专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5922725A Benzimidazole compounds and their use as modulators of the GABA.sub.A receptor complex 失效
标题翻译：苯并咪唑化合物及其用作GABA A受体复合物的调节剂
公开(公告)号：US5922725A
公开(公告)日：1999-07-13
申请号：US945123
申请日：1997-12-23
申请人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
发明人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
IPC分类号： C07D401/14 , A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/28 , A61P43/00 , C07D235/06 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D521/00
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl, all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, halogen, CF.sub.3, amino, nitro, cyano, acylamino, acyl, phenyl and monocyclic heteroaryl;one of R.sup.6 and R.sup.7 is hydrogen and the other is --CR'.dbd.NOR", wherein R' and R" each independently are hydrogen, alkyl, alkenyl, alkynyl or phenyl.The compounds are useful for the treartment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
摘要翻译： PCT No.PCT / EP96 / 01649 Sec。 371 1997年12月23日第 102（e）1997年12月23日PCT PCT 1996年4月19日PCT公布。 WO96 / 33191 PCT出版物日本特开1996年10月24日本专利申请公开了具有下式的化合物或其药学上可接受的盐或其氧化物，其中R 3为其中A，B和D各自为CH，或A，B和D中的一个为N，其他都是CH; R 11是苯基，苯并咪唑基或单环杂芳基，它们都可以被选自烷基，烷氧基，卤素，CF 3，氨基，硝基，氰基，酰氨基，酰基，苯基和单环杂芳基的取代基取代一次或多次。 R6和R7之一是氢，另一个是-CR'= NOR“，其中R'和R”各自独立地是氢，烷基，烯基，炔基或苯基。该化合物可用于各种中枢神经系统疾病如癫痫和其它惊厥性疾病，焦虑症，睡眠障碍和记忆障碍。

2. 发明授权

US5922724A Benzimidazole compounds and their use as modulators of the GABA a receptor complex 失效
标题翻译：苯并咪唑化合物及其用作GABA受体复合物的调节剂
公开(公告)号：US5922724A
公开(公告)日：1999-07-13
申请号：US945023
申请日：1998-02-05
申请人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
发明人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/28 , A61P43/00 , C07D235/06 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D521/00 , A61K31/425
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, phenyl, halogen, CF.sub.3, amino, nitro, cyano, acyl, acylamino, phenyl and monocyclic heteroaryl; andone of R.sup.6 and R.sup.7 is hydrogen and the other is furanyl or isoxazolyl each of which may be substituted one or more times with substituents selected from halogen, alkyl, alkoxy and phenyl. The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
摘要翻译： PCT No.PCT / EP96 / 01606 Sec。 371日期：1998年2月5日 102（e）1998年2月5日PCT PCT 1996年4月17日PCT公布。出版物WO96 / 33194 日本特开1996年10月24日本专利申请公开了具有下式的化合物或其药学上可接受的盐或其氧化物，其中R 3为其中A，B和D各自为CH，或A，B和D中的一个为N，其他都是CH; R11是苯基，苯并咪唑基或单环杂芳基，其全部可以被选自烷基，烷氧基，苯基，卤素，CF 3，氨基，硝基，氰基，酰基，酰氨基，苯基和单环杂芳基的取代基取代一次或多次; 并且R6和R7中的一个是氢，另一个是呋喃基或异恶唑基，其各自可以被选自卤素，烷基，烷氧基和苯基的取代基取代一次或多次。该化合物可用于治疗各种中枢神经系统疾病如癫痫和其他惊厥性疾病，焦虑症，睡眠障碍和记忆障碍。

3. 发明授权

US06649609B2 Benzimidazole derivatives and pharmaceutical compositions comprising these compounds 失效
标题翻译：苯并咪唑衍生物和包含这些化合物的药物组合物
公开(公告)号：US06649609B2
公开(公告)日：2003-11-18
申请号：US10012490
申请日：2001-12-12
申请人： Lene Teuber , Frank Watjen
发明人： Lene Teuber , Frank Watjen
IPC分类号： C07D23506
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel 1-phenylbenzimidazole derivatives having particular alkoxycarbonyl substituents in the 5-position of the benz ring and having particular cyclic substituents in the meta-position of the phenyl ring, as well as to pharmaceutical compositions containing these compounds and to methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of GABAA receptor complex, and in particular for inducing and maintaining anaesthesia, sedation, and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.
摘要翻译：本发明涉及在苯环的5-位上具有特定的烷氧基羰基取代基并且在苯环的间位具有特定的环状取代基的新的1-苯基苯并咪唑衍生物以及含有这些化合物的药物组合物和方法的治疗。本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABAα受体复合物的调节有反应，特别是诱导和维持麻醉，镇静和肌肉松弛以及对于打击儿童发热性惊厥。本发明的化合物也可以由兽医使用。

4. 发明授权

US5902813A Benzimidazole compounds, pharmaceutical compositions containing the compounds and their use 失效
标题翻译：苯并咪唑化合物，含有这些化合物的药物组合物及其应用
公开(公告)号：US5902813A
公开(公告)日：1999-05-11
申请号：US930216
申请日：1998-01-28
申请人： Lene Teuber , Frank Watjen
发明人： Lene Teuber , Frank Watjen
IPC分类号： C07D401/14 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4439 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/28 , A61P43/00 , C07D235/06 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D521/00 , C07D239/42
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sub.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl all of which may be substituted one or more times with substituents selected from alkyl, halogen, CF.sub.3, amino, nitro, cyano, acylamino, alkoxy, acyl, phenyl, and monocyclic heteroaryl, andone of R.sup.6 and R.sup.7 is hydrogen and the other is pyrrolyl which may be substituted one or more times with substituents selected from halohen, alkyl, phenyl, and alkoxy.The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
摘要翻译： PCT No.PCT / EP96 / 01654 Sec。 371日期1998年1月28日 102（e）日期1998年1月28日PCT 1996年4月19日PCT PCT。第WO96 / 33192号公报日本1996年10月24日本专利申请公开了具有下式的化合物或其药学上可接受的盐或其氧化物，其中R 3为其中A，B和D各自为CH，或A，B和D中的一个或二者为N，其他都是CH; R 11是苯基，苯并咪唑基或单环杂芳基，其全部可以被选自烷基，卤素，CF 3，氨基，硝基，氰基，酰氨基，烷氧基，酰基，苯基和单环杂芳基的取代基取代一次或多次， R6和R7是氢，另一个是可以被选自卤代，烷基，苯基和烷氧基的取代基取代一次或多次的吡咯基。该化合物可用于治疗各种中枢神经系统疾病如癫痫和其他惊厥性疾病，焦虑症，睡眠障碍和记忆障碍。

5. 发明申请

US20070021482A1 1,5,7-Trisubstituted benzimidazole derivatives and their use for modulating the gabaa receptor complex 失效
标题翻译： 1,5,7-三取代苯并咪唑衍生物及其用于调节gabaa受体复合物的用途
公开(公告)号：US20070021482A1
公开(公告)日：2007-01-25
申请号：US10575380
申请日：2004-10-20
申请人： Niall Hamilton , Susan Napier , Morag Easson , Andrew Cooke , Lene Teuber , Naheed Mirza , Frank Watjen
发明人： Niall Hamilton , Susan Napier , Morag Easson , Andrew Cooke , Lene Teuber , Naheed Mirza , Frank Watjen
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： A61K31/4184 , C07D235/06 , C07D401/04 , C07D401/06 , C07D401/10 , C07D403/06 , C07D403/12 , C07D405/04
摘要： This invention relates to novel 1,5,7-trisubstituted benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex.
摘要翻译：本发明涉及新的1,5,7-三取代苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应。

6. 发明授权

US06936613B2 Benzimidazole derivatives and pharmaceutical compositions comprising these compounds 失效
标题翻译：苯并咪唑衍生物和包含这些化合物的药物组合物
公开(公告)号：US06936613B2
公开(公告)日：2005-08-30
申请号：US10618727
申请日：2003-07-15
申请人： Lene Teuber , Frank Watjen
发明人： Lene Teuber , Frank Watjen
IPC分类号： A61K31/4184 , A61K31/422 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/551 , A61P21/00 , A61P21/02 , A61P23/00 , A61P25/00 , A61P25/08 , A61P25/20 , A61P25/22 , C07D235/06 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D407/10 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D521/00 , A61K31/495 , A61K31/415 , C07D235/24 , C07D403/00
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D401/12 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D413/14
摘要： The present invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for inducing and maintaining anesthesia, sedation and muscle relaxation, as well as for combating febrile convulsions in children. The compounds of the invention may also be used by veterinarians.
摘要翻译：本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于诱导和维持麻醉，镇静和肌肉松弛，以及打击儿童发热性惊厥。本发明的化合物也可以由兽医使用。

7. 发明授权

US06218547B1 1-phenyl-benzimidazole compounds and their use as GABA-a receptor modulators 失效
标题翻译： 1-苯基 - 苯并咪唑化合物及其作为GABA-a受体调节剂的用途
公开(公告)号：US06218547B1
公开(公告)日：2001-04-17
申请号：US09269643
申请日：1999-03-31
申请人： Lene Teuber , Frank Watjen
发明人： Lene Teuber , Frank Watjen
IPC分类号： C07D23502
CPC分类号： C07D235/06 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D413/04
摘要： The present invention relates to novel benzimidazole compounds, represented by general formula (I) in which o is 0, 1, 2 or 3; R1 represents an alkyl group, a phenyl group, or a monocyclic heterocyclic group, which groups may be substituted one or more times with substituents selected from alkyl, cycloalkyl, cycloalkyl-alkyl, alkoxy, halogen, trifluoromethyl, cyano, amino and nitro; or R1 represents a cyano group or a group of the formula -alkyl-CO2R2, alkenyl-CO2R2, —CO—R2, —CO2(CH2)mR2, or —C(R3)═N—OR2, R11 represents a group of formula —CO2—R9, or R11 represents a group of general formula (II) in which n is 0, 1, 2 or 3; or R11 may represent a group of general formula (III), in which n is 0, 1, 2 or 3; the novel compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, such as for example anxiety, sleep disorders, anaestesia, memory disorders, and epilepsia or other convulsive disorders.
摘要翻译：本发明涉及由通式（I）表示的新的苯并咪唑化合物，其中o为0,1,2或3; R1表示烷基，苯基或单环杂环基，该基团可以被选自烷基，环烷基，环烷基 - 烷基，烷氧基，卤素，三氟甲基，氰基，氨基和硝基的取代基取代一次或多次; 或R 1表示氰基或式 - 烷基-CO 2 R 2，烯基-CO 2 R 2，-CO-R 2，-CO 2（CH 2）m R 2或-C（R 3）= N-OR 2的基团，R 11表示式 -CO 2 -R 9或R 11表示其中n为0,1,2或3的通式（II）的基团; 或R 11可以表示通式（III）的基团，其中n为0,1,2或3; 本发明的新化合物可用于治疗对GABA A受体复合物调节有反应的中枢神经系统疾病和病症，例如焦虑症，睡眠障碍，麻醉，记忆障碍和癫痫或其它惊厥性疾病。

8. 发明授权

US5554632A Benzimidazole compounds 失效
公开(公告)号：US5554632A
公开(公告)日：1996-09-10
申请号：US352585
申请日：1994-12-09
申请人： Lene Teuber , Oskar Axelsson , Frank Watjen
发明人： Lene Teuber , Oskar Axelsson , Frank Watjen
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/55 , A61K31/5517 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/28 , C07D235/02 , C07D235/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/06 , C07D513/04 , C07D521/00
CPC分类号： C07D235/02 , C07D231/12 , C07D233/56 , C07D235/06 , C07D249/08 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/06 , C07D513/04
摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.

9. 发明授权

US5843945A AMPA antagonists and a method of treatment 失效
标题翻译： AMPA拮抗剂和治疗方法
公开(公告)号：US5843945A
公开(公告)日：1998-12-01
申请号：US951059
申请日：1997-10-15
申请人： Frank Watjen , Jorgen Drejer
发明人： Frank Watjen , Jorgen Drejer
IPC分类号： C07D471/04 , C07D487/04 , A61K31/55 , A61K31/495 , C07D487/00
CPC分类号： C07D471/04 , C07D487/04
摘要： The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n is 0 or 1; R.sup.6 is phenyl, naphthyl, thienyl, pyridyl, all of which may be substituted one or more times with substituents selected from the group consisting of halogen, CF.sub.3, NO.sub.2, amino, alkyl, alkoxy and phenyl; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b. The compounds are useful in the treatment of cerebrovascular disorders. ##STR1##
摘要翻译：本专利申请公开了具有式（I）的化合物或其药学上可接受的盐，其中R 1是氢，烷基或苄基; X是O或NOR2，其中R2是氢，烷基或苄基; Y是N-R4，其中R4是氢，OH或烷基; n为0或1; R6是苯基，萘基，噻吩基，吡啶基，它们都可以被选自卤素，CF 3，NO 2，氨基，烷基，烷氧基和苯基的取代基取代一次或多次; A是在标记a和b的位置与苯环稠合的5至7个原子的环。该化合物可用于治疗脑血管障碍。

10. 发明授权

US5780493A AMPA antagonists and method of treatment therewith 失效
标题翻译： AMPA拮抗剂及其治疗方法
公开(公告)号：US5780493A
公开(公告)日：1998-07-14
申请号：US951821
申请日：1997-10-16
申请人： Frank Watjen , Jorgen Drejer
发明人： Frank Watjen , Jorgen Drejer
IPC分类号： C07D471/04 , C07D487/04 , A61K31/40 , A61K31/44 , C07D401/00 , C07D487/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present patent application discloses compounds having formula (I) or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, alkyl or benzyl; X is O or NOR.sup.2, wherein R.sup.2 is hydrogen, alkyl or benzyl; Y is N--R.sup.4 wherein R.sup.4 is hydrogen, OH or alkyl; n is 0 or 1; R.sup.6 is phenyl, naphthyl, thienyl, pyridyl, all of which may be substituted one or more times with substituents selected from the group consisting of halogen; CF.sub.3, NO.sub.2, amino, alkyl, alkoxy and phenyl; A is a ring of five to seven atoms fused with the benzo ring at the positions marked a and b. The compounds are useful in the treatment of cerebrovascular disorders for example. ##STR1##
摘要翻译：本专利申请公开了具有式（I）的化合物或其药学上可接受的盐，其中R 1是氢，烷基或苄基; X是O或NOR2，其中R2是氢，烷基或苄基; Y是N-R4，其中R4是氢，OH或烷基; n为0或1; R6是苯基，萘基，噻吩基，吡啶基，它们都可以被选自卤素的取代基取代一次或多次; CF 3，NO 2，氨基，烷基，烷氧基和苯基; A是在标记a和b的位置与苯环稠合的5至7个原子的环。该化合物可用于治疗例如脑血管障碍。（一）

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式