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1. 发明申请

US20130011405A1 ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE 有权
标题翻译： ANTAGONIST抗CD40单克隆抗体及其使用方法
公开(公告)号：US20130011405A1
公开(公告)日：2013-01-10
申请号：US13612070
申请日：2012-09-12
申请人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst , Sharon Lea Aukerman , Daniel E. Lopes de Menezes
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst , Sharon Lea Aukerman , Daniel E. Lopes de Menezes
IPC分类号： A61K39/395 , A61P29/00 , A61P19/04 , A61P35/00 , A61P19/02 , A61P19/08 , A61P37/06 , A61P25/00 , A61P1/16 , A61P1/00 , A61P7/06 , A61P31/14 , A61P17/06 , A61P21/04 , A61P5/14 , A61P37/00 , A61P7/02 , A61P9/00 , A61P3/10 , A61P37/08 , A61P11/06 , A61P25/28 , C12N5/0781 , A61K39/44
CPC分类号： C07K16/2878 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要翻译：提供了用于治疗通过CD40表达细胞刺激CD40信号传导介导的疾病的组合物和方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

2. 发明授权

US08637032B2 Antagonist anti-CD40 monoclonal antibodies and methods for their use 有权
标题翻译：拮抗剂抗CD40单克隆抗体及其使用方法
公开(公告)号：US08637032B2
公开(公告)日：2014-01-28
申请号：US13612070
申请日：2012-09-12
申请人： Li Long , Asha Yabannavar , Isabel Zaror , Sang Hoon Lee , Deborah Hurst
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Sang Hoon Lee , Deborah Hurst
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要翻译：提供了用于治疗通过CD40表达细胞刺激CD40信号传导介导的疾病的组合物和方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

3. 发明授权

US08277810B2 Antagonist anti-CD40 antibodies 有权
标题翻译：拮抗剂抗CD40抗体
公开(公告)号：US08277810B2
公开(公告)日：2012-10-02
申请号：US11932472
申请日：2007-10-31
申请人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要翻译：提供了用于治疗通过CD40表达细胞刺激CD40信号传导介导的疾病的组合物和方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

4. 发明申请

US20080254026A1 ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE 有权
标题翻译： ANTAGONIST抗CD40单克隆抗体及其使用方法
公开(公告)号：US20080254026A1
公开(公告)日：2008-10-16
申请号：US11932472
申请日：2007-10-31
申请人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst , Sharon Lea Aukerman , Daniel E. Lopes de Menezes
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst , Sharon Lea Aukerman , Daniel E. Lopes de Menezes
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , A61P1/00 , A61P37/00 , G01N33/574 , C07H21/00
CPC分类号： C07K16/2878 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要翻译：提供了用于治疗通过CD40表达细胞刺激CD40信号传导介导的疾病的组合物和方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

5. 发明申请

US20080057070A1 Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use 审中-公开
标题翻译：拮抗剂抗Cd40单克隆抗体及其使用方法
公开(公告)号：US20080057070A1
公开(公告)日：2008-03-06
申请号：US10577390
申请日：2004-11-04
申请人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst
IPC分类号： A61K39/395 , A61P19/02 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , C07K16/28 , C12N15/13 , C12N5/20
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40 expressing cells, such as B cells.
摘要翻译：提供了通过CD40表达细胞上的CD40信号传导介导的治疗疾病的治疗方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

6. 发明申请

US20070274948A1 Methods of Therapy for Chronic Lymphocytic Leukemia 审中-公开
标题翻译：慢性淋巴细胞性白血病治疗方法
公开(公告)号：US20070274948A1
公开(公告)日：2007-11-29
申请号：US10566410
申请日：2004-06-04
申请人： Deborah Hurst , Cornelia Quadt , Maurice Wolin , Sandra Milan , Anders Osterborg
发明人： Deborah Hurst , Cornelia Quadt , Maurice Wolin , Sandra Milan , Anders Osterborg
IPC分类号： A61K38/20 , A61K39/395 , A61P35/02
CPC分类号： A61K38/2013 , A61K39/39541 , A61K2300/00
摘要： Methods for treating a human with chronic lymphocytic leukemia using a combination of an interleukin-2 and an anti-CD52 antibody are provided. These therapeutic agents are administered as two separate pharmaceutical compositions, one containing an IL-2, the other containing an anti-CD2 antibody, according to a dosing regiment. Administering of these two therapeutic agents together results in a positive therapeutic response that is improved with respect to that observed with anti-CD52 antibody alone.
摘要翻译：提供了使用白细胞介素-2和抗CD52抗体的组合治疗慢性淋巴细胞性白血病的人的方法。这些治疗剂以两种分开的药物组合物的形式给药，一种含有IL-2的药物组合物，另一种含有抗CD2抗体。将这两种治疗剂一起施用导致阳性治疗反应相对于单独用抗CD52抗体观察到的改善。

7. 发明授权

US06694523B2 Ergonomic compression glove for hand, wrist, thumb and forearm support 失效
标题翻译：人体工学压缩手套，手腕，拇指和前臂支撑
公开(公告)号：US06694523B2
公开(公告)日：2004-02-24
申请号：US10152642
申请日：2002-05-21
申请人： Deborah Hurst
发明人： Deborah Hurst
IPC分类号： A41D1900
CPC分类号： A41D19/01582 , Y10S2/03
摘要： The specification and drawings describe and show one or more embodiments of the present invention in the form of a compression glove for selective application for treatment of hand, wrist, forearm and thumb discomfort. Useful for prevention and relief of injuries caused by repetitive motions while handling implements, it has a flexible waterproof glove body with exposed fingertips. The glove includes a pair or series of layers of hermetically sealed material, that can capture pressurized air, when applied therein. It is formed through the patterned sealing of the layers of the glove together at select locations. This forms inflatable chambers that can selectively apply isolated points of pressure and support to the affected area.
摘要翻译：说明书和附图以用于治疗手，腕，前臂和拇指不适的选择性应用的压缩手套的形式描述并示出了本发明的一个或多个实施例。用于预防和缓解由重复运动造成的伤害，同时处理工具，它具有柔软的防水手套，具有暴露的指尖。手套包括一对或一系列密封材料层，当其中施加时可以捕获加压空气。它通过在选择的位置处将手套的层的图案化密封在一起形成。这形成了可以选择性地将受压区和支撑点施加到受影响区域的充气室。

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