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1. 发明授权

US5635202A Micro-encapsulated lactobacilli for medical applications 失效
公开(公告)号：US5635202A
公开(公告)日：1997-06-03
申请号：US614881
申请日：1996-03-13
申请人： Larry C. Ford
发明人： Larry C. Ford
IPC分类号： A61K9/02 , A61K9/00 , A61K9/16 , A61K9/50 , A61K35/74 , A61P1/12 , A61K9/70 , A61K9/20 , A61K9/48
CPC分类号： A61K35/747 , A61K9/0034 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5031 , Y10S424/15 , Y10S435/853 , Y10S435/854 , Y10S514/967
摘要： Micro-encapsulated lactobacilli bacteria are orally administered to mammals, including humans, to treat or prevent antibiotic associated or other chronic or acute diarrhea. Micro-encapsulated lactobacilli bacteria are topically administered to the skin to treat or prevent recurrent skin infections, and are administered intra-vaginally to treat or prevent vaginal yeast infections.

2. 发明授权

US5466463A Viracidal, bactericidal and spermicidal vaginal suppository 失效
标题翻译：杀菌，杀菌，杀精阴道栓剂
公开(公告)号：US5466463A
公开(公告)日：1995-11-14
申请号：US301966
申请日：1994-09-07
申请人： Larry C. Ford
发明人： Larry C. Ford
IPC分类号： A61K9/02 , A61K9/00 , A61K9/16 , A61K9/50 , A61K35/74 , A61K35/747 , A61F13/20 , A61F6/08 , C12N11/04
CPC分类号： A61K9/1635 , A61K31/14 , A61K31/4425 , A61K35/747 , A61K45/06 , A61K9/0034 , A61K9/1652 , A61K9/5026 , A61K9/5031 , Y10S424/15 , Y10S435/853 , Y10S435/854 , Y10S514/967
摘要： A vaginal suppository or other type of vaginal pessary such as cream, foam or ointment, which contains as its active ingredients at least one pharmaceutically acceptable, topically safe antimicrobial agent, such as an agent selected from the group of benzalkonium chloride, cetylpyridinium chloride, chlorhexidine gluconate and povidone iodine, imidiazolidinyl urea and diazolidinyl urea and a viable colony of micro-encapsulated lactobacilli bacteria. The viable lactobacilli are included in the suppository in micro encapsulated form, which protects the bacteria during storage of the suppository from the action of the bacteriocidal agent. When exposed to the vaginal milieu the micro encapsulation breaks down sufficiently to release the lactobacili bacteria. The lactobacilli bacteria serve to maintain or re-establish a healthy lactobacilli based flora on the vaginal wall, and excrete hydrogen peroxide and other bactericidins which suppress abnormal flora conditions that promote infections.
摘要翻译：含有阴道栓剂或其它类型的阴道子宫帽，如奶油，泡沫或软膏，其含有至少一种药学上可接受的局部安全的抗微生物剂作为其活性成分，例如选自苯扎氯铵，氯化十六烷基吡啶，氯己定葡萄糖酸盐和聚维酮碘，咪唑烷基脲和重氮烷基脲，以及微囊化乳杆菌的活菌。活的乳杆菌被包含在微胶囊形式的栓剂中，其在栓剂储存期间保护细菌免受杀菌剂的作用。当暴露于阴道环境时，微胶囊充分分解以释放乳酸菌。乳杆菌细菌用于维持或重建阴道壁上的基于乳酸杆菌的健康菌群，并排出过氧化氢和其它抑制促进感染的异常菌群的细菌。

3. 发明授权

US4255517A Lysozyme assay 失效
标题翻译：溶菌酶测定
公开(公告)号：US4255517A
公开(公告)日：1981-03-10
申请号：US9379
申请日：1979-02-02
申请人： Larry C. Ford
发明人： Larry C. Ford
IPC分类号： C12Q1/34
CPC分类号： C12Q1/34 , G01N2333/305 , G01N2333/924 , Y10S435/81
摘要： A new and improved assay for the determination of the enzyme lysozyme in biological samples which utilizes a plate assay based upon the bacterium Micrococcus lysodiekticus is described. The assay utilizes a novel composition for the assay medium which results in a reduction in assay incubation time to the point that the assay is complete after one-half hour. This reduction in time is achieved in part by the utilization of organic buffers in the assay medium and in part by the reduction of the ionic strength of the assay medium. by the use of this assay a novel technique for determining the integrity of the amniochorial membrane and maturity of fetal lungs are described.
摘要翻译：描述了一种用于测定生物样品中酶溶菌酶的新的和改进的测定法，其利用基于细菌微球菌溶血杆菌的平板测定法。该测定法利用了用于测定培养基的新型组合物，其导致测定孵育时间的降低，直到测定在半小时后完成。这个时间的减少部分地通过在测定培养基中利用有机缓冲液，部分地通过降低测定培养基的离子强度来实现。通过使用该测定法，描述了确定胎膜的完整性和胎儿肺成熟度的新技术。

4. 发明授权

US5614209A Micro-encapsulated lactobacilli for medical applications 失效
标题翻译：微胶囊乳杆菌用于医疗应用
公开(公告)号：US5614209A
公开(公告)日：1997-03-25
申请号：US614499
申请日：1996-03-13
申请人： Larry C. Ford
发明人： Larry C. Ford
IPC分类号： A61K9/02 , A61K9/00 , A61K9/16 , A61K9/50 , A61K35/74 , A61P1/12 , A61K9/70 , A61K9/20 , A61K9/48 , A61L15/16
CPC分类号： A61K35/747 , A61K9/0034 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5031 , Y10S424/15 , Y10S435/853 , Y10S435/854 , Y10S514/967
摘要： Micro-encapsulated lactobacilli bacteria are orally administered to mammals, including humans, to treat or prevent antibiotic associated or other chronic or acute diarrhea. Micro-encapsulated lactobacilli bacteria are topically administered to the skin to treat or prevent recurrent skin infections, and are administered intra-vaginally to treat or prevent vaginal yeast infections.
摘要翻译：对包括人在内的哺乳动物口服施用微囊化的乳杆菌，以治疗或预防抗生素相关或其它慢性或急性腹泻。将微囊化的乳杆菌细菌局部施用于皮肤以治疗或预防复发性皮肤感染，并且经阴道内给药以治疗或预防阴道酵母菌感染。

5. 发明授权

US5264619A Anti-androgenic cyclo and bicyclo alkenes 失效
标题翻译：抗雄激素环和双环烯烃
公开(公告)号：US5264619A
公开(公告)日：1993-11-23
申请号：US4972
申请日：1993-01-15
申请人： Larry C. Ford
发明人： Larry C. Ford
IPC分类号： A61K31/12 , A01N35/06 , A01N37/02 , A61P17/00 , A61P25/28 , A61P31/00 , A61P31/04 , A61P43/00 , C07C29/128 , C07C49/733 , C07C49/743 , C07C49/753 , C07C59/185 , C07C67/02 , C07C69/007 , C07C69/013 , C07C69/145 , C07C69/24 , C07F7/18 , A61K31/22
CPC分类号： C07C403/10 , C07C29/1285 , C07C403/08 , C07C49/733 , C07C49/743 , C07C49/753 , C07C59/185 , C07C69/007 , C07C69/013 , C07F7/1856 , C07C2101/14
摘要： Compounds having the formula (i), (ii) and (iii), ##STR1## where R is H, alkyl of 1 to 6 carbons, or CO--R.sub.2 where R.sub.2 is alkyl of 1 to 6 carbons; R.sub.1 is H, CH.sub.3, or (CH.sub.2).sub.m --CH.sub.3 ; n is an integer having the values of 2 to 10, m is an integer having the values of 1 to 6, have anti-androgen activity on secondary androgen receptor sites. The compounds are useful for treating mammals, including humans afflicted with acne, male pattern baldness, adhesions and keloids. The compounds are also effective for treating other diseases or conditions which are related to androgen receptors, such as undesirable formation of breast capsules in females after breast augmentation surgery, osteoarthritis and symptoms of Alzheimer's disease. The compounds also have inhibitory effect on the metabolism of certain microorganisms and fungi of the kind, the metabolism of which is normally known to be controllable by anti-androgen compounds.
摘要翻译：（i），（ii）和（iii）的化合物，其中R是H，1至6个碳原子的烷基或CO-R2 其中R 2是1至6个碳的烷基; R1是H，CH3或（CH2）m-CH3; n为2〜10的整数，m为1〜6的整数，在雄激素受体部位具有抗雄激素活性。该化合物可用于治疗哺乳动物，包括患有痤疮，男性型秃发，粘连和瘢痕疙瘩的人。所述化合物对于治疗与雄激素受体有关的其它疾病或病症也是有效的，例如在隆胸手术后的女性中不希望形成乳房胶囊，骨关节炎和阿尔茨海默病症状。这些化合物还对某些微生物和真菌的代谢具有抑制作用，这些微生物和真菌通常已知可以通过抗雄激素化合物控制。

6. 发明授权

US5733568A Micro-encapsulated lactobacilli for medical applications 失效
标题翻译：微胶囊乳杆菌用于医疗应用
公开(公告)号：US5733568A
公开(公告)日：1998-03-31
申请号：US459058
申请日：1995-06-02
申请人： Larry C. Ford
发明人： Larry C. Ford
IPC分类号： A61K9/02 , A61K9/00 , A61K9/16 , A61K9/50 , A61K35/74 , A61P1/12 , A61F13/20 , A61F6/08 , A61K9/14 , C12N11/04
CPC分类号： A61K35/747 , A61K9/0034 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5031 , Y10S424/15 , Y10S435/853 , Y10S435/854 , Y10S514/967
摘要： Micro-encapsulated lactobacilli bacteria are orally administered to mammals, including humans, to treat or prevent antibiotic associated or other chronic or acute diarrhea. Micro-encapsulated lactobacilli bacteria are topically administered to the skin to treat or prevent recurrent skin infections, and are administered intra-vaginally to treat or prevent vaginal yeast infections.
摘要翻译：对包括人在内的哺乳动物口服施用微囊化的乳杆菌，以治疗或预防抗生素相关或其它慢性或急性腹泻。将微囊化的乳杆菌细菌局部施用于皮肤以治疗或预防复发性皮肤感染，并且经阴道内给药以治疗或预防阴道酵母菌感染。

7. 发明授权

US5633012A Micro-encapsulated lactobacilli for medical applications 失效
公开(公告)号：US5633012A
公开(公告)日：1997-05-27
申请号：US627358
申请日：1996-04-05
申请人： Larry C. Ford
发明人： Larry C. Ford
IPC分类号： A61K9/02 , A61K9/00 , A61K9/16 , A61K9/50 , A61K35/74 , A61P1/12 , A61K9/48 , A61K9/20 , A61K9/70
CPC分类号： A61K35/747 , A61K9/0034 , A61K9/1635 , A61K9/1652 , A61K9/5026 , A61K9/5031 , Y10S424/15 , Y10S435/853 , Y10S435/854 , Y10S514/967
摘要： Micro-encapsulated lactobacilli bacteria are orally administered to mammals, including humans, to treat or prevent antibiotic associated or other chronic or acute diarrhea. Micro-encapsulated lactobacilli bacteria are topically administered to the skin to treat or prevent recurrent skin infections, and are administered intra-vaginally to treat or prevent vaginal yeast infections.

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