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1. 发明申请

US20080307546A1 Cyclin-dependent kinase inhibitors and uses thereof 审中-公开
标题翻译：细胞周期蛋白依赖性激酶抑制剂及其用途
公开(公告)号：US20080307546A1
公开(公告)日：2008-12-11
申请号：US11728573
申请日：2007-03-26
申请人： Lieven De Veylder , Tom Beeckman , Dirk Inze , Wim Van Camp , Luc Krols
发明人： Lieven De Veylder , Tom Beeckman , Dirk Inze , Wim Van Camp , Luc Krols
IPC分类号： C12N15/11 , A01H5/00
CPC分类号： C12N15/8261 , A01N65/08 , C07K14/415 , Y02A40/146 , A01N65/00 , A01N2300/00
摘要： Provided are DNA sequences encoding cyclin-dependent kinase inhibitor(s) as well as to methods for obtaining the same. Furthermore, vectors comprising said DNA sequences are described, wherein the DNA sequences are operatively linked to regulatory elements allowing expression in prokaryotic and/or eukaryotic host cells. In addition, proteins encoded by said DNA sequences, antibodies to said proteins and methods for their production are provided. Furthermore, regulatory sequences which naturally regulate the expression of the above described DNA sequences are described. Also described is a method for controlling or altering growth characteristics of a plant and/or a plant cell comprising introduction and/or expression of one or more cyclin-dependent kinase inhibitor(s) functional in a plant or parts thereof and/or one or more DNA sequences encoding such proteins. Also provided is a process for disruption plant cell division by interfering in the expression or activity of a cyclin-dependent protein kinase inhibitor using a DNA sequence according to the invention wherein said plant cell is part of a transgenic plant. Further described are diagnostic compositions comprising the aforementioned DNA sequences, proteins, antibodies and regulatory sequences. Methods for the identification of compounds being capable of activating or inhibiting the cyclin-dependent kinase inhibitors are described as well. Furthermore, transgenic plant cells, plant tissue and plants containing the above-described DNA sequences and vectors are described as well as the use of the aforementioned DNA sequences, vectors, proteins, antibodies, regulatory sequences and/or compounds identified by the method of the invention in plant cell and tissue culture, plant breeding and/or agriculture.
摘要翻译：提供编码细胞周期蛋白依赖性激酶抑制剂的DNA序列以及获得其的方法。此外，描述了包含所述DNA序列的载体，其中所述DNA序列可操作地连接到允许在原核和/或真核宿主细胞中表达的调节元件。此外，提供了由所述DNA序列编码的蛋白质，对所述蛋白质的抗体及其生产方法。此外，描述了天然调节上述DNA序列表达的调节序列。还描述了一种用于控制或改变植物和/或植物细胞的生长特征的方法，包括在植物或其部分和/或其中的一个或多个部分引入和/或表达功能性的一种或多种细胞周期蛋白依赖性激酶抑制剂和/ 更多编码这种蛋白质的DNA序列。还提供了通过使用根据本发明的DNA序列干扰细胞周期蛋白依赖性蛋白激酶抑制剂的表达或活性来破坏植物细胞分裂的方法，其中所述植物细胞是转基因植物的一部分。进一步描述了包含上述DNA序列，蛋白质，抗体和调控序列的诊断组合物。还描述了能够激活或抑制细胞周期蛋白依赖性激酶抑制剂的化合物的鉴定方法。此外，还描述了含有上述DNA序列和载体的转基因植物细胞，植物组织和植物以及上述DNA序列，载体，蛋白质，抗体，调节序列和/或化合物在植物细胞和组织培养，植物育种和/或农业中的发明。

2. 发明授权

US07265267B1 Cyclin-dependent kinase inhibitors and uses thereof 失效
标题翻译：细胞周期蛋白依赖性激酶抑制剂及其用途
公开(公告)号：US07265267B1
公开(公告)日：2007-09-04
申请号：US09574735
申请日：2000-05-18
申请人： Lieven De Veylder , Tom Beeckman , Dirk Inze , Wim Van Camp , Luc Krols
发明人： Lieven De Veylder , Tom Beeckman , Dirk Inze , Wim Van Camp , Luc Krols
IPC分类号： C12N15/82 , A01H5/00 , A01H5/02
CPC分类号： C07K14/415 , A01N65/08 , C12N15/8261 , Y02A40/146
摘要： Provided are DNA sequences encoding cyclin-dependent kinase inhibitor(s) as well as to methods for obtaining the same. Furthermore, vectors comprising said DNA sequences are described, wherein the DNA sequences are operatively linked to regulatory elements allowing expression in prokaryotic and/or eukaryotic host cells. In addition, proteins encoded by said DNA sequences, antibodies to said proteins and methods for their production are provided. Furthermore, regulatory sequences which naturally regulate the expression of the above described DNA sequences are described. Also described is a method for controlling or altering growth characteristics of a plant and/or a plant cell comprising introduction and/or expression of one or more cyclin-dependent kinase inhibitor(s) functional in a plant or parts thereof and/or one or more DNA sequences encoding such proteins. Also provided is a process for disruption plant cell division by interfering in the expression or activity of a cyclin-dependent protein kinase inhibitor using a DNA sequence according to the invention wherein said plant cell is part of a transgenic plant. Further described are diagnostic compositions comprising the aforementioned DNA sequences, proteins, antibodies and regulatory sequences. Methods for the identification of compounds being capable of activating or inhibiting the cyclin-dependent kinase inhibitors are described as well. Furthermore, transgenic plant cells, plant tissue and plants containing the above-described DNA sequences and vectors are described as well as the use of the aforementioned DNA sequences, vectors, proteins, antibodies, regulatory sequences and/or compounds identified by the method of the invention in plant cell and tissue culture, plant breeding and/or agriculture.
摘要翻译：提供编码细胞周期蛋白依赖性激酶抑制剂的DNA序列以及获得其的方法。此外，描述了包含所述DNA序列的载体，其中所述DNA序列可操作地连接到允许在原核和/或真核宿主细胞中表达的调节元件。此外，提供了由所述DNA序列编码的蛋白质，对所述蛋白质的抗体及其生产方法。此外，描述了天然调节上述DNA序列表达的调节序列。还描述了一种用于控制或改变植物和/或植物细胞的生长特征的方法，包括在植物或其部分和/或其中的一个或多个部分引入和/或表达功能性的一种或多种细胞周期蛋白依赖性激酶抑制剂和/ 更多编码这种蛋白质的DNA序列。还提供了通过使用根据本发明的DNA序列干扰细胞周期蛋白依赖性蛋白激酶抑制剂的表达或活性来破坏植物细胞分裂的方法，其中所述植物细胞是转基因植物的一部分。进一步描述了包含上述DNA序列，蛋白质，抗体和调控序列的诊断组合物。还描述了能够激活或抑制细胞周期蛋白依赖性激酶抑制剂的化合物的鉴定方法。此外，还描述了含有上述DNA序列和载体的转基因植物细胞，植物组织和植物以及上述DNA序列，载体，蛋白质，抗体，调节序列和/或化合物在植物细胞和组织培养，植物育种和/或农业中的发明。

3. 发明申请

US20080134355A1 Plants Having Improved Growth Characteristics And Method For Making The Same 失效
标题翻译：具有改善生长特性的植物和制作相同的方法
公开(公告)号：US20080134355A1
公开(公告)日：2008-06-05
申请号：US11792001
申请日：2005-11-30
申请人： Wim Van Camp
发明人： Wim Van Camp
IPC分类号： C12N15/82 , C12N15/87 , C07H21/04 , A01H1/00 , A01H5/00 , C12N5/02 , C12N9/12
CPC分类号： C12N15/8261 , C12N9/1205 , Y02A40/146
摘要： The present invention concerns a method for improving growth characteristics of plants by modulating activity of a mutant CDKA kinase or a homologue thereof in a plant and/or modulating expression of a nucleic acid encoding such mutant CDKA. One such method comprises introducing into a plant a mutant CDKA nucleic acid molecule or mutant functional variant thereof. The invention also provides an isolated CKA mutant protein and nucleic acids encoding such protein. The invention furthermore relates to transgenic plants having improved growth characteristics, which plants have modulated expression of a nucleic acid encoding a mutant CDKA kinase. The present invention also concerns constructs useful in the methods of the invention.
摘要翻译：本发明涉及通过调节植物中突变体CDKA激酶或其同源物的活性和/或调节编码这种突变CDKA的核酸表达来改善植物生长特性的方法。一种这样的方法包括向植物中引入突变体CDKA核酸分子或其突变体功能变体。本发明还提供了分离的CKA突变蛋白和编码这种蛋白质的核酸。本发明还涉及具有改善的生长特性的转基因植物，该植物调节了编码突变CDKA激酶的核酸的表达。本发明还涉及可用于本发明方法的构建体。

4. 发明申请

US20140259212A1 Process for the Production of Fine Chemicals 审中-公开
标题翻译：精细化工生产工艺
公开(公告)号：US20140259212A1
公开(公告)日：2014-09-11
申请号：US13510783
申请日：2010-11-18
申请人： Gunnar Plesch , Astrid Blau , Michael Manfred Herold , Beate Kamlage , Birgit Wendel , Piotr Puzio , Stefan Henkes , Volker Haake , Wim Van Camp , Holger Fahnenstich , Bryan McKersie , Wesley Bruce , Nicole Christiansen
发明人： Gunnar Plesch , Astrid Blau , Michael Manfred Herold , Beate Kamlage , Birgit Wendel , Piotr Puzio , Stefan Henkes , Volker Haake , Wim Van Camp , Holger Fahnenstich , Bryan McKersie , Wesley Bruce , Nicole Christiansen
IPC分类号： C12P1/00 , C12N15/82
CPC分类号： C12N15/8261 , C12N15/8243 , C12P1/00 , Y02A40/146
摘要： The present invention relates to a process for the production of a fine chemical in a non-human organism, like a microorganism, a plant cell, a plant, a plant tissue or in one or more parts thereof. The invention furthermore relates to nucleic acid molecules, polypeptides, nucleic acid constructs, expression cassettes, vectors, antibodies, host cells, plant tissue, propagation material, harvested material, plants, microorganisms as well as agricultural compositions and to their use.
摘要翻译：本发明涉及在非人体生物体如微生物，植物细胞，植物，植物组织或其一个或多个部分中生产精细化学品的方法。本发明还涉及核酸分子，多肽，核酸构建体，表达盒，载体，抗体，宿主细胞，植物组织，繁殖材料，收获的材料，植物，微生物以及农业组合物及其用途。

5. 发明授权

US07847157B2 Plants having improved growth characteristics and method for making the same 失效
标题翻译：具有改善生长特性的植物及其制备方法
公开(公告)号：US07847157B2
公开(公告)日：2010-12-07
申请号：US11792001
申请日：2005-11-30
申请人： Wim Van Camp
发明人： Wim Van Camp
IPC分类号： C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C12N15/8261 , C12N9/1205 , Y02A40/146
摘要： The present invention concerns a method for improving growth characteristics of plants by modulating activity of a mutant CDKA kinase or a homologue thereof in a plant and/or modulating expression of a nucleic acid encoding such mutant CDKA. One such method comprises introducing into a plant a mutant CDKA nucleic acid molecule or mutant functional variant thereof. The invention also provides an isolated CKA mutant protein and nucleic acids encoding such protein. The invention furthermore relates to transgenic plants having improved growth characteristics, which plants have modulated expression of a nucleic acid encoding a mutant CDKA kinase. The present invention also concerns constructs useful in the methods of the invention.
摘要翻译：本发明涉及通过调节植物中突变体CDKA激酶或其同源物的活性和/或调节编码这种突变CDKA的核酸表达来改善植物生长特性的方法。一种这样的方法包括向植物中引入突变体CDKA核酸分子或其突变体功能变体。本发明还提供了分离的CKA突变蛋白和编码这种蛋白质的核酸。本发明还涉及具有改善的生长特性的转基因植物，该植物调节了编码突变CDKA激酶的核酸的表达。本发明还涉及可用于本发明方法的构建体。

6. 发明申请

US20080262160A1 Monodisperse Polymers Containing (Alkyl)Acrylic Acid Moieties, Precursors and Methods for Making them and their Applications 审中-公开
标题翻译：含有（烷基）丙烯酸部分的单分散聚合物，前体及其制备方法及其应用
公开(公告)号：US20080262160A1
公开(公告)日：2008-10-23
申请号：US11571508
申请日：2005-06-30
申请人： Filip Du Prez , Wim Van Camp , Stefan A. F. Bon
发明人： Filip Du Prez , Wim Van Camp , Stefan A. F. Bon
IPC分类号： C08F20/26 , C08F2/38
CPC分类号： C08F122/105 , C08F220/26 , C08F220/38 , C08F293/00 , C08F293/005 , C08F2438/02 , C08F2438/03
摘要： This invention relates to monodisperse or nearly monodisperse (co)polymers containing acrylic or (α-substituted)acrylic acid moieties, polymeric precursors thereof as well as methods for making them by at least partial hydrolysis of said polymeric precursors. The invention also relates to compositions comprising such (co)polymers optionally in combination with polymer processing additives for use in various fields of technology including imaging applications.
摘要翻译：本发明涉及含有丙烯酸或（α-取代的）丙烯酸部分的单分散或几乎单分散（共）聚合物，其聚合物前体以及通过至少部分水解所述聚合物前体制备它们的方法。本发明还涉及包含任选与聚合物加工添加剂组合的这种（共）聚合物的组合物，其用于各种技术领域，包括成像应用。

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