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1. 发明授权

US07217513B2 Apparatus and method for isolating a nucleic acid from a sample 失效
标题翻译：从样品中分离核酸的装置和方法
公开(公告)号：US07217513B2
公开(公告)日：2007-05-15
申请号：US10193742
申请日：2002-07-10
申请人： Lalitha Parameswaran , Albert Young , Laura T. Bortolin , Mark A. Hollis , James Harper , Johanna Bobrow
发明人： Lalitha Parameswaran , Albert Young , Laura T. Bortolin , Mark A. Hollis , James Harper , Johanna Bobrow
IPC分类号： C12Q1/68
CPC分类号： B01L3/0282 , B01L3/0241 , B01L3/5023 , B01L2400/0406 , B01L2400/0415 , B01L2400/049 , C12Q1/6806 , C12Q2565/137 , C12Q2549/125
摘要： A method for preparing a nucleic acid component of a sample for amplification includes contacting the sample with a porous support that deactivates a nucleic acid amplification inhibitor component of the sample and directing a fluid through the porous support, whereby the nucleic acid component of the sample is directed through at least a portion of the porous support and is separated from the support, thereby preparing the nucleic acid component for amplification. The method can be conducted in an apparatus that includes a porous support having a component that deactivates a nucleic acid amplification inhibitor component of a sample contacting the porous support and a housing having an opening and defining an interior, said interior being in fluid communication with the porous support, whereby at least a portion of a fluid directed through the opening is directed through at least a portion of the porous support and separates at least a portion of a nucleic acid component of a sample contacting the porous support from the support, thereby preparing the nucleic acid component for amplification.
摘要翻译：用于制备用于扩增的样品的核酸组分的方法包括使样品与多孔载体接触，多孔载体使样品的核酸扩增抑制剂组分失活并引导流体通过多孔载体，由此样品的核酸组分为引导通过多孔载体的至少一部分并与载体分离，由此制备用于扩增的核酸组分。该方法可以在包括多孔载体的装置中进行，所述多孔载体具有使与多孔载体接触的样品的核酸扩增抑制剂组分失活的组分和具有开口并限定内部的壳体，所述内部与多孔载体，其中通过开口引导的流体的至少一部分被引导通过多孔载体的至少一部分，并将与多孔载体接触的样品的核酸组分的至少一部分与载体分离，由此制备用于扩增的核酸组分。

2. 发明授权

US08062846B2 Apparatus for isolating a nucleic acid from a sample 有权
标题翻译：从样品中分离核酸的装置
公开(公告)号：US08062846B2
公开(公告)日：2011-11-22
申请号：US11804598
申请日：2007-05-18
申请人： Laura T. Bortolin , Lalitha Parameswaran , James Harper , Johanna Bobrow , Mark A. Hollis , Drew Chapman Brown , Eric Scott Clasen , John Calvin Schmidt
发明人： Laura T. Bortolin , Lalitha Parameswaran , James Harper , Johanna Bobrow , Mark A. Hollis , Drew Chapman Brown , Eric Scott Clasen , John Calvin Schmidt
IPC分类号： C12Q1/68 , B01D35/00 , B01L99/00
CPC分类号： B01L3/502 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/043 , B01L2300/044 , B01L2300/047 , B01L2300/048 , B01L2300/0609 , B01L2300/0672 , B01L2300/0681 , B01L2300/069 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , B01L2400/0644 , B01L2400/0683 , C07H21/04 , C12N15/1013
摘要： An apparatus for preparing a nucleic acid component of a sample for amplification includes a porous support having an agent that deactivates a nucleic acid amplification inhibitor component of the sample. The apparatus further includes a housing with an opening and defining an interior. The interior of the housing is in fluid communication with the porous support, and at least a portion of a fluid directed through the opening is directed through at least a portion of the porous support. The apparatus also includes a magnetic substrate for separating nucleic acid from a sample.
摘要翻译：用于制备用于扩增的样品的核酸组分的装置包括具有使样品的核酸扩增抑制剂组分失活的试剂的多孔载体。该装置还包括具有开口并限定内部的壳体。壳体的内部与多孔支撑件流体连通，并且引导通过开口的流体的至少一部分被引导通过多孔支撑件的至少一部分。该装置还包括用于从样品中分离核酸的磁性底物。

3. 发明申请

US20080131949A1 Apparatus and method for isolating a nucleic acid from a sample 有权
标题翻译：从样品中分离核酸的装置和方法
公开(公告)号：US20080131949A1
公开(公告)日：2008-06-05
申请号：US11804598
申请日：2007-05-18
申请人： Laura T. Bortolin , Lalitha Parameswaran , James Harper , Johanna Bobrow , Mark A. Hollis , Drew Chapman Brown , Eric Scott Clasen , John Calvin Schmidt
发明人： Laura T. Bortolin , Lalitha Parameswaran , James Harper , Johanna Bobrow , Mark A. Hollis , Drew Chapman Brown , Eric Scott Clasen , John Calvin Schmidt
IPC分类号： C12N13/00 , C12M1/00
CPC分类号： B01L3/502 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/043 , B01L2300/044 , B01L2300/047 , B01L2300/048 , B01L2300/0609 , B01L2300/0672 , B01L2300/0681 , B01L2300/069 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , B01L2400/0644 , B01L2400/0683 , C07H21/04 , C12N15/1013
摘要： A method for preparing a nucleic acid component of a sample for amplification includes contacting the sample with a porous support that deactivates a nucleic acid amplification inhibitor component of the sample and directing a fluid through the porous support, whereby the nucleic acid component of the sample is directed through at least a portion of the porous support and is separated from the support, thereby preparing the nucleic acid component for amplification. The sample is separated from raw sample components through means that include a magnetic substrate. An apparatus suitable for conducting the method of the invention also is described.
摘要翻译：用于制备用于扩增的样品的核酸组分的方法包括使样品与多孔载体接触，多孔载体使样品的核酸扩增抑制剂组分失活并引导流体通过多孔载体，由此样品的核酸组分为引导通过多孔载体的至少一部分并与载体分离，由此制备用于扩增的核酸组分。样品通过包括磁性底物的方式与原始样品组分分离。还描述了适用于进行本发明的方法的装置。

4. 发明申请

US20120276334A1 Surfaces with Controllable Wetting and Adhesion 审中-公开
标题翻译：具有可控润湿和附着力的表面
公开(公告)号：US20120276334A1
公开(公告)日：2012-11-01
申请号：US13402520
申请日：2012-02-22
申请人： Theodore Fedynyshyn , Shaun R. Berry , Lalitha Parameswaran
发明人： Theodore Fedynyshyn , Shaun R. Berry , Lalitha Parameswaran
IPC分类号： B32B3/30 , H05K1/18 , B05D5/12 , B29C59/00 , B05D5/02
CPC分类号： B08B17/065 , B05D5/04 , B05D5/08 , Y10T428/24355
摘要： Surfaces that have both micrometer- and nanometer-scale features can have controllable wetting and adhesion properties. The surfaces can be reversibly switched between states of greater and lesser hydrophobicity, and between states of greater and lesser droplet adhesion.
摘要翻译：具有微米级和纳米尺度特征的表面可以具有可控的润湿和粘附性能。表面可以在具有较大和较小疏水性的状态之间以及较大和较小的液滴粘附的状态之间可逆地切换。

5. 发明申请

US20050277204A1 Sample preparation methods and devices 审中-公开
标题翻译：样品制备方法和装置
公开(公告)号：US20050277204A1
公开(公告)日：2005-12-15
申请号：US11056518
申请日：2005-02-11
申请人： Mark Hollis , Nicholas Freeland Judson , Christina Rudzinski , Lalitha Parameswaran , Theodore Fedynyshyn , Catherine Cabrera , Laura Bortolin , Robert King , Matthew Angel
发明人： Mark Hollis , Nicholas Freeland Judson , Christina Rudzinski , Lalitha Parameswaran , Theodore Fedynyshyn , Catherine Cabrera , Laura Bortolin , Robert King , Matthew Angel
IPC分类号： C12M1/34 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/543
CPC分类号： C12M47/04 , G01N33/54326
摘要： The present invention provides improved devices for separating and/or detecting targets from biological, environmental, or chemical samples.
摘要翻译：本发明提供了用于从生物，环境或化学样品中分离和/或检测靶的改进装置。

6. 发明申请

US20050118570A1 Sample preparation methods and devices 审中-公开
标题翻译：样品制备方法和装置
公开(公告)号：US20050118570A1
公开(公告)日：2005-06-02
申请号：US10916784
申请日：2004-08-12
申请人： Mark Hollis , Nicholas Freeland Judson , Christina Rudzinski , Lalitha Parameswaran , Theodore Fedynyshyn , Catherine Cabrera , Laura Bortolin
发明人： Mark Hollis , Nicholas Freeland Judson , Christina Rudzinski , Lalitha Parameswaran , Theodore Fedynyshyn , Catherine Cabrera , Laura Bortolin
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54326 , B01L3/502 , C12Q1/6806 , C12Q2563/143 , C12Q2527/113
摘要： The present invention provides improved methods, compositions, and devices for separating and/or detecting targets from biological, environmental, or chemical samples.
摘要翻译：本发明提供用于从生物，环境或化学样品分离和/或检测靶的改进的方法，组合物和装置。

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