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1. 发明申请

WO2013045952A1 ANALYTICAL TEST STRIP WITH ISOLATED BODILY FLUID PHASE-SHIFT AND ANALYTE DETERMINATION SAMPLE CHAMBERS 审中-公开
标题翻译：分离体液相分析仪和分析测定样品分析仪的分析测试条
公开(公告)号：WO2013045952A1
公开(公告)日：2013-04-04
申请号：PCT/GB2012/052425
申请日：2012-10-01
申请人： LIFESCAN SCOTLAND LIMITED , McCOLL, David , SMITH, Antony , WHYTE, Lynsey , WHITEHEAD, Neil , DARLING, Ramsay
发明人： McCOLL, David , SMITH, Antony , WHYTE, Lynsey , WHITEHEAD, Neil , DARLING, Ramsay
IPC分类号： G01N27/327
CPC分类号： G01N27/3272
摘要： An analytical test strip ("ATS") for use with a hand-held test meter in the determination of an analyte in a bodily fluid sample includes an electrically insulting substrate (102), a first patterned conductor layer (104) disposed on the electrically insulating substrate and having a working electrode (128a, 128b) and a reference electrode (130). The ATS also includes an enzymatic reagent layer (106) disposed on the working electrode, a first patterned spacer layer (108) disposed over the first patterned conductor layer and defining both a first sample-receiving channel (112) and an analyte determination sample chamber (114) within the ATS, and a second patterned spacer layer (110) disposed over the first patterned spacer layer and defining at least a second sample-receiving channel (120). The ATS further includes a bodily fluid phase-shift sample chamber (116) in fluidic communication with the second sample-receiving channel. The first sample-receiving channel (112) and analyte determination sample chamber (114) are isolated from the second sample-receiving channel (120) and bodily fluid phase-shift sample chamber (116).
摘要翻译：在用于测定体液样品中的分析物的手持测试仪中使用的分析测试条（“ATS”）包括电绝缘基底（102），设置在电液体上的第一图案化导体层（104）绝缘基板并具有工作电极（128a，128b）和参考电极（130）。 ATS还包括设置在工作电极上的酶试剂层（106），设置在第一图案化导体层之上的第一图案化间隔层（108），并且限定第一样品接收通道（112）和分析物确定样品室（114），以及设置在所述第一图案化间隔层上并且限定至少第二样品接收通道（120）的第二图案化间隔层（110）。 ATS还包括与第二样品接收通道流体连通的体液相移样品室（116）。第一样品接收通道（112）和分析物确定样品室（114）与第二样品接收通道（120）和体液相移样品室（116）隔离。

2. 发明申请

WO2011144904A1 ANALYTICAL TEST STRIP WITH AN ELECTRODE HAVING ELECTROCHEMICALLY ACTIVE AND INERT ARES OF A PREDETERMINED SIZE AND DISTRIBUTION 审中-公开
标题翻译：具有预定尺寸和分布的电化学活性和惰性物质的电极的分析测试条
公开(公告)号：WO2011144904A1
公开(公告)日：2011-11-24
申请号：PCT/GB2011/000766
申请日：2011-05-19
申请人： LIFESCAN SCOTLAND LIMITED , MACFIE, Gavin , REDPATH, Craig , RODGERS, Jamie, Iain , WHITEHEAD, Neil
发明人： MACFIE, Gavin , REDPATH, Craig , RODGERS, Jamie, Iain , WHITEHEAD, Neil
IPC分类号： G01N33/49 , G01N33/487 , G01N27/26
CPC分类号： G01N27/3272
摘要： An electrochemical -based analytical test strip (10) for the determination of an analyte (e.g., glucose) in a bodily fluid sample (such as a whole blood sample) includes an electrically insulating base layer (12) and a patterned conductor layer (14) (for example, a gold patterned conductor layer) disposed over the electrically-insulating layer (12). The patterned conductor layer (14) includes at least one electrode (14a, 14b, 14c) with the electrode (14a, 14b, 14c) having electrochemically inert areas (26) and an electrochemically active area(s) (28). Moreover, the electrochemically inert areas (26) and electrochemically active area(s) (28) are of a predetermined size and a predetermined distribution such that electrochemical response of the electrode (14a, 14b, 14c) during use of the electrochemical -based analytical test strip (10) is essentially equivalent to a predetermined electrochemical response.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条（10）包括电绝缘基底层（12）和图案化导体层（14））（例如，金图案化导体层），设置在电绝缘层（12）上。图案化导体层（14）包括具有电化学惰性区域（26）和电化学活性区域（28）的电极（14a，14b，14c）的至少一个电极（14a，14b，14c）。此外，电化学惰性区域（26）和电化学活性区域（28）具有预定尺寸和预定分布，使得在使用电化学基分析期间电极（14a，14b，14c）的电化学响应测试条（10）基本上等于预定的电化学响应。

3. 发明申请

WO2013190073A1 ANALYTICAL TEST STRIP WITH CAPILLARY SAMPLE-RECEIVING CHAMBERS SEPARATED BY STOP JUNCTIONS 审中-公开
标题翻译：带停止接头分开的毛细管样品接收器的分析测试条
公开(公告)号：WO2013190073A1
公开(公告)日：2013-12-27
申请号：PCT/EP2013/062952
申请日：2013-06-20
申请人： LIFESCAN SCOTLAND LIMITED
发明人： WHITEHEAD, Neil , SLOSS, Scott , SMITH, Antony , WHYTE, Lynsey , MCCOLL, David , HOWIE, David , DARLING, Ramsay , MCLAREN, James
IPC分类号： G01N33/543
CPC分类号： C12Q1/006 , G01N33/526
摘要： An analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a first and second capillary sample-receiving chambers and first and second stop junctions that are disposed between the first and second capillary sample-receiving chambers. The first stop junction defines a discontinuity boundary of the first capillary sample-receiving chamber and the second stop junction defines a discontinuity boundary of the second capillary sample-receiving chamber. In addition, the first stop junction and the second stop junction are disposed such that bodily fluid sample flow between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber during use of the analytical test strip is prevented.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的分析测试条包括第一和第二毛细管样品接收室以及设置在第一和第二毛细管样品接收室之间的第一和第二停止接头和第二毛细管样品接收室。第一停止接头限定第一毛细管样品接收室的不连续边界，并且第二停止接头限定第二毛细管样品接收室的不连续边界。此外，第一停止接点和第二停止接点被布置成使得在使用分析测试条期间，体液样本在第一毛细管样品接收室和第二毛细管样品接收室之间流动。

4. 发明申请

WO2013117924A1 ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH FILL-SPEED CONFIGURED REAGENT LAYER 审中-公开
标题翻译：基于电化学的分析测试条带快速配置的试剂层
公开(公告)号：WO2013117924A1
公开(公告)日：2013-08-15
申请号：PCT/GB2013/050275
申请日：2013-02-06
申请人： LIFESCAN SCOTLAND LIMITED
发明人： WHITEHEAD, Neil , PHILLIPS, Stuart , MORRIS, David , MCILRATH, Ramsay , MACLEOD, Robert , WHYTE, Lynsey , CAMPBELL, Karn , DARLING, Ramsay , MCLAREN, James , BAIN, Russell
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , C12Q1/006
摘要： An electrochemical-based analytical test strip ("EBAT") for the determination of an analyte in a bodily fluid sample includes an electrically insulating substrate layer with a distal end and a patterned conductor layer that is disposed over the electrically-insulating substrate layer and has a working electrode ("WE") and a counter/reference electrode ("C/RE"). The EBAT also includes a patterned insulation layer with an electrode exposure window configured to expose a WE exposed portion and a C/RE exposed portion, an enzymatic reagent layer; and a patterned spacer layer. In addition, the patterned insulation layer and the patterned spacer layer define a sample receiving chamber with a sample-receiving opening at the distal end of the electrically insulating substrate layer and that extends across the WE exposed portion and the C/RE exposed portion. Furthermore, the enzymatic reagent layer is disposed over the working electrode and counter/reference electrode exposed portions and extends no more than 400µm toward the sample-receiving opening.
摘要翻译：用于测定体液样品中的分析物的基于电化学的分析测试条（“EBAT”）包括具有远端的电绝缘基底层和布置在电绝缘基底层上的图案化导体层，并且具有工作电极（“WE”）和计数器/参考电极（“C / RE”）。 EBAT还包括具有电极曝光窗口的图案化绝缘层，其被配置为暴露WE暴露部分和C / RE暴露部分，酶试剂层; 和图案化间隔层。此外，图案化绝缘层和图案化间隔层限定了在电绝缘基底层的远端处具有样品接收开口并且穿过WE暴露部分和C / RE暴露部分延伸的样品接收室。此外，酶试剂层设置在工作电极和对置/参比电极暴露部分上方，朝向样品接收开口延伸不超过400μm。

5. 发明申请

WO2013190270A1 ANALYTICAL TEST STRIP WITH CAPILLARY SAMPLE-RECEIVING CHAMBERS SEPARATED BY A PHYSICAL BARRIER ISLAND 审中-公开
标题翻译：带有毛细管样本接收板的分析测试条由物理障碍物岛分离
公开(公告)号：WO2013190270A1
公开(公告)日：2013-12-27
申请号：PCT/GB2013/051552
申请日：2013-06-13
申请人： LIFESCAN SCOTLAND LIMITED
发明人： WHYTE, Lynsey , SLOSS, Scott , MCCOLL, David , WHITEHEAD, Neil , SMITH, Antony
IPC分类号： B01L3/00 , G01N27/327
CPC分类号： G01N27/3272 , B01L3/502 , B01L2300/0825 , G01N27/3274 , G01N33/492
摘要： An analytical test strip for the determination of an analyte (such as glucose and/or hematocrit) in a bodily fluid sample (such as a whole blood sample) includes a first capillary sample-receiving chamber, a second capillary sample-receiving chamber, and a physical barrier island disposed between the first and second capillary sample-receiving chambers. Moreover, the physical island barrier is disposed such that bodily fluid sample flow between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber is prevented during use of the analytical test strip.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖和/或血细胞比容）的分析测试条包括第一毛细管样品接收室，第二毛细管样品接收室和设置在第一和第二毛细管样品接收室之间的物理屏障岛。此外，物理岛屏障设置成在分析测试条的使用期间防止了体液样品在第一毛细管样品接收室和第二毛细管样品接收室之间流动。

6. 发明申请

WO2013190072A1 ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH INTERSECTING SAMPLE-RECEIVING CHAMBERS 审中-公开
标题翻译：基于电化学分析测试条带接口采样样品
公开(公告)号：WO2013190072A1
公开(公告)日：2013-12-27
申请号：PCT/EP2013/062950
申请日：2013-06-20
申请人： LIFESCAN SCOTLAND LIMITED
发明人： WHYTE, Lynsey , SLOSS, Scott , WHITEHEAD, Neil , MCCOLL, David , SMITH, Antony
IPC分类号： C12Q1/00
CPC分类号： G01N27/327 , C12Q1/004 , C12Q1/006
摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (for example, hematocrit) includes a first sample-receiving chamber with first and second sample-application openings, and first and second electrodes. The first and second electrodes are disposed in the first sample-receiving chamber between the first and second sample-application openings. The electrochemical-based analytical test strip also includes a second sample-receiving chamber and a plurality of electrodes disposed in the second sample-receiving chamber. In addition, the second sample-receiving chamber intersects the first sample-receiving chamber between the first and second electrodes, thereby defining a chamber intersection.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）和/或体液样品的特性（例如，血细胞比容）的基于电化学的分析测试条包括第一样品接收室，其具有第一和第二样品施加开口，以及第一和第二电极。第一和第二电极设置在第一和第二样品施加开口之间的第一样品接收室中。基于电化学的分析测试条还包括第二样品接收室和设置在第二样品接收室中的多个电极。此外，第二样本接收室在第一和第二电极之间与第一样本接收室相交，由此限定腔室交叉。

7. 发明申请

WO2015197645A1 END-FILL ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH PERPENDICULAR INTERSECTING SAMPLE-RECEIVING CHAMBERS 审中-公开
标题翻译：基于电化学的电泳分析测试条带连续采样样品接收器
公开(公告)号：WO2015197645A1
公开(公告)日：2015-12-30
申请号：PCT/EP2015/064151
申请日：2015-06-23
申请人： LIFESCAN SCOTLAND LIMITED
发明人： COOPER, Alexander , SMITH, Antony , WHYTE, Lynsey , WHITEHEAD, Neil , MCCOLL, David , GUTHRIE, Brian , LLOYD, Timothy , MASSARI, Rossano , FORLANI, Christian
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , B01L2300/0645 , G01N27/3272 , G01N31/164 , G01N33/0031 , G01N2030/645
摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber. Moreover, the first and second sample-determination chambers intersect the sample-entry chamber perpendicular (or nearly perpendicular) to one another and the first sample-determination chamber also intersects the sample-entry chamber in an aligned manner. The test strip can also include a shield electrode disposed in the sample-entry chamber, wherein the shield electrode is in electrical communication with one of the at least third electrode and fourth electrode.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）和/或体液样品的特征（例如，血细胞比容）的基于电化学的分析测试条包括样品具有设置在基于电化学的分析测试条的端部边缘上的样品施加开口的第一和第二样品室，以及与样品入口室直接流体连通的第一和第二样品测定室。基于电化学的分析测试条还包括设置在第一样品测定室中的第一和第二电极（例如第一和第二血细胞比容电极）和设置在第二样品中的第三和第四电极（例如工作和参考电极）测定室。此外，第一和第二样品确定室将样品入口室彼此垂直（或几乎垂直）相交，并且第一样品测定室也以对准的方式与样品入口室相交。测试条还可以包括设置在样本入口室中的屏蔽电极，其中屏蔽电极与至少第三电极和第四电极中的一个电连通。

8. 发明申请

WO2014135623A1 METHODS AND SYSTEMS TO DETERMINE FILL DIRECTION AND FILL ERROR IN ANALYTE MEASUREMENTS 审中-公开
标题翻译：用于确定分析仪测量中的填充方向和填充错误的方法和系统
公开(公告)号：WO2014135623A1
公开(公告)日：2014-09-12
申请号：PCT/EP2014/054322
申请日：2014-03-06
申请人： LIFESCAN SCOTLAND LIMITED
发明人： SMITH, Antony , WHITEHEAD, Neil , WHYTE, Lynsey
IPC分类号： G01N27/327 , B01L3/00
CPC分类号： G01N27/3274 , B01L3/502715 , B01L2200/04 , B01L2200/10 , B01L2200/143 , B01L2300/0825 , B01L2400/0406 , G01N27/3273
摘要： Various embodiments for methods and systems that allow for detecting of a direction in which a sample is flowing towards a plurality of electrodes and detecting a fill error of an electrochemical test strip (100). This includes monitoring the working electrodes (8,9,10,12,14,15) such that it is possible to determine fill direction/ location by determining which electrode breaches a predetermined threshold first. This applies to systems with a plurality of electrodes in a number of orientations. Further, for systems which have analyte measurements along with physical characteristic measurement, it is also possible to achieve the same objectives by determining when each measurement (analyte measurement versus physical characteristic measurement) happens relative to the other. For test strips which can be filled from either side, the role of any electrode can change depending on the determination of fill direction. A measurement electrode can double up as a fill detect/full sufficiency electrode if it is determined that based on fill direction this electrode is now the last electrode in the chamber.
摘要翻译：允许检测样品朝向多个电极流动的方向并检测电化学测试条（100）的填充误差的方法和系统的各种实施例。这包括监视工作电极（8,9,10,12,14,15），使得可以通过确定哪个电极首先违反预定阈值来确定填充方向/位置。这适用于具有多个取向的多个电极的系统。此外，对于具有分析物测量以及物理特性测量的系统，还可以通过确定何时每次测量（分析物测量与物理特性测量）相对于另一测量发生相同的目标。对于可以从任一侧填充的测试条，任何电极的作用可以根据填充方向的确定而改变。如果确定基于填充方向，该电极现在是腔室中的最后一个电极，则测量电极可以作为填充检测/充足电极倍增。

9. 发明公开

EP3161471A1 END-FILL ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH PERPENDICULAR INTERSECTING SAMPLE-RECEIVING CHAMBERS 审中-公开
标题翻译：具有垂直相互作用样品接收室的端部充满电化学分析测试条
公开(公告)号：EP3161471A1
公开(公告)日：2017-05-03
申请号：EP15730802.4
申请日：2015-06-23
申请人： Lifescan Scotland Limited
发明人： COOPER, Alexander , SMITH, Antony , WHYTE, Lynsey , WHITEHEAD, Neil , MCCOLL, David , GUTHRIE, Brian , LLOYD, Timothy , MASSARI, Rossano , FORLANI, Christian
IPC分类号： G01N27/327
CPC分类号： G01N27/327 , B01L2300/0645 , G01N27/3272 , G01N31/164 , G01N33/0031 , G01N2030/645
摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (e.g., hematocrit) includes a sample-entry chamber with a sample-application opening disposed on an end edge of the electrochemical-based analytical test strip, and first and second sample-determination chambers, each in direct fluidic communication with the sample-entry chamber. The electrochemical-based analytical test strip also includes first and second electrodes (such as first and second hematocrit electrodes) disposed in the first sample-determination chamber, and a third and fourth electrodes (for example working and reference electrodes) disposed in the second sample-determination chamber. Moreover, the first and second sample-determination chambers intersect the sample-entry chamber perpendicular (or nearly perpendicular) to one another and the first sample-determination chamber also intersects the sample-entry chamber in an aligned manner. The test strip can also include a shield electrode disposed in the sample-entry chamber, wherein the shield electrode is in electrical communication with one of the at least third electrode and fourth electrode.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）和/或体液样品（例如血细胞比容）的特征的基于电化学的分析测试条包括样品具有设置在基于电化学的分析测试条的端部边缘上的样品施加开口的第一样品室和第二样品测定室，第一和第二样品测定室均与样品进入室直接流体连通。基于电化学的分析测试条还包括设置在第一样品确定室中的第一和第二电极（例如第一和第二血细胞比容电极）以及设置在第二样品中的第三和第四电极（例如工作和参考电极） - 测定室。此外，第一和第二样本确定室彼此垂直（或几乎垂直）与样本进入室相交，并且第一样本确定室也与样本进入室以对齐的方式相交。

10. 发明公开

EP2812444A1 ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH FILL-SPEED CONFIGURED REAGENT LAYER 有权
标题翻译：分析测试条上FÜLLGESCHWINDIGKEITSKONFIGURIERTER试剂电化学BASE
公开(公告)号：EP2812444A1
公开(公告)日：2014-12-17
申请号：EP13705233.8
申请日：2013-02-06
申请人： Lifescan Scotland Limited
发明人： WHITEHEAD, Neil , PHILLIPS, Stuart , MORRIS, David , MCILRATH, Joanne , MACLEOD, Robert , WHYTE, Lynsey , CAMPBELL, Karn , DARLING, Ramsay , MCLAREN, James , BAIN, Russell
IPC分类号： C12Q1/00
CPC分类号： C12Q1/001 , C12Q1/006
摘要： An electrochemical-based analytical test strip ("EBAT") for the determination of an analyte in a bodily fluid sample includes an electrically insulating substrate layer with a distal end and a patterned conductor layer that is disposed over the electrically-insulating substrate layer and has a working electrode ("WE") and a counter/reference electrode ("C/RE"). The EBAT also includes a patterned insulation layer with an electrode exposure window configured to expose a WE exposed portion and a C/RE exposed portion, an enzymatic reagent layer; and a patterned spacer layer. In addition, the patterned insulation layer and the patterned spacer layer define a sample receiving chamber with a sample-receiving opening at the distal end of the electrically insulating substrate layer and that extends across the WE exposed portion and the C/RE exposed portion. Furthermore, the enzymatic reagent layer is disposed over the working electrode and counter/reference electrode exposed portions and extends no more than 400µm toward the sample-receiving opening.

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