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1. 发明授权

US07081343B2 Methods for identifying modulators of NF-KB activity 有权
公开(公告)号：US07081343B2
公开(公告)日：2006-07-25
申请号：US09884875
申请日：2001-06-18
申请人： Lin-feng Chen , Wolfgang Fischle , Eric M. Verdin , Warner C. Greene
发明人： Lin-feng Chen , Wolfgang Fischle , Eric M. Verdin , Warner C. Greene
IPC分类号： G01N33/53 , C12Q1/34 , C12Q1/02
CPC分类号： C07K14/4702
摘要： The present invention provides methods for identification of agents that modulate NF-κB activity through modulation of the acetylation and deacetylation of the RelA subunit of NF-κB.

2. 发明授权

US07745173B2 Histone deacetylase and methods of use thereof 有权
标题翻译：组蛋白脱乙酰酶及其使用方法
公开(公告)号：US07745173B2
公开(公告)日：2010-06-29
申请号：US12013277
申请日：2008-01-11
申请人： Eric M. Verdin , Wolfgang Fischle , Franck O. Dequiedt
发明人： Eric M. Verdin , Wolfgang Fischle , Franck O. Dequiedt
IPC分类号： C12Q1/00
CPC分类号： C12N9/16 , A61K38/00 , C07K2319/00
摘要： The present invention provides nucleic acid molecules that encode histone deacetylase, as well as recombinant vectors and host cells that include the subject nucleic acid molecules. Also provided are histone deacetylase polypeptide compositions. The histone deacteylase nucleic acid molecules are useful in a variety of diagnostic and therapeutic applications, which are also provided.
摘要翻译：本发明提供了编码组蛋白脱乙酰酶的核酸分子，以及包含受试核酸分子的重组载体和宿主细胞。还提供了组蛋白脱乙酰酶多肽组合物。组蛋白去活化酶核酸分子可用于各种诊断和治疗应用，其也被提供。

3. 发明申请

US20100022624A1 Methods of Treating Smooth Muscle Cell Disorders 有权
标题翻译：治疗平滑肌细胞疾病的方法
公开(公告)号：US20100022624A1
公开(公告)日：2010-01-28
申请号：US12567500
申请日：2009-09-25
申请人： Eric M. Verdin , David Waltregny , Vincent Castronovo
发明人： Eric M. Verdin , David Waltregny , Vincent Castronovo
IPC分类号： A61K31/7105
CPC分类号： G01N33/5061 , C12Q1/6881 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N33/57442 , G01N33/57446 , G01N33/57492 , G01N33/6887
摘要： The present invention provides methods of detecting cells showing smooth muscle differentiation. The present invention further provides methods of detecting tumor cells. The present invention further provides compositions and methods for treating smooth muscle cell disorders.
摘要翻译：本发明提供检测显示平滑肌分化的细胞的方法。本发明还提供了检测肿瘤细胞的方法。本发明还提供了治疗平滑肌细胞病症的组合物和方法。

4. 发明授权

US08114853B2 Methods of treating smooth muscle cell disorders 有权
标题翻译：平滑肌细胞疾病的治疗方法
公开(公告)号：US08114853B2
公开(公告)日：2012-02-14
申请号：US12567500
申请日：2009-09-25
申请人： Eric M. Verdin , David Waltregny , Vincent Castronovo
发明人： Eric M. Verdin , David Waltregny , Vincent Castronovo
IPC分类号： A61K31/70 , C12Q1/68 , C07H21/02 , C07H21/04 , C12N5/00
CPC分类号： G01N33/5061 , C12Q1/6881 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N33/57442 , G01N33/57446 , G01N33/57492 , G01N33/6887
摘要： The present invention provides methods of detecting cells showing smooth muscle differentiation. The present invention further provides methods of detecting tumor cells. The present invention further provides compositions and methods for treating smooth muscle cell disorders.
摘要翻译：本发明提供检测显示平滑肌分化的细胞的方法。本发明还提供了检测肿瘤细胞的方法。本发明还提供了治疗平滑肌细胞病症的组合物和方法。

5. 发明申请

US20100160262A1 COMPOSITIONS AND METHODS FOR MODULATING SIRTUIN ACTIVITY 审中-公开
标题翻译：用于调节SIRTUIN活性的组合物和方法
公开(公告)号：US20100160262A1
公开(公告)日：2010-06-24
申请号：US12343177
申请日：2008-12-23
申请人： Melanie Ott , Eric M. Verdin , Manfred Jung
发明人： Melanie Ott , Eric M. Verdin , Manfred Jung
IPC分类号： A61K31/655 , G01N33/573 , A61K31/538 , A61K31/551 , A61K31/497 , A61K31/506 , A61K31/52 , A61K31/4725
CPC分类号： A61K31/4725 , A61K31/497 , A61K31/506 , A61K31/52 , A61K31/538 , A61K31/551 , A61K31/655
摘要： The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide. The present invention further provides active agents that modulate sirtuin activity or expression; and compositions, including pharmaceutical compositions, comprising the active agents.
摘要翻译：本发明提供了涉及调节沉默调节蛋白的活性和/或sirtuin mRNA和/或sirtuin多肽水平的治疗方法。在一些实施方案中，本发明提供了涉及调节SIRT1活性和/或SIRT mRNA和/或多肽水平的治疗方法。本发明提供抑制SIRT1 Tat脱乙酰酶活性的方法。抑制SIRT1 Tat脱乙酰酶活性的方法可用于治疗免疫缺陷病毒感染，特别是人类免疫缺陷病毒（HIV）感染。因此，本发明提供了治疗免疫缺陷病毒感染的方法，通常涉及抑制SIRT1 Tat脱乙酰酶的活性。本发明进一步提供了鉴定调节沉默调节蛋白的活性（例如，SIRT1活性）的药剂的方法，特别是sirtuins与底物（例如，结合和/或脱乙酰化）例如病毒底物如Tat多肽的能力。本发明还提供调节沉默调节蛋白的活性或表达的活性剂; 和包含活性剂的组合物，包括药物组合物。

6. 发明授权

US09474788B2 Methods for the reactivation of latent HIV using cytosine methylation inhibitors and NF-KB activators 有权
标题翻译：使用胞嘧啶甲基化抑制剂和NF-κB活化剂重新激活潜伏HIV的方法
公开(公告)号：US09474788B2
公开(公告)日：2016-10-25
申请号：US13088136
申请日：2011-04-15
申请人： Eric M. Verdin , Steven E. Kauder
发明人： Eric M. Verdin , Steven E. Kauder
IPC分类号： A61K38/19 , A61K31/15 , A61K31/166 , A61K31/353 , A61K31/405 , A61K31/495 , A61K31/513 , A61K31/7068 , A61K38/17 , A61K38/20 , A61K45/06
CPC分类号： A61K38/191 , A61K31/15 , A61K31/166 , A61K31/353 , A61K31/405 , A61K31/495 , A61K31/513 , A61K31/7068 , A61K38/1709 , A61K38/2006 , A61K45/06 , C12N2740/16011 , A61K2300/00
摘要： The present disclosure provides methods and compositions for reactivating latent immunodeficiency virus in an immunodeficiency virus-infected cell. The methods generally involve contacting an immunodeficiency virus-infected cell with a synergistically effective amount of an inhibitor of cytosine methylation and an NF-κB activator. The present disclosure provides methods and compositions for reducing the reservoir of latent immunodeficiency virus in an individual, and for treating an immunodeficiency virus infection in an individual.
摘要翻译：本公开提供了在免疫缺陷病毒感染的细胞中重新激活潜伏性免疫缺陷病毒的方法和组合物。所述方法通常包括使免疫缺陷病毒感染的细胞与协同有效量的胞嘧啶甲基化抑制剂和NF-κB活化剂接触。本公开提供了用于减少个体中潜伏性免疫缺陷病毒的储库并用于治疗个体中的免疫缺陷病毒感染的方法和组合物。

7. 发明授权

US07884081B2 Methods of modulating tubulin deacetylast activity 有权
标题翻译：调节微管蛋白脱乙酰酶活性的方法
公开(公告)号：US07884081B2
公开(公告)日：2011-02-08
申请号：US12029333
申请日：2008-02-11
申请人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
发明人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
IPC分类号： A01N43/04 , A01N43/62 , A61K31/535 , C12N9/00 , C12N5/00 , C12Q1/34
CPC分类号： C12Q1/34 , C12Q1/32 , G01N2333/98 , G01N2500/02
摘要： The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a cell. The invention further provides methods of modulating cellular proliferation by modulating the activity of tubulin deacetylase.
摘要翻译：本发明提供了鉴定调节微管蛋白脱乙酰酶多肽的水平或活性的试剂以及通过该方法鉴定的试剂的方法。本发明还提供调节细胞中微管蛋白脱乙酰酶活性的方法。本发明还提供了通过调节微管蛋白脱乙酰酶的活性来调节细胞增殖的方法。

8. 发明授权

US07544467B2 Method for the identification of compounds capable of activating latent human immunodeficiency virus (HIV) 有权
标题翻译：用于鉴定能够激活潜伏性人体免疫缺陷病毒（HIV）的化合物的方法
公开(公告)号：US07544467B2
公开(公告)日：2009-06-09
申请号：US11746404
申请日：2007-05-09
申请人： Eric M. Verdin , Albert Jordan
发明人： Eric M. Verdin , Albert Jordan
IPC分类号： C12Q1/20 , A61K39/21
CPC分类号： C07K14/005 , C12N5/0636 , C12N15/86 , C12N2503/02 , C12N2510/00 , C12N2740/16022 , C12N2740/16043 , C12N2830/00 , C12N2830/60 , C12N2840/203
摘要： The present invention provides isolated cells that comprise, integrated into the genome of the cell, a transcription-competent immunodeficiency virus or a transcription-competent immunodeficiency virus-based retroviral vector. Under basal in vitro culture conditions, the immunodeficiency virus is latent, and the expression of the latent immunodeficiency virus can be reactivated. The invention farther provides methods of making a subject cell. The invention further provides screening methods for identifying agents that activate a latent immunodeficiency virus; and screening method for identifying agents that block reactivation of latent immunodeficiency virus expression in response to T cell activation signals. The invention further provides agents identified in the subject screening assays. The invention further provides methods of treating an immunodeficiency virus infection.
摘要翻译：本发明提供了分离的细胞，其包含整合到细胞基因组中的转录感受态免疫缺陷病毒或基于转录的免疫缺陷病毒的逆转录病毒载体。在基础体外培养条件下，免疫缺陷病毒是潜伏的，潜伏免疫缺陷病毒的表达可以重新激活。本发明还提供了制作受试细胞的方法。本发明还提供用于鉴定激活潜伏性免疫缺陷病毒的试剂的筛选方法; 以及用于鉴定响应于T细胞活化信号阻断潜伏免疫缺陷病毒表达的再激活的试剂的筛选方法。本发明还提供在本发明筛选测定中鉴定的试剂。本发明还提供了治疗免疫缺陷病毒感染的方法。

9. 发明授权

US07485416B2 Screening methods for the identification of agents that inhibit SIRT1 Tat deacetylase activity 有权
标题翻译：用于鉴定抑制SIRT1 Tat脱乙酰酶活性的试剂的筛选方法
公开(公告)号：US07485416B2
公开(公告)日：2009-02-03
申请号：US11022192
申请日：2004-12-22
申请人： Melanie Ott , Eric M. Verdin , Manfred Jung
发明人： Melanie Ott , Eric M. Verdin , Manfred Jung
IPC分类号： C12Q1/70 , A61K39/21
CPC分类号： C12Q1/34 , C12Q1/26 , G01N2333/16 , G01N2333/918 , G01N2333/98 , G01N2500/02
摘要： The present invention provides treatment methods involving modulating a sirtuin activity and/or a sirtuin mRNA and/or a sirtuin polypeptide level. In some embodiments, the present invention provides treatment methods involving modulating SIRT1 activity and/or SIRT mRNA and/or polypeptide level. The present invention provides methods of inhibiting SIRT1 Tat deacetylase activity. Methods of inhibiting SIRT1 Tat deacetylase activity are useful for treating immunodeficiency virus infections, particularly human immunodeficiency virus (HIV) infection. Thus, the present invention provides methods of treating an immunodeficiency virus infection, generally involving inhibiting SIRT1 Tat deacetylase activity. The present invention further provides methods of identifying agents that modulate sirtuin activity (e.g., SIRT1 activity), particularly ability of sirtuins to interact with (e.g., bind and/or deacetylate) a substrate, e.g., a viral substrate such as a Tat polypeptide. The present invention further provides active agents that modulate sirtuin activity or expression; and compositions, including pharmaceutical compositions, comprising the active agents.
摘要翻译：本发明提供了涉及调节沉默调节蛋白的活性和/或sirtuin mRNA和/或sirtuin多肽水平的治疗方法。在一些实施方案中，本发明提供了涉及调节SIRT1活性和/或SIRT mRNA和/或多肽水平的治疗方法。本发明提供抑制SIRT1 Tat脱乙酰酶活性的方法。抑制SIRT1 Tat脱乙酰酶活性的方法可用于治疗免疫缺陷病毒感染，特别是人类免疫缺陷病毒（HIV）感染。因此，本发明提供了治疗免疫缺陷病毒感染的方法，通常涉及抑制SIRT1 Tat脱乙酰酶的活性。本发明进一步提供了鉴定调节沉默调节蛋白的活性（例如，SIRT1活性）的药剂的方法，特别是sirtuins与底物（例如，结合和/或脱乙酰化）例如病毒底物如Tat多肽的能力。本发明还提供调节沉默调节蛋白的活性或表达的活性剂; 和包含活性剂的组合物，包括药物组合物。

10. 发明授权

US07351542B2 Methods of modulating tubulin deacetylase activity 有权
标题翻译：调节微管蛋白脱乙酰酶活性的方法
公开(公告)号：US07351542B2
公开(公告)日：2008-04-01
申请号：US10441854
申请日：2003-05-19
申请人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
发明人： Eric M. Verdin , Brian J. North , Scott M. Ulrich
IPC分类号： C12Q1/00 , C12Q1/44 , G01N33/53 , C12N9/00 , A61K51/00 , A61K49/00 , C07H21/04
CPC分类号： C12Q1/34 , C12Q1/32 , G01N2333/98 , G01N2500/02
摘要： The present invention provides methods for identifying agents that modulate a level or an activity of tubulin deacetylase polypeptide, as well as agents identified by the methods. The invention further provides methods of modulating tubulin deacetylase activity in a cell. The invention further provides methods of modulating cellular proliferation by modulating the activity of tubulin deacetylase.
摘要翻译：本发明提供了鉴定调节微管蛋白脱乙酰酶多肽的水平或活性的试剂以及通过该方法鉴定的试剂的方法。本发明还提供调节细胞中微管蛋白脱乙酰酶活性的方法。本发明还提供了通过调节微管蛋白脱乙酰酶的活性来调节细胞增殖的方法。

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