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1. 发明申请

US20130011405A1 ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE 有权
标题翻译： ANTAGONIST抗CD40单克隆抗体及其使用方法
公开(公告)号：US20130011405A1
公开(公告)日：2013-01-10
申请号：US13612070
申请日：2012-09-12
申请人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst , Sharon Lea Aukerman , Daniel E. Lopes de Menezes
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst , Sharon Lea Aukerman , Daniel E. Lopes de Menezes
IPC分类号： A61K39/395 , A61P29/00 , A61P19/04 , A61P35/00 , A61P19/02 , A61P19/08 , A61P37/06 , A61P25/00 , A61P1/16 , A61P1/00 , A61P7/06 , A61P31/14 , A61P17/06 , A61P21/04 , A61P5/14 , A61P37/00 , A61P7/02 , A61P9/00 , A61P3/10 , A61P37/08 , A61P11/06 , A61P25/28 , C12N5/0781 , A61K39/44
CPC分类号： C07K16/2878 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要翻译：提供了用于治疗通过CD40表达细胞刺激CD40信号传导介导的疾病的组合物和方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

2. 发明申请

US20080254026A1 ANTAGONIST ANTI-CD40 MONOCLONAL ANTIBODIES AND METHODS FOR THEIR USE 有权
标题翻译： ANTAGONIST抗CD40单克隆抗体及其使用方法
公开(公告)号：US20080254026A1
公开(公告)日：2008-10-16
申请号：US11932472
申请日：2007-10-31
申请人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst , Sharon Lea Aukerman , Daniel E. Lopes de Menezes
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst , Sharon Lea Aukerman , Daniel E. Lopes de Menezes
IPC分类号： A61K39/395 , C07K16/18 , C12N5/06 , A61P1/00 , A61P37/00 , G01N33/574 , C07H21/00
CPC分类号： C07K16/2878 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要翻译：提供了用于治疗通过CD40表达细胞刺激CD40信号传导介导的疾病的组合物和方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

3. 发明授权

US08277810B2 Antagonist anti-CD40 antibodies 有权
标题翻译：拮抗剂抗CD40抗体
公开(公告)号：US08277810B2
公开(公告)日：2012-10-02
申请号：US11932472
申请日：2007-10-31
申请人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , A61K39/395 , A61K39/3955 , A61K45/06 , A61K47/6849 , A61K2039/505 , A61K2039/507 , A61N5/10 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Compositions and methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40-expressing cells, such as B cells.
摘要翻译：提供了用于治疗通过CD40表达细胞刺激CD40信号传导介导的疾病的组合物和方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

4. 发明申请

US20080057070A1 Antagonist Anti-Cd40 Monoclonal Antibodies and Methods for Their Use 审中-公开
标题翻译：拮抗剂抗Cd40单克隆抗体及其使用方法
公开(公告)号：US20080057070A1
公开(公告)日：2008-03-06
申请号：US10577390
申请日：2004-11-04
申请人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst
发明人： Li Long , Mohammad Luqman , Asha Yabannavar , Isabel Zaror , Bao-Lu Chen , Xiaofeng Lu , Sang Hoon Lee , Deborah Hurst
IPC分类号： A61K39/395 , A61P19/02 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , C07K16/28 , C12N15/13 , C12N5/20
CPC分类号： C07K16/2878 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： Methods of therapy for treating diseases mediated by stimulation of CD40 signaling on CD40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-CD40 antibody or antigen-binding fragment thereof to a patient in need thereof. The antagonist anti-CD40 antibody or antigen-binding fragment thereof is free of significant agonist activity, but exhibits antagonist activity when the antibody binds a CD40 antigen on a human CD40-expressing cell. Antagonist activity of the anti-CD40 antibody or antigen-binding fragment thereof beneficially inhibits proliferation and/or differentiation of human CD40 expressing cells, such as B cells.
摘要翻译：提供了通过CD40表达细胞上的CD40信号传导介导的治疗疾病的治疗方法。所述方法包括向有需要的患者施用治疗有效量的拮抗性抗CD40抗体或其抗原结合片段。拮抗性抗CD40抗体或其抗原结合片段没有显着的激动剂活性，但当抗体结合表达人CD40的细胞上的CD40抗原时，其表现出拮抗剂活性。抗CD40抗体或其抗原结合片段的拮抗作用有利地抑制人CD40表达细胞如B细胞的增殖和/或分化。

5. 发明授权

US08945564B2 Antagonist anti-CD40 antibody pharmaceutical compositions 有权
标题翻译：拮抗剂抗CD40抗体药物组合物
公开(公告)号：US08945564B2
公开(公告)日：2015-02-03
申请号：US12297382
申请日：2007-04-17
申请人： Xiaofeng Lu , Bao-Lu Chen , Kidisti Araya , Augustus Okhamafe
发明人： Xiaofeng Lu , Bao-Lu Chen , Kidisti Araya , Augustus Okhamafe
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2878 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/94
摘要： Stable liquid pharmaceutical compositions comprising an antagonist anti-CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody-containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.
摘要翻译：提供了包含拮抗性抗-CD40抗体作为治疗或预防活性成分的稳定的液体药物组合物和可用于其制备的方法。这些组合物包含拮抗性抗-CD40抗体，保持组合物的pH在约pH5.0和约pH7.0之间的缓冲剂和足以使液体组合物接近等渗的精氨酸-HCl的量。本发明的稳定的液体拮抗剂抗CD40抗体药物组合物可用于治疗具有自身免疫和/或炎性成分的增殖性疾病和疾病的方法。

6. 发明申请

US20090304706A1 ANTAGONIST ANTI-CD40 ANTIBODY PHARMACEUTICAL COMPOSITIONS 有权
标题翻译： ANTAGONIST抗CD40抗体药物组合物
公开(公告)号：US20090304706A1
公开(公告)日：2009-12-10
申请号：US12297382
申请日：2007-04-17
申请人： Xiaofeng Lu , Bao-Lu Chen , Kidisti Araya , Augustus Okhamafe
发明人： Xiaofeng Lu , Bao-Lu Chen , Kidisti Araya , Augustus Okhamafe
IPC分类号： A61K39/395
CPC分类号： C07K16/2878 , C07K2317/24 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/94
摘要： Stable liquid pharmaceutical compositions comprising an antagonist anti-CD40 antibody as a therapeutically or prophylactically active component and methods useful in their preparation are provided. These compositions comprise the antagonist anti-CD40 antibody, a buffering agent to maintain the pH of the composition between about pH 5.0 and about pH 7.0, and an amount of arginine-HCl sufficient to render the liquid composition near isotonic. The stable liquid antagonist anti-CD40 antibody-containing pharmaceutical compositions of the invention find use in methods for treating proliferative diseases and diseases having an autoimmune and/or inflammatory component.
摘要翻译：提供了包含拮抗性抗-CD40抗体作为治疗或预防活性成分的稳定的液体药物组合物和可用于其制备的方法。这些组合物包含拮抗性抗-CD40抗体，保持组合物的pH在约pH5.0和约pH7.0之间的缓冲剂和足以使液体组合物接近等渗的精氨酸-HCl的量。本发明的稳定的液体拮抗剂抗CD40抗体药物组合物可用于治疗具有自身免疫和/或炎性成分的增殖性疾病和疾病的方法。

7. 发明申请

US20140055069A1 ELECTRIC EXCITATION PERMANENT MAGNET SWITCH, ELECTRIC EXCITATION PERMANENT MAGNET SWITCH RELUCTANCE MOTOR AND ELECTRIC EXCITATION METHOD 有权
标题翻译：电激励永磁开关，电激励永磁电机开关电动机和电动励磁方式
公开(公告)号：US20140055069A1
公开(公告)日：2014-02-27
申请号：US14008251
申请日：2012-03-29
申请人： Shanshan Dai , Xiaofeng Lu
发明人： Shanshan Dai , Xiaofeng Lu
IPC分类号： H01H36/00
CPC分类号： H01H36/00 , H02K21/44 , H02K41/033 , H02K2201/15
摘要： Two magnetic poles of a permanent magnet of a permanent magnet switch and the two ends of an iron core wound with an excitation coil are connected to each other with the soft magnet having a salient pole. A motor uses the switch as the basic component of the stator and rotor, with two magnetic salient poles of each component being arranged axially, wherein the salient pole of the stator component and that of the rotor component are arranged in an opposite manner with an air gap, the excitation coil of the stator component and the rotor component at the symmetric axis position is taken as a phase line to access an excitation control power supply after serial connection or parallel connection. Electric excitation is carried out on the combined motor formed by shaft connection and rotation dislocation among single motors and the stator component in a bi-phase way simultaneously.
摘要翻译：永久磁铁开关的永磁体的两个磁极和缠绕有励磁线圈的铁芯的两端彼此连接，软磁体具有凸极。电动机使用开关作为定子和转子的基本部件，每个部件的两个磁性凸极轴向布置，其中定子部件的凸极和转子部件的凸极以与空气相反的方式布置将定子部件的励磁线圈和对称轴位置的转子部件作为相线进行串联连接或并联连接后接入励磁控制电源。在单电机和定子部件之间通过轴连接和旋转错位形成的组合电动机以双相方式同时进行电励磁。

8. 发明申请

US20140062379A1 SWITCHED RELUCTANCE MOTORS AND EXCITATION CONTROL METHODS FOR THE SAME 有权
标题翻译：切换式电动机及其激励控制方法
公开(公告)号：US20140062379A1
公开(公告)日：2014-03-06
申请号：US14008200
申请日：2012-03-29
申请人： Shanshan Dai , Xiaofeng Lu
发明人： Shanshan Dai , Xiaofeng Lu
IPC分类号： H02P25/08
CPC分类号： H02P25/08 , H02K7/085 , H02K19/103 , H02K21/185 , H02K21/225 , H02K2201/12
摘要： Provided are multiple switched reluctance motors and excitation control methods for same. Motors with various structures are provided having the same structural characteristics, a stator formed of an even number of salient pole pairs and a rotor formed of an even number of salient pole pairs. The salient poles of the stator salient pole pairs are arranged opposite the salient poles of the rotor salient pole pairs, with minimal air gaps left between said salient pole pairs, thus leaving the shortest magnetic return paths between the stator salient pole pairs and the rotor salient pole pairs arranged opposite one another, thus satisfying the minimum reluctance principle of the switched reluctance motor. In addition, due to the magnetic isolation between each stator salient pole pair, the performance of the magnetic pole of each stator salient pole pair is controlled by an excitation control power source and changed independently.
摘要翻译：提供多个开关磁阻电动机及其激励控制方法。具有各种结构的电动机具有相同的结构特征，由偶数凸极对形成的定子和由偶数凸极构成的转子。定子凸极对的极点与转子凸极对的突极相对，在所述凸极对之间留有最小的空隙，从而在定子凸极对与转子显极之间留下最短的磁回路极对彼此相对布置，从而满足开关磁阻电机的最小磁阻原理。另外，由于每个定子凸极对之间的磁隔离，每个定子凸极对的磁极的性能由励磁控制电源控制并独立改变。

9. 发明授权

US09647593B2 Switched reluctance motors and excitation control methods for the same 有权
公开(公告)号：US09647593B2
公开(公告)日：2017-05-09
申请号：US14008200
申请日：2012-03-29
申请人： Shanshan Dai , Xiaofeng Lu
发明人： Shanshan Dai , Xiaofeng Lu
IPC分类号： H02P25/08 , H02K7/08 , H02K19/10 , H02K21/18 , H02K21/22 , H02M1/14
CPC分类号： H02P25/08 , H02K7/085 , H02K19/103 , H02K21/185 , H02K21/225 , H02K2201/12
摘要： Provided are multiple switched reluctance motors and excitation control methods for same. Motors with various structures are provided having the same structural characteristics, a stator formed of an even number of salient pole pairs and a rotor formed of an even number of salient pole pairs. The salient poles of the stator salient pole pairs are arranged opposite the salient poles of the rotor salient pole pairs, with minimal air gaps left between said salient pole pairs, thus leaving the shortest magnetic return paths between the stator salient pole pairs and the rotor salient pole pairs arranged opposite one another, thus satisfying the minimum reluctance principle of the switched reluctance motor. In addition, due to the magnetic isolation between each stator salient pole pair, the performance of the magnetic pole of each stator salient pole pair is controlled by an excitation control power source and changed independently.

10. 发明授权

US08317051B2 Trash can lid 失效
标题翻译：垃圾桶盖
公开(公告)号：US08317051B2
公开(公告)日：2012-11-27
申请号：US12795662
申请日：2010-06-08
申请人： Jiaming Jin , Xiaofeng Lu , Zhongjun Zhou
发明人： Jiaming Jin , Xiaofeng Lu , Zhongjun Zhou
IPC分类号： B65D43/26 , B65D43/16
CPC分类号： B65F1/1607 , B65F1/1615 , B65F1/1623 , B65F1/1646
摘要： The present invention relates to Trash field. More particularly, the present invention relates to Trash can lid. The present invention provides a design of a big lid and a small lid. When an inhabitant usually disposes trash, he or she need only press a button to open the small lid. Since the small lid is connected with the big lid by magnetism and a spring buffer unit is installed in the seat of small lid, opening the small lid is very smooth, without any noise or vibration. When a dustman collects the trash, what he needs to do is only to open the big lid, being very convenient and sanitary.
摘要翻译：垃圾场技术领域本发明涉及垃圾场。更具体地说，本发明涉及垃圾桶盖。本发明提供一种大盖子和小盖子的设计。当一个居民通常处理垃圾时，他或她只需按一下按钮打开小盖子。由于小盖子通过磁力与大盖子连接，并且弹簧缓冲单元安装在小盖子的座椅中，打开小盖子非常光滑，没有任何噪音或振动。当垃圾收集垃圾时，他需要做的只是打开大盖子，非常方便卫生。

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