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1. 发明申请

US20090221635A1 QUINOLINYL AND BENZOTHIAZOLYL MODULATORS 有权
公开(公告)号：US20090221635A1
公开(公告)日：2009-09-03
申请号：US12372699
申请日：2009-02-17
申请人： Lawrence R. McGee , Jonathan B. Houze , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
发明人： Lawrence R. McGee , Jonathan B. Houze , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
IPC分类号： A61K31/47 , A61P29/00
CPC分类号： C07D277/68 , C07D215/12 , C07D215/20 , C07D215/36 , C07D215/48 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ. In particular, the compounds of the invention modulate the function of PPARγ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.

2. 发明授权

US06583157B2 Quinolinyl and benzothiazolyl modulators 有权
标题翻译：喹啉基和苯并噻唑基调节剂
公开(公告)号：US06583157B2
公开(公告)日：2003-06-24
申请号：US09894980
申请日：2001-06-27
申请人： Lawrence R. McGee , Jonathan B. Houze , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
发明人： Lawrence R. McGee , Jonathan B. Houze , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
IPC分类号： A61K3147
CPC分类号： C07D213/70 , C07C311/21 , C07D213/65 , C07D215/12 , C07D215/20 , C07D215/36 , C07D215/48 , C07D217/04 , C07D277/64 , C07D277/68 , C07D277/82 , C07D405/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PAPAR&ggr;. In particular, the compounds of the invention modulate the function of PAPAR&ggr;. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
摘要翻译：提供了可用于治疗或预防由PAPARGAMM介导的病症或病症的化合物，组合物和方法。特别地，本发明的化合物调节PAPARγ的功能。本发明的方法在治疗和/或预防糖尿病，肥胖，高胆固醇血症，类风湿性关节炎和动脉粥样硬化方面特别有用。

3. 发明授权

US07960408B2 Quinolinyl and benzothiazolyl modulators 有权
标题翻译：喹啉基和苯并噻唑基调节剂
公开(公告)号：US07960408B2
公开(公告)日：2011-06-14
申请号：US12372699
申请日：2009-02-17
申请人： Lawrence R. McGee , Jonathan B. Houze , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
发明人： Lawrence R. McGee , Jonathan B. Houze , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
IPC分类号： A61K31/04
CPC分类号： C07D277/68 , C07D215/12 , C07D215/20 , C07D215/36 , C07D215/48 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ. In particular, the compounds of the invention modulate the function of PPARγ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
摘要翻译：提供了可用于治疗或预防由PPARγ介导的病症或病症的化合物，组合物和方法。特别是本发明化合物调节PPARγ的功能。本发明的方法在治疗和/或预防糖尿病，肥胖，高胆固醇血症，类风湿性关节炎和动脉粥样硬化方面特别有用。

4. 发明授权

US07601841B2 Quinolinyl and benzothiazolyl modulators 有权
标题翻译：喹啉基和苯并噻唑基调节剂
公开(公告)号：US07601841B2
公开(公告)日：2009-10-13
申请号：US10719997
申请日：2003-11-20
申请人： Lawrence R. McGee , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
发明人： Lawrence R. McGee , Steven M. Rubenstein , Atsushi Hagiwara , Noboru Furukawa , Hisashi Shinkai
IPC分类号： C07D215/38 , A61K31/501 , A61K31/47
CPC分类号： C07D277/68 , C07D215/12 , C07D215/20 , C07D215/36 , C07D215/48 , C07D277/64 , C07D277/82 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Compounds, compositions and methods are provided that are useful in the treatment or prevention of a condition or disorder mediated by PPARγ. In particular, the compounds of the invention modulate the function of PPARγ. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis.
摘要翻译：提供了可用于治疗或预防由PPARgamma介导的病症或病症的化合物，组合物和方法。特别地，本发明的化合物调节PPARγ的功能。本发明的方法在治疗和/或预防糖尿病，肥胖，高胆固醇血症，类风湿性关节炎和动脉粥样硬化方面特别有用。

5. 发明授权

US07244727B2 Fused bicyclic nitrogen-containing heterocycles 失效
标题翻译：稠合双环含氮杂环
公开(公告)号：US07244727B2
公开(公告)日：2007-07-17
申请号：US10720844
申请日：2003-11-21
申请人： Brian M. Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon M. Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin L. McMinn , Nobuya Ogawa , Steven M. Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
发明人： Brian M. Fox , Noboru Furukawa , Xiaolin Hao , Kiyosei Iio , Takashi Inaba , Simon M. Jackson , Frank Kayser , Marc Labelle , Kexue Li , Takuya Matsui , Dustin L. McMinn , Nobuya Ogawa , Steven M. Rubenstein , Shoichi Sagawa , Kazuyuki Sugimoto , Masahiro Suzuki , Masahiro Tanaka , Guosen Ye , Atsuhito Yoshida , Jian Zhang
IPC分类号： C07D498/04 , A61K31/542 , A61P3/04 , A61P3/08 , C07D491/04 , C07D495/04 , A61K31/538 , A61K31/519
CPC分类号： C07D491/04
摘要： Compounds, pharmaceutical compositions and methods that are useful in the treatment or prevention of metabolic and cell proliferative diseases or conditions are provided herein. In particular, the invention provides compounds which modulate the activity of proteins involved in lipid metabolism and cell proliferation.
摘要翻译：本文提供了可用于治疗或预防代谢和细胞增殖性疾病或病症的化合物，药物组合物和方法。特别地，本发明提供调节参与脂质代谢和细胞增殖的蛋白质的活性的化合物。

6. 发明授权

US07140097B2 Method of manufacturing chip-type ceramic electronic component 有权
标题翻译：芯片型陶瓷电子部件的制造方法
公开(公告)号：US07140097B2
公开(公告)日：2006-11-28
申请号：US10633642
申请日：2003-08-05
申请人： Noboru Furukawa , Masahiko Kawase
发明人： Noboru Furukawa , Masahiko Kawase
IPC分类号： H01C17/00
CPC分类号： H01G4/30 , H01C1/028 , H01C7/008 , H01G2/12 , H01G4/12 , Y10T29/49082 , Y10T29/49083 , Y10T29/49085 , Y10T29/49126 , Y10T29/49128
摘要： A method of manufacturing a chip-type ceramic electronic component having stable electrical properties and excellent mechanical strength includes the steps of providing a plurality of green sheets having predetermined cutting positions, coating inorganic paste including the same ceramic material as that included in ceramic green sheets, and an inorganic material having higher resistivity than that of the ceramic material, on a region of each ceramic green sheet, and laminating a predetermined number of the ceramic green sheets to form a ceramic laminated product. Then, the ceramic laminated product is cut into a chip at the predetermined cutting positions and sintered to form a ceramic sintered compact, and external electrodes are formed at both ends of the ceramic sintered compact.
摘要翻译：制造具有稳定的电气性能和优异的机械强度的芯片型陶瓷电子部件的制造方法包括以下步骤：提供具有预定切割位置的多个生片，涂覆包括与陶瓷生片中所含陶瓷材料相同的陶瓷材料的无机糊剂，和比陶瓷材料高的电阻率的无机材料，在每个陶瓷生片的区域上，层叠预定数量的陶瓷生片以形成陶瓷层压产品。然后，在规定的切断位置将陶瓷层叠体切断成芯片，烧结而形成陶瓷烧结体，在陶瓷烧结体的两端形成外部电极。

7. 发明授权

US4494149A Facsimile communication data recording apparatus for facsimile transceiver 失效
标题翻译：用于传真收发机的传真通信数据记录装置
公开(公告)号：US4494149A
公开(公告)日：1985-01-15
申请号：US301666
申请日：1981-09-14
申请人： Noboru Furukawa
发明人： Noboru Furukawa
IPC分类号： H04N1/32
CPC分类号： H04N1/32106 , H04N1/32112 , H04N1/32122 , H04N2201/3202 , H04N2201/3205 , H04N2201/3214 , H04N2201/3215 , H04N2201/3216 , H04N2201/3271 , H04N2201/3274
摘要： A facsimile communication data recording apparatus includes a storage for memorizing various administrant data annexed to video data read from an original document. At every communication, administrant data are stored in the storage and, upon an increase thereof to a predetermined amount, a received data recording section of the apparatus is energized to print out the administrant data which are read from the storage. When all the administrant data are fully printed out without any trouble, the administrant data in the storage are cleared. In a preferred embodiment, a key switch for commanding an administrant data print-out operation is positioned in a suitable accessible part of the apparatus so that administrant data can be printed out selectively by closing the key switch. The data read from the storage are printed out within a predetermined area of a paper sheet in a variable arrangement which conforms to an amount of the stored data. Administrant data can be read from the storage and printed out as those concerning transmission and those concerning reception separately from each other.
摘要翻译：传真通信数据记录装置包括用于存储附加到从原始文档读取的视频数据的各种管理数据的存储器。在每个通信中，管理数据被存储在存储器中，并且在其增加到预定量时，对该装置的接收数据记录部分进行通电以打印从存储器读取的管理员数据。当所有的管理员数据完全打印出来没有任何麻烦时，存储中的管理员数据将被清除。在优选实施例中，用于命令管理员数据打印输出操作的按键开关位于设备的合适的可访问部分中，从而可以通过关闭钥匙开关来选择性地打印出管理员数据。从存储器读取的数据以符合存储数据量的可变布置在纸张的预定区域内打印出来。可以从存储器读取管理数据，并将它们作为关于传输的信息和关于接收的信息分开地打印出来。

8. 发明申请

US20070054839A1 Method of inhibiting remnant lipoprotein production 审中-公开
标题翻译：抑制残留脂蛋白生成的方法
公开(公告)号：US20070054839A1
公开(公告)日：2007-03-08
申请号：US11389542
申请日：2006-03-24
申请人： Hiroshi Okamoto , Noboru Furukawa , Tomohiko Sasase
发明人： Hiroshi Okamoto , Noboru Furukawa , Tomohiko Sasase
IPC分类号： A61K38/17 , A61K31/47 , A61K31/41 , A61K31/277 , A61K31/325
CPC分类号： A61K31/255 , A61K31/00 , A61K31/137 , A61K31/16 , A61K31/165 , A61K31/167 , A61K31/196 , A61K31/27 , A61K31/277 , A61K31/325 , A61K31/41 , A61K31/415 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/426 , A61K31/433 , A61K31/4402 , A61K31/4406 , A61K31/47 , A61K31/506
摘要： The present invention aims at provision of a method for inhibiting remnant lipoprotein production and a remnant lipoprotein production inhibitor, which includes administering a compound having a CETP inhibitory activity to an administration subject. The remnant lipoprotein production inhibitor of the present invention contains a compound having a CETP inhibitory activity as an active ingredient.
摘要翻译：本发明的目的在于提供一种抑制残留脂蛋白生成的方法和残留脂蛋白生成抑制剂，其包括向施用对象施用具有CETP抑制活性的化合物。本发明的残留脂蛋白生成抑制剂含有作为活性成分的具有CETP抑制活性的化合物。

9. 发明申请

US20060270705A1 Method for inhibiting lipid absorption and lipid absorption inhibitor 审中-公开
标题翻译：抑制脂质吸收抑制剂的方法
公开(公告)号：US20060270705A1
公开(公告)日：2006-11-30
申请号：US11375357
申请日：2006-03-14
申请人： Fumihiko Yonemori , Daisuke Takahashi , Noboru Furukawa
发明人： Fumihiko Yonemori , Daisuke Takahashi , Noboru Furukawa
IPC分类号： A61K31/4706 , A61K31/325 , A61K31/165 , A61K31/445
CPC分类号： A61K31/165 , A61K31/21 , A61K31/325 , A61K31/41 , A61K31/445 , A61K31/47 , A61K31/4706
摘要： The present invention relates to a method of inhibiting lipid absorption through the small intestine, which comprises administering a compound having a CETP inhibitory activity to an administration subject, and an inhibitor of lipid absorption through the small intestine characterized in that it comprises a compound having a CETP inhibitory activity as an active ingredient. The lipid absorption inhibitor of the present invention can prevent and/or treat diseases such as for example hyperlipidemia, arteriosclerosis, coronary artery diseases, obesity, diabetes, hypertension and metabolic syndrome by inhibiting lipid absorption through the small intestine.
摘要翻译：本发明涉及一种通过小肠抑制脂质吸收的方法，其包括向给药对象施用具有CETP抑制活性的化合物和通过小肠的脂质吸收抑制剂，其特征在于其包含具有 CETP抑制活性作为活性成分。本发明的脂质吸收抑制剂可以通过抑制通过小肠的脂质吸收来预防和/或治疗诸如高脂血症，动脉硬化，冠状动脉疾病，肥胖症，糖尿病，高血压和代谢综合征的疾病。

10. 发明授权

US4262294A Electrostatic printing apparatus comprising improved electrode drive means 失效
标题翻译：包括改进的电极驱动装置的静电印刷装置
公开(公告)号：US4262294A
公开(公告)日：1981-04-14
申请号：US929266
申请日：1978-07-31
申请人： Kazuyuki Hara , Mitsuru Kondo , Takeshi Kamada , Noboru Furukawa , Tamio Ohori
发明人： Kazuyuki Hara , Mitsuru Kondo , Takeshi Kamada , Noboru Furukawa , Tamio Ohori
IPC分类号： G03G15/05 , B41J2/40 , B41J2/41 , H04N1/032 , G03G15/044
CPC分类号： B41J2/41
摘要： A sheet of copy paper (24) is moved perpendicular to a linear array (22) of printing electrodes (221, 222, 223, 224 . . . ). The electrodes (221, 222, 223, 224 . . . ) are selectively energized to form an electrostatic charge pattern on the copy sheet (24) corresponding to one horizontal scan line of an original document. The electrostatic charge pattern is developed by a toner and the resulting toner image fixed to the copy sheet (24). The electrodes (221, 222, 223, 224 . . . ) are divided into a first set (221, 223, 225 . . . ) and a second set (222, 224, 226 . . . ), the electrodes in the second set (222, 224, 226 . . . ) being alternatingly spaced from the electrodes in the first set (221, 223, 225 . . . ) along the length of the array (22). The first set (221, 223, 225 . . . ) of electrodes are selectively energized during a first time period (t1) and the second set (222, 224, 226 . . . ) of electrodes are selectively energized during a subsequent second time period (t2). The second time period (t2) may be made longer than the first time period (t1) and/or a voltage (V2) applied to the second set (222, 224, 226 . . . ) of electrodes may be made higher than a voltage (V1) applied to the first set (221, 223, 225 . . . ) of electrodes.
摘要翻译：一张复印纸（24）垂直于印刷电极（221,222,223,224 ...）的线性阵列（22）移动。电极（221,222,223,224 ...）被选择性地激励，以在对应于原稿的一个水平扫描线的复印纸（24）上形成静电荷图案。静电荷图案由调色剂显影，并将所得到的调色剂图像固定在复印纸（24）上。电极（221,222,223,224 ...）分为第一组（221,223,225 ...）和第二组（222,224,226 ...），第二组中的电极（222,224,226 ...）沿着阵列（22）的长度与第一组（221,223,225 ...）中的电极交替地间隔开。电极的第一组（221,223,225 ...）在第一时间段（t1）期间被选择性地激励，并且在随后的第二时间期间电极的第二组（222,224,226 ...）被选择性地激励期间（t2）。可以使第二时间段（t2）比第一时间段（t1）长，和/或施加到电极的第二组（222,224,226 ...）的电压（V2）可以高于电压（V1）施加到电极的第一组（221,223,225 ...）上。

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