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1. 发明专利

AU2007321070A1 Methods and uses involving genetic abnormalities at chromosome 12 未知
公开(公告)号：AU2007321070A1
公开(公告)日：2008-05-22
申请号：AU2007321070
申请日：2007-11-13
申请人： RANKI ANNAMARI , DERMAGENE OY , HELLE MARKKU , KROHN KAI , HAHTOLA SONJA , HASSAN WAEL , KARENKO LEENA , PELTOMAKI PAIVI
发明人： HAHTOLA SONJA , HASSAN WAEL , RANKI ANNAMARI , KARENKO LEENA , KROHN KAI , HELLE MARKKU , PELTOMAKI PAIVI
IPC分类号： C12Q1/68

2. 发明公开

EP2092081A1 METHODS AND USES INVOLVING GENETIC ABNORMALITIES AT CHROMOSOME 12 有权
标题翻译：方法和基因异常12号染色体相关用途
公开(公告)号：EP2092081A1
公开(公告)日：2009-08-26
申请号：EP07823247.7
申请日：2007-11-13
申请人： Dermagene Oy , Krohn, Kai , Hassan, Wael , Peltomäki, Päivi , Helle, Markku , Hahtola, Sonja , Karenko, Leena , Ranki, Annamari
发明人： KROHN, Kai , HASSAN, Wael, University of Sharjah , PELTOMÄKI, Päivi , HELLE, Markku , HAHTOLA, Sonja , KARENKO, Leena , RANKI, Annamari
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/16
摘要： The present invention relates to the fields of genetics and oncology and provides methods for predicting and identifying tumors of epithelial origin. Specifically, the present invention relates to a novel method of predicting tumor initiation, tumor progression and/or carcinomas, the method comprising detecting genetic abnormality associated with tumors of epithelial origin. The present invention further relates to a novel method of identifying an individual with potential for developing carcinoma, the method comprising detection of genetic abnormalities. The present invention also relates to a method of predicting the progression of carcinomas and the transformation thereof to an aggressive variant, the method comprising detection of genetic abnormalities, which indicate the probability to develop carcinoma. The present invention also relates to a use of specific chromosomal region, a gene or a fragment thereof, and/or genetic markers for predicting tumor initiation, tumor progression and/or carcinoma. The present invention also relates to a use of specific chromosomal region or a gene or a fragment thereof in therapy, for the development of therapy, and for the preparation of a medicament for treating tumors of epithelial origin.

3. 发明公开

EP2092081A4 METHODS AND USES INVOLVING GENETIC ABNORMALITIES AT CHROMOSOME 12 有权
标题翻译：方法和基因异常21号染色体相关用途
公开(公告)号：EP2092081A4
公开(公告)日：2010-06-09
申请号：EP07823247
申请日：2007-11-13
申请人： HELSINGIN YLIOPISTON RAHASTOT , KROHN KAI , HASSAN WAEL , PELTOMAEKI PAEIVI , HELLE MARKKU , HAHTOLA SONJA , KARENKO LEENA , RANKI ANNAMARI
发明人： KROHN KAI , HASSAN WAEL , PELTOMAEKI PAEIVI , HELLE MARKKU , HAHTOLA SONJA , KARENKO LEENA , RANKI ANNAMARI
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/16

4. 发明申请

WO2008059112A1 METHODS AND USES INVOLVING GENETIC ABNORMALITIES AT CHROMOSOME 12 审中-公开
标题翻译：涉及染色体遗传异常的方法和用途12
公开(公告)号：WO2008059112A1
公开(公告)日：2008-05-22
申请号：PCT/FI2007/050611
申请日：2007-11-13
申请人： DERMAGENE OY , KROHN, Kai , HASSAN, Wael , PELTOMÄKI, Päivi , HELLE, Markku , HAHTOLA, Sonja , KARENKO, Leena , RANKI, Annamari
发明人： KROHN, Kai , HASSAN, Wael , PELTOMÄKI, Päivi , HELLE, Markku , HAHTOLA, Sonja , KARENKO, Leena , RANKI, Annamari
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/16
摘要： The present invention relates to the fields of genetics and oncology and provides methods for predicting and identifying tumors of epithelial origin. Specifically, the present invention relates to a novel method of predicting tumor initiation, tumor progression and/or carcinomas, the method comprising detecting genetic abnormality associated with tumors of epithelial origin. The present invention further relates to a novel method of identifying an individual with potential for developing carcinoma, the method comprising detection of genetic abnormalities. The present invention also relates to a method of predicting the progression of carcinomas and the transformation thereof to an aggressive variant, the method comprising detection of genetic abnormalities, which indicate the probability to develop carcinoma. The present invention also relates to a use of specific chromosomal region, a gene or a fragment thereof, and/or genetic markers for predicting tumor initiation, tumor progression and/or carcinoma. The present invention also relates to a use of specific chromosomal region or a gene or a fragment thereof in therapy, for the development of therapy, and for the preparation of a medicament for treating tumors of epithelial origin.
摘要翻译：本发明涉及遗传学和肿瘤学领域，并提供预测和鉴定上皮起源肿瘤的方法。具体地，本发明涉及一种预测肿瘤起始，肿瘤进展和/或癌的新方法，该方法包括检测与上皮起源的肿瘤相关的遗传异常。本发明还涉及鉴定具有发展癌潜力的个体的新方法，所述方法包括检测遗传异常。本发明还涉及预测癌的进展及其转化为侵略性变体的方法，所述方法包括检测遗传异常，其指示发生癌的可能性。本发明还涉及特定染色体区域，其基因或其片段的用途和/或用于预测肿瘤起始，肿瘤进展和/或癌症的遗传标记。本发明还涉及特异性染色体区域或其基因或片段在治疗中的用途，用于治疗的发展，以及用于制备治疗上皮肿瘤的药物。

5. 发明申请

WO2007071829A3 METHODS AND MEANS RELATED TO DISEASES 审中-公开
公开(公告)号：WO2007071829A3
公开(公告)日：2007-06-28
申请号：PCT/FI2006/050577
申请日：2006-12-21
申请人： DERMAGENE OY , RANKI, Annamari , HAHTOLA, Sonja , KARENKO, Leena , TUOMELA, Soile , LAHESMAA, Riitta , KROHN, Kai
发明人： RANKI, Annamari , HAHTOLA, Sonja , KARENKO, Leena , TUOMELA, Soile , LAHESMAA, Riitta , KROHN, Kai
IPC分类号： C12Q1/68 , G01N33/50 , C12N15/12
摘要： The present invention relates to the fields of genetics and oncology and provides methods for detecting cutaneous T-cell lymphomas (CTCL) or susceptibiiity to CTCL. Specifically, the present invention relates to a novel method for the diagnosis and fofiow-up of CTCL or CTCL subtype, the method comprising determination of expression of one or more genes, gene fragments or gene products. The present invention further relates to a novel method of detecting the response to CTCL therapy, the method comprising determining expression of one or more genes or gene fragments or gene products in a biological sample. The present invention further relates to a novel method of developing or improving CTCL therapy or developing anti- CTCL medicament, the method comprising screening agents affecting one or several of the genes or gene products. The present invention further relates to a novel method of treating CTCL patients, the method comprising affecting one or several of the genes or gene products. The present invention further relates to a novel test kit, the kit comprising the necessary means for detecting one or more genes, gene fragments or gene products. The present invention also relates to a use of one or more genes, gene fragments or gene products for determination, diagnosis or follow-up of CTCL or CTCL subtype and for detection of the response to CTCL therapy. The present invention also relates to a use of one or more target molecules for CTCL therapy or for the preparation of a medicament for treating CTCL.

6. 发明申请

WO2007071829A2 METHODS AND MEANS RELATED TO DISEASES 审中-公开
标题翻译：与疾病相关的方法和手段
公开(公告)号：WO2007071829A2
公开(公告)日：2007-06-28
申请号：PCT/FI2006050577
申请日：2006-12-21
申请人： DERMAGENE OY , RANKI ANNAMARI , HAHTOLA SONJA , KARENKO LEENA , TUOMELA SOILE , LAHESMAA RIITTA , KROHN KAI
发明人： RANKI ANNAMARI , HAHTOLA SONJA , KARENKO LEENA , TUOMELA SOILE , LAHESMAA RIITTA , KROHN KAI
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to the fields of genetics and oncology and provides methods for detecting cutaneous T-cell lymphomas (CTCL) or susceptibiiity to CTCL. Specifically, the present invention relates to a novel method for the diagnosis and fofiow-up of CTCL or CTCL subtype, the method comprising determination of expression of one or more genes, gene fragments or gene products. The present invention further relates to a novel method of detecting the response to CTCL therapy, the method comprising determining expression of one or more genes or gene fragments or gene products in a biological sample. The present invention further relates to a novel method of developing or improving CTCL therapy or developing anti- CTCL medicament, the method comprising screening agents affecting one or several of the genes or gene products. The present invention further relates to a novel method of treating CTCL patients, the method comprising affecting one or several of the genes or gene products. The present invention further relates to a novel test kit, the kit comprising the necessary means for detecting one or more genes, gene fragments or gene products. The present invention also relates to a use of one or more genes, gene fragments or gene products for determination, diagnosis or follow-up of CTCL or CTCL subtype and for detection of the response to CTCL therapy. The present invention also relates to a use of one or more target molecules for CTCL therapy or for the preparation of a medicament for treating CTCL.
摘要翻译：本发明涉及遗传学和肿瘤学领域，并提供了检测皮肤T细胞淋巴瘤（CTCL）或CTCL易感性的方法。具体而言，本发明涉及一种用于诊断和验证CTCL或CTCL亚型的新方法，所述方法包括测定一种或多种基因，基因片段或基因产物的表达。本发明还涉及检测对CTCL治疗的反应的新方法，所述方法包括测定生物样品中一种或多种基因或基因片段或基因产物的表达。本发明还涉及一种开发或改进CTCL治疗或开发抗CTCL药物的新方法，该方法包括影响一种或几种基因或基因产物的筛选剂。本发明还涉及一种治疗CTCL患者的新方法，该方法包括影响一种或几种基因或基因产物。本发明还涉及一种新的测试试剂盒，该试剂盒包含检测一种或多种基因，基因片段或基因产物的必要手段。本发明还涉及一种或多种基因，基因片段或基因产物用于测定，诊断或追踪CTCL或CTCL亚型以及检测对CTCL治疗的应答的用途。本发明还涉及一种或多种靶分子用于CTCL治疗或制备用于治疗CTCL的药物的用途。

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