专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06297238B1 Therapeutic agents 有权
标题翻译：治疗剂
公开(公告)号：US06297238B1
公开(公告)日：2001-10-02
申请号：US09689943
申请日：2000-10-12
申请人： Kevin Doyle , Paul Rafferty , Robert Steele , Allyson Turner , David Wilkins , Lee Arnold
发明人： Kevin Doyle , Paul Rafferty , Robert Steele , Allyson Turner , David Wilkins , Lee Arnold
IPC分类号： A61K314162
CPC分类号： C07D231/12 , C07D231/54 , C07D233/56 , C07D249/08 , C07D401/12 , C07D403/12 , C07D493/04 , C07D495/04
摘要： This invention realtes to compounds formula I and pharmaceutically acceptable salts thereof, which are inhibitors of protein kinase activity, pharmaceutical compositions thereof and provesses for their preparation.
摘要翻译：本发明涉及化合物Ⅰ及其药学上可接受的盐，它们是蛋白激酶活性的抑制剂，其药物组合物及其制备方法。

2. 发明申请

US20090062286A1 Crystal Structure of SMYD3 Protein 审中-公开
标题翻译： SMYD3蛋白的晶体结构
公开(公告)号：US20090062286A1
公开(公告)日：2009-03-05
申请号：US12115089
申请日：2008-05-05
申请人： Kenneth William Foreman , Frances E. Park , Lee Arnold
发明人： Kenneth William Foreman , Frances E. Park , Lee Arnold
IPC分类号： A61K31/41 , C12N9/10 , G06G7/58 , G01N33/53 , C07D257/04 , A61K31/421 , A61K31/519 , A61P35/00 , A61K31/5375 , A61K31/433 , C07D263/04 , C07D285/135 , C07D487/04 , C07D265/30
CPC分类号： C12N9/1007 , C07K2299/00 , G01N2500/04
摘要： The invention relates to SMYD3 methyltransferase (SMYD3), SMYD3 binding pockets or SMYD3-like binding pockets. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to SMYD3 methyltransferase protein, complexes of SMYD3 methyltransferase protein, homologues thereof, or SMYD3-like protein or protein complexes.
摘要翻译：本发明涉及SMYD3甲基转移酶（SMYD3），SMYD3结合口袋或SMYD3样结合口袋。本发明涉及一种计算机，包括用这种结合口袋的结构坐标编码的数据存储介质。本发明还涉及使用结构坐标来解决同源蛋白质或蛋白质复合物的结构的方法。本发明涉及使用结构坐标来筛选和设计结合SMYD3甲基转移酶蛋白质的化合物，SMYD3甲基转移酶蛋白质的复合物，其同源物或SMYD3样蛋白质或蛋白质复合物的方法。

3. 发明授权

US4184805A Fluid energy converting method and apparatus 失效
标题翻译：流体能量转换方法和装置
公开(公告)号：US4184805A
公开(公告)日：1980-01-22
申请号：US884816
申请日：1978-03-09
申请人： Lee Arnold
发明人： Lee Arnold
IPC分类号： F03D5/06
CPC分类号： F03D5/06 , F05B2210/16 , F05B2240/124 , Y02E10/70
摘要： There is disclosed a method and apparatus for converting the kinetic energy of a moving fluid stream into useful work by means of a cascade of thin airfoils positioned therein. In one embodiment, the airfoils are provided with at least two degrees of freedom and adjacent airfoils are movable out of phase. The airfoils are subjected to the aerodynamically induced oscillations caused by the aeroelastic phenomenon known as flutter and the oscillatory movement is then harnessed to do useful work. In an alternate embodiment, a cascade of airfoils is mechanically oscillated within a moving fluid stream to increase the propulsion of the fluid. Where the fluid is a liquid, the cascade includes a plurality of hydrofoils.
摘要翻译：公开了一种用于通过位于其中的薄翼型级联将运动流体流的动能转换成有用功的方法和装置。在一个实施例中，翼型件具有至少两个自由度，相邻的翼型件可以相位移动。翼型受到由称为颤振的气动弹性现象引起的空气动力学诱发振荡，然后利用振荡运动来进行有用的工作。在替代实施例中，叶片的级联机械地在移动的流体流中振荡以增加流体的推进。在流体是液体的情况下，级联包括多个水翼。

4. 发明申请

US20060235031A1 6,6-Bicyclic ring substituted heterobicyclic protein kinase inhibitors 有权
标题翻译： 6,6-双环取代杂双环蛋白激酶抑制剂
公开(公告)号：US20060235031A1
公开(公告)日：2006-10-19
申请号：US11095162
申请日：2005-03-31
申请人： Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
发明人： Lee Arnold , Heather Coate , Andrew Crew , Hanqing Dong , Kenneth Foreman , Ayako Honda , Radoslaw Laufer , An-Hu Li , Kristen Mulvihill , Mark Mulvihill , Anthony Nigro , Bijoy Panicker , Arno Steinig , Qingua Weng , Douglas Werner , Michael Wyle , Tao Zhang , Cara Cesario , Yingchuan Sun
IPC分类号： A61K31/52
CPC分类号： C07F5/025 , C07D471/04 , C07D487/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein, inhibit the IGF-1R enzyme and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer, inflammation, psoriasis, allergy/asthma, disease and conditions of the immune system, disease and conditions of the central nervous system.
摘要翻译：下式的化合物及其药学上可接受的盐，其中X 1，X 2，X 3，X 4， X 5，X 6，X 7，R 1和Q 1 在本文中定义，抑制IGF-1R酶，并且可用于治疗和/或预防过度增殖性疾病如癌症，炎症，牛皮癣，过敏/哮喘，免疫系统的疾病和状况，中枢的疾病和状况神经系统。

5. 发明授权

US07060822B1 2-pyrazolin-5-ones 有权
标题翻译： 2-吡唑啉-5-酮
公开(公告)号：US07060822B1
公开(公告)日：2006-06-13
申请号：US09621468
申请日：2000-07-24
申请人： Lee Arnold , Marina Moran Moset , Jose Maria Castellano Berlanga , Isabel Fernandez , David J. Calderwood , Paul Rafferty
发明人： Lee Arnold , Marina Moran Moset , Jose Maria Castellano Berlanga , Isabel Fernandez , David J. Calderwood , Paul Rafferty
IPC分类号： C07D413/00 , C07D401/00 , C07D403/00 , C07D411/00 , C07D231/02
CPC分类号： C07D401/14 , C07D231/20 , C07D401/06 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
摘要： Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.
摘要翻译：具有结构式I的化合物及其生理上可接受的盐是丝氨酸/苏氨酸和酪氨酸激酶活性的抑制剂。几种酪氨酸激酶（其活性被这些化合物抑制）参与血管发生过程。因此，这些化合物可以改善其中血管生成或内皮细胞过度增殖是一个因素的疾病状态。这些化合物可用于治疗癌症和过度增殖性疾病。

6. 发明授权

US07049312B1 Benzothiazinone and benzoxazinone compounds 有权
标题翻译：苯并噻嗪酮和苯并恶嗪酮化合物
公开(公告)号：US07049312B1
公开(公告)日：2006-05-23
申请号：US09585925
申请日：2000-06-02
申请人： Paul Rafferty , David Calderwood , Lee Arnold , Beatriz Gonzalez Pascual , Jose L. Ortego Martinez , Maria J. Perez de Vega , Isabel Fernandez
发明人： Paul Rafferty , David Calderwood , Lee Arnold , Beatriz Gonzalez Pascual , Jose L. Ortego Martinez , Maria J. Perez de Vega , Isabel Fernandez
IPC分类号： C07D513/04 , C07D417/12 , C07D417/14 , A61K31/5415 , A61K31/542
CPC分类号： C07D417/06 , C07D265/36 , C07D413/06 , C07D471/04
摘要： Q is —N=or CR2 X is S, O or NOR3 Y is —O—, —S—, —SO— or —SO2— R and R1 are each, independently, H, a substituted or unsubstituted aliphatic, aromatic, heteroaromatic or aralkyl group R2 is H or a substituent R3 is H, or —C(O)R4 R4 is a substituted or unsubstituted aliphatic or aromatic group n is an integer from 0 to 1 Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.
摘要翻译： Q是-N =或CR 2 X是S，O或NOR 3 Y是-O - ， - S - ， - SO-或-SO 2 R 1和R 2各自独立地为H，取代或未取代的脂族，芳族，杂芳族或芳烷基R 2是H或取代基R 3是H或-C（O）R 4 R 4是取代或未取代的脂族或芳族基团，n是0的整数具有结构式I的化合物及其生理上可接受的盐是丝氨酸/苏氨酸和酪氨酸激酶活性的抑制剂。几种酪氨酸激酶（其活性被这些化合物抑制）参与血管发生过程。因此，这些化合物可以改善其中血管生成或内皮细胞过度增殖是一个因素的疾病状态。这些化合物可用于治疗癌症和过度增殖性疾病。

7. 发明申请

US20060025383A1 Aminobenzoxazoles as therapeutic agents 审中-公开
标题翻译：氨基苯并恶唑作为治疗剂
公开(公告)号：US20060025383A1
公开(公告)日：2006-02-02
申请号：US11050609
申请日：2005-02-03
申请人： Neil Wishart , Michael Friedman , Lee Arnold , Bryant Yang , Shannon Fix-Stenzel , Anna Ericsson , Michael Michaelides , Xiao-Dong Qian , James Holms , Douglas Steinman , Zhengping Tian , Steven Wittenberger
发明人： Neil Wishart , Michael Friedman , Lee Arnold , Bryant Yang , Shannon Fix-Stenzel , Anna Ericsson , Michael Michaelides , Xiao-Dong Qian , James Holms , Douglas Steinman , Zhengping Tian , Steven Wittenberger
IPC分类号： A61K31/5377 , A61K31/519 , A61K31/695 , C07D487/02
CPC分类号： C07D487/04
摘要： A compound of Formula (I), wherein the substituents are as defined herein, which are useful as kinase inhibitors.
摘要翻译：式（I）的化合物，其中取代基如本文所定义，其可用作激酶抑制剂。

8. 发明授权

US07863444B2 4-aminopyrrolopyrimidines as kinase inhibitors 有权
标题翻译： 4-氨基吡咯并嘧啶作为激酶抑制剂
公开(公告)号：US07863444B2
公开(公告)日：2011-01-04
申请号：US09399083
申请日：1999-09-17
申请人： David Calderwood , Lee Arnold , Hormoz Mazdiyasni , Gavin C. Hirst , Bojuan B. Deng , David N. Johnston , Paul Rafferty , Gerald B. Tometzki , Helen L. Twigger , Rainer Munschauer
发明人： David Calderwood , Lee Arnold , Hormoz Mazdiyasni , Gavin C. Hirst , Bojuan B. Deng , David N. Johnston , Paul Rafferty , Gerald B. Tometzki , Helen L. Twigger , Rainer Munschauer
IPC分类号： C07D487/04 , A61K31/505
CPC分类号： C07D487/04
摘要： Chemical compounds having structural formula I and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the kinases whose activity is inhibited by these compounds are involved in immunologic, hyperproliferative or angiogenic processes. Thus, these compounds can ameliorate disase states where angiogenesis or endothelial cell hyperproliferaton is a factor. These compounds can be used to treat cancer, hyperproliferative disorders, rheumatoid artheritis, disorders of the immune system, transplant rejection, and inflammatory disorders.
摘要翻译：具有结构式I的化合物及其生理上可接受的盐是丝氨酸/苏氨酸和酪氨酸激酶活性的抑制剂。活性被这些化合物抑制的几种激酶参与免疫学，过度增殖或血管发生过程。因此，这些化合物可以改善其中血管生成或内皮细胞过度膨胀是一个因素的疾病状态。这些化合物可用于治疗癌症，过度增殖性疾病，类风湿性关节炎，免疫系统紊乱，移植排斥和炎症性疾病。

9. 发明申请

US20080014200A1 Combined treatment with 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitor and anti-cancer agents 审中-公开
标题翻译：联合治疗6,6-双环环取代杂双环蛋白激酶抑制剂和抗癌剂
公开(公告)号：US20080014200A1
公开(公告)日：2008-01-17
申请号：US11787236
申请日：2007-04-13
申请人： Lee Arnold , Qun-Sheng Ji , Mark Mulvihill
发明人： Lee Arnold , Qun-Sheng Ji , Mark Mulvihill
IPC分类号： A61K31/519 , A61K31/497 , A61K31/498 , A61K31/535 , A61K31/551 , A61K31/675 , A61K31/7068 , A61K39/395 , A61P35/00 , A61K38/50 , A61K31/704 , A61K31/573 , A61K31/5377 , A61K31/53 , A61K31/517
CPC分类号： A61K45/06 , A61K31/4985 , A61K31/519 , A61K31/53 , A61K2300/00
摘要： The present invention provides a method for treating tumors or tumor metastases in a patient, comprising administering to the patient simultaneously or sequentially a therapeutically effective amount of an anti-cancer agent and an IGF1R inhibitor compound of Formula I combination, with or without additional agents or treatments, such as other anti-cancer drugs or radiation therapy. The IGF1R inhibitor is represented by Formula I: wherein X1, X2, X3, X4, X5, X6, X7, R1, and Q1 are defined herein.
摘要翻译：本发明提供了一种用于治疗患者的肿瘤或肿瘤转移的方法，其包括向所述患者同时或依次施用治疗有效量的抗癌剂和式I组合的IGF1R抑制剂化合物，其具有或不具有另外的试剂或治疗，如其他抗癌药物或放射治疗。 IGF1R抑制剂由式I表示：其中X 1，X 2，X 3，X 4， X 5，X 6，X 7，R 1和Q 1，在本文中定义。

10. 发明申请

US20070208053A1 Fused heterobicyclic kinase inhibitors 审中-公开
标题翻译：融合的杂双环激酶抑制剂
公开(公告)号：US20070208053A1
公开(公告)日：2007-09-06
申请号：US11654814
申请日：2007-01-18
申请人： Lee Arnold , Xin Chen , Hanqing Dong , Andrew Garton , Mark Mulvihill , Colin Sambrook Smith , Gerard Thomas , Thomas Krulle , Jing Wang
发明人： Lee Arnold , Xin Chen , Hanqing Dong , Andrew Garton , Mark Mulvihill , Colin Sambrook Smith , Gerard Thomas , Thomas Krulle , Jing Wang
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Compounds of the formula and pharmaceutically acceptable salts thereof, wherein X1, X2, X3, X4, X5, X5, X7, R1, and Q1 are defined herein, inhibit kinase enzymes and are useful for the treatment and/or prevention of hyperproliferative diseases such as cancer. The compounds are also useful in the treatment of inflammation, allergy, asthma, disease and conditions of the immune system, disease and conditions of the nervous system, cardiovascular diseases, disease and conditions of the eye, dermatological diseases, osteoporosis, diabetes, multiple sclerosis, and infections.
摘要翻译：下式的化合物及其药学上可接受的盐，其中X 1，X 2，X 3，X 4， X 5，X 5，X 7，R 1和Q 1 在本文中定义，抑制激酶，并且可用于治疗和/或预防过度增殖性疾病如癌症。该化合物还可用于治疗炎症，过敏，哮喘，免疫系统的疾病和状况，神经系统的疾病和状况，心血管疾病，眼睛疾病和病症，皮肤病，骨质疏松症，糖尿病，多发性硬化和感染。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式