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1. 发明申请

US20080035842A1 Tandem Ion-Trap Time-Of-Flight Mass Spectrometer 有权
标题翻译：串联离子捕获飞行时间质谱仪
公开(公告)号：US20080035842A1
公开(公告)日：2008-02-14
申请号：US10598194
申请日：2005-02-23
申请人： Michael Sudakov , Li Ding
发明人： Michael Sudakov , Li Ding
IPC分类号： H01J49/40
CPC分类号： H01J49/40 , H01J49/004 , H01J49/423
摘要： A tandem linear ion trap and time-of-flight mass spectrometer, where the ion trap has a straight central axis orthogonal to the flight path of the mass spectrometer. The ion trap comprises a set of electrodes, (401, 403, 402, 404) at least one of the electrodes has a slit for ejecting ions towards the mass spectrometer; a set of DC voltage supplies (+V, −V, V1, V2) to provide discrete DC levels and a number of fast electronic switches (409) for connecting/disconnecting the DC supplies to at least two of the electrodes; a neutral gas filling the ion trap and a digital controller to provide a switching procedure of ion trapping, manipulation with ions, cooling and including a state at which all ions are ejected from the ion trap towards the mass spectrometer.
摘要翻译：串联线性离子阱和飞行时间质谱仪，其中离子阱具有与质谱仪的飞行路径正交的直的中心轴。离子阱包括一组电极（401,403,402,404），至少一个电极具有用于向质谱仪喷射离子的狭缝; 一组直流电压源（+ V，-V，V 1，V 2）以提供离散DC电平和多个用于将DC电源连接/断开至少两个电极的快速电子开关（409）填充离子阱的中性气体和数字控制器，以提供离子捕获，用离子的操作，冷却和包括从离子阱向质谱仪喷射所有离子的状态的切换过程。

2. 发明授权

US06965106B2 Method for dissociating ions using a quadrupole ion trap device 失效
标题翻译：使用四极离子阱装置离子离子的方法
公开(公告)号：US06965106B2
公开(公告)日：2005-11-15
申请号：US10487506
申请日：2002-08-23
申请人： Li Ding , Michael Sudakov
发明人： Li Ding , Michael Sudakov
IPC分类号： G01N27/62 , H01J49/42
CPC分类号： H01J49/424 , H01J49/0068
摘要： A method of trapping ions using a quadrupole ion trap device includes applying quadrupole excitation to trapped precursor ions causing them to be driven into the ring electrode where they undergo surface induced dissociation. The resultant product ions are then trapped within the ion trap device.
摘要翻译：使用四极离子阱捕获装置捕获离子的方法包括对捕获的前体离子施加四极杆激发，使得它们被驱动到环状电极中，在那里它们经历表面诱导的解离。然后将所得产物离子捕获在离子阱装置内。

3. 发明授权

US07285773B2 Quadrupole ion trap device and methods of operating a quadrupole ion trap device 有权
标题翻译：四极离子阱装置及操作四极离子阱装置的方法
公开(公告)号：US07285773B2
公开(公告)日：2007-10-23
申请号：US10494493
申请日：2002-10-24
申请人： Li Ding , Michael Sudakov
发明人： Li Ding , Michael Sudakov
IPC分类号： H01J49/42
CPC分类号： H01J49/424 , H01J49/06
摘要： A quadrupole ion trap device has a field adjusting electrode located outside the trapping region adjacent the aperture in the entrance end cap electrode, and optionally adjacent the aperture in the exit end cap electrode. The field adjusting electrode(s) controls field distortion in the vicinity of the apertures. By appropriately setting the voltages on the field adjusting electrodes the efficiency and resolution of operational processes such as ion introduction, precursor ion isolation and mass scanning can be improved.
摘要翻译：四极离子阱装置具有位于与入口端盖电极中的孔附近的捕获区域外部的场调节电极，并且可选地邻近出口端盖电极中的孔。场调节电极控制孔附近的场失真。通过适当地设定场调节电极上的电压，可以提高离子引入，前体离子隔离和质量扫描等操作过程的效率和分辨率。

4. 发明申请

US20050061966A1 Quadrupole ion trap device and methods of operating a quadrupole ion trap device 有权
标题翻译：四极离子阱装置及操作四极离子阱装置的方法
公开(公告)号：US20050061966A1
公开(公告)日：2005-03-24
申请号：US10494493
申请日：2002-10-24
申请人： Li Ding , Michael Sudakov
发明人： Li Ding , Michael Sudakov
IPC分类号： G01N27/62 , H01J49/06 , H01J49/42 , H01J49/00
CPC分类号： H01J49/424 , H01J49/06
摘要： A quadrupole ion trap device has a field adjusting electrode located outside the trapping region adjacent the aperture in the entrance end cap electrode, and optionally adjacent the aperture in the exit end cap electrode. The field adjusting electrode(s) controls field distortion in the vicinity of the apertures. By appropriately setting the voltages on the field adjusting electrodes the efficiency and resolution of operational processes such as ion introduction, precursor ion isolation and mass scanning can be improved.
摘要翻译：四极离子阱装置具有位于与入口端盖电极中的孔附近的捕获区域外部的场调节电极，并且可选地邻近出口端盖电极中的孔。场调节电极控制孔附近的场失真。通过适当地设定场调节电极上的电压，可以提高离子引入，前体离子隔离和质量扫描等操作过程的效率和分辨率。

5. 发明授权

US07897916B2 Tandem ion-trap time-of-flight mass spectrometer 有权
标题翻译：串联离子阱飞行时间质谱仪
公开(公告)号：US07897916B2
公开(公告)日：2011-03-01
申请号：US10598194
申请日：2005-02-23
申请人： Michael Sudakov , Li Ding
发明人： Michael Sudakov , Li Ding
IPC分类号： H01J49/42
CPC分类号： H01J49/40 , H01J49/004 , H01J49/423
摘要： A tandem linear ion trap and time-of-flight mass spectrometer, where the ion trap has a straight central axis orthogonal to the flight path of the mass spectrometer. The ion trap comprises a set of electrodes, (401, 403, 402, 404) at least one of the electrodes has a slit for ejecting ions towards the mass spectrometer; a set of DC voltage supplies (+V, −V, V1, V2) to provide discrete DC levels and a number of fast electronic switches (409) for connecting/disconnecting the DC supplies to at least two of the electrodes; a neutral gas filling the ion trap and a digital controller to provide a switching procedure of ion trapping, manipulation with ions, cooling and including a state at which all ions are ejected from the ion trap towards the mass spectrometer.
摘要翻译：串联线性离子阱和飞行时间质谱仪，其中离子阱具有与质谱仪的飞行路径正交的直的中心轴。离子阱包括一组电极（401,403,402,404），至少一个电极具有用于向质谱仪喷射离子的狭缝; 一组直流电压源（+ V，-V，V1，V2）以提供离散DC电平以及用于将DC电源连接/断开至少两个电极的多个快速电子开关（409）填充离子阱的中性气体和数字控制器，以提供离子捕获，用离子的操作，冷却和包括从离子阱向质谱仪喷射所有离子的状态的切换过程。

6. 发明授权

US09633143B2 Process and apparatus for generating a three-dimensional swept envelope of a vehicle 有权
公开(公告)号：US09633143B2
公开(公告)日：2017-04-25
申请号：US14110703
申请日：2012-04-05
申请人： Milton Santano Elias Carrasco , Daniel Akwera Shihundu , Billy Siu Fai Chan , Steven Kin-Shing Cheng , Christian Grant Milne , Guanggui Pei , Darren Earl Brown , Li Ding
发明人： Milton Santano Elias Carrasco , Daniel Akwera Shihundu , Billy Siu Fai Chan , Steven Kin-Shing Cheng , Christian Grant Milne , Guanggui Pei , Darren Earl Brown , Li Ding
IPC分类号： G06G7/48 , G06F17/50
CPC分类号： G06F17/5009 , G06F17/5095
摘要： A method, apparatus, media and signals for generating a computer representation of a three-dimensional swept envelope of a vehicle having a wheeled chassis operable to support a vehicle body for movement along a terrain is disclosed. The method involves receiving terrain data representing a 3D terrain, receiving data defining parameters of the vehicle, and receiving data defining a path for movement of the vehicle from an initial position on the terrain to a displaced position on the terrain. The method also involves disposing a computer representation of the vehicle on the 3D representation of the terrain at successive locations along the path using the parameters. Disposing involves determining points of engagement between wheels of the wheeled chassis and the 3D representation of the terrain to dispose the chassis with respect to the terrain, and determining a corresponding 3D location of the vehicle body with respect to the terrain. The method further involves generating a plurality of spatial extents of the vehicle at the successive locations, the spatial extents defining the 3D swept envelope of the vehicle when moving between the initial position and the displaced position. In another aspect a method for generating a computer representation of a three-dimensional swept envelope of an object moving along a guideway disposed with respect to a 3D representation of a terrain is disclosed.

7. 发明申请

US20130138093A1 OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX 有权
标题翻译：光学材料和修正折射指数的方法
公开(公告)号：US20130138093A1
公开(公告)日：2013-05-30
申请号：US13686952
申请日：2012-11-28
申请人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
发明人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
IPC分类号： A61B18/20 , A61F2/14
CPC分类号： A61F2/14 , A61B18/20 , A61F2/142 , A61F2/1451 , A61F2/147 , A61F2/16 , A61F9/008 , A61L27/16 , A61L27/18 , A61L27/52 , B29D11/00355 , B29D11/00461 , B29D11/023 , B29K2083/00 , B29K2105/0061 , C08J7/12 , C08J7/123 , C08J2333/14 , C08J2339/06 , C08J2383/04 , G02B1/041 , G02C7/022 , G02C2202/12 , G02C2202/14
摘要： An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.
摘要翻译：一种光学装置，包括具有已经用激光照射的选择区域的光学水凝胶，所述激光具有0.01nJ至50nJ的脉冲能量和600nm至900nm的波长。照射区域的特征在于折射率的正变化为0.01至0.06，并且表现出很小的或没有散射损失。用亲水性单体制备光学水凝胶。

8. 发明申请

US20130026359A1 METHOD AND APPARATUS FOR GENERATING AND ANALYZING IONS 有权
标题翻译：用于产生和分析离子的方法和装置
公开(公告)号：US20130026359A1
公开(公告)日：2013-01-31
申请号：US13634190
申请日：2011-04-22
申请人： Sumio Kumashiro , Wenjian Sun , Li Ding
发明人： Sumio Kumashiro , Wenjian Sun , Li Ding
IPC分类号： H01J49/26 , H01J49/04 , H01J49/16
CPC分类号： H01J49/10 , G01N27/622 , H01J49/066 , H01J49/161 , H01J49/164 , H01J49/165 , H01J49/24
摘要： The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.
摘要翻译：本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。气态中性分子通过解吸法在大气压下解吸。然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。

9. 发明授权

US08025892B2 Cosmetic particulate gel carriers for topically applied active agents 有权
标题翻译：用于局部施用的活性剂的化妆品颗粒状凝胶载体
公开(公告)号：US08025892B2
公开(公告)日：2011-09-27
申请号：US10017259
申请日：2001-11-12
申请人： Pascal E. Delrieu , Li Ding
发明人： Pascal E. Delrieu , Li Ding
IPC分类号： A61K31/14 , A61K8/02 , A61K9/14 , A61K9/50 , C11D1/62
CPC分类号： A61K8/042 , A61K8/025 , A61K8/11 , A61K8/365 , A61K8/645 , A61K8/676 , A61K8/73 , A61K8/731 , A61K8/735 , A61K2800/56 , A61Q19/00 , Y10S514/937 , Y10S514/944
摘要： Gel particles or beads can be prepared by forming a hot aqueous solution of a gelling agent, and discharging the hot gelling agent solution through a discharge orifice into a cold moving stream of hydrophobic liquid so that the gelling agent solution cools rapidly and good quality gel particles coalesce in the cold hydrophobic liquid stream. The cold hydrophobic liquid stream can be contained in a conduit so that the cold hydrophobic liquid stream moves past the discharge orifice and exerts a force on hot solution in the discharge orifice, the force acting to withdraw the hot solution from the discharge orifice. Optionally, the gel particles can be crushable gel beads 10 formed of an agar complex providing cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Various active agents 16 may be bound to restraining polymer 14, for, example ascorbic acid, lactic acid or papain.
摘要翻译：可以通过形成热胶凝剂的水溶液，并将热胶凝剂溶液通过排出孔排出到冷流动的疏水液体中，使得胶凝剂溶液快速冷却，并且优质的凝胶颗粒在冷疏水性液体流中聚结。冷疏水性液体流可以包含在导管中，使得冷的疏水性液体流移动通过排出孔，并且在排出孔中的热溶液上施加力，该力用于从排出孔抽出热溶液。任选地，凝胶颗粒可以是由琼脂复合物形成的可压碎凝胶珠10，其提供用于局部递送生物或化妆活性剂的化妆品，药物等递送载体。优选的琼脂珠10是具有抑制聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸酸或木瓜蛋白酶。

10. 发明申请

US20110049352A1 ION SOURCE 有权
标题翻译：离子源
公开(公告)号：US20110049352A1
公开(公告)日：2011-03-03
申请号：US12552476
申请日：2009-09-02
申请人： Li Ding , Wenjian Sun
发明人： Li Ding , Wenjian Sun
IPC分类号： H01J49/16 , H01J49/26
CPC分类号： H01J49/162 , H01J49/0463 , H01J49/165
摘要： This invention relates to a desorpton/ionization source operated under ambient conditions for direct analysis of solid or liquid samples on a surface. The source comprises of a laser desorption system and a UV/electrospray combined ionization system. The source is suitable for simultaneously ionizing samples with different polarity in a complex mixture. At the same time, the compact design of the source with multiple channels can maintain the level of local concentration of the analyte ions inside the source for higher efficiency of sample ionization and introduction.
摘要翻译：本发明涉及在环境条件下操作的用于在表面上直接分析固体或液体样品的解吸/离子源。该源包括激光解吸系统和UV /电喷雾组合电离系统。该源适用于在复杂混合物中同时电离不同极性的样品。同时，具有多个通道的源的紧凑设计可以保持源内的分析物离子的局部浓度水平，以提高样品电离和引入的效率。

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