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    • 7. 发明申请
    • NOVEL GERMINAL KINASE PROTEINS, COMPOSITIONS AND METHODS OF USE
    • 新型端粒激酶蛋白,组合物和使用方法
    • US20080108098A1
    • 2008-05-08
    • US11867504
    • 2007-10-04
    • Cindy LeoYing LuoXiang XuSimon Yu
    • Cindy LeoYing LuoXiang XuSimon Yu
    • C12Q1/48
    • C12N9/1205C12Q1/485G01N33/5041G01N2500/02
    • The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins, and proteins so encoded which are capable of modulating proliferation, survival, morphology, and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions are methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology, and migration in mammalian cells.
    • 本发明提供调节细胞增殖,存活,形态和迁移的组合物和方法。 提供了编码蛋白质的核酸和如此编码的能够调节哺乳动物细胞中增殖,存活,形态和迁移的蛋白质。 还提供了用于治疗与细胞增殖,存活,形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供组合物是用于诊断和预测这些疾病的方法。 进一步提供了用于鉴定能够调节哺乳动物细胞中增殖,存活,形态和迁移的生物活性剂的测定。
    • 10. 发明授权
    • Germinal center kinase proteins, compositions and methods of use
    • 生发中心激酶蛋白,组成和使用方法
    • US07265214B2
    • 2007-09-04
    • US10029115
    • 2001-10-19
    • Ying LuoSimon YuXiang XuCindy Leo
    • Ying LuoSimon YuXiang XuCindy Leo
    • C07H21/04C12Q1/68C12N5/02
    • C12N9/1205C12Q1/485G01N33/5041G01N2500/02
    • The present invention provides compositions and methods for modulating cell proliferation, survival, morphology, and migration. Nucleic acids encoding proteins and proteins so encoded which are capable of modulating proliferation, survival, morphology and migration in mammalian cells are provided. Compositions and methods for the treatment of disorders related to cell proliferation, survival, morphology and migration are also provided. Prophylactics and methods for the prevention of such disorders are also provided. Also provided are compositions and methods for diagnostic and prognostic determination of such disorders. Further provided are assays for the identification of bioactive agents capable of modulating proliferation, survival, morphology and migration in mammalian cells.
    • 本发明提供调节细胞增殖,存活,形态和迁移的组合物和方法。 提供了编码能够调节哺乳动物细胞中增殖,存活,形态和迁移的蛋白质和蛋白质的核酸。 还提供了用于治疗与细胞增殖,存活,形态和迁移相关的病症的组合物和方法。 还提供了预防和预防这种疾病的方法。 还提供了用于诊断和预测这些疾病的组合物和方法。 还提供了用于鉴定能够调节哺乳动物细胞中增殖,存活,形态和迁移的生物活性剂的测定。