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1. 发明申请

WO2004083366A3 METHODS UTILIZING NOVEL TARGET GENES RELATED TO IMMUNE-MEDIATED DISEASES 审中-公开
标题翻译：方法利用与免疫介导的疾病相关的新靶基因
公开(公告)号：WO2004083366A3
公开(公告)日：2004-12-23
申请号：PCT/FI2004000155
申请日：2004-03-17
申请人： LUND RIIKKA , CHEN ZHI , LAHESMAA RIITTA
发明人： LUND RIIKKA , CHEN ZHI , LAHESMAA RIITTA
IPC分类号： C12N20060101 , C12Q1/68 , G01N33/50 , G01N33/564
CPC分类号： G01N33/564 , G01N33/5047 , G01N33/505
摘要： The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or a predisposition to, an immune-related disorder in a subject.
摘要翻译：本发明提供了利用与免疫介导的疾病相关的新型靶基因如哮喘，变态反应和自身免疫性疾病的方法。本发明基于已知T辅助细胞来源的CD4 +前体细胞（Thp）极化的分子水平描述。特别地，本发明提供了鉴定能够调节CD4 +淋巴细胞极化的化合物的方法。本发明还涉及评估受试者中免疫相关病症的存在或其倾向的方法。

2. 发明专利

FI20041204A0 未知
公开(公告)号：FI20041204A0
公开(公告)日：2004-09-16
申请号：FI20041204
申请日：2004-09-16
申请人： LUND RIIKKA , LAHESMAA RIITTA
发明人： LUND RIIKKA , LAHESMAA RIITTA
IPC分类号： C12N20060101 , C12Q1/68 , C12N
摘要： The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or disposition to, an immune-related disorder in a subject.

3. 发明公开

EP1794315A4 METHODS FOR THE UTILIZATION OF NOVEL TARGET GENES RELATED TO IMMUNE-MEDIATED DISEASES 审中-公开
标题翻译：方法采用新型靶基因均与免疫介导的疾病相关
公开(公告)号：EP1794315A4
公开(公告)日：2009-11-18
申请号：EP05787813
申请日：2005-09-16
申请人： LUND RIIKKA , LAHESMAA RIITTA
发明人： LUND RIIKKA , LAHESMAA RIITTA
IPC分类号： C12Q1/68 , C12N20060101 , C12N5/08
CPC分类号： C12Q1/6881 , C12Q2600/136 , C12Q2600/158

4. 发明申请

WO2006030071A3 METHODS FOR THE UTILIZATION OF NOVEL TARGET GENES RELATED TO IMMUNE-MEDIATED DISEASES 审中-公开
标题翻译：利用与免疫介导的疾病有关的新靶基因的方法
公开(公告)号：WO2006030071A3
公开(公告)日：2006-05-04
申请号：PCT/FI2005050320
申请日：2005-09-16
申请人： LUND RIIKKA , LAHESMAA RIITTA
发明人： LUND RIIKKA , LAHESMAA RIITTA
IPC分类号： C12Q1/68 , C12N20060101 , C12N5/08
CPC分类号： C12Q1/6881 , C12Q2600/136 , C12Q2600/158
摘要： The present invention provides methods utilizing novel target genes related to immune-mediated diseases, such as asthma, allergy and autoimmune diseases. The invention is based on a molecular level description of the polarization of CD4+ precursor cells (Thp) from which T helper cells are known to originate. Particularly, the present invention provides a method of identifying a compound capable of modulating the polarization of CD4+ lymphocytes. The invention is also related to a method for assessing the presence of, or disposition to, an immune-related disorder in a subject.
摘要翻译：本发明提供了利用与免疫介导的疾病相关的新型靶基因如哮喘，变态反应和自身免疫性疾病的方法。本发明基于已知T辅助细胞来源的CD4 +前体细胞（Thp）极化的分子水平描述。特别地，本发明提供了鉴定能够调节CD4 +淋巴细胞极化的化合物的方法。本发明还涉及评估受试者中免疫相关病症的存在或倾向的方法。

5. 发明申请

WO2007071829A2 METHODS AND MEANS RELATED TO DISEASES 审中-公开
标题翻译：与疾病相关的方法和手段
公开(公告)号：WO2007071829A2
公开(公告)日：2007-06-28
申请号：PCT/FI2006050577
申请日：2006-12-21
申请人： DERMAGENE OY , RANKI ANNAMARI , HAHTOLA SONJA , KARENKO LEENA , TUOMELA SOILE , LAHESMAA RIITTA , KROHN KAI
发明人： RANKI ANNAMARI , HAHTOLA SONJA , KARENKO LEENA , TUOMELA SOILE , LAHESMAA RIITTA , KROHN KAI
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to the fields of genetics and oncology and provides methods for detecting cutaneous T-cell lymphomas (CTCL) or susceptibiiity to CTCL. Specifically, the present invention relates to a novel method for the diagnosis and fofiow-up of CTCL or CTCL subtype, the method comprising determination of expression of one or more genes, gene fragments or gene products. The present invention further relates to a novel method of detecting the response to CTCL therapy, the method comprising determining expression of one or more genes or gene fragments or gene products in a biological sample. The present invention further relates to a novel method of developing or improving CTCL therapy or developing anti- CTCL medicament, the method comprising screening agents affecting one or several of the genes or gene products. The present invention further relates to a novel method of treating CTCL patients, the method comprising affecting one or several of the genes or gene products. The present invention further relates to a novel test kit, the kit comprising the necessary means for detecting one or more genes, gene fragments or gene products. The present invention also relates to a use of one or more genes, gene fragments or gene products for determination, diagnosis or follow-up of CTCL or CTCL subtype and for detection of the response to CTCL therapy. The present invention also relates to a use of one or more target molecules for CTCL therapy or for the preparation of a medicament for treating CTCL.
摘要翻译：本发明涉及遗传学和肿瘤学领域，并提供了检测皮肤T细胞淋巴瘤（CTCL）或CTCL易感性的方法。具体而言，本发明涉及一种用于诊断和验证CTCL或CTCL亚型的新方法，所述方法包括测定一种或多种基因，基因片段或基因产物的表达。本发明还涉及检测对CTCL治疗的反应的新方法，所述方法包括测定生物样品中一种或多种基因或基因片段或基因产物的表达。本发明还涉及一种开发或改进CTCL治疗或开发抗CTCL药物的新方法，该方法包括影响一种或几种基因或基因产物的筛选剂。本发明还涉及一种治疗CTCL患者的新方法，该方法包括影响一种或几种基因或基因产物。本发明还涉及一种新的测试试剂盒，该试剂盒包含检测一种或多种基因，基因片段或基因产物的必要手段。本发明还涉及一种或多种基因，基因片段或基因产物用于测定，诊断或追踪CTCL或CTCL亚型以及检测对CTCL治疗的应答的用途。本发明还涉及一种或多种靶分子用于CTCL治疗或制备用于治疗CTCL的药物的用途。

6. 发明专利

FI20075054A0 未知
公开(公告)号：FI20075054A0
公开(公告)日：2007-01-26
申请号：FI20075054
申请日：2007-01-26
申请人： LAHESMAA RIITTA , TAHVANAINEN JOHANNA
发明人： LAHESMAA RIITTA , TAHVANAINEN JOHANNA

7. 发明申请

WO2008090263A1 PRELI - A NOVEL T-CELL REGULATOR 审中-公开
标题翻译： PRELI - 新型T细胞调节剂
公开(公告)号：WO2008090263A1
公开(公告)日：2008-07-31
申请号：PCT/FI2008050025
申请日：2008-01-28
申请人： LAHESMAA RIITTA , TAHVANAINEN JOHANNA
发明人： LAHESMAA RIITTA , TAHVANAINEN JOHANNA
IPC分类号： G01N33/50 , C07K14/47 , C12N15/12 , C40B30/06
CPC分类号： G01N33/505 , C07K14/47 , C07K14/4747 , C07K14/52 , C40B30/06 , C40B40/08 , G01N2510/00
摘要： The present invention provides a novel T-cell regulator Preli for use in the regulation of cell cultures. Preli can also be used as a target molecule in development of pharmaceuticals for the treatment of an immune-related disease. The present invention also provides a method of screening modulators of mitochondrial apoptosis signaling pathway in human T helper cells.
摘要翻译：本发明提供了用于调节细胞培养物的新型T细胞调节物Preli。 Preli也可以用作药物开发中用于治疗免疫相关疾病的靶分子。本发明还提供了筛选人T辅助细胞中线粒体凋亡信号通路调节剂的方法。

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