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1. 发明授权

US06468770B1 Nucleic acids and proteins of D. melanogaster insulin-like genes and uses thereof 有权
标题翻译：黑腹果蝇胰岛素样基因的核酸和蛋白质及其用途
公开(公告)号：US06468770B1
公开(公告)日：2002-10-22
申请号：US09201227
申请日：1998-11-30
申请人： Linda Nolan Keyes , Stephen Kohl Doberstein , Andrew Roy Buchman , Bindu Priya Reddy , David Andrew Ruddy
发明人： Linda Nolan Keyes , Stephen Kohl Doberstein , Andrew Roy Buchman , Bindu Priya Reddy , David Andrew Ruddy
IPC分类号： C12N1509
CPC分类号： C07K14/43581 , A01K2217/075
摘要： The present invention relates to D. melangaster insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of D. melangaster insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a D. melangaster insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a D. melangaster gene which modifies the function of, and/or functions in a signaling pathway with an insulin-like gene are provided. The invention further provides uses of Drosophila insulin-like nucliec acids and proteins, e.g., as media additives, and as pesticides.
摘要翻译：本发明涉及D. melangaster胰岛素样基因和鉴定胰岛素样基因的方法。该方法提供了D.瓜瓜那胰岛素样基因的核苷酸序列，其编码的蛋白质的氨基酸序列及其衍生物（例如片段）及其类似物。本发明还涉及包含胰岛素样蛋白的一个或多个结构域的胰岛素样蛋白的片段（及其衍生物和类似物）。提供了胰岛素样蛋白的抗体及其衍生物和类似物。提供了胰岛素样蛋白质的生产方法（例如，通过重组方法）及其衍生物和类似物。此外，提供了鉴定一种D.瓜兰特氏胰岛素样基因的生物学功能的方法，包括同时进行一个或多个基因的功能修饰（例如，过表达，低表达，突变，敲除）的各种方法。此外，提供了鉴定修饰胰岛素样基因的信号传导途径的功能和/或功能的D.瓜兰加斯特基因的方法。本发明还提供了果蝇胰岛素样核糖酸和蛋白质的用途，例如作为培养基添加剂和农药。

2. 发明授权

US06703491B1 Drosophila sequences 失效
标题翻译：果蝇序列
公开(公告)号：US06703491B1
公开(公告)日：2004-03-09
申请号：US09270767
申请日：1999-03-17
申请人： Sheila Akiko Homburger , Allen James Ebens, Jr. , Catherine Sue Erickson , Helen Louise Francis-Lang , Jonathan Scott Margolis , Bindu Priya Reddy , David Andrew Ruddy , Andrew Roy Buchman
发明人： Sheila Akiko Homburger , Allen James Ebens, Jr. , Catherine Sue Erickson , Helen Louise Francis-Lang , Jonathan Scott Margolis , Bindu Priya Reddy , David Andrew Ruddy , Andrew Roy Buchman
IPC分类号： C07H2104
CPC分类号： A01K67/0333 , A01K67/0336 , A01K67/0337 , A01K67/0339 , A01K2217/05 , A01K2217/075 , C07K14/70571
摘要： The present invention relates to Drosophila genes and methods for their use. The invention provides nucleotide sequences of Drosophila genes, amino acid sequences of the encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of proteins which comprise one or more domains of a Drosophila protein. Antibodies to Drosophila proteins, and derivatives and analogs thereof, are also provided. Also provided herein are vectors and host cells comprising such nucleic acids. Methods of production of a Drosophila protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Chimeric polypeptide molecules comprising polypeptides of the invention fused to heterologous polypeptide sequences are provided. Methods to identify the biological function of a Drosophila gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one gene, or of two or more genes simultaneously. Methods to identify a Drosophila gene which modifies the function of, and/or functions in a downstream pathway from, another gene are provided. The invention further provides for use of Drosophila proteins as media additives or pesticides.
摘要翻译：本发明涉及果蝇基因及其使用方法。本发明提供了果蝇基因的核苷酸序列，编码的蛋白质的氨基酸序列及其衍生物（例如片段）及其类似物。本发明还涉及包含果蝇蛋白的一个或多个结构域的蛋白质的片段（及其衍生物和类似物）。还提供了针对果蝇蛋白的抗体及其衍生物和类似物。本文还提供了包含这种核酸的载体和宿主细胞。提供了果蝇蛋白的生产方法（例如通过重组方法）及其衍生物和类似物。提供了包含与异源多肽序列融合的本发明多肽的嵌合多肽分子。提供鉴定果蝇基因生物学功能的方法，包括一种基因或两种或多种基因同时进行功能修饰（如过表达，低表达，突变，敲除）的各种方法。提供了鉴定另一基因的修饰下游途径的功能和/或功能的果蝇基因的方法。本发明还提供了果蝇蛋白质作为媒介添加剂或杀虫剂的用途。

3. 发明授权

US06511824B1 Nucleic acids and polypeptides of invertebrate TWIK channels and methods of use 有权
标题翻译：无脊椎动物TWIK通道的核酸和多肽及其使用方法
公开(公告)号：US06511824B1
公开(公告)日：2003-01-28
申请号：US09362842
申请日：1999-07-28
申请人： Andrew Roy Buchman , Christian Burks , Helen Louise Francis-Lang , Lucile A. Gillett , Jonathan Cagampang Heller , Casey Casimir Kopczynski , Jonathan Scott Margolis , Darren Mark Platt , Bindu Priya Reddy , Candace Swimmer , John W. Winslow , Yuling Luo
发明人： Andrew Roy Buchman , Christian Burks , Helen Louise Francis-Lang , Lucile A. Gillett , Jonathan Cagampang Heller , Casey Casimir Kopczynski , Jonathan Scott Margolis , Darren Mark Platt , Bindu Priya Reddy , Candace Swimmer , John W. Winslow , Yuling Luo
IPC分类号： C12N1500
CPC分类号： C07K14/43581 , A01K67/0333 , A01K67/0336 , A01K67/0337 , A01K67/0339 , A01K2217/05 , A01K2217/075 , C07K14/705 , C07K14/70571
摘要： Tandem pore domain weak inward rectifying K+ (TWIK) channel nucleic acids and proteins that have been isolated from Drosophila melanogaster and Leptinotarsa are described. The TWIK channel nucleic acids and proteins can be used to genetically modify metazoan invertebrate organisms, such as insects, coelomates, and pseudocoelomates, or cultured cells, resulting in TWIK channel expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds which are potential pesticidal agents or therapeutics that interact with TWIK channel proteins. They can also be used in methods for studying TWIK channel activity and identifying other genes that modulate the function of, or interact with, the TWIK channel gene.
摘要翻译：描述了从黑腹果蝇和Leptinotarsa分离的串联孔结构域弱内向整流K +（TWIK）通道核酸和蛋白质。 TWIK通道核酸和蛋白质可用于遗传修饰后生动物无脊椎动物生物体，如昆虫，群落和假细菌，或培养细胞，导致TWIK通道表达或错误表达。遗传修饰的生物体或细胞可用于筛选测定以鉴定候选化合物，其是潜在的杀虫剂或与TWIK通道蛋白相互作用的治疗剂。它们也可用于研究TWIK通道活性的方法，并鉴定调节TWIK通道基因功能或与之相互作用的其他基因。

4. 发明授权

US06627746B1 Nucleic acids and proteins of C. elegans insulin-like genes and uses thereof 失效
公开(公告)号：US06627746B1
公开(公告)日：2003-09-30
申请号：US09084303
申请日：1998-05-26
申请人： Stephen Kohl Doberstein , Darren Mark Platt , Kimberly Carr Ferguson , Andrew Roy Buchman , Sheila Akiko Homburger
发明人： Stephen Kohl Doberstein , Darren Mark Platt , Kimberly Carr Ferguson , Andrew Roy Buchman , Sheila Akiko Homburger
IPC分类号： C07H2104
CPC分类号： C07K14/43545 , A61K38/00
摘要： The present invention relates to C. elegans insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of C. elegans insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a C. elegans insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a C. elegans gene which modifies the function of, and/or functions in a downstream pathway from, an insulin-like gene are provided.

5. 发明授权

US06762291B1 Insect p53 tumor suppressor genes and proteins 失效
标题翻译：昆虫p53肿瘤抑制基因和蛋白质
公开(公告)号：US06762291B1
公开(公告)日：2004-07-13
申请号：US09524101
申请日：2000-03-13
申请人： Andrew Roy Buchman , Darren Mark Platt , Michael Martin Ollman , Lynn Marie Young , Madelyn Robin Demsky , Kevin Patrick Keegan , Lori Friedman , Casey Kopczynski , Jeffrey S. Larson , Stephanie A. Robertson
发明人： Andrew Roy Buchman , Darren Mark Platt , Michael Martin Ollman , Lynn Marie Young , Madelyn Robin Demsky , Kevin Patrick Keegan , Lori Friedman , Casey Kopczynski , Jeffrey S. Larson , Stephanie A. Robertson
IPC分类号： C12Q168
CPC分类号： C07K14/4746
摘要： A family of p53 tumor suppressor nucleic acid and protein isolated from several insect species is described. The p53 nucleic acid and protein can be used to genetically modify metazoan invertebrate organisms, such as insects and worms, or cultured cells, resulting in p53 expression or mis-expression. The genetically modified organisms or cells can be used in screening assays to identify candidate compounds that are potential pesticidal agents or therapeutics that interact with p53 protein. They can also be used in methods for studying p53 activity and identifying other genes that modulate the function of, or interact with, the p53 gene. Nucleic acid and protein sequences for Drosophila p33 and Rb tumor suppressors are also described.
摘要翻译：描述了从几种昆虫物种分离的p53肿瘤抑制核酸和蛋白质家族。 p53核酸和蛋白质可用于遗传修饰后生动物无脊椎动物生物体，如昆虫和蠕虫，或培养细胞，导致p53表达或错误表达。遗传修饰的生物体或细胞可用于筛选测定以鉴定与p53蛋白相互作用的潜在杀虫剂或治疗剂的候选化合物。它们也可用于研究p53活性的方法，并鉴定调节p53基因功能或与p53基因相互作用的其他基因。还描述了果蝇p33和Rb肿瘤抑制基因的核酸和蛋白质序列。

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