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1. 发明申请

US20070137663A1 Method of extracting sucrose esters from oriental tobacco 审中-公开
标题翻译：从东方烟草中提取蔗糖酯的方法
公开(公告)号：US20070137663A1
公开(公告)日：2007-06-21
申请号：US11291488
申请日：2005-12-01
申请人： Larry Taylor , Mehdi Ashraf-Khorassani , William Coleman
发明人： Larry Taylor , Mehdi Ashraf-Khorassani , William Coleman
IPC分类号： A24C1/00
CPC分类号： A24B15/24
摘要： The invention provides a method of extracting sucrose esters from Oriental tobacco, the method comprising: providing a Oriental tobacco material; contacting the solid Oriental tobacco material with a supercritical fluid, such as supercritical carbon dioxide, for a time and under conditions sufficient to extract sucrose esters from the Oriental tobacco into the supercritical fluid; and separating the supercritical fluid comprising extracted sucrose esters from the Oriental tobacco. The resulting extract can comprise more than 90% by weight of tetra-acyl sucrose esters, and can be used as a flavor additive for tobacco materials used in smoking articles.
摘要翻译：本发明提供从东方烟草中提取蔗糖酯的方法，其方法包括：提供东方烟草材料; 将固体东方烟草材料与超临界流体如超临界二氧化碳接触，时间和条件足以将蔗糖酯从东方烟草提取到超临界流体中; 并从东方烟草中分离包含提取的蔗糖酯的超临界流体。得到的提取物可以包含超过90重量％的四酰基蔗糖酯，并且可以用作用于吸烟制品的烟草材料的风味添加剂。

2. 发明授权

US06746695B1 Pharmaceutical preparations of bioactive substances extracted from natural sources 失效
标题翻译：从天然来源提取生物活性物质的药物制剂
公开(公告)号：US06746695B1
公开(公告)日：2004-06-08
申请号：US09578849
申请日：2000-05-26
申请人： Michael Z. Martin , Mehdi Ashraf-Khorassani , Larry Taylor
发明人： Michael Z. Martin , Mehdi Ashraf-Khorassani , Larry Taylor
IPC分类号： A61K3578
CPC分类号： A61K36/48 , A61K36/185 , A61K36/32 , A61K36/61 , A61K36/67 , A61K36/734 , A61K36/77 , A61K2300/00
摘要： This invention relates to methods of extracting and purifying bioactive substances from various plants and herbs. More specifically the invention relates to methods of extracting and separating bioactive substances from various plants and herbs, such as Kava root, Byrsonima species, Aesculus californica, Crataegus mexicana, Simmondsia chinensis, Pfaffia species, Alternanthera repens, Bursera species, Turnera species, Perezia species, Heimia salicifolia, Psidium species, Enterlobium species, Ptychopetalum olacoides, Liriosma ovata, and Chaunochiton kappleri, using supercritical fluid extraction and/or fluorocarbon solvent extract. The present invention further relates to separation of bioactive substances contained in extracts using packed column supercritical fluid chromatography or HPLC where dense gas with or without modifiers is the mobile phase. The present invention also relates to pharmaceutical preparations and dietary supplements which may be prepared with the extracted bioactive substances and use of such pharmaceutical preparations and dietary supplements to treat various human ailments.
摘要翻译：本发明涉及从各种植物和草药中提取和纯化生物活性物质的方法。更具体地说，本发明涉及从各种植物和草药中提取和分离生物活性物质的方法，例如卡瓦根，Byrsonima种，加利福尼亚cal ica，中华Cr ensis，Pfaffia物种，Alternanthera repens，Bursera物种，Turnera物种，Perezia物种使用超临界流体萃取和/或碳氟化合物溶剂提取物，海蜇，鱼腥草属，ium藜种，ol，ides ides，，，。。。。。。。。。。。。。。。。。。。。。本发明还涉及使用填充柱超临界流体色谱或HPLC分离萃取物中所含的生物活性物质，其中具有或不具有改性剂的致密气体是流动相。本发明还涉及可以用提取的生物活性物质制备的药物制剂和膳食补充剂，以及使用这些药物制剂和膳食补充剂来治疗各种人类疾病。

3. 发明授权

US5241998A Apparatus and method for packing particles 失效
标题翻译：用于包装颗粒的装置和方法
公开(公告)号：US5241998A
公开(公告)日：1993-09-07
申请号：US784768
申请日：1991-10-30
申请人： Mehdi Ashraf-Khorassani
发明人： Mehdi Ashraf-Khorassani
IPC分类号： G01N30/02 , G01N30/30 , G01N30/32 , G01N30/56
CPC分类号： G01N30/56 , G01N2030/3007 , G01N2030/565 , G01N30/02 , G01N30/32
摘要： The present invention is related to an apparatus for packing an analytical chromatography column having a first opening and a second opening with packing particles. The apparatus comprises means for providing solvent at a density essentially equal to the density of the packing particles. The providing means is in fluidic communication with the first opening of the column. The apparatus also comprises a first reservoir for containing the packing particles. The reservoir is in fluidic communication with the providing means such that solvent can mix with the particles in the first reservoir to form a slurry where the particles are suspended in the solvent and agglomeration of the packing particles is essentially absent when the slurry is introduced into the analytical chromatography column. There is also valve means in fluidic communication with the first reservoir and the first opening of the analytical column for controlling flow of the slurry of pressurized solvent and packing particles to the analytical column from the first reservoir. A fluid restrictor is fluidically connected to the second opening of the column for allowing the solvent to escape from the column while maintaining pressurization therein. The invention also relates to a method of packing an analytical column with packing particles. The method comprises the steps of pressurizing a first reservoir having packing particles disposed therein, with a solvent until the density of the solvent equals the density of the particles and forms a slurry where the particles are suspended in the solvent. Then, there is the step of fluidically connecting the first reservoir to an analytical column at essentially the same pressure as the first pressure such that the slurry flows into a chamber of the analytical column.
摘要翻译：本发明涉及一种用于包装分析色谱柱的装置，其具有第一开口和具有填充颗粒的第二开口。该装置包括以基本上等于包装颗粒的密度的密度提供溶剂的装置。提供装置与柱的第一开口流体连通。该设备还包括用于容纳填料颗粒的第一储存器。储存器与提供装置流体连通，使得溶剂可以与第一储存器中的颗粒混合以形成浆料，其中颗粒悬浮在溶剂中，并且当浆料被引入到浆料中时，填充颗粒的聚集基本上不存在分析色谱柱。还存在与第一储存器和分析柱的第一开口流体连通的阀装置，用于控制加压溶剂和填充颗粒的浆料从第一储存器流到分析柱。流体限流器流体连接到塔的第二开口，用于允许溶剂从塔中逸出，同时保持加压。本发明还涉及一种用包装颗粒包装分析柱的方法。该方法包括以下步骤：用溶剂对其中设置有填充颗粒的第一储存器加压，直到溶剂的密度等于颗粒的密度，并形成悬浮在溶剂中的浆料。然后，存在以与第一压力基本相同的压力将第一储存器流体连接到分析柱的步骤，使得浆料流入分析柱的室。

4. 发明授权

US5861122A Restrictor orifice for off-line supercritical fluid extraction collection system 失效
标题翻译：用于离线超临界流体萃取收集系统的限流孔
公开(公告)号：US5861122A
公开(公告)日：1999-01-19
申请号：US531046
申请日：1995-09-20
申请人： Mehdi Ashraf-Khorassani , Gregory Shogan , Raymond K. Houck
发明人： Mehdi Ashraf-Khorassani , Gregory Shogan , Raymond K. Houck
IPC分类号： B01D11/02 , G01N1/34 , G01N7/04 , G01N30/02 , G01N30/06 , B01D11/00 , G05D16/00
CPC分类号： G01N1/34 , B01D11/0203 , G01N7/04 , G01N2001/4061 , G01N2030/025 , G01N2030/062 , G01N30/02 , Y10T436/25875
摘要： The present invention pertains to an off-line collection system for use with supercritical fluid extraction. The system is comprised of apparatus for collecting analyte associated with the supercritical fluid extraction. The system is additionally comprised of an orifice for controlling flow of analyte to the collecting apparatus. The orifice converts analyte at a high pressure to a lower pressure. The orifice has a high pressure side which receives said high pressure analyte, and a lower pressure side in fluidic communication with the high pressure side which receives said high pressure analyte after it has been converted to a lower pressure. The high pressure side is capable of transporting analyte thereacross without essentially any loss thereof to the low pressure side which is in fluidic communication with the collecting apparatus. The analyte experiences essentially constant pressure as it is transported across the high pressure side. The system is also comprised of apparatus for desorbing the analyte from the collection apparatus. The desorbing apparatus is in fluidic communication with the collecting means. In a preferred embodiment, the system includes apparatus for purging the analyte. The purging apparatus is in fluidic communication with the collecting apparatus. Additionally, the collecting apparatus preferably includes a collection trap in which analyte is gathered, and apparatus for controlling the flow of analyte into the collection trap. The flow controlling apparatus is in fluidic communication with the collection trap and the purging apparatus. The flow control apparatus preferably includes an orifice.
摘要翻译：本发明涉及一种用于超临界流体萃取的离线收集系统。该系统由用于收集与超临界流体萃取物相关的分析物的装置组成。该系统另外包括用于控制分析物流向收集装置的孔口。孔口将分析物在高压下转换成较低的压力。孔口具有高压侧，其接收所述高压分析物，以及与高压侧流体连通的低压侧，其在将其转换成较低压力之后接收所述高压分析物。高压侧能够将其上的分析物输送到与收集装置流体连通的低压侧而基本上没有任何损失。分析物在高压侧运输时，基本上保持恒定的压力。该系统还包括用于从收集装置解吸分析物的装置。解吸装置与收集装置流体连通。在优选实施例中，该系统包括用于清除分析物的装置。清洗装置与收集装置流体连通。此外，收集装置优选地包括其中收集分析物的收集阱，以及用于控制分析物流入收集阱的装置。流量控制装置与收集阱和清洗装置流体连通。流量控制装置优选地包括孔口。

5. 发明授权

US5363886A Apparatus and method for packing particles 失效
标题翻译：用于包装颗粒的装置和方法
公开(公告)号：US5363886A
公开(公告)日：1994-11-15
申请号：US111999
申请日：1993-08-25
申请人： Mehdi Ashraf-Khorassani
发明人： Mehdi Ashraf-Khorassani
IPC分类号： G01N30/02 , G01N30/30 , G01N30/32 , G01N30/56 , B65B31/00
CPC分类号： G01N30/56 , G01N2030/3007 , G01N2030/565 , G01N30/02 , G01N30/32
摘要： The invention also relates to a method of packing an analytical column with packing particles. The method comprises the steps of pressurizing a first reservoir having packing particles disposed therein, with a solvent until the density of the solvent equals the density of the particles and forms a slurry where the particles are suspended in the solvent. Then, there is the step of fluidically connecting the first reservoir to an analytical column at essentially the same pressure as the first pressure such that the slurry flows into a chamber of the analytical column.
摘要翻译：本发明还涉及一种用包装颗粒包装分析柱的方法。该方法包括以下步骤：用溶剂对其中设置有填充颗粒的第一储存器加压，直到溶剂的密度等于颗粒的密度，并形成浆料，其中颗粒悬浮在溶剂中。然后，存在以与第一压力基本相同的压力将第一储存器流体连接到分析柱的步骤，使得浆料流入分析柱的室。

6. 发明授权

US5453198A Method for collecting analyte and an orifice for reducing pressure of a fluid 失效
标题翻译：用于收集分析物和用于减少流体压力的孔口的方法
公开(公告)号：US5453198A
公开(公告)日：1995-09-26
申请号：US993295
申请日：1992-12-21
申请人： Mehdi Ashraf-Khorassani , Gregory Shogan , Raymond K. Houck
发明人： Mehdi Ashraf-Khorassani , Gregory Shogan , Raymond K. Houck
IPC分类号： B01D11/02 , G01N1/34 , G01N7/04 , G01N30/02 , G01N30/06 , B01D11/04
CPC分类号： G01N1/34 , B01D11/0203 , G01N7/04 , G01N2001/4061 , G01N2030/025 , G01N2030/062 , G01N30/02 , Y10T436/25875
摘要： An orifice which includes a housing having a low pressure side with a first bore hole and a second bore hole. The low pressure side has a first channel and a second channel in fluidic communication with the first bore hole and the second bore hole, respectively. The housing also has a high pressure side with a third bore hole. The orifice also includes an adapter which has a tip, a fourth bore hole and a third channel in fluidic communication therewith. The third channel has a constant diameter for maintaining an essentially constant pressure thereacross when pressure is applied thereto such that fluid flowing through the third channel does not solidify. The adapter is sealingly received by the third bore hole such that the third channel and the first channel align. Additionally, the housing includes an interface plate disposed in the housing between the third channel and the first channel. The plate sealingly receives the tip of the adapter and allows for flow to exist between the third channel and the first channel through a plate hole. A method for collecting analyte. The method includes the steps of providing analyte obtained from supercritical fluid extraction to a collection trap through a high pressure side of an orifice.
摘要翻译：一种孔口，包括具有低压侧的壳体，其具有第一钻孔和第二钻孔。低压侧分别具有与第一钻孔和第二钻孔流体连通的第一通道和第二通道。壳体还具有具有第三钻孔的高压侧。孔口还包括具有尖端，第四钻孔和与其流体连通的第三通道的适配器。第三通道具有恒定的直径，用于在施加压力时保持基本恒定的压力，使得流过第三通道的流体不固化。适配器被第三钻孔密封地接收，使得第三通道和第一通道对准。此外，壳体包括设置在第三通道和第一通道之间的壳体中的接口板。板密封地接收适配器的尖端，并允许流动通过板孔存在于第三通道和第一通道之间。收集分析物的方法。该方法包括以下步骤：通过孔的高压侧将从超临界流体萃取获得的分析物提供到收集阱。

7. 发明授权

US5205987A Off-line supercritical fluid extraction collection system 失效
标题翻译：离线超临界流体萃取收集系统
公开(公告)号：US5205987A
公开(公告)日：1993-04-27
申请号：US662255
申请日：1991-02-28
申请人： Mehdi Ashraf-Khorassani , Gregory Shogan , Raymond K. Houck
发明人： Mehdi Ashraf-Khorassani , Gregory Shogan , Raymond K. Houck
IPC分类号： B01D11/02 , G01N1/34 , G01N7/04 , G01N30/02 , G01N30/06
CPC分类号： G01N1/34 , B01D11/0203 , G01N7/04 , G01N2001/4061 , G01N2030/025 , G01N2030/062 , G01N30/02 , Y10T436/25875
摘要： The present invention pertains to an off-line collection system for use with supercritical fluid extraction. The system is comprised of mechanism for collecting analyte associated with the supercritical fluid extraction. The system is additionally comprised of an orifice for controlling flow of analyte to the collecting mechanism. The orifice converts analyte at a high pressure to a lower pressure. The orifice has a high pressure side which receives said high pressure analyte, and a lower pressure side in fluidic communication with the high pressure side which receives said high pressure analyte after it has been converted to a lower pressure. The high pressure side is capable of transporting analyte thereacross without essentially any loss thereof to the low pressure side which is in fluidic communication with the collecting mechanism. The analyte experiences essentially constant pressure as it is transported across the high pressure side. The system is also comprised of mechanism for desorbing the analyte from the collection mechanism. The desorbing mechanism is in fluidic communication with the collecting mechanism. In a preferred embodiment, the system includes mechanism for purging the analyte. The purging mechanism is in fluidic communication with the collecting mechanism. Additionally, the collecting mechanism preferably includes a collection trap in which analyte is gathered, and mechanism for controlling the flow of analyte into the collection trap. The flow controlling mechanism is in fluidic communication with the collection trap and the purging mechanism. The flow control mechanism preferably includes an orifice.
摘要翻译：本发明涉及一种用于超临界流体萃取的离线收集系统。该系统由用于收集与超临界流体萃取物相关的分析物的机构组成。该系统还包括用于控制分析物流到收集机构的孔口。孔口将分析物在高压下转换成较低的压力。孔口具有高压侧，其接收所述高压分析物，以及与高压侧流体连通的低压侧，其在将其转换成较低压力之后接收所述高压分析物。高压侧能够将分析物在其上传输而基本上不会损失到与收集机构流体连通的低压侧。分析物在高压侧运输时，基本上保持恒定的压力。该系统还包括从收集机构解吸分析物的机理。解吸机构与收集机构流体连通。在优选实施例中，该系统包括用于清除分析物的机构。清洗机构与收集机构流体连通。此外，收集机构优选地包括其中收集分析物的收集阱，以及用于控制分析物流入收集阱的机构。流量控制机构与收集阱和清洗机构流体连通。流量控制机构优选地包括孔口。

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