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1. 发明授权

US4845181A Organic condensation polymers and method of making same 失效
标题翻译：有机缩聚物及其制备方法
公开(公告)号：US4845181A
公开(公告)日：1989-07-04
申请号：US249592
申请日：1988-09-26
申请人： Lawrence B. Kool , George M. Whitesides
发明人： Lawrence B. Kool , George M. Whitesides
IPC分类号： C08G18/00 , C08G18/08 , C08G18/67 , C08G61/00 , C08G79/00 , C08G85/00
CPC分类号： C08G61/00 , C08G18/00 , C08G18/0819 , C08G18/679 , C08G79/00 , C08G85/00
摘要： An organic condensation polymer made by reacting in solution of first compound having at least two anionic carbon sites bonded to each other either directly or through a chain of 1 to 30 carbon atoms, including a bisacetylide or a first compound having an anionic carbon site and a latent anionic carbon site bonded to each other either directly or through a chain of 1 to 30 carbon atoms, such as organometallic cyclopentadienides, with a second compound containing at least two electrophillic carbon sites bonded to each other either directly or through a chain of 1 to 30 carbon atoms, including diesters, dihalides, diamides or dianhydrides of polycarboxylic acids, and diisocyanates.
摘要翻译：通过使具有至少两个阴离子碳原子的第一化合物的溶液直接或通过1至30个碳原子的链彼此键合而形成的有机缩聚物，包括双乙酰基或具有阴离子碳位的第一化合物和潜在的阴离子碳位点直接或通过1至30个碳原子的链，例如有机金属环戊二烯类化合物彼此键合，其中第二化合物含有至少两个亲电子碳位点，彼此直接或通过1至 30个碳原子，包括二酯，二卤化物，二酰胺或多元羧酸的二酐和二异氰酸酯。

2. 发明授权

US09464642B2 Soft robotic actuators 有权
标题翻译：软机器人执行器
公开(公告)号：US09464642B2
公开(公告)日：2016-10-11
申请号：US13885967
申请日：2011-11-21
申请人： Filip Ilievski , Xin Chen , Aaron D. Mazzeo , George M. Whitesides , Robert F. Shepherd , Ramses V. Martinez , Won Jae Choi , Sen W. Kwok , Stephen Morin , Adam Stokes , Zhihong Nie
发明人： Filip Ilievski , Xin Chen , Aaron D. Mazzeo , George M. Whitesides , Robert F. Shepherd , Ramses V. Martinez , Won Jae Choi , Sen W. Kwok , Stephen Morin , Adam Stokes , Zhihong Nie
IPC分类号： F15B7/06 , B25J9/10 , B25J9/14 , F15B15/10 , B25J11/00
CPC分类号： F15B15/10 , B25J9/1075 , B25J9/142 , B25J11/00 , F15B7/06
摘要： A soft robotic device includes a flexible body having a width, a length and a thickness, wherein the thickness is at least 1 mm, the flexible body having at least one channel disposed within the flexible body, the channel defined by upper, lower and side walls, wherein at least one wall is strain limiting; and a pressurizing inlet in fluid communication with the at least one channel, the at least one channel positioned and arranged such that the wall opposite the strain limiting wall preferentially expands when the soft robotic device is pressurized through the inlet.
摘要翻译：软机器人装置包括具有宽度，长度和厚度的柔性体，其中所述厚度为至少1mm，所述柔性体具有设置在所述柔性体内的至少一个通道，所述通道由上，下和侧限定壁，其中至少一个壁是应变限制; 以及与所述至少一个通道流体连通的加压入口，所述至少一个通道定位和布置成使得当所述软自动装置通过所述入口被加压时，与所述应变限制壁相对的壁优先地膨胀。

3. 发明授权

US09409265B2 Three dimensional assembly of diamagnetic materials using magnetic levitation 有权
标题翻译：使用磁悬浮的抗磁材料三维组装
公开(公告)号：US09409265B2
公开(公告)日：2016-08-09
申请号：US13994595
申请日：2011-12-20
申请人： George M. Whitesides , Filip Ilievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
发明人： George M. Whitesides , Filip Ilievski , Audrey Ellerbee , Sergey S. Shevkoplyas , Katherine A. Mirica
IPC分类号： C30B30/04 , B23P19/04 , B03C1/01 , B03C1/28 , B81C3/00
CPC分类号： B23P19/04 , B03C1/01 , B03C1/288 , B03C2201/18 , B81C3/005 , B81C2203/054 , B81C2203/057 , B81C2203/058 , C30B30/04 , Y10S117/901 , Y10T29/49826
摘要： The ability to assemble three-dimensional structures using diamagnetic particles suspended in solutions containing paramagnetic cations is described. The major advantages of this separation device are that: (i) it is a simple apparatus that does not require electric power (a set of permanent magnets and gravity are sufficient for the diamagnetic separation and collection system to work); ii) the assembled structures can be removed from the paramagnetic solution for further processing after fixing the structure; iii) the assembly is fast; and iv) it is small, portable.
摘要翻译：描述了使用悬浮在含有顺磁阳离子的溶液中的反磁性颗粒组装三维结构的能力。这种分离装置的主要优点是：（i）它是一种不需要电力的简单装置（一组永磁体和重力足以使反磁性分离和收集系统工作）; ii）组装的结构可以在固定结构之后从顺磁溶液中除去以进一步处理; iii）装配快速; 和iv）它是小，便携式。

4. 发明授权

US08985547B2 Valves and reservoirs for microfluidic systems 有权
标题翻译：用于微流体系统的阀门和储存器
公开(公告)号：US08985547B2
公开(公告)日：2015-03-24
申请号：US11883260
申请日：2006-01-31
申请人： Douglas B. Weibel , Andrew Lee , Scott Potenta , Adam Siegel , Maarten Kruithof , George M. Whitesides
发明人： Douglas B. Weibel , Andrew Lee , Scott Potenta , Adam Siegel , Maarten Kruithof , George M. Whitesides
IPC分类号： F16K7/04 , F15B1/04 , B01L3/00 , F16K99/00
CPC分类号： F15B1/04 , B01L3/502738 , B01L3/502746 , B01L2200/0636 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , F15B2201/21 , F15B2201/305 , F15B2201/4053 , F16K99/0001 , F16K99/0026 , F16K99/0034 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , Y10T137/0318 , Y10T137/0396 , Y10T137/2213 , Y10T137/4824 , Y10T137/6161
摘要： A microfluidic valve assembly includes a structure defining a microfluidic fluid path and an actuator that can be moved between different positions controlling flow through the channel. In one embodiment, the actuator can be threaded into at least a portion of the structure, and can be moved rotationally between a first position, causing relatively greater constriction of a microfluidic fluid path, and a second position causing relatively lesser constriction of the fluid path. Actuating the actuator, e.g., by rotation, can deform material between the valve and the fluid path, thereby constricting at least a portion of the underlying fluid path and regulating the flow of a fluid in the fluid path. In another aspect, the invention provides a reservoir into which fluid can be placed and from which fluid can be introduced into a microfluidic system. In one embodiment, the reservoir is expandable and thereby able to store fluid under pressure for delivery to a microfluidic system.
摘要翻译：微流体阀组件包括限定微流体流体路径的结构和可以在控制流过通道的不同位置之间移动的致动器。在一个实施例中，致动器可以被螺纹连接到结构的至少一部分中，并且可以在第一位置和第二位置之间旋转地移动，第一位置引起微流体流体路径的相对较大的缩小，并且引起相对较小的流体路径收缩的第二位置。例如通过旋转来致动致动器可以在阀和流体路径之间变形材料，从而收缩下面的流体路径的至少一部分并且调节流体路径中的流体的流动。在另一方面，本发明提供了一种储存器，流体可以放置在该储存器中，并且可以从该储存器将流体引入到微流体系统中。在一个实施例中，储存器是可膨胀的并且因此能够在压力下存储流体以递送到微流体系统。

5. 发明申请

US20140206559A1 ASSAY FOR METASTATIC POTENTIAL OF TUMOR CELLS 审中-公开
标题翻译：肿瘤细胞分化潜能的测定
公开(公告)号：US20140206559A1
公开(公告)日：2014-07-24
申请号：US14119479
申请日：2012-05-23
申请人： George M. Whitesides , Ratmir Derda , Renee Fuller , Frederique T. Deiss
发明人： George M. Whitesides , Ratmir Derda , Renee Fuller , Frederique T. Deiss
IPC分类号： G01N33/483
CPC分类号： G01N33/4833 , G01N33/5091 , G01N33/574
摘要： The present invention relates to methods, compositions and kits related to a novel in vitro assay for a high-capacity and high-throughput method for measuring the ability of cancer cells to migrate in a three-dimensional cellular assay. The three-dimensional cellular invasion assay provides a method for determining and quantitating the metastatic potential and invasive capacity of a cancer cell. Other aspects of the invention further relate to the use of the in vitro assay to screen for agents and compounds capable of inhibiting intravasation, and thereby modulating the metastatic potential of cancer cells. The methods, compositions and three-dimensional assay provide a highly sensitive assay system capable of mimicking the in vivo cellular and molecular interactions required for successful completion of intravasation.
摘要翻译：本发明涉及与用于测量癌细胞在三维细胞测定中迁移的能力的高容量和高通量方法的新体外测定相关的方法，组合物和试剂盒。三维细胞侵袭测定提供了确定和定量癌细胞转移潜能和侵袭能力的方法。本发明的其它方面进一步涉及使用体外测定来筛选能够抑制渗透的药剂和化合物，从而调节癌细胞的转移潜力。方法，组合物和三维测定提供了能够模拟成功完成渗透所需的体内细胞和分子相互作用的高度灵敏的测定系统。

6. 发明授权

US08635749B2 Microadhesive systems and methods of making and using the same 有权
标题翻译：微胶粘系统及其制造和使用方法
公开(公告)号：US08635749B2
公开(公告)日：2014-01-28
申请号：US12844314
申请日：2010-07-27
申请人： Brian Mayers , Sandip Agarwal , Jeffrey Carbeck , David Ledoux , Kevin Randall Stewart , George M. Whitesides , Adam Winkleman
发明人： Brian Mayers , Sandip Agarwal , Jeffrey Carbeck , David Ledoux , Kevin Randall Stewart , George M. Whitesides , Adam Winkleman
IPC分类号： A44B18/00
CPC分类号： C09J7/00 , C09J2201/626
摘要： Disclosed are adhesive systems and methods of making and using such systems. Exemplary adhesive systems include protrusions and/or grooves that can interleave to form a reversible adhesive interaction.
摘要翻译：公开了制造和使用这种系统的粘合剂系统和方法。示例性的粘合剂系统包括可以交织以形成可逆粘合剂相互作用的突起和/或凹槽。

7. 发明申请

US20130280693A1 DENSITY-BASED SEPARATION OF BIOLOGICAL ANALYTES USING MULTIPHASE SYSTEMS 有权
公开(公告)号：US20130280693A1
公开(公告)日：2013-10-24
申请号：US13817985
申请日：2011-08-22
申请人： Charles R. Mace , Ashok A. Kumar , Dyann F. Wirth , George M. Whitesides
发明人： Charles R. Mace , Ashok A. Kumar , Dyann F. Wirth , George M. Whitesides
IPC分类号： G01N33/49 , G01N33/574
CPC分类号： G01N33/491 , B03B5/28 , B03B5/442 , B03D3/00 , G01N33/18 , G01N33/5375 , G01N33/57492
摘要： The disclosed methods use a multi-phase system to separate samples according to the density of an analyte of interest. The method uses a multi-phase system that comprises two or more phase-separated solutions and a phase component such as a surfactant or polymer. The density of the analyte of interest differs from the densities of the rest of the sample. The density of the analyte of interest is substantially the same as one or more phases. Thus, when the sample is introduced to the multi-phase system, the analyte of interest migrates to the phase having the same density as the analyte of interest, passing through one or more phases sequentially.

8. 发明授权

US08501416B2 Fluidic structures including meandering and wide channels 有权
标题翻译：流体结构包括曲折和宽通道
公开(公告)号：US08501416B2
公开(公告)日：2013-08-06
申请号：US11887487
申请日：2006-04-19
申请人： Vincent Linder , Samuel K. Sia , George M. Whitesides , Max Narovlyansky , Adam Siegel
发明人： Vincent Linder , Samuel K. Sia , George M. Whitesides , Max Narovlyansky , Adam Siegel
IPC分类号： G01N33/53
CPC分类号： G01N33/54366 , B01L3/502746 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0883 , B01L2400/0406 , G01N21/01 , G01N21/82 , G01N33/54373
摘要： The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analysis due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.
摘要翻译：本发明一般涉及微流体结构，更具体地涉及包括曲折和宽通道的微流体结构和方法。微流控系统可以提供用于执行各种反应和分析的有利环境，因为与常规系统相比，所需的样品和试剂量的减少，操作系统的尺寸的减小和反应时间的减少。不幸的是，微量流体通道的小尺寸有时会导致在不放大光学器件（例如显微镜或光电倍增管）的情况下检测物质的困难。一系列紧密包装的微通道，即曲折区域或具有大约毫米数量级的宽通道可以通过创建宽的测量区域来解决这个问题。尽管本发明主要描述了在微流体芯片上的异源免疫测定中使用曲折和宽通道，但是本发明可用于放大用于其他类型反应和/或测定的光学信号。

9. 发明申请

US20130034869A1 DEVICES AND METHODS FOR MULTIPLEXED ASSAYS 有权
标题翻译：多重测试的设备和方法
公开(公告)号：US20130034869A1
公开(公告)日：2013-02-07
申请号：US13576804
申请日：2011-02-03
申请人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascarenas , Xinyu Liu , Xiujun Li
发明人： George M. Whitesides , Katherine A. Mirica , Andres W. Martinez , Chao-Min Cheng , Scott T. Phillips , Monica Mascarenas , Xinyu Liu , Xiujun Li
IPC分类号： C12M1/34 , G01N21/78 , G01N33/53
CPC分类号： B01L3/502738 , B01L2200/10 , B01L2300/0627 , B01L2300/0681 , B01L2300/0887 , B01L2300/126 , B01L2300/161 , B01L2400/065
摘要： The disclosure provides low cost, portable three-dimensional devices for performing multiplexed assays. The devices comprise at least two substantially planar layers disposed in parallel planes, wherein one of the layers is movable relative to each other parallel to the planes to permit the establishment of fluid flow communication serially between the two layers.
摘要翻译：本公开提供了用于执行多重测定的低成本便携式三维装置。这些装置包括设置在平行平面中的至少两个基本上平坦的层，其中层之一可以相对于彼此平行于平面移动，以允许在两层之间串联建立流体流动连通。

10. 发明授权

US08124743B2 Purification of a bivalently active antibody using a non-chromatographic method 有权
标题翻译：使用非色谱法纯化二价活性抗体
公开(公告)号：US08124743B2
公开(公告)日：2012-02-28
申请号：US12303089
申请日：2007-06-01
申请人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
发明人： Vijay M. Krishnamurthy , Lara A. Estroff , Vincent Semetey , Samuel W. Thomas , George K. Kaufman , Zihni Basar Bilgicer , George M. Whitesides
IPC分类号： C07K16/00 , C07K1/22 , C07K1/30
CPC分类号： C07K16/065 , C07K16/468 , C07K2317/31 , C07K2317/54 , Y10S436/822
摘要： The present invention discloses a method of purifying bivalent antibodies or antibody fragments that are active at both Fab sites from a source of antibodies or antibody fragments using a non-chromatographic method that includes inducing the formation of cyclic immunoglobulin aggregates by addition of multivalent hapten to a salt solution of soluble antibodies or antibody fragments, wherein the multivalent hapten possesses a linker between the two haptens effective to prevent the binding of both haptens of the ligand to the same antibody or antibody fragment.
摘要翻译：本发明公开了一种纯化二价抗体或抗体片段的方法，所述二价抗体或抗体片段在使用非色谱法的抗体或抗体片段来源的两个Fab位点都是活性的，其包括通过将多价半抗原加入到可溶性抗体或抗体片段的盐溶液，其中多价半抗原具有两个半抗原之间的接头，其有效地防止配体的半抗原与相同的抗体或抗体片段的结合。

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