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1. 发明申请

US20060240456A1 Nanosized biological container and manufacture thereof 审中-公开
标题翻译：纳米化生物容器及其制造
公开(公告)号：US20060240456A1
公开(公告)日：2006-10-26
申请号：US11384792
申请日：2006-03-20
申请人： Liaohai Chen , Samuel Bader , Axel Hoffmann , Brian Kay , Lee Makowski
发明人： Liaohai Chen , Samuel Bader , Axel Hoffmann , Brian Kay , Lee Makowski
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： G01N33/5434 , B82Y15/00 , B82Y30/00
摘要： Nanosized biological containers that are “ghosts” of viruses for which capsids are independent of their endogenous viral nucleic acid cores, provide nano-particles of uniform size, and known numbers of sites for attachments of ligands. These containers can be filled with a fluorescent, magnetic, x-ray absorbent, nucleotide components or a radioactive particle and used as nanoscale markers.
摘要翻译：作为衣壳与其内源性病毒核酸核心无关的病毒的“鬼魂”的纳米化生物容器提供均匀大小的纳米颗粒，以及已知数目的配体附着位点。这些容器可以填充荧光，磁性，X射线吸收剂，核苷酸组分或放射性颗粒，并用作纳米级标记。

2. 发明授权

US4390970A Rotating register utilizing field effect transistors 失效
标题翻译：使用场效应晶体管的旋转寄存器
公开(公告)号：US4390970A
公开(公告)日：1983-06-28
申请号：US216237
申请日：1980-12-15
申请人： Brian Kay
发明人： Brian Kay
IPC分类号： G06F9/46 , H04M1/64 , G11C19/00
CPC分类号： H04M1/64 , G06F9/462
摘要： A storage register which may be used to store several sets of data. The storage register may also be used as a demultiplexer to separate two or more sets of data that were received by the register over a single data line. The storage register includes a closed circuit loop of pairs of field effect devices and pairs of clocking devices wherein the clocking devices are coupled between the field effect devices. Input and output terminals are coupled to selected field effect devices. Embodiments of this storage register permit several bits of information to be stored simultaneously in the closed circuit loop and still remain accessible to input and output terminals at different times controlled by the clocking means. A further embodiment provides for several closed circuit loops to be arranged for the parallel storage of data bits.
摘要翻译：一个可用于存储多组数据的存储寄存器。存储寄存器还可以用作解复用器，以通过单个数据线分离由寄存器接收的两组或更多组数据。存储寄存器包括一对场效应器件和时钟器件对的闭合回路，其中时钟器件耦合在场效应器件之间。输入和输出端子耦合到选定的场效应器件。该存储寄存器的实施例允许将几比特的信息同时存储在闭路回路中，并且在由时钟装置控制的不同时间仍然可以被输入和输出端子访问。另一实施例提供了若干闭环电路，用于并行存储数据位。

3. 发明申请

US20050069951A1 Identification of drugs using complementary combinatorial libraries 审中-公开
标题翻译：使用互补组合文库鉴定药物
公开(公告)号：US20050069951A1
公开(公告)日：2005-03-31
申请号：US10656250
申请日：2003-09-08
申请人： Dana Fowlkes , Brian Kay , Jeffrey Frelinger , Robin Hyde-Deruyscher
发明人： Dana Fowlkes , Brian Kay , Jeffrey Frelinger , Robin Hyde-Deruyscher
IPC分类号： C07K1/04 , G01N33/53 , G01N33/543
CPC分类号： G01N33/53 , C07K1/047
摘要： The present invention is directed to the identification of compounds in a compound library which can mediate the biological activity of a target receptor protein, even when the ligands which mediate that activity through binding to that receptor are not already known. The method of the invention includes the following three steps: (1) Screen a first combinatorial library for members binding to the target protein (TP) and hence capable of use as surrogates for the unknown ligand in steps (2) and (3). (2) Screen a second library, for compounds which inhibit the binding of one or more surrogates from step (1) to TP, and, optionally. (3) Determine whether the inhibitory compound mediates the biological activity of the said TP. The first library is composed of peptides, peptoids and/or nucleic acids, and the second is not.
摘要翻译：本发明涉及可以介导靶受体蛋白的生物活性的化合物文库中的化合物的鉴定，即使当通过结合该受体介导该活性的配体不是已知的时，也是如此。本发明的方法包括以下三个步骤：（1）筛选与靶蛋白（TP）结合的成员的第一组合文库，因此能够用作步骤（2）和（3）中未知配体的替代物。（2）筛选第二个文库，对于抑制一个或多个替代物从步骤（1）与TP的结合的化合物，以及任选的。（3）确定抑制性化合物是否介导所述TP的生物活性。第一个文库由肽，拟肽和/或核酸组成，第二个不是。

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