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1. 发明授权

US06468770B1 Nucleic acids and proteins of D. melanogaster insulin-like genes and uses thereof 有权
标题翻译：黑腹果蝇胰岛素样基因的核酸和蛋白质及其用途
公开(公告)号：US06468770B1
公开(公告)日：2002-10-22
申请号：US09201227
申请日：1998-11-30
申请人： Linda Nolan Keyes , Stephen Kohl Doberstein , Andrew Roy Buchman , Bindu Priya Reddy , David Andrew Ruddy
发明人： Linda Nolan Keyes , Stephen Kohl Doberstein , Andrew Roy Buchman , Bindu Priya Reddy , David Andrew Ruddy
IPC分类号： C12N1509
CPC分类号： C07K14/43581 , A01K2217/075
摘要： The present invention relates to D. melangaster insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of D. melangaster insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a D. melangaster insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a D. melangaster gene which modifies the function of, and/or functions in a signaling pathway with an insulin-like gene are provided. The invention further provides uses of Drosophila insulin-like nucliec acids and proteins, e.g., as media additives, and as pesticides.
摘要翻译：本发明涉及D. melangaster胰岛素样基因和鉴定胰岛素样基因的方法。该方法提供了D.瓜瓜那胰岛素样基因的核苷酸序列，其编码的蛋白质的氨基酸序列及其衍生物（例如片段）及其类似物。本发明还涉及包含胰岛素样蛋白的一个或多个结构域的胰岛素样蛋白的片段（及其衍生物和类似物）。提供了胰岛素样蛋白的抗体及其衍生物和类似物。提供了胰岛素样蛋白质的生产方法（例如，通过重组方法）及其衍生物和类似物。此外，提供了鉴定一种D.瓜兰特氏胰岛素样基因的生物学功能的方法，包括同时进行一个或多个基因的功能修饰（例如，过表达，低表达，突变，敲除）的各种方法。此外，提供了鉴定修饰胰岛素样基因的信号传导途径的功能和/或功能的D.瓜兰加斯特基因的方法。本发明还提供了果蝇胰岛素样核糖酸和蛋白质的用途，例如作为培养基添加剂和农药。

2. 发明授权

US06627746B1 Nucleic acids and proteins of C. elegans insulin-like genes and uses thereof 失效
公开(公告)号：US06627746B1
公开(公告)日：2003-09-30
申请号：US09084303
申请日：1998-05-26
申请人： Stephen Kohl Doberstein , Darren Mark Platt , Kimberly Carr Ferguson , Andrew Roy Buchman , Sheila Akiko Homburger
发明人： Stephen Kohl Doberstein , Darren Mark Platt , Kimberly Carr Ferguson , Andrew Roy Buchman , Sheila Akiko Homburger
IPC分类号： C07H2104
CPC分类号： C07K14/43545 , A61K38/00
摘要： The present invention relates to C. elegans insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of C. elegans insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a C. elegans insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a C. elegans gene which modifies the function of, and/or functions in a downstream pathway from, an insulin-like gene are provided.

3. 发明申请

US20120230980A1 OPTIMIZED Fc VARIANTS AND METHODS FOR THEIR GENERATION 有权
标题翻译：优化的Fc变体及其生成方法
公开(公告)号：US20120230980A1
公开(公告)日：2012-09-13
申请号：US13346604
申请日：2012-01-09
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： C07K16/28 , C12N15/13 , C12N5/10 , A61P37/04 , C12N1/19 , C12P21/02 , A61K39/395 , C07K17/00 , C12N1/21
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译：本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。

4. 发明授权

US07846671B2 Methods of screening for agents that modulate the interaction of RGS and Gαq and urinary incontinence 有权
标题翻译：筛选调节RGS和Gαq与尿失禁相互作用的药剂的方法
公开(公告)号：US07846671B2
公开(公告)日：2010-12-07
申请号：US10352843
申请日：2003-01-27
申请人： Mark Cockett , Chandra S. Ramanathan , Nicholas J. Lodge , Kevin Fitzgerald , Terry Stouch , Lisa Moore , Rachel M. Kindt , Jenny Kopczynski , Stephen Kohl Doberstein
发明人： Mark Cockett , Chandra S. Ramanathan , Nicholas J. Lodge , Kevin Fitzgerald , Terry Stouch , Lisa Moore , Rachel M. Kindt , Jenny Kopczynski , Stephen Kohl Doberstein
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/726 , G01N2333/916 , G01N2500/00 , G01N2800/341
摘要： The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods.
摘要翻译：本发明提供了可用于治疗或预防平滑肌疾病如尿失禁的方法和可用于这些方法的化合物。

5. 发明申请

US20090068177A1 Optimized Fc variants and methods for their generation 有权
标题翻译：优化的Fc变体及其生成方法
公开(公告)号：US20090068177A1
公开(公告)日：2009-03-12
申请号：US11981822
申请日：2007-10-31
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译：本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。

6. 发明申请

US20130058919A1 Optimized Fc Variants and Methods for their Generation 有权
标题翻译：优化的Fc变体及其产生方法
公开(公告)号：US20130058919A1
公开(公告)日：2013-03-07
申请号：US13406347
申请日：2012-02-27
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： C07K16/00 , C07K16/24 , C07K16/40 , C07K16/22 , A61K39/395 , A61P3/10 , A61P31/00 , A61P29/00 , A61P25/00 , A61P35/00 , A61P35/02 , A61P9/04 , C07K16/28 , A61P37/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译：本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。

7. 发明申请

US20090214526A1 Optimized Fc Variants and Methods for Their Generation 审中-公开
标题翻译：优化的Fc变体及其产生方法
公开(公告)号：US20090214526A1
公开(公告)日：2009-08-27
申请号：US11927488
申请日：2007-10-29
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C07K16/18 , A61P37/02
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译：本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。

8. 发明授权

US08093357B2 Optimized Fc variants and methods for their generation 有权
公开(公告)号：US08093357B2
公开(公告)日：2012-01-10
申请号：US11483378
申请日：2006-07-07
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： C07K1/00 , C07K16/00 , C07K17/00
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

9. 发明申请

US20090092599A1 Optimized Fc variants and methods for their generation 有权
公开(公告)号：US20090092599A1
公开(公告)日：2009-04-09
申请号：US11981823
申请日：2007-10-31
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C07K16/18
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.

10. 发明申请

US20090068175A1 Optimized FC Variants and Methods for Their Generation 有权
标题翻译：优化的FC变体及其产生方法
公开(公告)号：US20090068175A1
公开(公告)日：2009-03-12
申请号：US11927444
申请日：2007-10-29
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C12P21/08
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译：本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。

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