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1. 发明授权

US09056857B2 Methods for treating or preventing cancer and neurodegenerative diseases 有权
标题翻译：治疗或预防癌症和神经退行性疾病的方法
公开(公告)号：US09056857B2
公开(公告)日：2015-06-16
申请号：US13140741
申请日：2009-12-21
申请人： Lei Zhu , Yueming Li
发明人： Lei Zhu , Yueming Li
IPC分类号： A61K31/55 , A61K31/381 , C07D409/12 , A61K31/5513 , C07D333/34
CPC分类号： A61K31/5513 , A61K31/381 , C07D333/34 , C07D409/12
摘要： Provided are methods of treating or preventing a neurodegenerative disease comprising administering to a subject having a neurodegenerative disease an effective amount of a compound of Formula I: where X, R1, R2, subscript m, subscript n and subscript v are as defined herein.
摘要翻译：提供治疗或预防神经退行性疾病的方法，其包括向具有神经变性疾病的受试者施用有效量的式I化合物：其中X，R 1，R 2，下标m，下标n和下标v如本文所定义。

2. 发明申请

US20130158017A1 METHODS FOR TREATING OR PREVENTING CANCER AND NEURODEGENERATIVE DISEASES 有权
公开(公告)号：US20130158017A1
公开(公告)日：2013-06-20
申请号：US13140741
申请日：2009-12-21
申请人： Lei Zhu , Yueming Li
发明人： Lei Zhu , Yueming Li
IPC分类号： C07D409/12 , C07D333/34
CPC分类号： A61K31/5513 , A61K31/381 , C07D333/34 , C07D409/12
摘要： Provided are methods of treating or preventing a neurodegenerative disease comprising administering to a subject having a neurodegenerative disease an effective amount of a compound of Formula I: where X, R1, R2, subscript m, subscript n and subscript v are as defined herein.

3. 发明申请

US20110306605A1 COUMARIN-BASED COMPOUNDS FOR THE TREATMENT OF ALZHEIMER'S DISEASE AND CANCER 审中-公开
标题翻译：用于治疗阿尔茨海默病和癌症的基于欧马林的化合物
公开(公告)号：US20110306605A1
公开(公告)日：2011-12-15
申请号：US13140791
申请日：2009-12-21
申请人： Lei Zhu , Hakim Djaballah , Yueming Li , Christopher Chad Shelton
发明人： Lei Zhu , Hakim Djaballah , Yueming Li , Christopher Chad Shelton
IPC分类号： A61K31/5513 , A61P35/00 , A61P29/00 , A61K31/381
CPC分类号： C07D493/04 , C07D213/69 , C07D215/20 , C07D215/22 , C07D309/38 , C07D311/56 , C07D335/06 , C07D491/04 , C07D495/04
摘要： Compounds including those of the Formula I where X, R1, R2 and subscript t are as defined herein, useful as γ-secretase inhibitors, are provided, as are compositions comprising the compounds, as well as methods for use of the compounds for treating or preventing neurodegenerative diseases, such as, for instance, Alzheimer's disease.
摘要翻译：提供了包括式I的化合物，其中X，R 1，R 2和下标t如本文所定义，可用作γ-分泌酶抑制剂，以及包含该化合物的组合物以及用于治疗或预防神经变性疾病，例如阿尔茨海默氏病。

4. 发明申请

US20180354957A1 SUBSTITUTED 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20180354957A1
公开(公告)日：2018-12-13
申请号：US16058299
申请日：2018-08-08
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Rando Allikmets , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides a compound having the structure: wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; and B is a substituted or unsubstituted heterobicycle, wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.

5. 发明申请

US20180222919A1 N-ALKYL-2-PHENOXYETHANAMINES, THEIR PREPARATION AND USE 审中-公开
公开(公告)号：US20180222919A1
公开(公告)日：2018-08-09
申请号：US15944334
申请日：2018-04-03
申请人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
发明人： Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
IPC分类号： C07D498/04 , C07D213/79 , C07D213/80 , C07D231/56 , C07D237/24 , C07C233/56 , C07D249/04 , C07D471/04 , C07D487/04 , C07D491/052 , C07D239/28
CPC分类号： C07D498/04 , C07C233/56 , C07D213/79 , C07D213/80 , C07D231/56 , C07D237/24 , C07D239/28 , C07D249/04 , C07D471/04 , C07D487/04 , C07D491/052
摘要： The present invention provides a compound having the structure: (structurally represented) wherein R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl; R6 is alkyl; A is absent or present, and when present is —C(O)— or —C(O)NH—; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is —C(O)—, or a pharmaceutically acceptable salt thereof.

6. 发明授权

US08995609B2 X-ray compton scatter imaging on volumetric CT systems 有权
标题翻译：体积CT系统的X射线压缩分散成像
公开(公告)号：US08995609B2
公开(公告)日：2015-03-31
申请号：US13565337
申请日：2012-08-02
申请人： Lei Zhu , Tianye Niu
发明人： Lei Zhu , Tianye Niu
IPC分类号： A61B6/00 , G01N23/04 , G21K1/02 , A61B6/03
CPC分类号： G01N23/046 , A61B6/032 , A61B6/4078 , A61B6/4233 , A61B6/483 , A61B6/508 , G01N2223/419 , G01N2223/612 , G21K1/02 , G21K2207/005
摘要： Briefly described, in an exemplary form, the present invention discloses a system, method and apparatus for X-ray Compton scatter imaging. In one exemplary embodiment, the present invention uses two detectors in a volumetric CT system. A first detector is positioned generally in-line with the angle of attack of the incoming energy, or, generally in-line of path x, where x is the path of the incoming energy. The first, or primary, detector detects various forms of radiation emanating from an object undergoing testing. In some embodiments, the present invention further comprises a Compton scattering system positioned generally normal to path x. In some embodiments, the Compton scattering subsystem comprises a second detector and a pin-hole collimator. The second detector detects Compton scattering energy from the object being tested.
摘要翻译：简要描述，在示例性形式中，本发明公开了一种用于X射线康普顿散射成像的系统，方法和装置。在一个示例性实施例中，本发明在体积CT系统中使用两个检测器。第一检测器通常与入射能量的迎角定位，或者通常沿着路径x排列，其中x是入射能量的路径。第一或第一检测器检测从经历测试的对象发出的各种形式的辐射。在一些实施例中，本发明还包括通常垂直于路径x定位的康普顿散射系统。在一些实施例中，康普顿散射子系统包括第二检测器和针孔准直器。第二个检测器检测来自被测物体的康普顿散射能量。

7. 发明授权

US08933225B2 Process for the synthesis of E1 activating enzyme inhibitors 有权
标题翻译：合成E1活化酶抑制剂的方法
公开(公告)号：US08933225B2
公开(公告)日：2015-01-13
申请号：US12221399
申请日：2008-08-01
申请人： Ian Armitage , Eric L. Elliott , Marianne Langston , Steven P. Langston , Quentin J. McCubbin , Hirotake Mizutani , Matthew Stirling , Lei Zhu
发明人： Ian Armitage , Eric L. Elliott , Marianne Langston , Steven P. Langston , Quentin J. McCubbin , Hirotake Mizutani , Matthew Stirling , Lei Zhu
IPC分类号： C07D487/04 , C07C219/24 , C07D241/50 , C07D211/96 , C07D295/22 , C07C217/52 , C07D471/08 , C07C215/44 , C07D213/89 , C07D239/30 , C07C211/35
CPC分类号： C07D487/04 , C07C215/44 , C07C217/52 , C07C219/24 , C07C315/04 , C07C317/50 , C07C2601/08 , C07D211/96 , C07D213/89 , C07D241/50 , C07D295/22 , C07D305/08 , C07D471/08 , Y02P20/55
摘要： Disclosed are processes and synthetic intermediates for the synthesis of compounds of formula (V) wherein the variables have the definitions contained herein. Such compounds are E1 activating enzyme inhibitors, and are useful for the treatment of disorders of cell proliferation, particularly cancer, and other disorders associated with E1 activity.
摘要翻译：公开了用于合成式（V）化合物的方法和合成中间体，其中变量具有本文所含的定义。这些化合物是E1活化酶抑制剂，并且可用于治疗细胞增殖，特别是癌症和与E1活性相关的其它病症的病症。

8. 发明授权

US08809906B2 Semiconductor optical device 有权
标题翻译：半导体光学器件
公开(公告)号：US08809906B2
公开(公告)日：2014-08-19
申请号：US13613177
申请日：2012-09-13
申请人： Lei Zhu , Shigeaki Sekiguchi , Shinsuke Tanaka , Kenichi Kawaguchi
发明人： Lei Zhu , Shigeaki Sekiguchi , Shinsuke Tanaka , Kenichi Kawaguchi
IPC分类号： H01L31/102
CPC分类号： G02B6/122 , G02B6/29352 , G02B2006/121 , G02F1/025 , H01L31/105
摘要： A semiconductor optical device includes a first clad layer, a second clad layer and an optical waveguide layer sandwiched between the first clad layer and the second clad layer, wherein the optical waveguide layer includes a first semiconductor layer, a second semiconductor layer disposed on the first semiconductor layer and extending in one direction, and a third semiconductor layer covering a top surface of the second semiconductor layer, and wherein the first semiconductor layer includes an n-type region disposed on one side of the second semiconductor layer, a p-type region disposed on the other side of the second semiconductor layer, and an i-type region disposed between the n-type region and the p-type region, and wherein the second semiconductor layer has a band gap narrower than band gaps of the first semiconductor layer and the third semiconductor layer.
摘要翻译：半导体光学器件包括第一覆盖层，第二覆盖层和夹在第一覆盖层和第二覆盖层之间的光波导层，其中，光波导层包括第一半导体层，第二半导体层，设置在第一覆盖层半导体层并且沿一个方向延伸，以及覆盖第二半导体层的顶表面的第三半导体层，并且其中第一半导体层包括设置在第二半导体层一侧的n型区域，p型区域设置在第二半导体层的另一侧，以及设置在n型区域和p型区域之间的i型区域，并且其中第二半导体层具有比第一半导体层的带隙窄的带隙和第三半导体层。

9. 发明授权

US08705827B2 Scatter correction methods 有权
标题翻译：分散校正方法
公开(公告)号：US08705827B2
公开(公告)日：2014-04-22
申请号：US13088134
申请日：2011-04-15
申请人： Lei Zhu , Tianye Niu
发明人： Lei Zhu , Tianye Niu
IPC分类号： G06K9/00
CPC分类号： G06T5/002 , G06T5/50 , G06T11/005 , G06T2207/10081 , G06T2207/20224
摘要： Described herein are improved methods for correcting cone beam computed tomography signals to reduce scatter contamination contained therein. Generally, the improved methods involve generating a plurality of two-dimensional projection images of a subject from a three-dimensional multi-detector computed tomography image of the subject. This is followed by subtracting the plurality of two-dimensional projection images from a plurality of two-dimensional cone beam projection images of the subject to produce a plurality of two-dimensional estimated error projections that comprise an estimated error in the plurality of two-dimensional cone beam projection images. The plurality of two-dimensional estimated error projection images are subtracted from the plurality of two-dimensional cone beam projection images to generate a plurality of two-dimensional corrected cone beam projection images. A three-dimensional corrected cone beam computed tomography image of the subject is then constructed from the plurality of two-dimensional corrected cone beam projection images.
摘要翻译：这里描述了用于校正锥形束计算机断层摄影信号以减少其中包含的散射污染的改进方法。通常，改进的方法包括从受试者的三维多检测器计算机断层摄影图像生成受试者的多个二维投影图像。随后从对象的多个二维锥形束投影图像中减去多个二维投影图像，以产生多个二维估计误差投影，其包括多个二维投影图像中的估计误差锥形投影图像。从多个二维锥形束投影图像中减去多个二维估计误差投影图像，以产生多个二维校正锥束投影图像。然后从多个二维校正的锥形束投影图像中构建被摄体的三维校正锥束计算机断层摄影图像。

10. 发明申请

US20130032715A1 X-RAY COMPTON SCATTER IMAGING ON VOLUMETRIC CT SYSTEMS 有权
标题翻译：体积CT系统的X射线压缩扫描成像
公开(公告)号：US20130032715A1
公开(公告)日：2013-02-07
申请号：US13565337
申请日：2012-08-02
申请人： Lei Zhu , Tianye Niu
发明人： Lei Zhu , Tianye Niu
IPC分类号： G01N23/02 , G21K1/02 , A61B6/03
CPC分类号： G01N23/046 , A61B6/032 , A61B6/4078 , A61B6/4233 , A61B6/483 , A61B6/508 , G01N2223/419 , G01N2223/612 , G21K1/02 , G21K2207/005
摘要： Briefly described, in an exemplary form, the present invention discloses a system, method and apparatus for X-ray Compton scatter imaging. In one exemplary embodiment, the present invention uses two detectors in a volumetric CT system. A first detector is positioned generally in-line with the angle of attack of the incoming energy, or, generally in-line of path x, where x is the path of the incoming energy. The first, or primary, detector detects various forms of radiation emanating from an object undergoing testing. In some embodiments, the present invention further comprises a Compton scattering system positioned generally normal to path x. In some embodiments, the Compton scattering subsystem comprises a second detector and a pin-hole collimator. The second detector detects Compton scattering energy from the object being tested.
摘要翻译：简要描述，在示例性形式中，本发明公开了一种用于X射线康普顿散射成像的系统，方法和装置。在一个示例性实施例中，本发明在体积CT系统中使用两个检测器。第一检测器通常与入射能量的迎角定位，或者通常沿着路径x排列，其中x是入射能量的路径。第一或第一检测器检测从经历测试的对象发出的各种形式的辐射。在一些实施例中，本发明还包括通常垂直于路径x定位的康普顿散射系统。在一些实施例中，康普顿散射子系统包括第二检测器和针孔准直器。第二个检测器检测来自被测物体的康普顿散射能量。

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