曲康唑，酮康唑，甲硝唑，克霉唑，氟康唑，teraconazole，咪康唑，替硝唑，恶唑，氯霉素，制霉菌素，环吡氯胺等）。

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