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1. 发明申请

US20130309255A1 BIOMARKERS, USES OF BIOMARKERS AND A METHOD OF IDENTIFYING BIOMARKERS 审中-公开
标题翻译：生物标志物，生物标记物的使用和识别生物标志物的方法
公开(公告)号：US20130309255A1
公开(公告)日：2013-11-21
申请号：US13993678
申请日：2011-11-30
申请人： Vincent Castronovo , Andrei Turtoi
发明人： Vincent Castronovo , Andrei Turtoi
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , G01N33/57438 , G01N2800/60
摘要： The invention relates to the use of one or more of protein myoferlin, protein latent-transforming growth factor beta binding protein2, protein transforming growth factor beta induced protein ig-h3, protein asporin, protein tenascin, protein periostin, protein galectin, protein fibronectin, protein prolargin, protein protein-glutamine gamma-glutamyl transferase 2, protein agrin, protein adipocyte enhancer-binding protein 1, protein annexin A6, protein laminin alpha-2 subunit, proteinlaminin subunit alpha-4, protein mimecan, protein Ras-related protein Rap-2b, protein collagen alpha-1 (XIV) chain, protein collagen alpha-3 (VI) chain, protein latent-transforming growth factor beta binding protein 1, protein V type proton ATPase catalytic subunit A, protein laminin alpha-4 and protein transmembrane protein 62 as a biomarker for pancreatic cancer, or a predisposition thereto. The invention also relates to ligands directed to the above-mentioned biomarkers, for use in the therapeutic and/or prophylactic treatment of a pancreatic cancer.
摘要翻译：本发明涉及一种或多种蛋白质肌球蛋白，蛋白质潜伏转化生长因子β结合蛋白2，蛋白质转化生长因子β诱导蛋白ig-h3，蛋白质阿霉素，蛋白质腱蛋白，蛋白质骨膜素，蛋白质半乳凝素，蛋白质纤连蛋白，蛋白质脱水蛋白，蛋白质 - 谷氨酰胺γ-谷氨酰转移酶2，蛋白质集聚蛋白，蛋白质脂肪细胞增强子结合蛋白1，蛋白质膜联蛋白A6，蛋白层粘连蛋白α-2亚基，蛋白质蛋白亚基α-4，蛋白质组蛋白，蛋白质Ras相关蛋白质Rap -2b，蛋白质胶原α-1（XIV）链，蛋白质胶原α-3（VI）链，蛋白质潜伏转化生长因子β结合蛋白1，蛋白质V型质子ATP酶催化亚基A，蛋白质层粘连蛋白α-4和蛋白质跨膜蛋白62作为胰腺癌的生物标志物，或其易感性。本发明还涉及针对上述生物标志物的配体，用于胰腺癌的治疗和/或预防性治疗。

2. 发明申请

US20090163414A1 IN-VITRO METHOD FOR SCREENING ACCESSIBLE BIOLOGICAL MARKERS IN PATHOLOGICAL TISSUES 审中-公开
标题翻译：在病理组织中筛选可行生物标志物的体外方法
公开(公告)号：US20090163414A1
公开(公告)日：2009-06-25
申请号：US12160200
申请日：2006-12-13
申请人： Vincent Castronovo , David Waltregny , Philippe Kischel
发明人： Vincent Castronovo , David Waltregny , Philippe Kischel
IPC分类号： A61K38/17 , G01N33/53 , A61P35/00
CPC分类号： G01N33/6842
摘要： The present invention refers to an in vitro method for screening specific disease biological markers which are accessible from the extracellular space in pathologic tissues comprising the steps of: immersing a native pathologic tissue sample in a solution containing a labelling reagent for labelling proteins, wherein accessible proteins are labelled by the labelling reagent; purifying the labelled proteins; analyzing the labelled proteins or fragments thereof; determining the differential expression pattern of the labelled proteins in the native pathologic tissue samples compared to normal tissue samples; and judging that the labelled protein(s) having higher expression in the native pathologic tissue sample compared to normal tissue samples or being expressed more frequently in respective native pathologic tissue samples compared to normal tissue samples is/are biological marker(s) for pathologic tissue, which are accessible for high-affinity ligands from the extracellular space.
摘要翻译：本发明涉及一种用于筛选可从病理组织中的细胞外空间接近的特异性疾病生物标志物的体外方法，包括以下步骤：将天然病理组织样品浸入含有用于标记蛋白质的标记试剂的溶液中，其中可接近的蛋白质被标记试剂标记; 纯化标记的蛋白质; 分析标记的蛋白质或其片段; 确定与正常组织样品相比，天然病理组织样品中标记蛋白质的差异表达模式; 并且判断与正常组织样品相比在天然病理组织样品中具有较高表达的标记蛋白或与正常组织样品相比在相应的天然病理组织样品中更频繁地表达的标记蛋白是用于病理组织的生物标志物，其可从细胞外空间的高亲和力配体获得。

3. 发明申请

US20100022624A1 Methods of Treating Smooth Muscle Cell Disorders 有权
标题翻译：治疗平滑肌细胞疾病的方法
公开(公告)号：US20100022624A1
公开(公告)日：2010-01-28
申请号：US12567500
申请日：2009-09-25
申请人： Eric M. Verdin , David Waltregny , Vincent Castronovo
发明人： Eric M. Verdin , David Waltregny , Vincent Castronovo
IPC分类号： A61K31/7105
CPC分类号： G01N33/5061 , C12Q1/6881 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N33/57442 , G01N33/57446 , G01N33/57492 , G01N33/6887
摘要： The present invention provides methods of detecting cells showing smooth muscle differentiation. The present invention further provides methods of detecting tumor cells. The present invention further provides compositions and methods for treating smooth muscle cell disorders.
摘要翻译：本发明提供检测显示平滑肌分化的细胞的方法。本发明还提供了检测肿瘤细胞的方法。本发明还提供了治疗平滑肌细胞病症的组合物和方法。

4. 发明授权

US08114853B2 Methods of treating smooth muscle cell disorders 有权
标题翻译：平滑肌细胞疾病的治疗方法
公开(公告)号：US08114853B2
公开(公告)日：2012-02-14
申请号：US12567500
申请日：2009-09-25
申请人： Eric M. Verdin , David Waltregny , Vincent Castronovo
发明人： Eric M. Verdin , David Waltregny , Vincent Castronovo
IPC分类号： A61K31/70 , C12Q1/68 , C07H21/02 , C07H21/04 , C12N5/00
CPC分类号： G01N33/5061 , C12Q1/6881 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N33/57442 , G01N33/57446 , G01N33/57492 , G01N33/6887
摘要： The present invention provides methods of detecting cells showing smooth muscle differentiation. The present invention further provides methods of detecting tumor cells. The present invention further provides compositions and methods for treating smooth muscle cell disorders.
摘要翻译：本发明提供检测显示平滑肌分化的细胞的方法。本发明还提供了检测肿瘤细胞的方法。本发明还提供了治疗平滑肌细胞病症的组合物和方法。

5. 发明申请

US20060051815A1 Methods of treating smooth muscle cell disorders 审中-公开
标题翻译：平滑肌细胞疾病的治疗方法
公开(公告)号：US20060051815A1
公开(公告)日：2006-03-09
申请号：US11166669
申请日：2005-06-23
申请人： Eric Verdin , David Waltregny , Vincent Castronovo
发明人： Eric Verdin , David Waltregny , Vincent Castronovo
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/53
CPC分类号： G01N33/5061 , C12Q1/6881 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , G01N33/57434 , G01N33/57442 , G01N33/57446 , G01N33/57492 , G01N33/6887
摘要： The present invention provides methods of detecting cells showing smooth muscle differentiation. The present invention further provides methods of detecting tumor cells. The present invention further provides compositions and methods for treating smooth muscle cell disorders.
摘要翻译：本发明提供检测显示平滑肌分化的细胞的方法。本发明还提供了检测肿瘤细胞的方法。本发明还提供了治疗平滑肌细胞病症的组合物和方法。

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