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1. 发明申请

WO2007035563A3 MALFUNCTION DETECTION VIA PRESSURE PULSATION 审中-公开
公开(公告)号：WO2007035563A3
公开(公告)日：2007-03-29
申请号：PCT/US2006/036164
申请日：2006-09-18
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , BOHM, Sebastian , ZHAO, Mingqi , ANEX, Deon
发明人： KRULEVITCH, Peter , BOHM, Sebastian , ZHAO, Mingqi , ANEX, Deon
IPC分类号： B01D57/02
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.

2. 发明申请

WO2007035564A2 MALFUNCTION DETECTION WITH DERIVATIVE CALCULATION 审中-公开
标题翻译：具有衍生计算的故障检测
公开(公告)号：WO2007035564A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036165
申请日：2006-09-18
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , BOHM, Sebastian , ZHAO, Minggi , ANEX, Deon
发明人： KRULEVITCH, Peter , BOHM, Sebastian , ZHAO, Minggi , ANEX, Deon
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Systems and methods of detecting occlusions and fluid-loss conditions (e.g., disconnects and/or leakages) in an infusion pump are discussed. For example, electrokinetic infusion pumps may develop an occlusion in the fluid flow path, which can disrupt control of fluid dispersed from the pump. As well, an infusion set disconnect can also result in a fluid-loss that can be disruptive. Such disruptions can be troublesome to systems that control the infusion pump, such as closed loop controllers. Accordingly, systems and methods described herein can be used to detect such occlusions and fluid-loss conditions during infusion pump operation. For example, a position sensor can be used to monitor fluid flow from the infusion pump, with the measurement being compared with an expected value to detect an occlusion or fluid-loss condition. Other algorithms for utilizing the position sensor are also described.
摘要翻译：讨论了检测输液泵中的闭塞和流体损失状况（例如断开和/或泄漏）的系统和方法。例如，电动输液泵可能在流体流动路径中产生闭塞，这可能破坏从泵分散的流体的控制。同样，输液器断开也可能导致流体损失，这可能是破坏性的。对于控制输液泵的系统，例如闭环控制器，这种中断可能是麻烦的。因此，本文所述的系统和方法可用于在输注泵操作期间检测这种闭塞和流体损失状况。例如，位置传感器可用于监测来自输注泵的流体流动，其中测量值与预期值进行比较以检测堵塞或流体损失状况。还描述了用于利用位置传感器的其它算法。

3. 发明申请

WO2007035658A2 INFUSION PUMPS WITH A POSITION DETECTOR 审中-公开
标题翻译：具有位置检测器的输液泵
公开(公告)号：WO2007035658A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036330
申请日：2006-09-18
申请人： LIFESCAN, INC. , ZHAO, Mingqi , KRULEVITCH, Peter
发明人： ZHAO, Mingqi , KRULEVITCH, Peter
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/1452 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/702
摘要： An infusion pump (e.g., an electrokinetic infusion pump) includes an infusion pump module and an engine that can drive a moveable piston non-mechanically. In addition, the infusion pump module includes a position detector configured for sensing a dispensing state of the infusion pump module. Such information can be utilized in a control scheme to control fluid displacement within and out of the pump. Descriptions of different types of position detectors, such as magnetic sensors (e.g., an anisotropic magnetic resistive sensor), and their implementation in detecting infusion pump fluid displacement are described.
摘要翻译：输液泵（例如，电动输液泵）包括可以非机械地驱动可移动活塞的输液泵模块和发动机。此外，输液泵模块包括位置检测器，其被配置为感测输注泵模块的分配状态。这样的信息可以用于控制方案中以控制泵内和泵外的流体位移。描述不同类型的位置检测器，例如磁传感器（例如，各向异性磁阻传感器）及其在检测输液泵流体位移中的实现。

4. 发明申请

WO2007035666A2 ELECTROKINETIC INFUSION PUMP SYSTEM 审中-公开
标题翻译：电动注入泵系统
公开(公告)号：WO2007035666A2
公开(公告)日：2007-03-29
申请号：PCT/US2006/036340
申请日：2006-09-18
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , BENETT, William , ROBERTS, Neil, E. , BOHM, Sebastian , SIEH, Zara
发明人： KRULEVITCH, Peter , BENETT, William , ROBERTS, Neil, E. , BOHM, Sebastian , SIEH, Zara
IPC分类号： A61M1/00
CPC分类号： A61M5/14244 , A61M5/14248 , A61M5/1452 , A61M5/16831 , A61M5/172 , A61M2005/14513 , A61M2205/3317 , A61M2205/3389
摘要： Various methods and devices are provided for delivering an infusion liquid using an electrokinetic infusion pump. The electrokinetic infusion pump can generally include an infusion housing having an infusion reservoir. The infusion reservoir has an infusion outlet and is capable of containing an infusion liquid. A plunger is movably coupled to the infusion housing and is adapted to be manually displaced relative to the infusion housing to load the infusion reservoir with infusion liquid. A movable partition can be disposed within the infusion housing and has a first surface in communication with an electrokinetic solution and a second surface, isolated from the first surface, in communication with the infusion reservoir. The electrokinetic infusion pump can further include an electrokinetic engine integrated within the plunger and adapted to selectively deliver electric potential across an electrokinetic porous media to cause the electrokinetic solution within the electrokinetic engine to displace the movable partition to effect delivery of at least a portion of the infusion liquid through the infusion outlet.
摘要翻译：提供了使用电动输液泵输送输液的各种方法和装置。电动输液泵通常可以包括具有输液容器的输液壳体。输液容器具有输液出口并且能够容纳输注液体。柱塞可移动地联接到输液壳体并适于相对于输液壳体手动移位以将输液储液器装载输液。可移动分隔件可以设置在输液壳体内并且具有与电动溶液连通的第一表面和与输液储存器连通的与第一表面隔开的第二表面。电动输液泵可以进一步包括集成在柱塞内的电动发动机，并且适于在电动多孔介质上选择性地递送电势，以使电动力发动机内的电动力溶液移位可动分隔物以实现至少一部分输液通过输液出口。

5. 发明申请

WO2011047298A2 PALM ACTIVATED DRUG DELIVERY DEVICE 审中-公开
标题翻译： PALM活性药物递送装置
公开(公告)号：WO2011047298A2
公开(公告)日：2011-04-21
申请号：PCT/US2010/052894
申请日：2010-10-15
申请人： CENTOCOR ORTHO BIOTECH INC. , OLSON, Lorin, P. , KRULEVITCH, Peter , GLENCROSS, James , WANG, Jingli , FOLEY, Nicholas , ZHAO, Mingqi
发明人： OLSON, Lorin, P. , KRULEVITCH, Peter , GLENCROSS, James , WANG, Jingli , FOLEY, Nicholas , ZHAO, Mingqi
IPC分类号： A61M5/32 , A61M5/20
CPC分类号： A61M5/3202 , A61M5/20 , A61M5/2033 , A61M5/2046 , A61M5/2053 , A61M5/3129 , A61M5/315 , A61M5/31511 , A61M5/3157 , A61M5/3204 , A61M5/321 , A61M5/3243 , A61M5/326 , A61M5/3287 , A61M5/50 , A61M5/5086 , A61M2005/2026 , A61M2005/208 , A61M2005/3123 , A61M2005/3125 , A61M2005/3126 , A61M2005/3247 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/584 , A61M2205/586
摘要： Disclosed is a device for the parenteral delivery of a medication, such as a drug. The device includes upper and lower housings in which the upper housing is configured to move relative to the lower housing as a result of application of an external force to permit the user of the device to control the rate at which the drug is administered.
摘要翻译：公开了一种用于肠胃外递送药物如药物的装置。该装置包括上部壳体和下部壳体，其中上部壳体被构造成由于施加外力而允许装置的使用者控制药物施用的速率而相对于下部壳体移动。 p>

6. 发明申请

WO2010009382A2 ANALYTE MEASUREMENT AND MANAGEMENT DEVICE AND ASSOCIATED METHODS 审中-公开
标题翻译：分析测量和管理设备及相关方法
公开(公告)号：WO2010009382A2
公开(公告)日：2010-01-21
申请号：PCT/US2009/050971
申请日：2009-07-17
申请人： LIFESCAN, INC. , SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARTLE, Robert
发明人： SIEH, Zara , HORWITZ, David , PRICE, David , KRULEVITCH, Peter , SAVAGE, Donna , SHARTLE, Robert
IPC分类号： A61B5/00 , G06F3/048 , H04L9/32 , G08B1/08 , G06F15/16 , G06N5/02
CPC分类号： A61B5/4839 , A61B5/14532 , G06F19/00 , G06F19/3418 , G06F19/3468 , G16H40/63
摘要： Various embodiments of a diabetes management system are provided. One exemplary system may include an analyte measurement device and a therapeutic agent delivery device. The measurement device includes a measurement unit, display, and first wireless module. The therapeutic agent delivery device has a delivery device housing, delivery mechanism disposed in the housing that delivers a dosage of the agent to the user upon actuation by the user or health care provider, and a second wireless module. The second module, automatically, without prompting from a user or any active input or action by the user, transmits a signal to the first wireless module indicative of: (a) type of therapeutic agent delivered; and (b) amount of therapeutic agent delivered to the user; or (c) type of therapeutic agent device from which the therapeutic agent was administered. Also described are diabetes management devices and methods.
摘要翻译：提供了糖尿病管理系统的各种实施例。一个示例性系统可以包括分析物测量装置和治疗剂递送装置。测量装置包括测量单元，显示器和第一无线模块。治疗剂递送装置具有输送装置壳体，设置在壳体中的输送机构，其在用户或医疗保健提供者致动时将剂量的剂量递送给使用者，以及第二无线模块。自动地，第二模块在不提示用户或用户的任何有效输入或动作的情况下，向第一无线模块发送指示：（a）递送的治疗剂的类型; 和（b）递送给使用者的治疗剂量; 或（c）施用治疗剂的治疗剂装置的类型。还描述了糖尿病管理装置和方法。

7. 发明申请

WO2010098931A1 DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS 审中-公开
标题翻译：药物递送管理系统和方法
公开(公告)号：WO2010098931A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022245
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SIEH, Zara , ZHAO, Mitch
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SIEH, Zara , ZHAO, Mitch
IPC分类号： A61M5/00
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a "smart" drug delivery pen are provided which include a drug delivery pen having an inertial sensor or accelerometer. A system is also provided that includes the smart drug pen in conjunction with a data management unit(s) DMU. Various exemplary methods for use of the pens and systems are also described and illustrated.
摘要翻译：提供了一种“智能”药物递送笔的各种实施例，其包括具有惯性传感器或加速度计的药物输送笔。还提供了一种系统，其包括结合数据管理单元DMU的智能药笔。还描述和示出了用于笔和系统的各种示例性方法。

8. 发明申请

WO2010098928A1 DRUG DELIVERY SYSTEM 审中-公开
标题翻译：药物递送系统
公开(公告)号：WO2010098928A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022241
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara
IPC分类号： A61M5/315
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a "smart" drug delivery system are provided which includes an add-on module and a reusable or disposable drug pen. Upon attachment to the pen, the add-on module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reusage of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module.
摘要翻译：提供了“智能”药物递送系统的各种实施例，其包括附加模块和可重复使用或一次性药物笔。附加模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，笔是否被引发或摇动以充分混合胰岛素混合物，传输与胰岛素相关的信息剂量和注射到数据管理单元，提供提醒，错误警告或关于不正确使用或重复使用针头的信息，轨道上留下的药物量或笔的使用持续时间，以及在药物到期时的使用时间，或提供用于定位放错的笔和模块的声音报警器。

9. 发明申请

WO2008157212A1 FLEXIBLE CANNULA OR MEDICAL DEVICE CONDUIT 审中-公开
标题翻译：柔性肛门或医疗器械导管
公开(公告)号：WO2008157212A1
公开(公告)日：2008-12-24
申请号：PCT/US2008/066667
申请日：2008-06-12
申请人： LIFESCAN, INC. , CORDIS CORPORATION , KRULEVITCH, Peter , OLSON, Lorin, P. , SIEH, Zara , SAVAGE, Donna , CICHOCKI, Frank, R.
发明人： KRULEVITCH, Peter , OLSON, Lorin, P. , SIEH, Zara , SAVAGE, Donna , CICHOCKI, Frank, R.
IPC分类号： A61M5/158 , A61M5/32 , A61M25/00
CPC分类号： A61M5/158 , A61M5/3275 , A61M5/329 , A61M25/0009 , A61M25/0068 , A61M25/007 , A61M2005/1585 , A61M2005/1587 , A61M2205/0266
摘要： A flexible cannula of medical device conduit (1300) includes an elongated framework (1302) formed from a flexible material (e.g., Nitinol) with a body portion, sharp head (1310), distal end ans proximal end. The flexible medical device conduit also includes a flexible tube (1314) at least partially jacketing the elongated framework between the distal end and the proximal end. Moreover, the sharp head is disposed at the distal end and is configured for subcutaneous skin insertion and the elongated framework and flexible tube define at least one conduit (1315) between the elongated framework and the flexible tube, the conduit having an opening at the distal end.
摘要翻译：医疗器械导管（1300）的柔性套管包括由柔性材料（例如镍钛诺）形成的细长骨架（1302），其具有主体部分，尖头（1310），远端和近端。柔性医疗装置导管还包括柔性管（1314），该柔性管至少部分地将细长骨架夹在远端和近端之间。此外，尖头设置在远端并且构造成用于皮下皮肤插入，并且细长骨架和柔性管限定细长框架和柔性管之间的至少一个导管（1315），所述导管在远端处具有开口结束。

10. 发明申请

WO2010098929A1 DRUG DELIVERY MANAGEMENT SYSTEMS AND METHODS 审中-公开
标题翻译：药物递送管理系统和方法
公开(公告)号：WO2010098929A1
公开(公告)日：2010-09-02
申请号：PCT/US2010/022242
申请日：2010-01-27
申请人： LIFESCAN, INC. , KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara , PRICE, David, M., D.
发明人： KRULEVITCH, Peter , WILK, Robert , KRAFT, Ulrich , SAVAGE, Donna , FOLEY, Nick , GLENCROSS, James , SHEPHERD, David , SIEH, Zara , PRICE, David, M., D.
IPC分类号： A61B5/00 , A61K38/28
CPC分类号： A61M5/315 , A61B5/002 , A61B5/14532 , A61M5/24 , A61M5/3129 , A61M5/3146 , A61M5/31525 , A61M5/31551 , A61M2005/3126 , A61M2005/3142 , A61M2205/14 , A61M2205/18 , A61M2205/215 , A61M2205/3317 , A61M2205/3553 , A61M2205/3561 , A61M2205/3569 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/584 , A61M2205/6054 , A61M2205/6081 , A61M2205/8212 , A61M2209/04 , G01D5/1655 , G06F19/00 , G06F19/3468
摘要： Various embodiments of a "smart" drug delivery system are provided which includes an add-on module and a reusable or disposable drug pen in conjunction with a data management unit(s) DMU. Upon attachment to the pen, the add-on module may: determine dosage selected, injection of selected dosage, duration of injection, time of injection, whether the pen has been primed or shaken to thoroughly mix up insulin mixtures, transmit information relating to insulin dosage and injection to a data management unit, provide reminders, error warning or messages on improper usage or reusage of needles, track amount of drug remaining on board the pen or duration of usage of pen with respect to expiry of the drug on board, or provide an audible alarm for locating misplaced pen and module. Methods of using the drug delivery system are also described.
摘要翻译：提供了“智能”药物递送系统的各种实施例，其包括与数据管理单元DMU结合的附加模块和可重复使用或一次性药物笔。附加模块可以：确定所选择的剂量，所选剂量的注射，注射持续时间，注射时间，笔是否被引发或摇动以充分混合胰岛素混合物，传输与胰岛素相关的信息剂量和注射到数据管理单元，提供提醒，错误警告或关于不正确使用或重复使用针头的信息，轨道上留下的药物量或笔的使用持续时间，以及在药物到期时的使用时间，或提供用于定位放错的笔和模块的声音报警器。还描述了使用药物递送系统的方法。

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